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Aliases for TMEM19 Gene

Aliases for TMEM19 Gene

  • Transmembrane Protein 19 2 3 4 5

External Ids for TMEM19 Gene

Previous GeneCards Identifiers for TMEM19 Gene

  • GC12P070367
  • GC12P070368
  • GC12P072079
  • GC12P069128

Summaries for TMEM19 Gene

GeneCards Summary for TMEM19 Gene

TMEM19 (Transmembrane Protein 19) is a Protein Coding gene.

Additional gene information for TMEM19 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM19 Gene

Genomics for TMEM19 Gene

GeneHancer (GH) Regulatory Elements for TMEM19 Gene

Promoters and enhancers for TMEM19 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J071683 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 600.7 +0.6 630 6.1 SP1 CC2D1A ELF3 ZFX MNT CBFA2T2 NKRF POLR2A MLLT1 ZNF384 TMEM19 ZFC3H1 ENSG00000257515 ENSG00000258064
GH12J071661 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.8 -22.6 -22572 5.4 SP1 CC2D1A ZFX ELF3 SIX5 CBFA2T2 ZNF148 NKRF MLLT1 ZNF121 THAP2 ZFC3H1 TMEM19 ENSG00000257515 ENSG00000212461
GH12J071731 Enhancer 1.1 FANTOM5 Ensembl ENCODE 11.8 +45.5 45549 1.7 CC2D1A ELF3 CTCF AHR EGR1 KAT8 CAVIN1 IKZF1 ZNF600 ZNF585B TMEM19 ZFC3H1 ENSG00000257515 RAB21
GH12J071709 Enhancer 0.8 Ensembl ENCODE 12.2 +24.1 24114 2.4 SMARCC1 CEBPB JUN SP1 JUND MAX MXI1 FOS EP300 FOSL1 ENSG00000257515 TMEM19 ZFC3H1
GH12J071753 Enhancer 0.9 FANTOM5 11.4 +67.0 67045 0.1 CC2D1A CBFA2T2 TRIM24 SMARCA4 MTA1 GMEB1 DPF2 IKZF1 LEF1 HDAC1 RAB21 TMEM19 THAP2 ZFC3H1 ENSG00000212461 ENSG00000257515
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TMEM19 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TMEM19 gene promoter:
  • AML1a
  • Nkx3-1
  • Nkx3-1 v1
  • Nkx3-1 v2
  • Nkx3-1 v3
  • Nkx3-1 v4
  • SRF
  • SRF (504 AA)
  • TBP
  • TFIID

Genomic Locations for TMEM19 Gene

Genomic Locations for TMEM19 Gene
chr12:71,686,087-71,705,046
(GRCh38/hg38)
Size:
18,960 bases
Orientation:
Plus strand
chr12:72,079,867-72,097,840
(GRCh37/hg19)
Size:
17,974 bases
Orientation:
Plus strand

Genomic View for TMEM19 Gene

Genes around TMEM19 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM19 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM19 Gene

Proteins for TMEM19 Gene

  • Protein details for TMEM19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96HH6-TMM19_HUMAN
    Recommended name:
    Transmembrane protein 19
    Protein Accession:
    Q96HH6
    Secondary Accessions:
    • B2RDL2
    • Q53FY3
    • Q9NV41

    Protein attributes for TMEM19 Gene

    Size:
    336 amino acids
    Molecular mass:
    36392 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM19 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM19 Gene

Post-translational modifications for TMEM19 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM19 Gene

No data available for DME Specific Peptides for TMEM19 Gene

Domains & Families for TMEM19 Gene

Gene Families for TMEM19 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TMEM19 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM19 Gene

GenScript: Design optimal peptide antigens:
  • Transmembrane protein 19 (TMM19_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96HH6

UniProtKB/Swiss-Prot:

TMM19_HUMAN :
  • Belongs to the TMEM19 family.
Family:
  • Belongs to the TMEM19 family.
genes like me logo Genes that share domains with TMEM19: view

Function for TMEM19 Gene

Phenotypes From GWAS Catalog for TMEM19 Gene

Gene Ontology (GO) - Molecular Function for TMEM19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with TMEM19: view
genes like me logo Genes that share phenotypes with TMEM19: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TMEM19

