Aliases for TMEM182 Gene

Aliases for TMEM182 Gene

  • Transmembrane Protein 182 2 3 4 5
  • FLJ30294 2
  • TMEM182 5

External Ids for TMEM182 Gene

Previous GeneCards Identifiers for TMEM182 Gene

  • GC02P103353
  • GC02P097144

Summaries for TMEM182 Gene

GeneCards Summary for TMEM182 Gene

TMEM182 (Transmembrane Protein 182) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TMEM182 Gene

Genomics for TMEM182 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TMEM182 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J102735 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 250.7 -0.4 -404 3 MXD4 CEBPA SMAD5 ZNF217 POLR2A ELF1 ZIC2 KDM6A THAP11 SIN3A MFSD9 HSALNG0017440 TMEM182 lnc-RFX8-4 lnc-MFSD9-7 SLC9A2
GH02J102761 Promoter/Enhancer 1.2 EPDnew Ensembl ENCODE dbSUPER 250.3 +25.9 25941 3.1 BCL6 JUND HLF TMEM182 MFSD9 HSALNG0017440 HSALNG0017443
GH02J102797 Promoter 0.8 EPDnew 250.2 +60.9 60915 0.1 HOMEZ FOXA2 RXRA ZBTB33 BCL6 JUND FOXA1 NR2F6 REST CEBPG TMEM182 HSALNG0017440 HSALNG0017443
GH02J102801 Enhancer 1.1 Ensembl ENCODE dbSUPER 0.2 +66.1 66125 3.1 BHLHE40 FOXA2 NBN TAL1 RXRA ZBTB33 SKIL BCL6 JUND SPI1 MFSD9 HSALNG0017443 HSALNG0017440 TMEM182
GH02J102753 Enhancer 0.6 Ensembl 0.4 +16.7 16686 0.8 CTCF TRIM22 SMC3 TEAD3 RAD21 ZNF664 TEAD4 ARID3A MIXL1 ZNF24 MFSD9 HSALNG0017440 TMEM182 HSALNG0017443
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TMEM182 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TMEM182

Top Transcription factor binding sites by QIAGEN in the TMEM182 gene promoter:
  • AP-4
  • E47
  • FOXJ2
  • FOXJ2 (long isoform)
  • GATA-1
  • GATA-2
  • Nkx2-5
  • Pbx1a
  • SRY
  • Tal-1

Genomic Locations for TMEM182 Gene

Latest Assembly
282,996 bases
Plus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
80,745 bases
Plus strand

(GRCh37/hg19 by Ensembl)
106,986 bases
Plus strand

Genomic View for TMEM182 Gene

Genes around TMEM182 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM182 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM182 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM182 Gene

Proteins for TMEM182 Gene

  • Protein details for TMEM182 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 182
    Protein Accession:
    Secondary Accessions:
    • C9JML7
    • Q3B7B8
    • Q53TT9
    • Q6GMU0
    • Q8WW45
    • Q96NR4

    Protein attributes for TMEM182 Gene

    229 amino acids
    Molecular mass:
    25879 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH73844.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=AAI07695.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for TMEM182 Gene


neXtProt entry for TMEM182 Gene

Post-translational modifications for TMEM182 Gene

  • Glycosylation at Asn102 and Asn47
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TMEM182 Gene

Domains & Families for TMEM182 Gene

Gene Families for TMEM182 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for TMEM182 Gene


Suggested Antigen Peptide Sequences for TMEM182 Gene

GenScript: Design optimal peptide antigens:
  • Transmembrane protein 182 (TM182_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TMEM182 family.
  • Belongs to the TMEM182 family.
genes like me logo Genes that share domains with TMEM182: view

Function for TMEM182 Gene

Phenotypes From GWAS Catalog for TMEM182 Gene

Gene Ontology (GO) - Molecular Function for TMEM182 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TMEM182: view
genes like me logo Genes that share phenotypes with TMEM182: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMEM182

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM182 Gene

Localization for TMEM182 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM182 Gene

