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Aliases for TMEM189 Gene

Aliases for TMEM189 Gene

  • Transmembrane Protein 189 2 3 5
  • KUA 3 4

External Ids for TMEM189 Gene

Previous GeneCards Identifiers for TMEM189 Gene

  • GC20M048134
  • GC20M048740
  • GC20M045488
  • GC20M048699

Summaries for TMEM189 Gene

Entrez Gene Summary for TMEM189 Gene

  • Co-transcription of this gene and the neighboring downstream gene (ubiquitin-conjugating enzyme E2 variant 1) generates a rare read-through transcript, which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. The protein encoded by this individual gene lacks a UEV1 domain but includes three transmembrane regions. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2009]

GeneCards Summary for TMEM189 Gene

TMEM189 (Transmembrane Protein 189) is a Protein Coding gene. Diseases associated with TMEM189 include Timothy Grass Allergy and Fish Allergy. Gene Ontology (GO) annotations related to this gene include ubiquitin protein ligase binding and ubiquitin-like protein transferase activity. An important paralog of this gene is TMEM189-UBE2V1.

Additional gene information for TMEM189 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM189 Gene

Genomics for TMEM189 Gene

GeneHancer (GH) Regulatory Elements for TMEM189 Gene

Promoters and enhancers for TMEM189 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20I050140 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 557.4 +6.1 6079 14.1 HDGF PKNOX1 FOXA2 SMAD1 ARNT ZFP64 ARID4B NEUROD1 SIN3A YBX1 TMEM189 TMEM189-UBE2V1 SNAI1 SLC9A8 DDX27 LINC01273 ADNP B4GALT5 DPM1 PTPN1
GH20I050258 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 8.3 -106.3 -106276 3.5 HDGF PKNOX1 FOXA2 ARNT ZBTB7B ZNF48 ZNF207 SMARCB1 ZNF623 ZNF592 CEBPB ENSG00000232043 ADNP DPM1 PSMD10P1 SNAI1 MIR645 SNORD12B TMEM189 SLC9A8
GH20I050269 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 5.8 -124.8 -124780 19.2 HDGF PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B NEUROD1 SIN3A YBX1 CEBPB SLC9A8 ADNP PTPN1 SNAI1 LINC01270 DPM1 ENSG00000232043 SMIM25 LINC01273
GH20I050218 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 6.2 -69.6 -69603 9.2 ZFP64 ZBTB7B ZNF48 YY1 ELK1 FOS ZNF202 RXRA SMARCB1 ZNF623 CEBPB SLC9A8 SNAI1 ADNP LINC01273 PTPN1 DPM1 RNF114 PSMD10P1 MIR645
GH20I050455 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 6.2 -302.6 -302552 1.9 FOXA2 MLX ZFP64 ARID4B DMAP1 ZNF48 SLC30A9 RXRA SP5 MXD4 SNAI1 CEBPB ENSG00000232043 PTPN1 TMEM189 COX6CP2 RN7SL636P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TMEM189 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TMEM189 gene promoter:

Genomic Locations for TMEM189 Gene

Genomic Locations for TMEM189 Gene
35,545 bases
Minus strand

Genomic View for TMEM189 Gene

Genes around TMEM189 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM189 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM189 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM189 Gene

Proteins for TMEM189 Gene

  • Protein details for TMEM189 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 189
    Protein Accession:

    Protein attributes for TMEM189 Gene

    270 amino acids
    Molecular mass:
    31135 Da
    Quaternary structure:
    No Data Available
    • TMEM189/KUA and UBE2V1/UEV1 are adjacent genes which can produce independent proteins and can also be fused to form a TMEM189-UBE2V1 hybrid protein.

    Alternative splice isoforms for TMEM189 Gene


neXtProt entry for TMEM189 Gene

Post-translational modifications for TMEM189 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM189 Gene

No data available for DME Specific Peptides for TMEM189 Gene

Domains & Families for TMEM189 Gene

Gene Families for TMEM189 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TMEM189 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM189: view

No data available for UniProtKB/Swiss-Prot for TMEM189 Gene

Function for TMEM189 Gene

Phenotypes From GWAS Catalog for TMEM189 Gene

Gene Ontology (GO) - Molecular Function for TMEM189 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031625 ubiquitin protein ligase binding IBA --
GO:0061630 ubiquitin protein ligase activity IBA --
genes like me logo Genes that share ontologies with TMEM189: view
genes like me logo Genes that share phenotypes with TMEM189: view

Animal Models for TMEM189 Gene

MGI Knock Outs for TMEM189:

