Aliases for TMEM186 Gene
Aliases for TMEM186 Gene
External Ids for TMEM186 Gene
- HGNC: 24530
- Entrez Gene: 25880
- Ensembl: ENSG00000184857
- UniProtKB: Q96B77
Previous HGNC Symbols for TMEM186 Gene
- C16orf51
Previous GeneCards Identifiers for TMEM186 Gene
- GC16M008798
- GC16M008889
- GC16M008811
- GC16M008874
Summaries for TMEM186 Gene
-
This gene encodes a potential transmembrane protein. [provided by RefSeq, Dec 2012]
GeneCards Summary for TMEM186 Gene
TMEM186 (Transmembrane Protein 186) is a Protein Coding gene.
Additional gene information for TMEM186 Gene
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM186 Gene
Genomics for TMEM186 Gene
GeneHancer (GH) Regulatory Elements for TMEM186 Gene
Promoters and enhancers for TMEM186 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH16I008796 | Promoter/Enhancer | 2.1 | EPDnew Ensembl ENCODE | 550.8 | -0.4 | -378 | 3.1 | HDGF PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 ZBTB7B YY1 | PMM2 TMEM186 CARHSP1 ENSG00000260276 RNU7-63P GC16M008818 | |
| GH16I008792 | Enhancer | 0.8 | ENCODE | 0.4 | +5.6 | 5569 | 0.2 | ELF3 MLX ARID4B ZSCAN9 RAD21 RARA ZNF143 RUNX3 THAP11 MIXL1 | RNU7-63P PMM2 GC16M008781 TMEM186 | |
| GH16I008787 | Enhancer | 0.6 | ENCODE | 0.4 | +8.7 | 8688 | 2 | RXRA TAF1 HLF MAX RAD21 YY1 ZKSCAN1 JUND ATF3 HNF4G | GC16M008781 PMM2 CARHSP1 ENSG00000260276 RNU7-63P TMEM186 | |
| GH16I008817 | Enhancer | 0.4 | ENCODE | 0.4 | -19.6 | -19611 | 0.2 | ZNF121 RUNX3 | CARHSP1 RNU7-63P ENSG00000260276 GC16M008818 TMEM186 PMM2 | |
| GH16I008819 | Enhancer | 0.2 | ENCODE | 0.3 | -21.9 | -21929 | 0.3 | CARHSP1 RNU7-63P GC16M008818 TMEM186 PMM2 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around TMEM186 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the TMEM186 gene promoter:
Regulatory Element Products
Genomic Locations for TMEM186 Gene
Genomic Locations for TMEM186 Gene
- chr16:8,780,384-8,797,648
- (GRCh38/hg38)
- Size:
- 17,265 bases
- Orientation:
- Minus strand
- chr16:8,874,241-8,891,505
- (GRCh37/hg19)
Genomic View for TMEM186 Gene
Genes around TMEM186 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 16p13.2 by Ensembl
- 16p13.2 by Entrez Gene
- 16p13.2 by HGNC
TMEM186 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TMEM186 Gene
Proteins for TMEM186 Gene
-
Protein details for TMEM186 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q96B77-TM186_HUMAN
- Recommended name:
- Transmembrane protein 186
- Protein Accession:
- Q96B77
- B2RAY0
- Q9Y4T4
Protein attributes for TMEM186 Gene
- Size:
- 213 amino acids
- Molecular mass:
- 24893 Da
- Quaternary structure:
- No Data Available
Protein Expression for TMEM186 Gene
Post-translational modifications for TMEM186 Gene
Other Protein References for TMEM186 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for TMEM186
- Invitrogen Antibodies for TMEM186
- antibodies-online: Search results for 4 available TMEM186 Antibodies ranked by validation data
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-
Quality Products:
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Protein Products
-
OriGene Purified Proteins for TMEM186
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- Search GeneTex for Proteins for TMEM186
Assay Products
No data available for DME Specific Peptides for TMEM186 Gene
Domains & Families for TMEM186 Gene
Gene Families for TMEM186 Gene
- Human Protein Atlas (HPA):
-
- Predicted membrane proteins
Suggested Antigen Peptide Sequences for TMEM186 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q96B77- Family:
-
- Belongs to the TMEM186 family.
