The TMEM189-UEV mRNA is an infrequent but naturally occurring read-through transcript of the neighboring TMEM189 and UBE2V1 genes. Ubiquitin-conjugating E2 enzyme variant proteins constitute a distinct subfamily within the E2 protein family. They have sequence similarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that is critical for the cata... See more...

Aliases for TMEM189-UBE2V1 Gene

Aliases for TMEM189-UBE2V1 Gene

  • TMEM189-UBE2V1 Readthrough 2 3 5 13
  • Transmembrane Protein 189-Ubiquitin-Conjugating Enzyme E2 Variant 1 Read-Through 3
  • TMEM189-UBE2V1 Readthrough Transcript 3
  • TMEM189-UBE2V1 Fusion Protein 3
  • HCG2044781 13
  • CROC-1B 3
  • KUA-UEV 3
  • CROC1B 3

External Ids for TMEM189-UBE2V1 Gene

Previous GeneCards Identifiers for TMEM189-UBE2V1 Gene

  • GC20M048133
  • GC20M048697
  • GC20M045446

Summaries for TMEM189-UBE2V1 Gene

Entrez Gene Summary for TMEM189-UBE2V1 Gene

  • The TMEM189-UEV mRNA is an infrequent but naturally occurring read-through transcript of the neighboring TMEM189 and UBE2V1 genes. Ubiquitin-conjugating E2 enzyme variant proteins constitute a distinct subfamily within the E2 protein family. They have sequence similarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that is critical for the catalytic activity of E2s. The protein produced by this transcript has UEV1 B domains but the protein is localized to the cytoplasm rather than to the nucleus. The significance of this read-through mRNA and the function of its protein product has not yet been determined. [provided by RefSeq, Oct 2010]

GeneCards Summary for TMEM189-UBE2V1 Gene

TMEM189-UBE2V1 (TMEM189-UBE2V1 Readthrough) is a Protein Coding gene. Among its related pathways are IL-1 signaling pathway. Gene Ontology (GO) annotations related to this gene include acid-amino acid ligase activity. An important paralog of this gene is TMEM189.

Gene Wiki entry for TMEM189-UBE2V1 Gene

Additional gene information for TMEM189-UBE2V1 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TMEM189-UBE2V1 Gene

Genomics for TMEM189-UBE2V1 Gene

GeneHancer (GH) Regulatory Elements for TMEM189-UBE2V1 Gene

Promoters and enhancers for TMEM189-UBE2V1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TMEM189-UBE2V1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TMEM189-UBE2V1

Top Transcription factor binding sites by QIAGEN in the TMEM189-UBE2V1 gene promoter:
  • c-Myb
  • E47
  • ITF-2
  • NF-kappaB1
  • SEF-1 (1)
  • Tal-1beta
  • ZID

Genomic Locations for TMEM189-UBE2V1 Gene

Genomic Locations for TMEM189-UBE2V1 Gene
chr20:50,081,124-50,153,798
(GRCh38/hg38)
Size:
72,675 bases
Orientation:
Minus strand
chr20:48,697,661-48,770,335
(GRCh37/hg19)
Size:
72,675 bases
Orientation:
Minus strand

Genomic View for TMEM189-UBE2V1 Gene

Genes around TMEM189-UBE2V1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM189-UBE2V1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM189-UBE2V1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM189-UBE2V1 Gene

Proteins for TMEM189-UBE2V1 Gene

  • Protein details for TMEM189-UBE2V1 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    I3L0A0-I3L0A0_HUMAN
    Recommended name:
    HCG2044781
    Protein Accession:
    I3L0A0

    Protein attributes for TMEM189-UBE2V1 Gene

    Size:
    370 amino acids
    Molecular mass:
    42209 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM189-UBE2V1 Gene

Protein Expression for TMEM189-UBE2V1 Gene

Post-translational modifications for TMEM189-UBE2V1 Gene

No Post-translational modifications

Other Protein References for TMEM189-UBE2V1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM189-UBE2V1 Gene

Domains & Families for TMEM189-UBE2V1 Gene

Gene Families for TMEM189-UBE2V1 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TMEM189-UBE2V1 Gene

genes like me logo Genes that share domains with TMEM189-UBE2V1: view

No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for TMEM189-UBE2V1 Gene

Function for TMEM189-UBE2V1 Gene

Phenotypes From GWAS Catalog for TMEM189-UBE2V1 Gene

Gene Ontology (GO) - Molecular Function for TMEM189-UBE2V1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0061631 ubiquitin conjugating enzyme activity IBA --
genes like me logo Genes that share ontologies with TMEM189-UBE2V1: view
genes like me logo Genes that share phenotypes with TMEM189-UBE2V1: view

miRNA for TMEM189-UBE2V1 Gene

miRTarBase miRNAs that target TMEM189-UBE2V1

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM189-UBE2V1 Gene

Localization for TMEM189-UBE2V1 Gene

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TMEM189-UBE2V1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM189-UBE2V1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for TMEM189-UBE2V1 Gene

