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Aliases for TMEM187 Gene

Aliases for TMEM187 Gene

  • Transmembrane Protein 187 2 3 5
  • DXS9878E 3 4
  • CXorf12 3 4
  • ITBA1 3 4
  • Chromosome X Open Reading Frame 12 2
  • Protein ITBA1 4

External Ids for TMEM187 Gene

Previous HGNC Symbols for TMEM187 Gene

  • CXorf12

Previous GeneCards Identifiers for TMEM187 Gene

  • GC0XP152891
  • GC0XP153237
  • GC0XP141899

Summaries for TMEM187 Gene

Entrez Gene Summary for TMEM187 Gene

  • This gene consists of two exons and encodes a multi-pass membrane protein. An alternatively spliced transcript variant encoding the same protein has been found, but its biological validity is not determined. [provided by RefSeq, May 2010]

GeneCards Summary for TMEM187 Gene

TMEM187 (Transmembrane Protein 187) is a Protein Coding gene.

Additional gene information for TMEM187 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM187 Gene

Genomics for TMEM187 Gene

GeneHancer (GH) Regulatory Elements for TMEM187 Gene

Promoters and enhancers for TMEM187 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI153965 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 603.8 -1.8 -1811 10 HDGF PKNOX1 CLOCK FOXA2 ARNT ZFP64 SIN3A FEZF1 DMAP1 ZNF2 TMEM187 HCFC1 HCFC1-AS1 SNORA70 SLC10A3 SNORA56 DKC1 EMD FAM3A ABCD1
GH0XI153922 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 47.9 -45.5 -45512 7.7 HDGF HNRNPUL1 PKNOX1 CLOCK SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 ARHGAP4 TMEM187 HCFC1 SNORA70 DKC1 SLC10A3 EMD HCFC1-AS1 FLNA GC0XP153923
GH0XI154038 Enhancer 1.3 FANTOM5 Ensembl ENCODE 45.1 +71.0 70977 9.2 CTCF ZSCAN4 ZNF133 MAX EBF1 CEBPG FEZF1 ZIC2 RAD21 TEAD3 TMEM187 HCFC1 HCFC1-AS1 IKBKG ABCD1 DNASE1L1 MECP2 FAM50A ATP6AP1 EMD
GH0XI154017 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 29.1 +47.7 47683 4.2 HDGF RB1 ZNF2 YY1 ZNF335 GLIS2 EGR1 ZNF143 ATF7 RUNX3 MIR718 IRAK1 GC0XP154020 TMEM187 MECP2
GH0XI153980 Enhancer 1.3 FANTOM5 Ensembl ENCODE 41.7 +11.5 11490 7.3 HDGF PKNOX1 TAF9B RB1 NFRKB TCF12 ZNF121 ZNF766 RUNX3 RXRA TMEM187 ARHGAP4 MECP2 ABCD1 TAZ RENBP DNASE1L1 MIR3202-1 MIR3202-2 MIR718
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TMEM187 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TMEM187 gene promoter:

Genomic Locations for TMEM187 Gene

Genomic Locations for TMEM187 Gene
chrX:153,972,327-153,983,195
(GRCh38/hg38)
Size:
10,869 bases
Orientation:
Plus strand
chrX:153,237,778-153,248,646
(GRCh37/hg19)

Genomic View for TMEM187 Gene

Genes around TMEM187 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM187 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM187 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM187 Gene

Proteins for TMEM187 Gene

  • Protein details for TMEM187 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14656-TM187_HUMAN
    Recommended name:
    Transmembrane protein 187
    Protein Accession:
    Q14656
    Secondary Accessions:
    • B2RC47
    • Q6IAV7

    Protein attributes for TMEM187 Gene

    Size:
    261 amino acids
    Molecular mass:
    29148 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM187 Gene

Post-translational modifications for TMEM187 Gene

No Post-translational modifications

Other Protein References for TMEM187 Gene

No data available for DME Specific Peptides for TMEM187 Gene

Domains & Families for TMEM187 Gene

Gene Families for TMEM187 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TMEM187 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM187 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM187: view

No data available for UniProtKB/Swiss-Prot for TMEM187 Gene

Function for TMEM187 Gene

Phenotypes From GWAS Catalog for TMEM187 Gene

Gene Ontology (GO) - Molecular Function for TMEM187 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with TMEM187: view
genes like me logo Genes that share phenotypes with TMEM187: view

miRNA for TMEM187 Gene

miRTarBase miRNAs that target TMEM187

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM187 Gene

Localization for TMEM187 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM187 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM187 gene
Compartment Confidence
plasma membrane 3
nucleus 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoli (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TMEM187 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030133 transport vesicle IDA --
genes like me logo Genes that share ontologies with TMEM187: view

