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Aliases for TMEM190 Gene

Aliases for TMEM190 Gene

  • Transmembrane Protein 190 2 3 5
  • MDAC1 3 4

External Ids for TMEM190 Gene

Previous GeneCards Identifiers for TMEM190 Gene

  • GC19P060581
  • GC19P055888
  • GC19P052210

Summaries for TMEM190 Gene

GeneCards Summary for TMEM190 Gene

TMEM190 (Transmembrane Protein 190) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include protein self-association.

Additional gene information for TMEM190 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM190 Gene

Genomics for TMEM190 Gene

GeneHancer (GH) Regulatory Elements for TMEM190 Gene

Promoters and enhancers for TMEM190 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I055371 Promoter/Enhancer 1.8 EPDnew FANTOM5 Ensembl ENCODE 566 -1.4 -1435 7.1 FOXA2 SIN3A ZNF48 GLIS2 ATF7 FOS SP5 REST SMARCB1 GLIS1 TMEM190 RPL28 FAM71E2 EPS8L1 ZNF628 IL11 ENSG00000269275
GH19I055337 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 12.5 -37.0 -37008 4 CLOCK MLX FEZF1 DMAP1 YY1 E2F8 ZNF143 ZNF548 SP3 NFYC KMT5C ENSG00000276831 LENG8-AS1 U2AF2 LENG8 ZNF628 ENSG00000235681 ENSG00000267523 ENSG00000267096 FAM71E2
GH19I055368 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE 14.5 -6.8 -6846 2.9 PKNOX1 SIN3A GLI4 ZNF48 ZNF121 GLIS2 SP3 NFYC REST SMARCB1 IL11 TMEM190 RPL28 COX6B2 NAT14 ZNF579 FAM71E2
GH19I055320 Promoter/Enhancer 1.8 EPDnew FANTOM5 Ensembl ENCODE 11.6 -53.5 -53510 5.7 BACH1 ZNF384 CEBPG E4F1 ZNF316 POLR2A SCRT2 NFE2 MAFK CREM TMEM150B FCAR FAM71E2 IL11 TMEM190 HSPBP1 BRSK1 PPP6R1 RPL28 TMEM238
GH19I055300 Promoter/Enhancer 1.4 Ensembl ENCODE 11.6 -75.0 -74989 2 SIN3A ZBTB7B POLR2B GLIS2 ZNF207 ZNF143 ATF7 RUNX3 KLF13 SP3 TMEM86B TMEM150B KMT5C HSPBP1 PPP6R1 RPL28 TMEM238 UBE2S TMEM190 ZNF628
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TMEM190 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TMEM190 gene promoter:

Genomic Locations for TMEM190 Gene

Genomic Locations for TMEM190 Gene
chr19:55,376,836-55,378,244
(GRCh38/hg38)
Size:
1,409 bases
Orientation:
Plus strand
chr19:55,888,204-55,889,612
(GRCh37/hg19)

Genomic View for TMEM190 Gene

Genes around TMEM190 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM190 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM190 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM190 Gene

Proteins for TMEM190 Gene

  • Protein details for TMEM190 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WZ59-TM190_HUMAN
    Recommended name:
    Transmembrane protein 190
    Protein Accession:
    Q8WZ59
    Secondary Accessions:
    • A6NJL5

    Protein attributes for TMEM190 Gene

    Size:
    177 amino acids
    Molecular mass:
    19457 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM190 Gene

Post-translational modifications for TMEM190 Gene

No Post-translational modifications

Other Protein References for TMEM190 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM190 Gene

Domains & Families for TMEM190 Gene

Gene Families for TMEM190 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TMEM190 Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM190 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM190: view

No data available for UniProtKB/Swiss-Prot for TMEM190 Gene

Function for TMEM190 Gene

Phenotypes From GWAS Catalog for TMEM190 Gene

Gene Ontology (GO) - Molecular Function for TMEM190 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0043621 protein self-association IEA --
genes like me logo Genes that share ontologies with TMEM190: view
genes like me logo Genes that share phenotypes with TMEM190: view

Animal Models for TMEM190 Gene

MGI Knock Outs for TMEM190:

