The TMEM181 gene encodes a putative G protein-coupled receptor expressed on the cell surface (Carette et al., 2009 [PubMed 19965467]; Wollscheid et al., 2009 [PubMed 19349973]).[supplied by OMIM, Jan 2010] See more...

Aliases for TMEM181 Gene

Aliases for TMEM181 Gene

  • Transmembrane Protein 181 2 3 4 5
  • KIAA1423 2 3 4
  • G Protein-Coupled Receptor 178 2 3
  • GPR178 3 4

External Ids for TMEM181 Gene

Previous HGNC Symbols for TMEM181 Gene

  • KIAA1423
  • GPR178

Previous GeneCards Identifiers for TMEM181 Gene

  • GC06P158867
  • GC06P156428

Summaries for TMEM181 Gene

Entrez Gene Summary for TMEM181 Gene

  • The TMEM181 gene encodes a putative G protein-coupled receptor expressed on the cell surface (Carette et al., 2009 [PubMed 19965467]; Wollscheid et al., 2009 [PubMed 19349973]).[supplied by OMIM, Jan 2010]

GeneCards Summary for TMEM181 Gene

TMEM181 (Transmembrane Protein 181) is a Protein Coding gene. Diseases associated with TMEM181 include Chancroid and Isolated Growth Hormone Deficiency, Type Ib. Gene Ontology (GO) annotations related to this gene include toxic substance binding.

UniProtKB/Swiss-Prot Summary for TMEM181 Gene

  • Mediates action of cytolethal distending toxins (CDT), which are secreted by many pathogenic bacteria. Expression level of TMEM181 is rate-limiting for intoxication.

Additional gene information for TMEM181 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TMEM181 Gene

Genomics for TMEM181 Gene

GeneHancer (GH) Regulatory Elements for TMEM181 Gene

Promoters and enhancers for TMEM181 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J158535 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 500.7 +0.9 903 3.3 NRF1 ZIC2 REST ZBTB10 ZBTB11 ZNF423 GABPA AFF1 ZBTB26 TRIM28 TMEM181 piR-52337
GH06J158559 Promoter/Enhancer 1.6 ENCODE CraniofacialAtlas dbSUPER 23 +24.4 24359 3.3 HNRNPK EP300 SIN3A TCF12 NRF1 POLR2G USF1 PHF8 FOS SIX5 piR-49838 piR-53641 piR-52337 TMEM181 DYNLT1 SYTL3
GH06J158641 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 7.6 +108.2 108173 5.7 HNRNPK EP300 SIN3A NRF1 POLR2G NCOR1 PHF8 JUND FOS ZFX DYNLT1 SYTL3 HSALNG0054685 lnc-TMEM181-1 TMEM181 GTF2H5
GH06J158648 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 7.5 +115.9 115908 8.2 EP300 SP1 JUND FOS RELA MEF2C MYC RCOR1 REST TRIM22 SYTL3 DYNLT1 TATDN2P2 TAGAP ENSG00000213076 RNU6-293P TMEM181 lnc-TMEM181-1 piR-57133-532
GH06J158807 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 5.5 +277.7 277656 13.4 HNRNPK CTCF ZSCAN5C SIN3A NRF1 TCF12 USF1 POLR2G SP1 NCOR1 EZR WTAP ENSG00000213076 RNU6-293P RSPH3 SYTL3 TMEM181 DYNLT1 TAGAP EZR-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TMEM181 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TMEM181

Top Transcription factor binding sites by QIAGEN in the TMEM181 gene promoter:
  • aMEF-2
  • Evi-1
  • Hlf
  • MEF-2
  • MEF-2A
  • NRSF form 1
  • NRSF form 2
  • Pax-2
  • Pax-2a
  • Pax-6

Genomic Locations for TMEM181 Gene

Genomic Locations for TMEM181 Gene
chr6:158,536,432-158,635,435
(GRCh38/hg38)
Size:
99,004 bases
Orientation:
Plus strand
chr6:158,957,468-159,056,467
(GRCh37/hg19)
Size:
99,000 bases
Orientation:
Plus strand

Genomic View for TMEM181 Gene

Genes around TMEM181 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM181 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM181 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM181 Gene

Proteins for TMEM181 Gene

  • Protein details for TMEM181 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P2C4-TM181_HUMAN
    Recommended name:
    Transmembrane protein 181
    Protein Accession:
    Q9P2C4
    Secondary Accessions:
    • Q5VTU1

    Protein attributes for TMEM181 Gene

    Size:
    612 amino acids
    Molecular mass:
    69325 Da
    Quaternary structure:
    • Interacts with cytolethal distending toxin.
    SequenceCaution:
    • Sequence=BAA92661.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

neXtProt entry for TMEM181 Gene

Post-translational modifications for TMEM181 Gene

  • Glycosylation at Asn185 and Asn299
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TMEM181 Gene

Domains & Families for TMEM181 Gene

Gene Families for TMEM181 Gene

Protein Domains for TMEM181 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM181 Gene

GenScript: Design optimal peptide antigens:
  • TMEM181 protein (Q8N4V6_HUMAN)
  • Transmembrane protein 181 (TM181_HUMAN)
genes like me logo Genes that share domains with TMEM181: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for TMEM181 Gene

Function for TMEM181 Gene

Molecular function for TMEM181 Gene

UniProtKB/Swiss-Prot Function:
Mediates action of cytolethal distending toxins (CDT), which are secreted by many pathogenic bacteria. Expression level of TMEM181 is rate-limiting for intoxication.

