Aliases for TMEM185B Gene

Aliases for TMEM185B Gene

  • Transmembrane Protein 185B 2 3 4 5
  • Family With Sequence Similarity 11, Member B 2 3
  • Transmembrane Protein 185B (Pseudogene) 2 3
  • FAM11B 3 4
  • Putative Transmembrane Protein 185B 3
  • Protein FAM11B 4
  • Ee3_2 3

External Ids for TMEM185B Gene

Previous HGNC Symbols for TMEM185B Gene

  • FAM11B

Previous GeneCards Identifiers for TMEM185B Gene

  • GC02M120696
  • GC02M120978
  • GC02M113302

Summaries for TMEM185B Gene

GeneCards Summary for TMEM185B Gene

TMEM185B (Transmembrane Protein 185B) is a Protein Coding gene. Diseases associated with TMEM185B include Bare Lymphocyte Syndrome, Type Ii. An important paralog of this gene is TMEM185A.

Additional gene information for TMEM185B Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TMEM185B Gene

Genomics for TMEM185B Gene

GeneHancer (GH) Regulatory Elements for TMEM185B Gene

Promoters and enhancers for TMEM185B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J120222 Promoter/Enhancer 1.7 Ensembl ENCODE CraniofacialAtlas 509.8 -0.2 -193 4.8 ZBTB40 CTCF SIN3A MYC POLR2G USF1 GTF2E2 PHF8 ZFX ZIC2 TMEM185B piR-56436 RALB
GH02J119541 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 10.2 +676.6 676618 10.8 FOXK2 ZNF217 BCLAF1 JUND SIX5 PHB2 ZBTB26 TARDBP REST RFX1 CFAP221 SCTR TMEM185B TMEM177 EPB41L5 piR-32325-075
GH02J120011 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 7.5 +210.2 210163 3.2 ZBTB40 EP300 POLR2G SP1 NCOR1 PHF8 JUND ZFX REST POLR2A EPB41L5 TMEM185B C2orf76 piR-33432-295
GH02J121074 Enhancer 1.4 VISTA ENCODE 10 -852.0 -851986 1.1 NRF1 TCF12 BCLAF1 GTF2E2 ZNF639 ZIC2 REST SNRNP70 POLR2A ZBTB10 HQ292142 lnc-TFCP2L1-6 RPL12P15 NIFK TMEM185B ENSG00000234455 FJ601684-250
GH02J120203 Enhancer 1 FANTOM5 Ensembl 12.4 +17.6 17607 11.2 CTCF ZIC2 GABPA REST TGIF2 RAD21 CTBP1 SMC3 SAP130 YY1 RALB TMEM185B MTATP6P26 lnc-RALB-7 ENSG00000202046 ENSG00000224789
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TMEM185B on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TMEM185B

Top Transcription factor binding sites by QIAGEN in the TMEM185B gene promoter:
  • AML1a
  • C/EBPalpha
  • E2F
  • E2F-1
  • E47
  • LyF-1
  • NRSF form 1
  • NRSF form 2
  • Pax-3
  • Sox5

Genomic Locations for TMEM185B Gene

Genomic Locations for TMEM185B Gene
chr2:120,217,471-120,223,408
(GRCh38/hg38)
Size:
5,938 bases
Orientation:
Minus strand
chr2:120,975,047-120,980,984
(GRCh37/hg19)
Size:
5,938 bases
Orientation:
Minus strand

Genomic View for TMEM185B Gene

Genes around TMEM185B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM185B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM185B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM185B Gene

Proteins for TMEM185B Gene

  • Protein details for TMEM185B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H7F4-T185B_HUMAN
    Recommended name:
    Transmembrane protein 185B
    Protein Accession:
    Q9H7F4
    Secondary Accessions:
    • A8K1G5
    • Q53T33
    • Q66K44
    • Q8IZ77

    Protein attributes for TMEM185B Gene

    Size:
    350 amino acids
    Molecular mass:
    40599 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB14938.1; Type=Frameshift; Evidence={ECO:0000305};

neXtProt entry for TMEM185B Gene

Post-translational modifications for TMEM185B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM185B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM185B Gene

Domains & Families for TMEM185B Gene

Gene Families for TMEM185B Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TMEM185B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM185B Gene

GenScript: Design optimal peptide antigens:
  • Protein FAM11B (T185B_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9H7F4

