Aliases for TMEM19 Gene

Aliases for TMEM19 Gene

  • Transmembrane Protein 19 2 3 4 5
  • FLJ10936 2
  • TMEM19 5

External Ids for TMEM19 Gene

Previous GeneCards Identifiers for TMEM19 Gene

  • GC12P070367
  • GC12P070368
  • GC12P072079
  • GC12P069128

Summaries for TMEM19 Gene

GeneCards Summary for TMEM19 Gene

TMEM19 (Transmembrane Protein 19) is a Protein Coding gene. Diseases associated with TMEM19 include Marantic Endocarditis.

Additional gene information for TMEM19 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TMEM19 Gene

Genomics for TMEM19 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TMEM19 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TMEM19 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TMEM19

Top Transcription factor binding sites by QIAGEN in the TMEM19 gene promoter:
  • AML1a
  • Nkx3-1
  • Nkx3-1 v1
  • Nkx3-1 v2
  • Nkx3-1 v3
  • Nkx3-1 v4
  • SRF
  • SRF (504 AA)
  • TBP
  • TFIID

Genomic Locations for TMEM19 Gene

Genomic Locations for TMEM19 Gene
chr12:71,686,082-71,705,047
(GRCh38/hg38)
Size:
18,966 bases
Orientation:
Plus strand
chr12:72,079,867-72,097,840
(GRCh37/hg19)
Size:
17,974 bases
Orientation:
Plus strand

Genomic View for TMEM19 Gene

Genes around TMEM19 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM19 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM19 Gene

Proteins for TMEM19 Gene

  • Protein details for TMEM19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96HH6-TMM19_HUMAN
    Recommended name:
    Transmembrane protein 19
    Protein Accession:
    Q96HH6
    Secondary Accessions:
    • B2RDL2
    • Q53FY3
    • Q9NV41

    Protein attributes for TMEM19 Gene

    Size:
    336 amino acids
    Molecular mass:
    36392 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM19 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM19 Gene

Post-translational modifications for TMEM19 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM19 Gene

No data available for DME Specific Peptides for TMEM19 Gene

Domains & Families for TMEM19 Gene

Gene Families for TMEM19 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TMEM19 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM19 Gene

GenScript: Design optimal peptide antigens:
  • Transmembrane protein 19 (TMM19_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96HH6

UniProtKB/Swiss-Prot:

TMM19_HUMAN :
  • Belongs to the TMEM19 family.
Family:
  • Belongs to the TMEM19 family.
genes like me logo Genes that share domains with TMEM19: view

Function for TMEM19 Gene

Phenotypes From GWAS Catalog for TMEM19 Gene

Gene Ontology (GO) - Molecular Function for TMEM19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with TMEM19: view
genes like me logo Genes that share phenotypes with TMEM19: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TMEM19

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMEM19

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM19 Gene

Localization for TMEM19 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM19 Gene

Membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM19 gene
Compartment Confidence
plasma membrane 3
nucleus 1
endoplasmic reticulum 0

Gene Ontology (GO) - Cellular Components for TMEM19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA,IBA 21873635
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM19: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TMEM19 Gene

Pathways & Interactions for TMEM19 Gene

PathCards logo

SuperPathways for TMEM19 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMEM19 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM19 Gene

Drugs & Compounds for TMEM19 Gene

No Compound Related Data Available

Transcripts for TMEM19 Gene

mRNA/cDNA for TMEM19 Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMEM19

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM19 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8
SP1: -
SP2:
SP3: -

Relevant External Links for TMEM19 Gene

GeneLoc Exon Structure for
TMEM19

Expression for TMEM19 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TMEM19 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Liver (Hepatobiliary System)

Protein differential expression in normal tissues from HIPED for TMEM19 Gene

This gene is overexpressed in Retina (19.0), Lung (13.9), and Blymphocyte (13.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMEM19 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TMEM19

SOURCE GeneReport for Unigene cluster for TMEM19 Gene:

Hs.644802

Evidence on tissue expression from TISSUES for TMEM19 Gene

  • Nervous system(4.4)
  • Lung(4.2)
genes like me logo Genes that share expression patterns with TMEM19: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM19 Gene

Orthologs for TMEM19 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TMEM19 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TMEM19 30 31
  • 99.6 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia TMEM19 30 31
  • 90 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia TMEM19 30 31
  • 88.26 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Tmem19 30
  • 86.56 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 86 (a)
OneToMany
-- 31
  • 82 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Tmem19 30 17 31
  • 83.98 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia TMEM19 31
  • 77 (a)
OneToOne
Chicken
(Gallus gallus)
Aves TMEM19 30 31
  • 72.24 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia TMEM19 31
  • 65 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia tmem19 30
  • 73.13 (n)
Str.11046 30
Zebrafish
(Danio rerio)
Actinopterygii tmem19 30 31
  • 64.69 (n)
OneToOne
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13441 30
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012271 30
  • 53.8 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta CG10171 30 31
  • 51.22 (n)
OneToOne
Thale Cress
(Arabidopsis thaliana)
eudicotyledons AT5G19930 30
  • 48.74 (n)
Rice
(Oryza sativa)
Liliopsida Os01g0507300 30
  • 44.32 (n)
Species where no ortholog for TMEM19 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for TMEM19 Gene

ENSEMBL:
Gene Tree for TMEM19 (if available)
TreeFam:
Gene Tree for TMEM19 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TMEM19: view image

Paralogs for TMEM19 Gene

No data available for Paralogs for TMEM19 Gene

Variants for TMEM19 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TMEM19 Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
723352 Benign: not provided 71,696,504(+) T/A MISSENSE_VARIANT
785420 Benign: not provided 71,700,847(+) C/G MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for TMEM19 Gene

Structural Variations from Database of Genomic Variants (DGV) for TMEM19 Gene

Variant ID Type Subtype PubMed ID
nsv472483 CNV novel sequence insertion 20440878
nsv524634 CNV loss 19592680
nsv832451 CNV loss 17160897

Variation tolerance for TMEM19 Gene

Residual Variation Intolerance Score: 66.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.45; 54.84% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM19 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM19

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM19 Gene

Disorders for TMEM19 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TMEM19 Gene - From: DISEASES

Disorder Aliases PubMed IDs
marantic endocarditis
  • non-bacterial thrombotic endocarditis
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with TMEM19: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TMEM19 Gene

Publications for TMEM19 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3
  3. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  4. Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations. (PMID: 31515488) Fragoza R … Yu H (Nature communications 2019) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3

Products for TMEM19 Gene

Sources for TMEM19 Gene