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMEM19

Clone Products

  • Applied Biological Materials (abm): Clones for TMEM19 - Now 50% OFF >
  • * TMEM19 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * TMEM19 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM19 Gene

Localization for TMEM19 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM19 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM19 gene
Compartment Confidence
plasma membrane 3
endoplasmic reticulum 0

Gene Ontology (GO) - Cellular Components for TMEM19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA,IBA 21873635
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM19: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TMEM19 Gene

Pathways & Interactions for TMEM19 Gene

PathCards logo

SuperPathways for TMEM19 Gene

No Data Available

Interacting Proteins for TMEM19 Gene

Gene Ontology (GO) - Biological Process for TMEM19 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM19 Gene

Drugs & Compounds for TMEM19 Gene

No Compound Related Data Available

Transcripts for TMEM19 Gene

mRNA/cDNA for TMEM19 Gene

Unigene Clusters for TMEM19 Gene

Transmembrane protein 19:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMEM19

Clone Products

  • Applied Biological Materials (abm): Clones for TMEM19 - Now 50% OFF >
  • * TMEM19 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * TMEM19 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM19 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8
SP1: -
SP2:
SP3: -

Relevant External Links for TMEM19 Gene

GeneLoc Exon Structure for
TMEM19
ECgene alternative splicing isoforms for
TMEM19

Expression for TMEM19 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM19 Gene

Protein differential expression in normal tissues from HIPED for TMEM19 Gene

This gene is overexpressed in Retina (19.0), Lung (13.9), and Blymphocyte (13.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMEM19 Gene



NURSA nuclear receptor signaling pathways regulating expression of TMEM19 Gene:

TMEM19

SOURCE GeneReport for Unigene cluster for TMEM19 Gene:

Hs.644802

Evidence on tissue expression from TISSUES for TMEM19 Gene

  • Lung(4.2)
  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with TMEM19: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM19 Gene

Orthologs for TMEM19 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TMEM19 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM19 34 35
  • 99.6 (n)
dog
(Canis familiaris)
Mammalia TMEM19 35 34
  • 90 (n)
OneToOne
cow
(Bos Taurus)
Mammalia TMEM19 35 34
  • 88.26 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem19 34
  • 86.56 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 86 (a)
OneToMany
-- 35
  • 82 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Tmem19 35 34 17
  • 83.98 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMEM19 35
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM19 35 34
  • 72.24 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM19 35
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem19 34
  • 73.13 (n)
Str.11046 34
zebrafish
(Danio rerio)
Actinopterygii tmem19 34 35
  • 64.69 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13441 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012271 34
  • 53.8 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG10171 34 35
  • 51.22 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G19930 34
  • 48.74 (n)
rice
(Oryza sativa)
Liliopsida Os01g0507300 34
  • 44.32 (n)
Species where no ortholog for TMEM19 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM19 Gene

ENSEMBL:
Gene Tree for TMEM19 (if available)
TreeFam:
Gene Tree for TMEM19 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TMEM19: view image

Paralogs for TMEM19 Gene

No data available for Paralogs for TMEM19 Gene

Variants for TMEM19 Gene

Sequence variations from dbSNP and Humsavar for TMEM19 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000005058 -- 71,690,431(+) G/A intron_variant
rs1000114555 -- 71,696,988(+) C/T intron_variant
rs1000250792 -- 71,696,791(+) C/T intron_variant
rs1000267475 -- 71,703,249(+) A/C 3_prime_UTR_variant
rs1000464337 -- 71,695,660(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM19 Gene

Variant ID Type Subtype PubMed ID
nsv472483 CNV novel sequence insertion 20440878
nsv524634 CNV loss 19592680
nsv832451 CNV loss 17160897

Variation tolerance for TMEM19 Gene

Residual Variation Intolerance Score: 66.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.45; 54.84% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM19 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM19

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM19 Gene

Disorders for TMEM19 Gene

Additional Disease Information for TMEM19

No disorders were found for TMEM19 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM19 Gene

Publications for TMEM19 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58
  4. Next-generation sequencing to generate interactome datasets. (PMID: 21516116) Yu H … Vidal M (Nature methods 2011) 3 58
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 58

Products for TMEM19 Gene

Sources for TMEM19 Gene

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