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Aliases for TMEM184B Gene

Aliases for TMEM184B Gene

  • Transmembrane Protein 184B 2 3 5
  • Putative MAPK-Activating Protein FM08 3 4
  • C22orf5 3 4
  • Chromosome 22 Open Reading Frame 5 2
  • HSPC256 3
  • HS5O6A 3
  • FM08 3

External Ids for TMEM184B Gene

Previous HGNC Symbols for TMEM184B Gene

  • C22orf5

Previous GeneCards Identifiers for TMEM184B Gene

  • GC22M036945
  • GC22M038615
  • GC22M021581
  • GC22M038396
  • GC22M038520
  • GC22M038830
  • GC22M039968
  • GC22M040658
  • GC22M041107
  • GC22M041511

Summaries for TMEM184B Gene

GeneCards Summary for TMEM184B Gene

TMEM184B (Transmembrane Protein 184B) is a Protein Coding gene. An important paralog of this gene is TMEM184A.

UniProtKB/Swiss-Prot for TMEM184B Gene

  • May activate the MAP kinase signaling pathway.

Gene Wiki entry for TMEM184B Gene

Additional gene information for TMEM184B Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM184B Gene

Genomics for TMEM184B Gene

GeneHancer (GH) Regulatory Elements for TMEM184B Gene

Promoters and enhancers for TMEM184B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22I038269 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 560.2 +1.1 1050 4.3 HDGF HDAC1 SMAD1 RB1 ARID4B SIN3A ZBTB40 ZNF2 ZEB1 ZNF335 TMEM184B RN7SL704P
GH22I038246 Promoter/Enhancer 0.7 EPDnew dbSUPER 550.3 +26.9 26919 0.1 TMEM184B RN7SL704P
GH22I038174 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 23.6 +94.2 94225 8.7 MLX DMAP1 YBX1 IRF4 YY1 SLC30A9 E2F8 ZNF143 MCM3 SP3 PLA2G6 DDX17 MAFF ENSG00000228274 CSNK1E ANKRD54 CBY1 ENSG00000230912 GGA1 TMEM184B
GH22I038227 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 24.4 +43.5 43496 4.2 SOX13 CTCF TFAP4 KLF1 FOXA2 SAP130 JUN MAX ZNF48 RAD21 ENSG00000235246 TMEM184B MAFF PICK1 GTPBP1 JOSD1 CSNK1E GC22P038220
GH22I038308 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 12.7 -41.2 -41203 11.9 HDGF PKNOX1 SMAD1 FOXA2 MLX ARID4B SIN3A DMAP1 YY1 SLC30A9 CSNK1E TMEM184B PICK1 MAFF KCNJ4 KDELR3 POLR2F SOX10 PDXP GGA1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TMEM184B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TMEM184B gene promoter:

Genomic Locations for TMEM184B Gene

Genomic Locations for TMEM184B Gene
56,658 bases
Minus strand

Genomic View for TMEM184B Gene

Genes around TMEM184B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM184B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM184B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM184B Gene

Proteins for TMEM184B Gene

  • Protein details for TMEM184B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 184B
    Protein Accession:
    Secondary Accessions:
    • A8K9D7
    • Q63HM8
    • Q7Z421
    • Q8NBM5
    • Q9UGT8
    • Q9UGT9
    • Q9UGV5

    Protein attributes for TMEM184B Gene

    407 amino acids
    Molecular mass:
    45562 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC11607.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAB51403.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for TMEM184B Gene

Post-translational modifications for TMEM184B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TMEM184B Gene

Domains & Families for TMEM184B Gene

Gene Families for TMEM184B Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for TMEM184B Gene

Suggested Antigen Peptide Sequences for TMEM184B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TMEM184 family.
  • Belongs to the TMEM184 family.
genes like me logo Genes that share domains with TMEM184B: view

Function for TMEM184B Gene

Molecular function for TMEM184B Gene

UniProtKB/Swiss-Prot Function:
May activate the MAP kinase signaling pathway.

