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Aliases for TMEM184C Gene

Aliases for TMEM184C Gene

  • Transmembrane Protein 184C 2 3 5
  • Transmembrane Protein 34 2 3 4
  • TMEM34 3 4

External Ids for TMEM184C Gene

Previous HGNC Symbols for TMEM184C Gene

  • TMEM34

Previous GeneCards Identifiers for TMEM184C Gene

  • GC04P148760
  • GC04P148538
  • GC04P144265

Summaries for TMEM184C Gene

GeneCards Summary for TMEM184C Gene

TMEM184C (Transmembrane Protein 184C) is a Protein Coding gene. An important paralog of this gene is TMEM184B.

UniProtKB/Swiss-Prot for TMEM184C Gene

  • Possible tumor suppressor which may play a role in cell growth.

Additional gene information for TMEM184C Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM184C Gene

Genomics for TMEM184C Gene

GeneHancer (GH) Regulatory Elements for TMEM184C Gene

Promoters and enhancers for TMEM184C Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04I147616 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 562.3 +0.3 304 1.9 HDGF PKNOX1 ARID4B SIN3A DMAP1 YY1 POLR2B E2F8 ZNF143 FOS TMEM184C ENSG00000251298 PRMT9 GC04P147631
GH04I147590 Enhancer 0.8 Ensembl ENCODE 20.8 -27.0 -26970 0.4 CTCF ZNF654 TRIM22 ZNF384 REST RAD21 CC2D1A FOXK2 SMC3 ZNF143 TMEM184C LINC02507 ENSG00000251298
GH04I147596 Enhancer 0.6 ENCODE 22.5 -19.9 -19932 1.2 MAX CEBPB MNT EP300 JUND POLR2A ELK1 RCOR1 FOS CHD2 TMEM184C ENSG00000251298 LINC02507
GH04I147767 Enhancer 1.1 Ensembl ENCODE 10.4 +151.1 151128 1 PKNOX1 ARNT SIN3A FEZF1 ZNF2 GLIS2 ZNF213 KLF7 TSHZ1 ZNF488 ARHGAP10 TMEM184C GC04P147773 RNA5SP165
GH04I147581 Enhancer 0.6 ENCODE 13.7 -35.3 -35290 1.8 ELK4 SRF TEAD4 TAL1 CEBPB CBFA2T3 EP300 TCF12 NCOR1 HDAC2 TMEM184C LINC02507 ENSG00000251298
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TMEM184C on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TMEM184C gene promoter:

Genomic Locations for TMEM184C Gene

Genomic Locations for TMEM184C Gene
54,674 bases
Plus strand

Genomic View for TMEM184C Gene

Genes around TMEM184C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM184C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM184C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM184C Gene

Proteins for TMEM184C Gene

  • Protein details for TMEM184C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 184C
    Protein Accession:
    Secondary Accessions:
    • D3DP04
    • Q86X84
    • Q969I7
    • Q9NXM2

    Protein attributes for TMEM184C Gene

    438 amino acids
    Molecular mass:
    50142 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAK55526.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA90988.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for TMEM184C Gene


neXtProt entry for TMEM184C Gene

Post-translational modifications for TMEM184C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM184C Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM184C Gene

Domains & Families for TMEM184C Gene

Gene Families for TMEM184C Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TMEM184C Gene


Suggested Antigen Peptide Sequences for TMEM184C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TMEM184 family.
  • Belongs to the TMEM184 family.
genes like me logo Genes that share domains with TMEM184C: view

Function for TMEM184C Gene

Molecular function for TMEM184C Gene

UniProtKB/Swiss-Prot Function:
Possible tumor suppressor which may play a role in cell growth.

Phenotypes From GWAS Catalog for TMEM184C Gene

Gene Ontology (GO) - Molecular Function for TMEM184C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity IBA --
genes like me logo Genes that share ontologies with TMEM184C: view

Phenotypes for TMEM184C Gene

GenomeRNAi human phenotypes for TMEM184C:
genes like me logo Genes that share phenotypes with TMEM184C: view

Animal Model Products

miRNA for TMEM184C Gene

miRTarBase miRNAs that target TMEM184C

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM184C Gene

Localization for TMEM184C Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM184C Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM184C gene
Compartment Confidence
plasma membrane 3
nucleus 2
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TMEM184C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA,IBA --
genes like me logo Genes that share ontologies with TMEM184C: view

Pathways & Interactions for TMEM184C Gene

SuperPathways for TMEM184C Gene

No Data Available

Interacting Proteins for TMEM184C Gene

Gene Ontology (GO) - Biological Process for TMEM184C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IBA --
genes like me logo Genes that share ontologies with TMEM184C: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM184C Gene