Pathways & Interactions for TMEM189-UBE2V1 Gene

PathCards logo

SuperPathways for TMEM189-UBE2V1 Gene

SuperPathway Contained pathways
1 IL-1 signaling pathway
genes like me logo Genes that share pathways with TMEM189-UBE2V1: view

Pathways by source for TMEM189-UBE2V1 Gene

1 BioSystems pathway for TMEM189-UBE2V1 Gene

Interacting Proteins for TMEM189-UBE2V1 Gene

;

Gene Ontology (GO) - Biological Process for TMEM189-UBE2V1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006301 postreplication repair IBA --
GO:0070534 protein K63-linked ubiquitination IBA --
genes like me logo Genes that share ontologies with TMEM189-UBE2V1: view

No data available for SIGNOR curated interactions for TMEM189-UBE2V1 Gene

Drugs & Compounds for TMEM189-UBE2V1 Gene

No Compound Related Data Available

Transcripts for TMEM189-UBE2V1 Gene

mRNA/cDNA for TMEM189-UBE2V1 Gene

2 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM189-UBE2V1 Gene

No ASD Table

Relevant External Links for TMEM189-UBE2V1 Gene

GeneLoc Exon Structure for
TMEM189-UBE2V1

Expression for TMEM189-UBE2V1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TMEM189-UBE2V1 Gene

Protein differential expression in normal tissues from HIPED for TMEM189-UBE2V1 Gene

This gene is overexpressed in Heart (38.6), Skin (20.4), and Brain (10.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from MOPED for TMEM189-UBE2V1 Gene



Protein tissue co-expression partners for TMEM189-UBE2V1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TMEM189-UBE2V1

genes like me logo Genes that share expression patterns with TMEM189-UBE2V1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM189-UBE2V1 Gene

Orthologs for TMEM189-UBE2V1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TMEM189-UBE2V1 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Gm20431 31
  • 92 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia TMEM189 31
  • 88 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 31
  • 83 (a)
OneToMany
cow
(Bos Taurus)
Mammalia TMEM189 31
  • 82 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia TMEM189 31
  • 66 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM189 31
  • 63 (a)
OneToMany
chicken
(Gallus gallus)
Aves TMEM189 31
  • 70 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 51 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii tmem189 31
  • 60 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Kua 31
  • 43 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y53C10A.5 31
  • 37 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons MMZ1 30
  • 56.3 (n)
rice
(Oryza sativa)
Liliopsida Os03g0712300 30
  • 55.47 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 47 (a)
OneToMany
Species where no ortholog for TMEM189-UBE2V1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TMEM189-UBE2V1 Gene

ENSEMBL:
Gene Tree for TMEM189-UBE2V1 (if available)
TreeFam:
Gene Tree for TMEM189-UBE2V1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TMEM189-UBE2V1: view image

Paralogs for TMEM189-UBE2V1 Gene

genes like me logo Genes that share paralogs with TMEM189-UBE2V1: view

Variants for TMEM189-UBE2V1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TMEM189-UBE2V1 Gene

SNP ID Clinical significance and condition Chr 20 pos Variation AA Info Type
747277 Benign: not provided 50,082,792(-) G/A NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for TMEM189-UBE2V1 Gene

Structural Variations from Database of Genomic Variants (DGV) for TMEM189-UBE2V1 Gene

Variant ID Type Subtype PubMed ID
esv34129 CNV loss 18971310
esv3646041 CNV loss 21293372
nsv1061982 CNV loss 25217958
nsv1072546 CNV deletion 25765185
nsv1078793 CNV insertion 25765185
nsv474090 CNV novel sequence insertion 20440878
nsv833999 CNV loss 17160897
nsv834000 CNV gain+loss 17160897
nsv964407 CNV duplication 23825009

Variation tolerance for TMEM189-UBE2V1 Gene

Residual Variation Intolerance Score: 34.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.03; 68.60% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM189-UBE2V1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM189-UBE2V1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM189-UBE2V1 Gene

Disorders for TMEM189-UBE2V1 Gene

Additional Disease Information for TMEM189-UBE2V1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for TMEM189-UBE2V1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM189-UBE2V1 Gene

Publications for TMEM189-UBE2V1 Gene

  1. Fusion of the human gene for the polyubiquitination coeffector UEV1 with Kua, a newly identified gene. (PMID: 11076860) Thomson TM … Guigó R (Genome research 2000) 2 3 23 54
  2. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PMID: 20677014) Shimada M … Tokunaga K (Human genetics 2010) 3 41 54
  3. A Map of Human Mitochondrial Protein Interactions Linked to Neurodegeneration Reveals New Mechanisms of Redox Homeostasis and NF-κB Signaling. (PMID: 29128334) Malty RH … Babu M (Cell systems 2017) 3 54
  4. RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. (PMID: 29117863) Choudhury NR … Michlewski G (BMC biology 2017) 3 54
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C … Emili A (Nature 2015) 3 54

Products for TMEM189-UBE2V1 Gene

Sources for TMEM189-UBE2V1 Gene