Membrane. Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM182 gene
Compartment Confidence
plasma membrane 3
nucleus 2
extracellular 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TMEM182 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM182: view

Pathways & Interactions for TMEM182 Gene

PathCards logo

SuperPathways for TMEM182 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMEM182 Gene


No data available for Pathways by source and SIGNOR curated interactions for TMEM182 Gene

Drugs & Compounds for TMEM182 Gene

No Compound Related Data Available

Transcripts for TMEM182 Gene

mRNA/cDNA for TMEM182 Gene

16 NCBI additional mRNA sequence :
11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMEM182

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM182 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b
SP2: -

Relevant External Links for TMEM182 Gene

GeneLoc Exon Structure for

Expression for TMEM182 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TMEM182 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMEM182 Gene

This gene is overexpressed in Heart - Left Ventricle (x15.9), Heart - Atrial Appendage (x13.5), and Muscle - Skeletal (x9.0).

Protein differential expression in normal tissues from HIPED for TMEM182 Gene

This gene is overexpressed in Heart (49.4) and Tonsil (19.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMEM182 Gene

Protein tissue co-expression partners for TMEM182 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TMEM182

SOURCE GeneReport for Unigene cluster for TMEM182 Gene:


Evidence on tissue expression from TISSUES for TMEM182 Gene

  • Heart(4.4)
  • Nervous system(4.2)
  • Liver(4)
  • Muscle(2.5)
genes like me logo Genes that share expression patterns with TMEM182: view

Primer products for research

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM182 Gene

Orthologs for TMEM182 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM182 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMEM182 30 31
  • 99.27 (n)
(Canis familiaris)
Mammalia TMEM182 30 31
  • 89.81 (n)
(Bos Taurus)
Mammalia TMEM182 30 31
  • 87.05 (n)
(Rattus norvegicus)
Mammalia Tmem182 30
  • 85.74 (n)
(Mus musculus)
Mammalia Tmem182 30 17 31
  • 85.3 (n)
(Monodelphis domestica)
Mammalia TMEM182 31
  • 84 (a)
(Ornithorhynchus anatinus)
Mammalia TMEM182 31
  • 83 (a)
(Gallus gallus)
Aves TMEM182 30 31
  • 73.68 (n)
(Anolis carolinensis)
Reptilia TMEM182 31
  • 62 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia tmem182 30
  • 65.79 (n)
Str.9107 30
(Danio rerio)
Actinopterygii tmem182 30 31
  • 57.4 (n)
TMEM182 (2 of 2) 31
  • 33 (a)
Species where no ortholog for TMEM182 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for TMEM182 Gene

Gene Tree for TMEM182 (if available)
Gene Tree for TMEM182 (if available)
Evolutionary constrained regions (ECRs) for TMEM182: view image

Paralogs for TMEM182 Gene

No data available for Paralogs for TMEM182 Gene

Variants for TMEM182 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TMEM182 Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
rs79354230 Benign: not provided 102,764,375(+) G/A
NM_144632.5(TMEM182):c.279G>A (p.Pro93=)
rs887987 - p.Trp223Arg

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for TMEM182 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for TMEM182 Gene

Variant ID Type Subtype PubMed ID
esv2720464 CNV deletion 23290073
nsv834319 CNV gain 17160897

Variation tolerance for TMEM182 Gene

Residual Variation Intolerance Score: 57.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.90; 18.62% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM182 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM182 Gene

Disorders for TMEM182 Gene

Additional Disease Information for TMEM182

Genetic Association Database
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for TMEM182 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM182 Gene

Publications for TMEM182 Gene

  1. Expression and regulation of transcript for the novel transmembrane protein Tmem182 in the adipocyte and muscle lineage. (PMID: 18803820) Wu Y … Smas CM (BMC research notes 2008) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. TNF-α-induced miR-450a mediates TMEM182 expression to promote oral squamous cell carcinoma motility. (PMID: 30893332) Hsing EW … Chang JY (PloS one 2019) 3

Products for TMEM182 Gene

Sources for TMEM182 Gene