Co-transcription of this gene and the neighboring downstream gene (ubiquitin-conjugating enzyme E2 variant 1) generates a rare read-through transcript, which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. The protein encoded by this individual gene lacks a UEV1 domain but includes three transmembrane regions. Alternative splic... See more...

Aliases for TMEM189 Gene

Aliases for TMEM189 Gene

  • Transmembrane Protein 189 2 3 4 5
  • KUA 3 4
  • CarF 3

External Ids for TMEM189 Gene

Previous GeneCards Identifiers for TMEM189 Gene

  • GC20M048134
  • GC20M048740
  • GC20M045488
  • GC20M048699

Summaries for TMEM189 Gene

Entrez Gene Summary for TMEM189 Gene

  • Co-transcription of this gene and the neighboring downstream gene (ubiquitin-conjugating enzyme E2 variant 1) generates a rare read-through transcript, which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. The protein encoded by this individual gene lacks a UEV1 domain but includes three transmembrane regions. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2009]

GeneCards Summary for TMEM189 Gene

TMEM189 (Transmembrane Protein 189) is a Protein Coding gene. Diseases associated with TMEM189 include Chlorhexidine Allergy and Rocuronium Allergy. Gene Ontology (GO) annotations related to this gene include ubiquitin protein ligase binding and ubiquitin-like protein transferase activity. An important paralog of this gene is TMEM189-UBE2V1.

Additional gene information for TMEM189 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TMEM189 Gene

Genomics for TMEM189 Gene

GeneHancer (GH) Regulatory Elements for TMEM189 Gene

Promoters and enhancers for TMEM189 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TMEM189 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TMEM189

Top Transcription factor binding sites by QIAGEN in the TMEM189 gene promoter:
  • AhR
  • AP-2gamma
  • AP-4
  • ARP-1
  • CREB
  • deltaCREB
  • NF-kappaB
  • NF-kappaB1

Genomic Locations for TMEM189 Gene

Genomic Locations for TMEM189 Gene
35,545 bases
Minus strand
72,673 bases
Minus strand

Genomic View for TMEM189 Gene

Genes around TMEM189 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM189 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM189 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM189 Gene

Proteins for TMEM189 Gene

  • Protein details for TMEM189 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 189
    Protein Accession:

    Protein attributes for TMEM189 Gene

    270 amino acids
    Molecular mass:
    31135 Da
    Quaternary structure:
    No Data Available
    • TMEM189/KUA and UBE2V1/UEV1 are adjacent genes which can produce independent proteins and can also be fused to form a TMEM189-UBE2V1 hybrid protein.

    Alternative splice isoforms for TMEM189 Gene


neXtProt entry for TMEM189 Gene

Post-translational modifications for TMEM189 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM189 Gene

No data available for DME Specific Peptides for TMEM189 Gene

Domains & Families for TMEM189 Gene

Gene Families for TMEM189 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TMEM189 Gene


Suggested Antigen Peptide Sequences for TMEM189 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ56328, highly similar to Homo sapiens ubiquitin-conjugating enzyme variant Kua (Kua), mRNA (Q5TGE2_HUMAN)
  • Transmembrane protein 189 (TM189_HUMAN)
genes like me logo Genes that share domains with TMEM189: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for TMEM189 Gene

Function for TMEM189 Gene

Phenotypes From GWAS Catalog for TMEM189 Gene

genes like me logo Genes that share phenotypes with TMEM189: view

Animal Models for TMEM189 Gene

MGI Knock Outs for TMEM189:

Animal Model Products

CRISPR Products

miRNA for TMEM189 Gene

miRTarBase miRNAs that target TMEM189

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TMEM189 Gene

Localization for TMEM189 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM189 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM189 gene
Compartment Confidence
endoplasmic reticulum 4
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1
cytosol 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TMEM189 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM189: view

Pathways & Interactions for TMEM189 Gene

PathCards logo

SuperPathways for TMEM189 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMEM189 Gene


No data available for Pathways by source and SIGNOR curated interactions for TMEM189 Gene

Drugs & Compounds for TMEM189 Gene

No Compound Related Data Available

Transcripts for TMEM189 Gene

mRNA/cDNA for TMEM189 Gene

7 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM189 Gene

No ASD Table

Relevant External Links for TMEM189 Gene

GeneLoc Exon Structure for

Expression for TMEM189 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TMEM189 Gene

