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Aliases for TMEM189-UBE2V1 Gene

Aliases for TMEM189-UBE2V1 Gene

  • TMEM189-UBE2V1 Readthrough 2 3 5
  • Transmembrane Protein 189-Ubiquitin-Conjugating Enzyme E2 Variant 1 Read-Through 3
  • TMEM189-UBE2V1 Readthrough Transcript 3
  • TMEM189-UBE2V1 Fusion Protein 3
  • CROC-1B 3
  • KUA-UEV 3
  • CROC1B 3

External Ids for TMEM189-UBE2V1 Gene

Previous GeneCards Identifiers for TMEM189-UBE2V1 Gene

  • GC20M048133
  • GC20M048697
  • GC20M045446

Summaries for TMEM189-UBE2V1 Gene

Entrez Gene Summary for TMEM189-UBE2V1 Gene

  • The TMEM189-UEV mRNA is an infrequent but naturally occurring read-through transcript of the neighboring TMEM189 and UBE2V1 genes. Ubiquitin-conjugating E2 enzyme variant proteins constitute a distinct subfamily within the E2 protein family. They have sequence similarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that is critical for the catalytic activity of E2s. The protein produced by this transcript has UEV1 B domains but the protein is localized to the cytoplasm rather than to the nucleus. The significance of this read-through mRNA and the function of its protein product has not yet been determined. [provided by RefSeq, Oct 2010]

GeneCards Summary for TMEM189-UBE2V1 Gene

TMEM189-UBE2V1 (TMEM189-UBE2V1 Readthrough) is a Protein Coding gene. Among its related pathways are IL-1 signaling pathway. Gene Ontology (GO) annotations related to this gene include acid-amino acid ligase activity. An important paralog of this gene is TMEM189.

Gene Wiki entry for TMEM189-UBE2V1 Gene

Additional gene information for TMEM189-UBE2V1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM189-UBE2V1 Gene

Genomics for TMEM189-UBE2V1 Gene

GeneHancer (GH) Regulatory Elements for TMEM189-UBE2V1 Gene

Promoters and enhancers for TMEM189-UBE2V1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20I050140 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 550.4 +6.1 6079 14.1 HDGF PKNOX1 FOXA2 SMAD1 ARNT ZFP64 ARID4B NEUROD1 SIN3A YBX1 TMEM189 TMEM189-UBE2V1 SNAI1 SLC9A8 DDX27 LINC01273 ADNP B4GALT5 DPM1 PTPN1
GH20I050109 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 0.3 +41.6 41571 5 HDGF PKNOX1 FOXA2 SMAD1 ARID4B SIN3A DMAP1 ZBTB7B IRF4 YY1 UBE2V1 ADNP DDX27 DPM1 MOCS3 RNF114 LINC01273 SPATA2 ZFAS1 GC20M050093
GH20I050115 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 0.3 +37.9 37926 1.6 PKNOX1 SMAD1 MLX ARID4B NEUROD1 SIN3A DMAP1 YY1 POLR2B ZNF766 UBE2V1 LINC01273 GC20M050093 TMEM189-UBE2V1
GH20I050136 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 0.4 +15.4 15437 4 HDGF FOXA2 ZNF48 YY1 GLIS2 ZNF143 FOS RXRA ZNF623 NFIL3 SLC9A8 SNAI1 B4GALT5 PTPN1 LINC01273 CEBPB TMEM189 RNF114 TMEM189-UBE2V1 UBE2V1
GH20I050120 Enhancer 1.4 Ensembl ENCODE dbSUPER 0.3 +32.2 32236 2.2 FOXA2 MLX ARID4B NEUROD1 SIN3A YBX1 DMAP1 ZBTB7B ZNF48 ETS1 MOCS3 RNF114 ADNP LINC01273 DPM1 DDX27 ENSG00000232043 MIR645 PTPN1 UBE2V1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TMEM189-UBE2V1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TMEM189-UBE2V1 gene promoter:

Genomic Locations for TMEM189-UBE2V1 Gene

Genomic Locations for TMEM189-UBE2V1 Gene
72,675 bases
Minus strand

Genomic View for TMEM189-UBE2V1 Gene

Genes around TMEM189-UBE2V1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM189-UBE2V1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM189-UBE2V1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM189-UBE2V1 Gene

Proteins for TMEM189-UBE2V1 Gene

  • Protein details for TMEM189-UBE2V1 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    Recommended name:
    Protein Accession:

    Protein attributes for TMEM189-UBE2V1 Gene

    370 amino acids
    Molecular mass:
    42209 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM189-UBE2V1 Gene

Protein Expression for TMEM189-UBE2V1 Gene

Post-translational modifications for TMEM189-UBE2V1 Gene

No Post-translational modifications

Other Protein References for TMEM189-UBE2V1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM189-UBE2V1 Gene

Domains & Families for TMEM189-UBE2V1 Gene

Gene Families for TMEM189-UBE2V1 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TMEM189-UBE2V1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM189-UBE2V1: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for TMEM189-UBE2V1 Gene

Function for TMEM189-UBE2V1 Gene

Phenotypes From GWAS Catalog for TMEM189-UBE2V1 Gene

Gene Ontology (GO) - Molecular Function for TMEM189-UBE2V1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031625 ubiquitin protein ligase binding IBA --
GO:0061630 ubiquitin protein ligase activity IBA --
genes like me logo Genes that share ontologies with TMEM189-UBE2V1: view
genes like me logo Genes that share phenotypes with TMEM189-UBE2V1: view