Phenotypes From GWAS Catalog for TMEM181 Gene

Gene Ontology (GO) - Molecular Function for TMEM181 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015643 toxic substance binding IDA,IEA 19965467
genes like me logo Genes that share ontologies with TMEM181: view
genes like me logo Genes that share phenotypes with TMEM181: view

Animal Models for TMEM181 Gene

MGI Knock Outs for TMEM181:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TMEM181 Gene

Localization for TMEM181 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM181 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM181 gene
Compartment Confidence
plasma membrane 3
golgi apparatus 2
nucleus 1
endoplasmic reticulum 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TMEM181 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM181: view

Pathways & Interactions for TMEM181 Gene

PathCards logo

SuperPathways for TMEM181 Gene

No Data Available

Interacting Proteins for TMEM181 Gene

;

Gene Ontology (GO) - Biological Process for TMEM181 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009405 pathogenesis IMP 19965467
genes like me logo Genes that share ontologies with TMEM181: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM181 Gene

Drugs & Compounds for TMEM181 Gene

No Compound Related Data Available

Transcripts for TMEM181 Gene

mRNA/cDNA for TMEM181 Gene

7 REFSEQ mRNAs :
16 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM181 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b
SP1: - - -
SP2: - - - -
SP3: -
SP4: -

Relevant External Links for TMEM181 Gene

GeneLoc Exon Structure for
TMEM181

Expression for TMEM181 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TMEM181 Gene

mRNA differential expression in normal tissues according to GTEx for TMEM181 Gene

This gene is overexpressed in Artery - Tibial (x10.1).

Protein differential expression in normal tissues from HIPED for TMEM181 Gene

This gene is overexpressed in Pancreas (22.3), Lung (11.2), Testis (11.1), Peripheral blood mononuclear cells (9.9), and Islet of Langerhans (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TMEM181 Gene



Protein tissue co-expression partners for TMEM181 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TMEM181

SOURCE GeneReport for Unigene cluster for TMEM181 Gene:

Hs.99145

Evidence on tissue expression from TISSUES for TMEM181 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with TMEM181: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM181 Gene

Orthologs for TMEM181 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM181 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM181 31 30
  • 99.13 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem181c-ps 31
  • 95 (a)
OneToMany
Tmem181b-ps 31 31
  • 95 (a)
OneToMany
Tmem181a 17 31 30
  • 84.71 (n)
rat
(Rattus norvegicus)
Mammalia Tmem181 30
  • 87.22 (n)
dog
(Canis familiaris)
Mammalia TMEM181 31 30
  • 85.51 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM181 31
  • 85 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TMEM181 31 30
  • 84.54 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMEM181 31
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM181 31 30
  • 76.76 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM181 31
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem181 30
  • 72.22 (n)
zebrafish
(Danio rerio)
Actinopterygii tmem181 31 30
  • 67.7 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000778 30
  • 56.27 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG13409 31 30
  • 54.32 (n)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 43 (a)
OneToOne
Species where no ortholog for TMEM181 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM181 Gene

ENSEMBL:
Gene Tree for TMEM181 (if available)
TreeFam:
Gene Tree for TMEM181 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TMEM181: view image

Paralogs for TMEM181 Gene

No data available for Paralogs for TMEM181 Gene

Variants for TMEM181 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TMEM181 Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
774648 Benign: not provided 158,608,455(+) C/T MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT

Additional dbSNP identifiers (rs#s) for TMEM181 Gene

Structural Variations from Database of Genomic Variants (DGV) for TMEM181 Gene

Variant ID Type Subtype PubMed ID
dgv3422n106 CNV deletion 24896259
esv2664518 CNV deletion 23128226
esv2672819 CNV deletion 23128226
esv2732998 CNV deletion 23290073
esv2732999 CNV deletion 23290073
esv2733000 CNV deletion 23290073
esv3540742 CNV deletion 23714750
esv3540743 CNV deletion 23714750
esv3611399 CNV loss 21293372
nsv1074972 CNV deletion 25765185
nsv1152744 CNV deletion 26484159
nsv349061 CNV insertion 16902084
nsv518771 CNV loss 19592680
nsv955906 CNV deletion 24416366

Variation tolerance for TMEM181 Gene

Residual Variation Intolerance Score: 69.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.52; 44.02% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM181 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM181

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM181 Gene

Disorders for TMEM181 Gene

MalaCards: The human disease database

(3) MalaCards diseases for TMEM181 Gene - From: DISEASES

Disorder Aliases PubMed IDs
chancroid
  • ulcus molle, skin
isolated growth hormone deficiency, type ib
  • pituitary dwarfism i
spindle cell hemangioma
  • sch
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TMEM181

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TMEM181: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TMEM181 Gene

Publications for TMEM181 Gene

  1. Haploid genetic screens in human cells identify host factors used by pathogens. (PMID: 19965467) Carette JE … Brummelkamp TR (Science (New York, N.Y.) 2009) 3 4 54
  2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 54
  3. A general model of G protein-coupled receptor sequences and its application to detect remote homologs. (PMID: 16452613) Wistrand M … Sonnhammer EL (Protein science : a publication of the Protein Society 2006) 2 3 54
  4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 54
  5. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 3 4 54

Products for TMEM181 Gene

Sources for TMEM181 Gene