Aliases for TMEM184B Gene

Aliases for TMEM184B Gene

  • Transmembrane Protein 184B 2 3 4 5
  • Putative MAPK-Activating Protein FM08 3 4
  • C22orf5 3 4
  • HS5O6A 2 3
  • FM08 2 3
  • Chromosome 22 Open Reading Frame 5 2
  • DKFZP586A1024 2
  • TMEM184B 5
  • HSPC256 3

External Ids for TMEM184B Gene

Previous HGNC Symbols for TMEM184B Gene

  • C22orf5

Previous GeneCards Identifiers for TMEM184B Gene

  • GC22M036945
  • GC22M038615
  • GC22M021581
  • GC22M038396
  • GC22M038520
  • GC22M043825
  • GC22M044203
  • GC22M044536
  • GC22M045381
  • GC22M038830
  • GC22M039968
  • GC22M040658
  • GC22M041107
  • GC22M041511
  • GC22M041929
  • GC22M042360
  • GC22M043452
  • GC22M046237

Summaries for TMEM184B Gene

GeneCards Summary for TMEM184B Gene

TMEM184B (Transmembrane Protein 184B) is a Protein Coding gene. Diseases associated with TMEM184B include Amyloidosis, Finnish Type. An important paralog of this gene is TMEM184A.

UniProtKB/Swiss-Prot Summary for TMEM184B Gene

Gene Wiki entry for TMEM184B Gene

Additional gene information for TMEM184B Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TMEM184B Gene

Genomics for TMEM184B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TMEM184B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TMEM184B on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TMEM184B

Top Transcription factor binding sites by QIAGEN in the TMEM184B gene promoter:
  • ATF6
  • E4BP4
  • Elk-1
  • FOXC1
  • Hlf
  • MZF-1
  • Pax-4a
  • PPAR-alpha
  • Spz1
  • Zic1

Genomic Locations for TMEM184B Gene

Latest Assembly
53,723 bases
Minus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
53,719 bases
Minus strand

(GRCh37/hg19 by Ensembl)
53,743 bases
Minus strand

Genomic View for TMEM184B Gene

Genes around TMEM184B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM184B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM184B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM184B Gene

Proteins for TMEM184B Gene

  • Protein details for TMEM184B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 184B
    Protein Accession:
    Secondary Accessions:
    • A8K9D7
    • Q63HM8
    • Q7Z421
    • Q8NBM5
    • Q9UGT8
    • Q9UGT9
    • Q9UGV5

    Protein attributes for TMEM184B Gene

    407 amino acids
    Molecular mass:
    45562 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC11607.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAB51403.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for TMEM184B Gene

Post-translational modifications for TMEM184B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibodies for research

  • Boster Bio Antibodies for TMEM184B
  • Santa Cruz Biotechnology (SCBT) Antibodies for TMEM184B

No data available for DME Specific Peptides for TMEM184B Gene

Domains & Families for TMEM184B Gene

Gene Families for TMEM184B Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for TMEM184B Gene

  • Protein of unknown function

Suggested Antigen Peptide Sequences for TMEM184B Gene

GenScript: Design optimal peptide antigens:
  • Putative MAPK-activating protein FM08 (T184B_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TMEM184 family.
  • Belongs to the TMEM184 family.
genes like me logo Genes that share domains with TMEM184B: view

Function for TMEM184B Gene

Molecular function for TMEM184B Gene

UniProtKB/Swiss-Prot Function:
May activate the MAP kinase signaling pathway.

Phenotypes From GWAS Catalog for TMEM184B Gene

Gene Ontology (GO) - Molecular Function for TMEM184B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity IBA 21873635
genes like me logo Genes that share ontologies with TMEM184B: view
genes like me logo Genes that share phenotypes with TMEM184B: view

Animal Models for TMEM184B Gene

MGI Knock Outs for TMEM184B:

Animal Models for research

  • Taconic Biosciences Mouse Models for TMEM184B

miRNA for TMEM184B Gene

miRTarBase miRNAs that target TMEM184B

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMEM184B

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TMEM184B Gene

Localization for TMEM184B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM184B Gene

Membrane. Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM184B gene
Compartment Confidence
plasma membrane 3
nucleus 2
extracellular 1
cytoskeleton 1
mitochondrion 1
endosome 1
cytosol 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Golgi apparatus (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TMEM184B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA,IBA 21873635
genes like me logo Genes that share ontologies with TMEM184B: view