Phenotypes From GWAS Catalog for TMEM184B Gene

Gene Ontology (GO) - Molecular Function for TMEM184B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity IBA --
genes like me logo Genes that share ontologies with TMEM184B: view
genes like me logo Genes that share phenotypes with TMEM184B: view

Animal Models for TMEM184B Gene

MGI Knock Outs for TMEM184B:

Animal Model Products

  • Taconic Biosciences Mouse Models for TMEM184B

CRISPR Products

miRNA for TMEM184B Gene

miRTarBase miRNAs that target TMEM184B

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TMEM184B Gene

Localization for TMEM184B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM184B Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM184B gene
Compartment Confidence
plasma membrane 3
nucleus 2
cytosol 2
golgi apparatus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Golgi apparatus (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TMEM184B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA,IEA --
genes like me logo Genes that share ontologies with TMEM184B: view

Pathways & Interactions for TMEM184B Gene

SuperPathways for TMEM184B Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMEM184B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IBA --
genes like me logo Genes that share ontologies with TMEM184B: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM184B Gene

Drugs & Compounds for TMEM184B Gene

No Compound Related Data Available

Transcripts for TMEM184B Gene

Unigene Clusters for TMEM184B Gene

Transmembrane protein 184B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM184B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d ^ 8 ^ 9a · 9b · 9c · 9d ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b · 13c
SP1: - - - - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - -
SP4: - -
SP5: - - -
SP6: -
SP7: - - - - - - - -
SP8: - - -
SP10: -

Relevant External Links for TMEM184B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM184B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM184B Gene

Protein differential expression in normal tissues from HIPED for TMEM184B Gene

This gene is overexpressed in Retina (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TMEM184B Gene

Protein tissue co-expression partners for TMEM184B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TMEM184B Gene:


SOURCE GeneReport for Unigene cluster for TMEM184B Gene:


Evidence on tissue expression from TISSUES for TMEM184B Gene

  • Lung(4.5)
  • Pancreas(4.5)
  • Nervous system(4.5)
genes like me logo Genes that share expression patterns with TMEM184B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM184B Gene

Orthologs for TMEM184B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TMEM184B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMEM184B 33 34
  • 99.43 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 95 (a)
-- 34
  • 90 (a)
(Bos Taurus)
Mammalia TMEM184B 33 34
  • 94.51 (n)
(Canis familiaris)
Mammalia TMEM184B 33 34
  • 92.79 (n)
(Mus musculus)
Mammalia Tmem184b 33 16 34
  • 91.07 (n)
(Monodelphis domestica)
Mammalia TMEM184B 34
  • 91 (a)
(Rattus norvegicus)
Mammalia Tmem184b 33
  • 90.83 (n)
(Gallus gallus)
Aves TMEM184B 33 34
  • 83.62 (n)
(Anolis carolinensis)
Reptilia TMEM184B 34
  • 87 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem184b 33
  • 78.62 (n)
Str.15225 33
(Danio rerio)
Actinopterygii tmem184bb 34
  • 78 (a)
tmem184ba 33 34
  • 77.84 (n)
TMEM184B (2 of 3) 34
  • 75 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006101 33
  • 66.95 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG12004 33 34
  • 66.41 (n)
(Caenorhabditis elegans)
Secernentea F40E10.6 33 34
  • 61.11 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 34
  • 21 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 61 (a)
Species where no ortholog for TMEM184B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMEM184B Gene

Gene Tree for TMEM184B (if available)
Gene Tree for TMEM184B (if available)

Paralogs for TMEM184B Gene

Paralogs for TMEM184B Gene

(2) SIMAP similar genes for TMEM184B Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with TMEM184B: view

Variants for TMEM184B Gene

Sequence variations from dbSNP and Humsavar for TMEM184B Gene

SNP ID Clin Chr 22 pos Variation AA Info Type
rs1000024834 -- 38,262,727(-) G/A genic_upstream_transcript_variant, intron_variant
rs1000031938 -- 38,268,858(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000055199 -- 38,267,534(-) G/A genic_upstream_transcript_variant, intron_variant
rs1000066553 -- 38,240,524(-) A/G intron_variant
rs1000083960 -- 38,268,585(-) G/A genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM184B Gene

Variant ID Type Subtype PubMed ID
esv2659372 CNV deletion 23128226
esv2670091 CNV deletion 23128226
esv2673581 CNV deletion 23128226
esv2724225 CNV deletion 23290073
esv2724226 CNV deletion 23290073
esv2724227 CNV deletion 23290073
esv3647725 CNV loss 21293372
nsv1136676 CNV deletion 24896259
nsv1136677 CNV deletion 24896259
nsv834194 CNV loss 17160897

Variation tolerance for TMEM184B Gene

Residual Variation Intolerance Score: 14.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.81; 17.08% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM184B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM184B Gene

Disorders for TMEM184B Gene

Additional Disease Information for TMEM184B

No disorders were found for TMEM184B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM184B Gene

Publications for TMEM184B Gene

  1. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I … O'Brien KP (Nature 1999) 2 3 4 58
  2. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PMID: 16303743) Otsuki T … Isogai T (DNA research : an international journal for rapid publication of reports on genes and genomes 2005) 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins JE … Dunham I (Genome biology 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for TMEM184B Gene

Sources for TMEM184B Gene

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