Protein differential expression in normal tissues from HIPED for TMEM189 Gene

This gene is overexpressed in Bone (44.6) and Placenta (17.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TMEM189 Gene

Protein tissue co-expression partners for TMEM189 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TMEM189

Evidence on tissue expression from TISSUES for TMEM189 Gene

  • Skin(2.8)
genes like me logo Genes that share expression patterns with TMEM189: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM189 Gene

Orthologs for TMEM189 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM189 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMEM189 31 30
  • 99.63 (n)
(Canis familiaris)
Mammalia TMEM189 30
  • 92.59 (n)
-- 31
  • 83 (a)
(Mus musculus)
Mammalia Gm20431 31
  • 92 (a)
Tmem189 17 30
  • 88.52 (n)
(Bos Taurus)
Mammalia TMEM189 31 30
  • 90.74 (n)
(Rattus norvegicus)
Mammalia Tmem189 30
  • 89.51 (n)
(Monodelphis domestica)
Mammalia TMEM189 31
  • 66 (a)
(Ornithorhynchus anatinus)
Mammalia TMEM189 31
  • 63 (a)
(Gallus gallus)
Aves TMEM189 31 30
  • 72.4 (n)
(Anolis carolinensis)
Reptilia -- 31
  • 51 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem189 30
  • 70.16 (n)
(Danio rerio)
Actinopterygii tmem189 31 30
  • 69.42 (n)
fruit fly
(Drosophila melanogaster)
Insecta Kua 31
  • 43 (a)
(Caenorhabditis elegans)
Secernentea Y53C10A.5 31
  • 37 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 47 (a)
Species where no ortholog for TMEM189 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMEM189 Gene

Gene Tree for TMEM189 (if available)
Gene Tree for TMEM189 (if available)
Evolutionary constrained regions (ECRs) for TMEM189: view image

Paralogs for TMEM189 Gene

(2) SIMAP similar genes for TMEM189 Gene using alignment to 6 proteins:

  • TM189_HUMAN
  • F8W924_HUMAN
  • G3V2F7_HUMAN
genes like me logo Genes that share paralogs with TMEM189: view

Variants for TMEM189 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TMEM189 Gene

SNP ID Clinical significance and condition Chr 20 pos Variation AA Info Type
rs2026757 - p.Trp7Gly

Additional dbSNP identifiers (rs#s) for TMEM189 Gene

Structural Variations from Database of Genomic Variants (DGV) for TMEM189 Gene

Variant ID Type Subtype PubMed ID
esv34129 CNV loss 18971310
nsv1061982 CNV loss 25217958
nsv1072546 CNV deletion 25765185
nsv474090 CNV novel sequence insertion 20440878
nsv834000 CNV gain+loss 17160897

Variation tolerance for TMEM189 Gene

Residual Variation Intolerance Score: 48.4% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM189 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM189 Gene

Disorders for TMEM189 Gene

MalaCards: The human disease database

(22) MalaCards diseases for TMEM189 Gene - From: DISEASES

Disorder Aliases PubMed IDs
chlorhexidine allergy
rocuronium allergy
  • esmeron allergy
acute inferolateral myocardial infarction
  • acute myocardial infarction of inferolateral wall
apple allergy
  • malus domestica fruit allergy
apricot allergy
  • prunus armeniaca fruit allergy
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TMEM189

genes like me logo Genes that share disorders with TMEM189: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TMEM189 Gene

Publications for TMEM189 Gene

  1. Fusion of the human gene for the polyubiquitination coeffector UEV1 with Kua, a newly identified gene. (PMID: 11076860) Thomson TM … Guigó R (Genome research 2000) 2 3 4 23 54
  2. A bacterial light response reveals an orphan desaturase for human plasmalogen synthesis. (PMID: 31604315) Gallego-García A … Elías-Arnanz M (Science (New York, N.Y.) 2019) 2 3 54
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  4. Molecular basis of T cell-mediated recognition of pancreatic cancer cells. (PMID: 11280764) Ito M … Itoh K (Cancer research 2001) 3 4 54
  5. RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. (PMID: 29117863) Choudhury NR … Michlewski G (BMC biology 2017) 3 54

Products for TMEM189 Gene

Sources for TMEM189 Gene