Function for TMEM186 Gene
Phenotypes for TMEM186 Gene
- GenomeRNAi human phenotypes for TMEM186:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for TMEM186
-
-
ViGene Biosciences lentiviral particle packaged cDNA for TMEM186 gene
-
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CRISPR Products
-
OriGene CRISPR knockouts for TMEM186
- genomics-online: gRNA clones - Search results for available TMEM186 gene related products
- Applied Biological Materials CRISPR for TMEM186
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for TMEM186
- GenScript: Design CRISPR guide RNA sequences for TMEM186
miRNA for TMEM186 Gene
- miRTarBase miRNAs that target TMEM186
miRNA Products
- Search ViGene Biosciences for TMEM186
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TMEM186
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- genomics-online: shRNA clones - Search results for available TMEM186 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for TMEM186 gene
Clone Products
- Sino Biological Human cDNA Clone for TMEM186
- VectorBuilder custom plasmid, inducible vectors for TMEM186
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TMEM186
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available TMEM186 gene related products
- orf clones - Search results for available TMEM186 gene related products
- Applied Biological Materials Clones for TMEM186
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for TMEM186
-
ViGene Biosciences adenoviral particle packaged cDNA for TMEM186 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for TMEM186 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for TMEM186 gene
No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM186 Gene
Localization for TMEM186 Gene
Subcellular locations from UniProtKB/Swiss-Prot for TMEM186 Gene
- Membrane; Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| mitochondrion | 5 |
| plasma membrane | 2 |
| cytoskeleton | 2 |
| cytosol | 2 |
- Cell Junctions (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005739 | mitochondrion | IDA | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
Pathways & Interactions for TMEM186 Gene
No Data Available
No data available for Pathways by source and SIGNOR curated interactions for TMEM186 Gene
Transcripts for TMEM186 Gene
mRNA/cDNA for TMEM186 Gene
- (1) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (94) Selected AceView cDNA sequences:
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for TMEM186 Gene
CRISPR Products
-
OriGene CRISPR knockouts for TMEM186
- genomics-online: gRNA clones - Search results for available TMEM186 gene related products
- Applied Biological Materials CRISPR for TMEM186
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for TMEM186
- GenScript: Design CRISPR guide RNA sequences for TMEM186
miRNA Products
- Search ViGene Biosciences for TMEM186
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TMEM186
- Browse OriGene Inhibitory RNA Products For TMEM186
- genomics-online: shRNA clones - Search results for available TMEM186 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for TMEM186 gene
Clone Products
- Sino Biological Human cDNA Clone for TMEM186
- VectorBuilder custom plasmid, inducible vectors for TMEM186
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TMEM186
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available TMEM186 gene related products
- orf clones - Search results for available TMEM186 gene related products
- Applied Biological Materials Clones for TMEM186
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for TMEM186 Gene
This gene is overexpressed in Liver (14.8), Rectum (14.3), Frontal cortex (11.3), Testis (10.5), and Pancreas (6.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TMEM186 Gene
NURSA nuclear receptor signaling pathways regulating expression of TMEM186 Gene:
TMEM186SOURCE GeneReport for Unigene cluster for TMEM186 Gene:
Hs.513330Evidence on tissue expression from TISSUES for TMEM186 Gene
- Nervous system(4.2)
Primer Products
-
OriGene qPCR primer pairs and template standards for TMEM186
-
OriGene qPCR primer pairs for TMEM186
- genomics-online: primer clones - Search results for available TMEM186 gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM186 Gene
Orthologs for TMEM186 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | TMEM186 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | TMEM186 33 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Tmem186 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Tmem186 33 16 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | TMEM186 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | TMEM186 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | TMEM186 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | tmem186 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | zgc:194539 33 |
|
||
| TMEM186 34 |
|
OneToOne | |||
| fruit fly (Drosophila melanogaster) |
Insecta | CG4627 34 |
|
OneToOne |
- Species where no ortholog for TMEM186 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- dog (Canis familiaris)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for TMEM186 Gene
No data available for Paralogs for TMEM186 Gene
Variants for TMEM186 Gene
| SNP ID | Clin | Chr 16 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs104894532 | conflicting-interpretations-of-pathogenicity, Carbohydrate-deficient glycoprotein syndrome type I | 8,797,908(-) | G/A/T | upstream_transcript_variant | |
| rs1057516943 | likely-pathogenic, Carbohydrate-deficient glycoprotein syndrome type I | 8,797,909(-) | C/A/T | upstream_transcript_variant | |
| rs563744399 | uncertain-significance, Congenital disorder of glycosylation | 8,797,813(-) | G/A | upstream_transcript_variant | |
| rs751782324 | uncertain-significance, Congenital disorder of glycosylation | 8,797,849(-) | C/A/T | upstream_transcript_variant | |
| rs768021123 | likely-pathogenic, Carbohydrate-deficient glycoprotein syndrome type I | 8,797,906(-) | C/ | upstream_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv341n27 | CNV | gain | 19166990 |
| dgv4906n54 | CNV | gain | 21841781 |
| esv2763129 | CNV | gain | 21179565 |
| esv3637841 | CNV | gain | 21293372 |
| esv3637845 | CNV | gain | 21293372 |
| esv3892787 | CNV | gain | 25118596 |
| nsv1036281 | CNV | gain | 25217958 |
| nsv1047172 | CNV | gain | 25217958 |
| nsv457394 | CNV | gain | 19166990 |
| nsv457398 | CNV | gain | 19166990 |
| nsv476924 | CNV | novel sequence insertion | 20440878 |
| nsv571424 | CNV | gain | 21841781 |
| nsv571427 | CNV | gain | 21841781 |
| nsv571428 | CNV | gain | 21841781 |
| nsv819097 | CNV | loss | 19587683 |
Residual Variation Intolerance Score:
86.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.94;
19.49% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for TMEM186 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- TMEM186
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM186 Gene
Disorders for TMEM186 Gene
Additional Disease Information for TMEM186
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for TMEM186 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM186 Gene
Publications for TMEM186 Gene
- Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 2 3 4 58
- Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
- Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
- The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
Products for TMEM186 Gene
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- OriGene Purified Proteins for TMEM186
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- Cyagen custom Knockout/knockin (KOKI) mouse models for TMEM186
- VectorBuilder custom plasmid, inducible vectors for TMEM186
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TMEM186
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 4 available TMEM186 Antibodies ranked by validation data
- Compare Top TMEM186 Antibodies
- Quality Products:
- antibodies-online: Search results for available TMEM186 related products ranked by validation data
- antibodies-online: Search results for available TMEM186 related products ranked by validation data
- Search GeneTex for Antibodies for TMEM186
- Search GeneTex for Proteins for TMEM186
- ViGene Biosciences adenoviral particle packaged cDNA for TMEM186 gene
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- genomics-online: cdna clones - Search results for available TMEM186 gene related products
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Sources for TMEM186 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