Animal Model Products

miRNA for TMEM189 Gene

miRTarBase miRNAs that target TMEM189

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TMEM189 Gene

Localization for TMEM189 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM189 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM189 gene
Compartment Confidence
endoplasmic reticulum 4
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TMEM189 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0005783 endoplasmic reticulum IDA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM189: view

Pathways & Interactions for TMEM189 Gene

SuperPathways for TMEM189 Gene

No Data Available

Interacting Proteins for TMEM189 Gene

Selected Interacting proteins: A5PLL7-TM189_HUMAN for TMEM189 Gene via IID

Gene Ontology (GO) - Biological Process for TMEM189 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with TMEM189: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM189 Gene

Drugs & Compounds for TMEM189 Gene

No Compound Related Data Available

Transcripts for TMEM189 Gene

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM189 Gene

No ASD Table

Relevant External Links for TMEM189 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM189 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM189 Gene

Protein differential expression in normal tissues from HIPED for TMEM189 Gene

This gene is overexpressed in Bone (44.6) and Placenta (17.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TMEM189 Gene

Protein tissue co-expression partners for TMEM189 Gene

NURSA nuclear receptor signaling pathways regulating expression of TMEM189 Gene:


Evidence on tissue expression from TISSUES for TMEM189 Gene

  • Skin(2.8)
genes like me logo Genes that share expression patterns with TMEM189: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM189 Gene

Orthologs for TMEM189 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM189 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMEM189 33 34
  • 99.63 (n)
(Canis familiaris)
Mammalia TMEM189 33
  • 92.59 (n)
-- 34
  • 83 (a)
(Mus musculus)
Mammalia Gm20431 34
  • 92 (a)
Tmem189 33 16
  • 88.52 (n)
(Bos Taurus)
Mammalia TMEM189 33 34
  • 90.74 (n)
(Rattus norvegicus)
Mammalia Tmem189 33
  • 89.51 (n)
(Monodelphis domestica)
Mammalia TMEM189 34
  • 66 (a)
(Ornithorhynchus anatinus)
Mammalia TMEM189 34
  • 63 (a)
(Gallus gallus)
Aves TMEM189 33 34
  • 72.4 (n)
(Anolis carolinensis)
Reptilia -- 34
  • 51 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem189 33
  • 70.16 (n)
(Danio rerio)
Actinopterygii tmem189 33 34
  • 69.42 (n)
fruit fly
(Drosophila melanogaster)
Insecta Kua 34
  • 43 (a)
(Caenorhabditis elegans)
Secernentea Y53C10A.5 34
  • 37 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 47 (a)
Species where no ortholog for TMEM189 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMEM189 Gene

Gene Tree for TMEM189 (if available)
Gene Tree for TMEM189 (if available)

Paralogs for TMEM189 Gene

Paralogs for TMEM189 Gene

(2) SIMAP similar genes for TMEM189 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with TMEM189: view

Variants for TMEM189 Gene

Sequence variations from dbSNP and Humsavar for TMEM189 Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs1000070167 -- 50,151,211(-) C/A/T intron_variant, splice_donor_variant
rs1000101479 -- 50,144,441(-) A/G intron_variant
rs1000223296 -- 50,143,436(-) C/T intron_variant
rs1000307000 -- 50,127,840(-) A/T intron_variant
rs1000336555 -- 50,155,040(-) G/A/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM189 Gene

Variant ID Type Subtype PubMed ID
esv34129 CNV loss 18971310
nsv1061982 CNV loss 25217958
nsv1072546 CNV deletion 25765185
nsv474090 CNV novel sequence insertion 20440878
nsv834000 CNV gain+loss 17160897

Variation tolerance for TMEM189 Gene

Residual Variation Intolerance Score: 48.4% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM189 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM189 Gene

Disorders for TMEM189 Gene

MalaCards: The human disease database

(2) MalaCards diseases for TMEM189 Gene - From: DISEASES

Disorder Aliases PubMed IDs
timothy grass allergy
fish allergy
  • allergy to fish
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TMEM189

genes like me logo Genes that share disorders with TMEM189: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TMEM189 Gene

Publications for TMEM189 Gene

  1. Fusion of the human gene for the polyubiquitination coeffector UEV1 with Kua, a newly identified gene. (PMID: 11076860) Thomson TM … Guigó R (Genome research 2000) 2 3 4 22 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Molecular basis of T cell-mediated recognition of pancreatic cancer cells. (PMID: 11280764) Ito M … Itoh K (Cancer research 2001) 3 4 58
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 58
  5. A census of human soluble protein complexes. (PMID: 22939629) Havugimana PC … Emili A (Cell 2012) 3 58

Products for TMEM189 Gene

Sources for TMEM189 Gene

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