Pathways & Interactions for TMEM187 Gene

SuperPathways for TMEM187 Gene

No Data Available

Interacting Proteins for TMEM187 Gene

Selected Interacting proteins: Q14656-TM187_HUMAN for TMEM187 Gene via UniProtKB

Symbol External ID(s) Details
SPAG4

Gene Ontology (GO) - Biological Process for TMEM187 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with TMEM187: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM187 Gene

Drugs & Compounds for TMEM187 Gene

No Compound Related Data Available

Transcripts for TMEM187 Gene

mRNA/cDNA for TMEM187 Gene

Unigene Clusters for TMEM187 Gene

Transmembrane protein 187:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM187 Gene

No ASD Table

Relevant External Links for TMEM187 Gene

GeneLoc Exon Structure for
TMEM187
ECgene alternative splicing isoforms for
TMEM187

Expression for TMEM187 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM187 Gene

NURSA nuclear receptor signaling pathways regulating expression of TMEM187 Gene:

TMEM187

SOURCE GeneReport for Unigene cluster for TMEM187 Gene:

Hs.23119

mRNA Expression by UniProt/SwissProt for TMEM187 Gene:

Q14656-TM187_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for TMEM187 Gene

  • Nervous system(4.3)
  • Intestine(4.2)
  • Muscle(4.1)
  • Eye(4)
genes like me logo Genes that share expression patterns with TMEM187: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM187 Gene

Orthologs for TMEM187 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM187 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM187 33 34
  • 98.72 (n)
cow
(Bos Taurus)
Mammalia TMEM187 33 34
  • 76.97 (n)
dog
(Canis familiaris)
Mammalia TMEM187 33 34
  • 76.65 (n)
oppossum
(Monodelphis domestica)
Mammalia TMEM187 34
  • 56 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM187 34
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem187 33
  • 57.87 (n)
zebrafish
(Danio rerio)
Actinopterygii tmem187 33 34
  • 59.08 (n)
Species where no ortholog for TMEM187 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM187 Gene

ENSEMBL:
Gene Tree for TMEM187 (if available)
TreeFam:
Gene Tree for TMEM187 (if available)

Paralogs for TMEM187 Gene

No data available for Paralogs for TMEM187 Gene

Variants for TMEM187 Gene

Sequence variations from dbSNP and Humsavar for TMEM187 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs398122908 pathogenic, Mental retardation 3, X-linked 153,971,810(+) A/G upstream_transcript_variant
rs1000646328 -- 153,971,661(+) C/G upstream_transcript_variant
rs1000733473 -- 153,981,254(+) C/G intron_variant
rs1000933507 -- 153,971,902(+) C/G upstream_transcript_variant
rs1001209479 -- 153,977,512(+) T/C genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM187 Gene

Variant ID Type Subtype PubMed ID
esv33199 CNV gain+loss 17666407
esv33784 CNV gain+loss 17666407
nsv469867 CNV loss 16826518
nsv519506 CNV gain 19592680

Variation tolerance for TMEM187 Gene

Residual Variation Intolerance Score: 37.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.10; 75.48% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM187 Gene

Human Gene Mutation Database (HGMD)
TMEM187
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM187

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM187 Gene

Disorders for TMEM187 Gene

Additional Disease Information for TMEM187

No disorders were found for TMEM187 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM187 Gene

Publications for TMEM187 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  2. The complete sequence of the host cell factor 1 (HCFC1) gene and its promoter: a role for YY1 transcription factor in the regulation of its expression. (PMID: 8661027) Zoppè M … Vezzoni P (Genomics 1996) 2 3 58
  3. Characterization and fine localization of two new genes in Xq28 using the genomic sequence/EST database screening approach. (PMID: 8786131) Faranda S … Vezzoni P (Genomics 1996) 3 4 58
  4. TMEM187-IRAK1 Polymorphisms Associated with Rheumatoid Arthritis Susceptibility in Tunisian and French Female Populations: Influence of Geographic Origin. (PMID: 28271077) Khalifa O … Apparailly F (Journal of immunology research 2017) 3 58
  5. Prominent use of distal 5' transcription start sites and discovery of a large number of additional exons in ENCODE regions. (PMID: 17567994) Denoeud F … Reymond A (Genome research 2007) 3 58

Products for TMEM187 Gene

Sources for TMEM187 Gene

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