Pathways & Interactions for TMEM184B Gene

PathCards logo

SuperPathways for TMEM184B Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMEM184B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IBA 21873635
genes like me logo Genes that share ontologies with TMEM184B: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM184B Gene

Drugs & Compounds for TMEM184B Gene

No Compound Related Data Available

Transcripts for TMEM184B Gene

mRNA/cDNA for TMEM184B Gene

17 NCBI additional mRNA sequence :
13 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMEM184B

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM184B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d ^ 8 ^ 9a · 9b · 9c · 9d ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b · 13c
SP1: - - - - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - -
SP4: - -
SP5: - - -
SP6: -
SP7: - - - - - - - -
SP8: - - -
SP10: -

Relevant External Links for TMEM184B Gene

GeneLoc Exon Structure for

Expression for TMEM184B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TMEM184B Gene

Protein differential expression in normal tissues from HIPED for TMEM184B Gene

This gene is overexpressed in Retina (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TMEM184B Gene

Protein tissue co-expression partners for TMEM184B Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TMEM184B

SOURCE GeneReport for Unigene cluster for TMEM184B Gene:


Evidence on tissue expression from TISSUES for TMEM184B Gene

  • Pancreas(4.5)
  • Nervous system(4.5)
  • Lung(4.5)
genes like me logo Genes that share expression patterns with TMEM184B: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM184B Gene

Orthologs for TMEM184B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TMEM184B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMEM184B 30 31
  • 99.43 (n)
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 95 (a)
-- 31
  • 90 (a)
(Bos Taurus)
Mammalia TMEM184B 30 31
  • 94.51 (n)
(Canis familiaris)
Mammalia TMEM184B 30 31
  • 92.79 (n)
(Mus musculus)
Mammalia Tmem184b 30 17 31
  • 91.07 (n)
(Monodelphis domestica)
Mammalia TMEM184B 31
  • 91 (a)
(Rattus norvegicus)
Mammalia Tmem184b 30
  • 90.83 (n)
(Gallus gallus)
Aves TMEM184B 30 31
  • 83.62 (n)
(Anolis carolinensis)
Reptilia TMEM184B 31
  • 87 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia tmem184b 30
  • 78.62 (n)
Str.15225 30
(Danio rerio)
Actinopterygii tmem184bb 31
  • 78 (a)
tmem184ba 30 31
  • 77.84 (n)
TMEM184B (2 of 3) 31
  • 75 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006101 30
  • 66.95 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta CG12004 30 31
  • 66.41 (n)
(Caenorhabditis elegans)
Secernentea F40E10.6 30 31
  • 61.11 (n)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 31
  • 21 (a)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 61 (a)
Species where no ortholog for TMEM184B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for TMEM184B Gene

Gene Tree for TMEM184B (if available)
Gene Tree for TMEM184B (if available)
Evolutionary constrained regions (ECRs) for TMEM184B: view image

Paralogs for TMEM184B Gene

Paralogs for TMEM184B Gene

(2) SIMAP similar genes for TMEM184B Gene using alignment to 4 proteins:

  • T184B_HUMAN
  • B0QY30_HUMAN
  • F2Z397_HUMAN
genes like me logo Genes that share paralogs with TMEM184B: view

Variants for TMEM184B Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for TMEM184B Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for TMEM184B Gene

Variant ID Type Subtype PubMed ID
esv2659372 CNV deletion 23128226
esv2670091 CNV deletion 23128226
esv2673581 CNV deletion 23128226
esv2724225 CNV deletion 23290073
esv2724226 CNV deletion 23290073
esv2724227 CNV deletion 23290073
esv3647725 CNV loss 21293372
nsv1136676 CNV deletion 24896259
nsv1136677 CNV deletion 24896259
nsv834194 CNV loss 17160897

Variation tolerance for TMEM184B Gene

Residual Variation Intolerance Score: 14.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.81; 17.08% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM184B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TMEM184B Gene

Disorders for TMEM184B Gene

MalaCards: The human disease database

(1) MalaCards diseases for TMEM184B Gene - From: COP

Disorder Aliases PubMed IDs
amyloidosis, finnish type
  • amyloidosis v
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TMEM184B

genes like me logo Genes that share disorders with TMEM184B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TMEM184B Gene

Publications for TMEM184B Gene

  1. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I … O'Brien KP (Nature 1999) 2 3 4
  2. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PMID: 16303743) Otsuki T … Isogai T (DNA research : an international journal for rapid publication of reports on genes and genomes 2005) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins JE … Dunham I (Genome biology 2004) 3 4

Products for TMEM184B Gene

Sources for TMEM184B Gene