Animal Model Products

CRISPR Products

miRNA for TMEM190 Gene

miRTarBase miRNAs that target TMEM190

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TMEM190 Gene

Localization for TMEM190 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM190 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM190 gene
Compartment Confidence
nucleus 5
extracellular 3
plasma membrane 2

Gene Ontology (GO) - Cellular Components for TMEM190 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002079 inner acrosomal membrane IEA --
GO:0005634 nucleus HDA,IDA 21630459
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM190: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TMEM190 Gene

Pathways & Interactions for TMEM190 Gene

SuperPathways for TMEM190 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMEM190 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002244 hematopoietic progenitor cell differentiation IEA --
genes like me logo Genes that share ontologies with TMEM190: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM190 Gene

Drugs & Compounds for TMEM190 Gene

No Compound Related Data Available

Transcripts for TMEM190 Gene

mRNA/cDNA for TMEM190 Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMEM190 Gene

Transmembrane protein 190:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM190 Gene

No ASD Table

Relevant External Links for TMEM190 Gene

GeneLoc Exon Structure for
TMEM190
ECgene alternative splicing isoforms for
TMEM190

Expression for TMEM190 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM190 Gene

mRNA differential expression in normal tissues according to GTEx for TMEM190 Gene

This gene is overexpressed in Testis (x20.3), Fallopian Tube (x10.1), Cervix - Endocervix (x7.1), and Lung (x5.4).

Protein differential expression in normal tissues from HIPED for TMEM190 Gene

This gene is overexpressed in Testis (54.7) and Ovary (14.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TMEM190 Gene



Protein tissue co-expression partners for TMEM190 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TMEM190 Gene:

TMEM190

SOURCE GeneReport for Unigene cluster for TMEM190 Gene:

Hs.590943
genes like me logo Genes that share expression patterns with TMEM190: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM190 Gene

Orthologs for TMEM190 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TMEM190 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM190 33 34
  • 99.44 (n)
cow
(Bos Taurus)
Mammalia TMEM190 33 34
  • 81.02 (n)
dog
(Canis familiaris)
Mammalia TMEM190 33 34
  • 80.59 (n)
mouse
(Mus musculus)
Mammalia Tmem190 33 16 34
  • 75.41 (n)
rat
(Rattus norvegicus)
Mammalia Tmem190 33
  • 74.66 (n)
oppossum
(Monodelphis domestica)
Mammalia TMEM190 34
  • 43 (a)
OneToOne
Species where no ortholog for TMEM190 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TMEM190 Gene

ENSEMBL:
Gene Tree for TMEM190 (if available)
TreeFam:
Gene Tree for TMEM190 (if available)

Paralogs for TMEM190 Gene

No data available for Paralogs for TMEM190 Gene

Variants for TMEM190 Gene

Sequence variations from dbSNP and Humsavar for TMEM190 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000124409 -- 55,377,627(+) T/C coding_sequence_variant, intron_variant, synonymous_variant
rs1000407479 -- 55,377,279(+) G/A intron_variant
rs1000945858 -- 55,376,800(+) T/G 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1001754667 -- 55,375,685(+) G/A upstream_transcript_variant
rs1001799612 -- 55,378,462(+) G/A downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM190 Gene

Variant ID Type Subtype PubMed ID
nsv953624 CNV deletion 24416366
nsv516199 CNV loss 19592680
nsv470162 CNV loss 18288195
esv2718966 CNV deletion 23290073
esv2718965 CNV deletion 23290073

Variation tolerance for TMEM190 Gene

Residual Variation Intolerance Score: 69.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.74; 15.58% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM190 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM190

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM190 Gene

Disorders for TMEM190 Gene

Additional Disease Information for TMEM190

No disorders were found for TMEM190 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM190 Gene

Publications for TMEM190 Gene

  1. Characterization of mouse sperm TMEM190, a small transmembrane protein with the trefoil domain: evidence for co-localization with IZUMO1 and complex formation with other sperm proteins. (PMID: 21273369) Nishimura H … Primakoff P (Reproduction (Cambridge, England) 2011) 2 3 58
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58
  3. Proteomic characterization of the human sperm nucleus. (PMID: 21630459) de Mateo S … Oliva R (Proteomics 2011) 3 58
  4. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58

Products for TMEM190 Gene

Sources for TMEM190 Gene

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