UniProtKB/Swiss-Prot:

T185B_HUMAN :
  • Belongs to the TMEM185 family.
Family:
  • Belongs to the TMEM185 family.
genes like me logo Genes that share domains with TMEM185B: view

Function for TMEM185B Gene

Phenotypes From GWAS Catalog for TMEM185B Gene

Animal Model Products

  • Taconic Biosciences Mouse Models for TMEM185B

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMEM185B

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM185B Gene

Localization for TMEM185B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM185B Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TMEM185B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM185B: view

No data available for Subcellular locations from COMPARTMENTS for TMEM185B Gene

Pathways & Interactions for TMEM185B Gene

PathCards logo

SuperPathways for TMEM185B Gene

No Data Available

Interacting Proteins for TMEM185B Gene

STRING Interaction Network Preview (showing top 2 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000453399 Q9H7F4-T185B_HUMAN for TMEM185B Gene via STRING IID

;

Gene Ontology (GO) - Biological Process for TMEM185B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM185B Gene

Drugs & Compounds for TMEM185B Gene

No Compound Related Data Available

Transcripts for TMEM185B Gene

mRNA/cDNA for TMEM185B Gene

1 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMEM185B

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM185B Gene

No ASD Table

Relevant External Links for TMEM185B Gene

GeneLoc Exon Structure for
TMEM185B

Expression for TMEM185B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TMEM185B Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TMEM185B

SOURCE GeneReport for Unigene cluster for TMEM185B Gene:

Hs.376722

Evidence on tissue expression from TISSUES for TMEM185B Gene

  • Intestine(4)
  • Skin(4)
  • Nervous system(4)
genes like me logo Genes that share expression patterns with TMEM185B: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM185B Gene

Orthologs for TMEM185B Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM185B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM185B 30
  • 99.81 (n)
mouse
(Mus musculus)
Mammalia TMEM185B 31
  • 96 (a)
OneToOne
Tmem185b 17 30
  • 88.76 (n)
dog
(Canis familiaris)
Mammalia TMEM185B 31 30
  • 93.14 (n)
OneToOne
cow
(Bos Taurus)
Mammalia TMEM185B 31 30
  • 90.29 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 89 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Tmem185b 30
  • 88.76 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 88 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 31
  • 88 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 88 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii TMEM185A 31
  • 83 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001144 30
  • 55.49 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG14194 31 30
  • 54.6 (n)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea CELE_Y116A8C.9 30
  • 49.67 (n)
Y116A8C.9 31
  • 31 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.679 31
  • 52 (a)
OneToMany
Species where no ortholog for TMEM185B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TMEM185B Gene

ENSEMBL:
Gene Tree for TMEM185B (if available)
TreeFam:
Gene Tree for TMEM185B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TMEM185B: view image

Paralogs for TMEM185B Gene

Paralogs for TMEM185B Gene

(2) SIMAP similar genes for TMEM185B Gene using alignment to 1 proteins:

  • T185B_HUMAN

Pseudogenes.org Pseudogenes for TMEM185B Gene

genes like me logo Genes that share paralogs with TMEM185B: view

Variants for TMEM185B Gene

Additional dbSNP identifiers (rs#s) for TMEM185B Gene

Structural Variations from Database of Genomic Variants (DGV) for TMEM185B Gene

Variant ID Type Subtype PubMed ID
nsv1000477 CNV gain 25217958
nsv508164 CNV deletion 20534489
nsv834346 CNV gain 17160897

Variation tolerance for TMEM185B Gene

Gene Damage Index Score: 1.40; 27.63% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM185B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM185B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TMEM185B Gene

Disorders for TMEM185B Gene

MalaCards: The human disease database

(1) MalaCards diseases for TMEM185B Gene - From: DISEASES

Disorder Aliases PubMed IDs
bare lymphocyte syndrome, type ii
  • bls, type ii
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TMEM185B

genes like me logo Genes that share disorders with TMEM185B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TMEM185B Gene

Publications for TMEM185B Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  3. A novel gene, FAM11A, associated with the FRAXF CpG island is transcriptionally silent in FRAXF full mutation. (PMID: 12404111) Shaw MA … Gécz J (European journal of human genetics : EJHG 2002) 2 3 54
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 54
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 54

Products for TMEM185B Gene

Sources for TMEM185B Gene