Aliases for TMEM183A Gene

Aliases for TMEM183A Gene

  • Transmembrane Protein 183A 2 3 4 5
  • C1orf37 3 4
  • Chromosome 1 Open Reading Frame 37 2

External Ids for TMEM183A Gene

Previous HGNC Symbols for TMEM183A Gene

  • C1orf37

Previous GeneCards Identifiers for TMEM183A Gene

  • GC01P201245
  • GC01P202976

Summaries for TMEM183A Gene

GeneCards Summary for TMEM183A Gene

TMEM183A (Transmembrane Protein 183A) is a Protein Coding gene. Diseases associated with TMEM183A include Inflammatory Bowel Disease 7.

Additional gene information for TMEM183A Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TMEM183A Gene

Genomics for TMEM183A Gene

GeneHancer (GH) Regulatory Elements for TMEM183A Gene

Promoters and enhancers for TMEM183A Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TMEM183A on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TMEM183A

Top Transcription factor binding sites by QIAGEN in the TMEM183A gene promoter:
  • CUTL1
  • E2F
  • E2F-1
  • IRF-7A
  • Nkx2-5
  • p53
  • SRF
  • SRF (504 AA)

Genomic Locations for TMEM183A Gene

Genomic Locations for TMEM183A Gene
chr1:203,007,374-203,024,848
(GRCh38/hg38)
Size:
17,475 bases
Orientation:
Plus strand
chr1:202,976,514-202,993,976
(GRCh37/hg19)
Size:
17,463 bases
Orientation:
Plus strand

Genomic View for TMEM183A Gene

Genes around TMEM183A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM183A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM183A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM183A Gene

Proteins for TMEM183A Gene

  • Protein details for TMEM183A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IXX5-T183A_HUMAN
    Recommended name:
    Transmembrane protein 183A
    Protein Accession:
    Q8IXX5
    Secondary Accessions:
    • A8K5W1
    • Q6NW15
    • Q96E06

    Protein attributes for TMEM183A Gene

    Size:
    376 amino acids
    Molecular mass:
    42826 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM183A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM183A Gene

Post-translational modifications for TMEM183A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM183A Gene

No data available for DME Specific Peptides for TMEM183A Gene

Domains & Families for TMEM183A Gene

Gene Families for TMEM183A Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TMEM183A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM183A Gene

GenScript: Design optimal peptide antigens:
  • cDNA, FLJ93446 (A8K5W1_HUMAN)
  • Transmembrane protein 183A (T183A_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8IXX5

UniProtKB/Swiss-Prot:

T183A_HUMAN :
  • Belongs to the TMEM183 family.
Family:
  • Belongs to the TMEM183 family.
genes like me logo Genes that share domains with TMEM183A: view

Function for TMEM183A Gene

Gene Ontology (GO) - Molecular Function for TMEM183A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TMEM183A: view
genes like me logo Genes that share phenotypes with TMEM183A: view

Animal Model Products

CRISPR Products

miRNA for TMEM183A Gene

miRTarBase miRNAs that target TMEM183A

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMEM183A

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM183A Gene

Localization for TMEM183A Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM183A Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM183A gene
Compartment Confidence
nucleus 2
cytosol 2
plasma membrane 1
mitochondrion 0
peroxisome 0
endoplasmic reticulum 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (2)
  • Nucleoplasm (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TMEM183A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM183A: view

Pathways & Interactions for TMEM183A Gene

PathCards logo

SuperPathways for TMEM183A Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMEM183A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM183A Gene

Drugs & Compounds for TMEM183A Gene

No Compound Related Data Available

Transcripts for TMEM183A Gene

mRNA/cDNA for TMEM183A Gene

8 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMEM183A

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM183A Gene

No ASD Table

Relevant External Links for TMEM183A Gene

GeneLoc Exon Structure for
TMEM183A

Expression for TMEM183A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TMEM183A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TMEM183A

SOURCE GeneReport for Unigene cluster for TMEM183A Gene:

Hs.497443

Evidence on tissue expression from TISSUES for TMEM183A Gene

  • Nervous system(4.7)
  • Intestine(4.3)
genes like me logo Genes that share expression patterns with TMEM183A: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM183A Gene

Orthologs for TMEM183A Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM183A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM183A 31 30
  • 99.82 (n)
OneToOne
cow
(Bos Taurus)
Mammalia TMEM183 31
  • 95 (a)
OneToOne
LOC534797 30
  • 94.5 (n)
dog
(Canis familiaris)
Mammalia TMEM183A 31 30
  • 94.15 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMEM183A 31
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem183a 30
  • 92.11 (n)
mouse
(Mus musculus)
Mammalia Tmem183a 17 31 30
  • 91.11 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM183A 31
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM183A 31 30
  • 78.97 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM183A 31
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem183a 30
  • 64.04 (n)
Str.10764 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.18610 30
zebrafish
(Danio rerio)
Actinopterygii tmem183a 31 30
  • 65.83 (n)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13905 30
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004102 30
  • 43.91 (n)
fruit fly
(Drosophila melanogaster)
Insecta fsd 31
  • 21 (a)
OneToOne
Species where no ortholog for TMEM183A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM183A Gene

ENSEMBL:
Gene Tree for TMEM183A (if available)
TreeFam:
Gene Tree for TMEM183A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TMEM183A: view image

Paralogs for TMEM183A Gene

(1) SIMAP similar genes for TMEM183A Gene using alignment to 1 proteins:

  • T183A_HUMAN
genes like me logo Genes that share paralogs with TMEM183A: view

No data available for Paralogs for TMEM183A Gene

Variants for TMEM183A Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TMEM183A Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs193920903 Uncertain Significance: Malignant tumor of prostate 203,016,141(+) G/A SPLICE_DONOR_VARIANT
rs11558253 - p.Arg10Met
rs6678040 - p.Ala80Thr

Additional dbSNP identifiers (rs#s) for TMEM183A Gene

Structural Variations from Database of Genomic Variants (DGV) for TMEM183A Gene

Variant ID Type Subtype PubMed ID
nsv1110666 CNV insertion 24896259
nsv4132 CNV insertion 18451855
nsv832370 CNV loss 17160897
nsv946592 CNV duplication 23825009

Variation tolerance for TMEM183A Gene

Residual Variation Intolerance Score: 44.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.20; 75.99% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM183A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM183A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM183A Gene

Disorders for TMEM183A Gene

MalaCards: The human disease database

(1) MalaCards diseases for TMEM183A Gene - From: DISEASES

Disorder Aliases PubMed IDs
inflammatory bowel disease 7
  • ibd7
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TMEM183A

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TMEM183A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TMEM183A Gene

Publications for TMEM183A Gene

  1. Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study. (PMID: 19536175) Ehret GB … Chakravarti A (European journal of human genetics : EJHG 2009) 3 41 54
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  3. A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape. (PMID: 30833792) Hubel P … Pichlmair A (Nature immunology 2019) 3 54
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 54
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 54

Products for TMEM183A Gene

Sources for TMEM183A Gene