Drugs & Compounds for TMEM184C Gene

No Compound Related Data Available

Transcripts for TMEM184C Gene

mRNA/cDNA for TMEM184C Gene

Unigene Clusters for TMEM184C Gene

Transmembrane protein 184C:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM184C Gene

No ASD Table

Relevant External Links for TMEM184C Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM184C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM184C Gene

Protein differential expression in normal tissues from HIPED for TMEM184C Gene

This gene is overexpressed in Kidney (21.0), Liver (16.6), and Fetal Brain (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TMEM184C Gene

Protein tissue co-expression partners for TMEM184C Gene

NURSA nuclear receptor signaling pathways regulating expression of TMEM184C Gene:


SOURCE GeneReport for Unigene cluster for TMEM184C Gene:


mRNA Expression by UniProt/SwissProt for TMEM184C Gene:

Tissue specificity: Widely expressed with higher expression in lung, kidney, spleen, pancreas, thymus, prostate, testis, ovary, small intestine and thyroid.

Evidence on tissue expression from TISSUES for TMEM184C Gene

  • Intestine(4.2)
  • Lung(4.2)
  • Thyroid gland(2)
  • Nervous system(2)
genes like me logo Genes that share expression patterns with TMEM184C: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM184C Gene

Orthologs for TMEM184C Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TMEM184C Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMEM184C 33 34
  • 97.49 (n)
(Canis familiaris)
Mammalia TMEM184C 33 34
  • 92.77 (n)
(Bos Taurus)
Mammalia TMEM184C 33
  • 90.87 (n)
TMEM34 34
  • 87 (a)
(Monodelphis domestica)
Mammalia TMEM184C 34
  • 83 (a)
(Rattus norvegicus)
Mammalia Tmem184c 33
  • 76.31 (n)
(Mus musculus)
Mammalia Tmem184c 33 16 34
  • 75.84 (n)
(Ornithorhynchus anatinus)
Mammalia TMEM184C 34
  • 75 (a)
(Gallus gallus)
Aves TMEM184C 33 34
  • 78.29 (n)
(Anolis carolinensis)
Reptilia TMEM184C 34
  • 82 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem184c 33
  • 73.47 (n)
Str.14637 33
(Danio rerio)
Actinopterygii tmem184c 33 34
  • 70.99 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008048 33
  • 51.52 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG5850 33 34
  • 51 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 34
  • 23 (a)
-- 36
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G23070 33
  • 46.78 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 44 (a)
Species where no ortholog for TMEM184C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM184C Gene

Gene Tree for TMEM184C (if available)
Gene Tree for TMEM184C (if available)

Paralogs for TMEM184C Gene

Paralogs for TMEM184C Gene

(2) SIMAP similar genes for TMEM184C Gene using alignment to 2 proteins: Pseudogenes for TMEM184C Gene

genes like me logo Genes that share paralogs with TMEM184C: view

Variants for TMEM184C Gene

Sequence variations from dbSNP and Humsavar for TMEM184C Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1000551635 -- 147,632,079(+) AGGAG/AG intron_variant
rs1000622543 -- 147,630,103(+) T/C intron_variant
rs1000883621 -- 147,636,543(+) G/T genic_downstream_transcript_variant, non_coding_transcript_variant
rs1000899940 -- 147,632,401(+) A/G intron_variant
rs1000938354 -- 147,637,633(+) T/C downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM184C Gene

Variant ID Type Subtype PubMed ID
nsv1019205 CNV loss 25217958
nsv1146650 CNV deletion 26484159
nsv830110 CNV loss 17160897

Variation tolerance for TMEM184C Gene

Residual Variation Intolerance Score: 16.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.25; 5.49% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM184C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM184C Gene

Disorders for TMEM184C Gene

Additional Disease Information for TMEM184C

No disorders were found for TMEM184C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM184C Gene

Publications for TMEM184C Gene

  1. Down-regulation of an inhibitor of cell growth, transmembrane protein 34 (TMEM34), in anaplastic thyroid cancer. (PMID: 17072649) Akaishi J … Shimizu K (Journal of cancer research and clinical oncology 2007) 3 4 22 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Gene expression profiling in human fetal liver and identification of tissue- and developmental-stage-specific genes through compiled expression profiles and efficient cloning of full-length cDNAs. (PMID: 11483580) Yu Y … He F (Genome research 2001) 3 4 58
  4. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta GD … Pelletier L (Cell 2015) 3 58
  5. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H … Mohammed S (Journal of proteome research 2013) 4 58

Products for TMEM184C Gene

Sources for TMEM184C Gene

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