Animal Model Products

miRNA for TMEM189-UBE2V1 Gene

miRTarBase miRNAs that target TMEM189-UBE2V1

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM189-UBE2V1 Gene

Localization for TMEM189-UBE2V1 Gene

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TMEM189-UBE2V1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM189-UBE2V1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for TMEM189-UBE2V1 Gene

Pathways & Interactions for TMEM189-UBE2V1 Gene

SuperPathways for TMEM189-UBE2V1 Gene

SuperPathway Contained pathways
1 IL-1 signaling pathway
genes like me logo Genes that share pathways with TMEM189-UBE2V1: view

Pathways by source for TMEM189-UBE2V1 Gene

1 BioSystems pathway for TMEM189-UBE2V1 Gene

Interacting Proteins for TMEM189-UBE2V1 Gene

Gene Ontology (GO) - Biological Process for TMEM189-UBE2V1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006301 postreplication repair IBA --
GO:0070534 protein K63-linked ubiquitination IBA --
genes like me logo Genes that share ontologies with TMEM189-UBE2V1: view

No data available for SIGNOR curated interactions for TMEM189-UBE2V1 Gene

Drugs & Compounds for TMEM189-UBE2V1 Gene

No Compound Related Data Available

Transcripts for TMEM189-UBE2V1 Gene

mRNA/cDNA for TMEM189-UBE2V1 Gene

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM189-UBE2V1 Gene

No ASD Table

Relevant External Links for TMEM189-UBE2V1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM189-UBE2V1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM189-UBE2V1 Gene

Protein differential expression in normal tissues from HIPED for TMEM189-UBE2V1 Gene

This gene is overexpressed in Heart (38.6), Skin (20.4), and Brain (10.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from PaxDb and MOPED for TMEM189-UBE2V1 Gene

Protein tissue co-expression partners for TMEM189-UBE2V1 Gene

genes like me logo Genes that share expression patterns with TMEM189-UBE2V1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM189-UBE2V1 Gene

Orthologs for TMEM189-UBE2V1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TMEM189-UBE2V1 Gene

Organism Taxonomy Gene Similarity Type Details
(Mus musculus)
Mammalia Gm20431 34
  • 92 (a)
(Pan troglodytes)
Mammalia TMEM189 34
  • 88 (a)
(Canis familiaris)
Mammalia -- 34
  • 83 (a)
(Bos Taurus)
Mammalia TMEM189 34
  • 82 (a)
(Monodelphis domestica)
Mammalia TMEM189 34
  • 66 (a)
(Ornithorhynchus anatinus)
Mammalia TMEM189 34
  • 63 (a)
(Gallus gallus)
Aves TMEM189 34
  • 70 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 51 (a)
(Danio rerio)
Actinopterygii tmem189 34
  • 60 (a)
fruit fly
(Drosophila melanogaster)
Insecta Kua 34
  • 43 (a)
(Caenorhabditis elegans)
Secernentea Y53C10A.5 34
  • 37 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons MMZ1 33
  • 56.3 (n)
(Oryza sativa)
Liliopsida Os03g0712300 33
  • 55.47 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 47 (a)
Species where no ortholog for TMEM189-UBE2V1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TMEM189-UBE2V1 Gene

Gene Tree for TMEM189-UBE2V1 (if available)
Gene Tree for TMEM189-UBE2V1 (if available)

Paralogs for TMEM189-UBE2V1 Gene

Paralogs for TMEM189-UBE2V1 Gene

genes like me logo Genes that share paralogs with TMEM189-UBE2V1: view

Variants for TMEM189-UBE2V1 Gene

Sequence variations from dbSNP and Humsavar for TMEM189-UBE2V1 Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs1000070167 -- 50,151,211(-) C/A/T intron_variant
rs1000101479 -- 50,144,441(-) A/G intron_variant
rs1000139210 -- 50,103,234(-) T/A intron_variant
rs1000149984 -- 50,121,955(-) C/T intron_variant
rs1000172044 -- 50,084,886(-) G/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM189-UBE2V1 Gene

Variant ID Type Subtype PubMed ID
esv34129 CNV loss 18971310
esv3646041 CNV loss 21293372
nsv1061982 CNV loss 25217958
nsv1072546 CNV deletion 25765185
nsv1078793 CNV insertion 25765185
nsv474090 CNV novel sequence insertion 20440878
nsv833999 CNV loss 17160897
nsv834000 CNV gain+loss 17160897
nsv964407 CNV duplication 23825009

Variation tolerance for TMEM189-UBE2V1 Gene

Residual Variation Intolerance Score: 34.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.03; 68.60% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM189-UBE2V1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM189-UBE2V1 Gene

Disorders for TMEM189-UBE2V1 Gene

Additional Disease Information for TMEM189-UBE2V1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for TMEM189-UBE2V1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM189-UBE2V1 Gene

Publications for TMEM189-UBE2V1 Gene

  1. Fusion of the human gene for the polyubiquitination coeffector UEV1 with Kua, a newly identified gene. (PMID: 11076860) Thomson TM … Guigó R (Genome research 2000) 2 3 22 58
  2. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PMID: 20677014) Shimada M … Tokunaga K (Human genetics 2010) 3 44 58
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C … Emili A (Nature 2015) 3 58
  4. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta GD … Pelletier L (Cell 2015) 3 58
  5. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T … Taylor TD (PloS one 2010) 3 58

Products for TMEM189-UBE2V1 Gene

Sources for TMEM189-UBE2V1 Gene

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