This gene encodes a potential transmembrane protein. [provided by RefSeq, Dec 2012] See more...

Aliases for TMEM186 Gene

Aliases for TMEM186 Gene

  • Transmembrane Protein 186 2 3 4 5
  • C16orf51 3 4
  • Chromosome 16 Open Reading Frame 51 2
  • DKFZP564K2062 2
  • TMEM186 5

External Ids for TMEM186 Gene

Previous HGNC Symbols for TMEM186 Gene

  • C16orf51

Previous GeneCards Identifiers for TMEM186 Gene

  • GC16M008798
  • GC16M008889
  • GC16M008811
  • GC16M008874

Summaries for TMEM186 Gene

Entrez Gene Summary for TMEM186 Gene

  • This gene encodes a potential transmembrane protein. [provided by RefSeq, Dec 2012]

GeneCards Summary for TMEM186 Gene

TMEM186 (Transmembrane Protein 186) is a Protein Coding gene. Diseases associated with TMEM186 include Congenital Disorder Of Glycosylation, Type In and Benign Epilepsy With Centrotemporal Spikes.

Additional gene information for TMEM186 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TMEM186 Gene

Genomics for TMEM186 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TMEM186 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TMEM186 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TMEM186

Top Transcription factor binding sites by QIAGEN in the TMEM186 gene promoter:
  • AREB6
  • c-Ets-1
  • C/EBPalpha
  • FOXJ2
  • FOXJ2 (long isoform)
  • HEN1
  • Pax-2
  • Pax-2a
  • STAT3

Genomic Locations for TMEM186 Gene

Latest Assembly
chr16:8,780,384-8,797,642
(GRCh38/hg38)
Size:
17,259 bases
Orientation:
Minus strand

Previous Assembly
chr16:8,889,037-8,891,496
(GRCh37/hg19 by Entrez Gene)
Size:
2,460 bases
Orientation:
Minus strand

chr16:8,874,241-8,891,505
(GRCh37/hg19 by Ensembl)
Size:
17,265 bases
Orientation:
Minus strand

Genomic View for TMEM186 Gene

Genes around TMEM186 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM186 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM186 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM186 Gene

Proteins for TMEM186 Gene

  • Protein details for TMEM186 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96B77-TM186_HUMAN
    Recommended name:
    Transmembrane protein 186
    Protein Accession:
    Q96B77
    Secondary Accessions:
    • B2RAY0
    • Q9Y4T4

    Protein attributes for TMEM186 Gene

    Size:
    213 amino acids
    Molecular mass:
    24893 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM186 Gene

Post-translational modifications for TMEM186 Gene

  • Ubiquitination at Lys55
  • Modification sites at PhosphoSitePlus

Other Protein References for TMEM186 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM186 Gene

Domains & Families for TMEM186 Gene

Gene Families for TMEM186 Gene

Protein Domains for TMEM186 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM186 Gene

GenScript: Design optimal peptide antigens:
  • Transmembrane protein 186 (TM186_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96B77

UniProtKB/Swiss-Prot:

TM186_HUMAN :
  • Belongs to the TMEM186 family.
Family:
  • Belongs to the TMEM186 family.
genes like me logo Genes that share domains with TMEM186: view

Function for TMEM186 Gene

Phenotypes From GWAS Catalog for TMEM186 Gene

Gene Ontology (GO) - Molecular Function for TMEM186 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 32814053
genes like me logo Genes that share ontologies with TMEM186: view
genes like me logo Genes that share phenotypes with TMEM186: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMEM186

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM186 Gene

Localization for TMEM186 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM186 Gene

Membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM186 gene
Compartment Confidence
mitochondrion 5
plasma membrane 2
cytoskeleton 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TMEM186 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM186: view

Pathways & Interactions for TMEM186 Gene

PathCards logo

SuperPathways for TMEM186 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMEM186 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM186 Gene

Drugs & Compounds for TMEM186 Gene

No Compound Related Data Available

Transcripts for TMEM186 Gene

mRNA/cDNA for TMEM186 Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMEM186

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM186 Gene

No ASD Table

Relevant External Links for TMEM186 Gene

GeneLoc Exon Structure for
TMEM186

Expression for TMEM186 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TMEM186 Gene

Protein differential expression in normal tissues from HIPED for TMEM186 Gene

This gene is overexpressed in Liver (14.8), Rectum (14.3), Frontal cortex (11.3), Testis (10.5), and Pancreas (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TMEM186 Gene



Protein tissue co-expression partners for TMEM186 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TMEM186

SOURCE GeneReport for Unigene cluster for TMEM186 Gene:

Hs.513330

Evidence on tissue expression from TISSUES for TMEM186 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with TMEM186: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM186 Gene

Orthologs for TMEM186 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM186 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TMEM186 30 31
  • 99.37 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia TMEM186 30 31
  • 77.99 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Tmem186 30
  • 77.31 (n)
Mouse
(Mus musculus)
Mammalia Tmem186 30 17 31
  • 74.96 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia TMEM186 31
  • 50 (a)
OneToOne
Chicken
(Gallus gallus)
Aves TMEM186 30 31
  • 51.36 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia TMEM186 31
  • 33 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia tmem186 30
  • 51.1 (n)
Zebrafish
(Danio rerio)
Actinopterygii zgc:194539 30
  • 51.27 (n)
TMEM186 31
  • 32 (a)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta CG4627 31
  • 27 (a)
OneToOne
Species where no ortholog for TMEM186 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for TMEM186 Gene

ENSEMBL:
Gene Tree for TMEM186 (if available)
TreeFam:
Gene Tree for TMEM186 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TMEM186: view image

Paralogs for TMEM186 Gene

No data available for Paralogs for TMEM186 Gene

Variants for TMEM186 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TMEM186 Gene

SNP ID Clinical significance and condition Chr 16 pos Variation AA Info Type
rs147436106 Benign: not provided 8,797,614(-) T/C
NM_015421.4(TMEM186):c.1A>G (p.Met1Val)
INITIATIOR_CODON_VARIANT,MISSENSE

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for TMEM186 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for TMEM186 Gene

Variant ID Type Subtype PubMed ID
dgv341n27 CNV gain 19166990
dgv4906n54 CNV gain 21841781
esv2763129 CNV gain 21179565
esv3637841 CNV gain 21293372
esv3637845 CNV gain 21293372
esv3892787 CNV gain 25118596
nsv1036281 CNV gain 25217958
nsv1047172 CNV gain 25217958
nsv457394 CNV gain 19166990
nsv457398 CNV gain 19166990
nsv476924 CNV novel sequence insertion 20440878
nsv571424 CNV gain 21841781
nsv571427 CNV gain 21841781
nsv571428 CNV gain 21841781
nsv819097 CNV loss 19587683

Variation tolerance for TMEM186 Gene

Residual Variation Intolerance Score: 86.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.94; 19.49% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM186 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM186

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM186 Gene

Disorders for TMEM186 Gene

MalaCards: The human disease database

(2) MalaCards diseases for TMEM186 Gene - From: COP

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TMEM186

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with TMEM186: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TMEM186 Gene

Publications for TMEM186 Gene

  1. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 2 3 4
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 41
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains. (PMID: 32814053) Haenig C … Wanker EE (Cell reports 2020) 3
  5. Global Interactome Mapping of Mitochondrial Intermembrane Space Proteases Identifies a Novel Function for HTRA2. (PMID: 31617661) Botham A … Schimmer A (Proteomics 2019) 3

Products for TMEM186 Gene

Sources for TMEM186 Gene