Aliases for TMEM179B Gene

Aliases for TMEM179B Gene

  • Transmembrane Protein 179B 2 3 4 5

External Ids for TMEM179B Gene

Previous GeneCards Identifiers for TMEM179B Gene

  • GC11P062312
  • GC11P062554
  • GC11P058884

Summaries for TMEM179B Gene

GeneCards Summary for TMEM179B Gene

TMEM179B (Transmembrane Protein 179B) is a Protein Coding gene. Among its related pathways are Innate Immune System.

Additional gene information for TMEM179B Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TMEM179B Gene

Genomics for TMEM179B Gene

GeneHancer (GH) Regulatory Elements for TMEM179B Gene

Promoters and enhancers for TMEM179B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TMEM179B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TMEM179B gene promoter:
  • AML1a
  • AREB6
  • Brachyury
  • c-Myc
  • C/EBPalpha
  • GATA-2
  • Lmo2
  • p300
  • RFX1
  • RREB-1

Genomic Locations for TMEM179B Gene

Genomic Locations for TMEM179B Gene
chr11:62,787,399-62,790,400
(GRCh38/hg38)
Size:
3,002 bases
Orientation:
Plus strand
chr11:62,554,874-62,557,877
(GRCh37/hg19)
Size:
3,004 bases
Orientation:
Plus strand

Genomic View for TMEM179B Gene

Genes around TMEM179B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM179B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM179B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM179B Gene

Proteins for TMEM179B Gene

  • Protein details for TMEM179B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z7N9-T179B_HUMAN
    Recommended name:
    Transmembrane protein 179B
    Protein Accession:
    Q7Z7N9

    Protein attributes for TMEM179B Gene

    Size:
    219 amino acids
    Molecular mass:
    23550 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM179B Gene

Post-translational modifications for TMEM179B Gene

  • Glycosylation at Asn48 and Asn136
  • Modification sites at PhosphoSitePlus

Other Protein References for TMEM179B Gene

No data available for DME Specific Peptides for TMEM179B Gene

Domains & Families for TMEM179B Gene

Gene Families for TMEM179B Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for TMEM179B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM179B Gene

GenScript: Design optimal peptide antigens:
  • Transmembrane protein 179B (T179B_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q7Z7N9

UniProtKB/Swiss-Prot:

T179B_HUMAN :
  • Belongs to the TMEM179 family.
Family:
  • Belongs to the TMEM179 family.
genes like me logo Genes that share domains with TMEM179B: view

Function for TMEM179B Gene

Phenotypes From GWAS Catalog for TMEM179B Gene

genes like me logo Genes that share phenotypes with TMEM179B: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TMEM179B

CRISPR Products

miRNA for TMEM179B Gene

miRTarBase miRNAs that target TMEM179B

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM179B Gene

Localization for TMEM179B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM179B Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM179B gene
Compartment Confidence
plasma membrane 5
nucleus 4
lysosome 4

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TMEM179B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IDA --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0016607 nuclear speck IDA --
genes like me logo Genes that share ontologies with TMEM179B: view

Pathways & Interactions for TMEM179B Gene

PathCards logo

SuperPathways for TMEM179B Gene

genes like me logo Genes that share pathways with TMEM179B: view

Pathways by source for TMEM179B Gene

3 Reactome pathways for TMEM179B Gene

Gene Ontology (GO) - Biological Process for TMEM179B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043312 neutrophil degranulation TAS --
genes like me logo Genes that share ontologies with TMEM179B: view

No data available for SIGNOR curated interactions for TMEM179B Gene

Drugs & Compounds for TMEM179B Gene

No Compound Related Data Available

Transcripts for TMEM179B Gene

mRNA/cDNA for TMEM179B Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM179B Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b
SP1: -
SP2: - -
SP3:

Relevant External Links for TMEM179B Gene

GeneLoc Exon Structure for
TMEM179B
ECgene alternative splicing isoforms for
TMEM179B

Expression for TMEM179B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM179B Gene

Protein differential expression in normal tissues from HIPED for TMEM179B Gene

This gene is overexpressed in Peripheral blood mononuclear cells (22.5), Testis (8.7), and Skin (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TMEM179B Gene



Protein tissue co-expression partners for TMEM179B Gene

NURSA nuclear receptor signaling pathways regulating expression of TMEM179B Gene:

TMEM179B

SOURCE GeneReport for Unigene cluster for TMEM179B Gene:

Hs.381134
genes like me logo Genes that share expression patterns with TMEM179B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM179B Gene

Orthologs for TMEM179B Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM179B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM179B 33 32
  • 100 (n)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM179B 33 32
  • 89.04 (n)
OneToOne
cow
(Bos Taurus)
Mammalia TMEM179B 33 32
  • 88.07 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem179b 17 33 32
  • 85.24 (n)
rat
(Rattus norvegicus)
Mammalia Tmem179b 32
  • 84.48 (n)
oppossum
(Monodelphis domestica)
Mammalia TMEM179B 33
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM179B 33
  • 60 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii tmem179b 33
  • 39 (a)
OneToMany
TMEM179B (1 of 2) 33
  • 37 (a)
OneToMany
Species where no ortholog for TMEM179B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM179B Gene

ENSEMBL:
Gene Tree for TMEM179B (if available)
TreeFam:
Gene Tree for TMEM179B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TMEM179B: view image

Paralogs for TMEM179B Gene

No data available for Paralogs for TMEM179B Gene

Variants for TMEM179B Gene

Sequence variations from dbSNP and Humsavar for TMEM179B Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000067794 -- 62,786,746(+) T/C upstream_transcript_variant
rs1000081793 -- 62,786,984(+) T/C upstream_transcript_variant
rs1001085217 -- 62,787,648(+) G/A intron_variant
rs1001272030 -- 62,787,085(+) C/T upstream_transcript_variant
rs1002308087 -- 62,787,940(+) T/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM179B Gene

Variant ID Type Subtype PubMed ID
nsv508636 CNV deletion 20534489
nsv509416 CNV insertion 20534489
nsv555175 CNV loss 21841781

Variation tolerance for TMEM179B Gene

Residual Variation Intolerance Score: 28% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.51; 11.10% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM179B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM179B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM179B Gene

Disorders for TMEM179B Gene

Additional Disease Information for TMEM179B

No disorders were found for TMEM179B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM179B Gene

Publications for TMEM179B Gene

  1. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 56
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 56
  3. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H … Mohammed S (Journal of proteome research 2013) 4 56
  4. A census of human soluble protein complexes. (PMID: 22939629) Havugimana PC … Emili A (Cell 2012) 3 56
  5. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PMID: 19690332) Mayya V … Han DK (Science signaling 2009) 4 56

Products for TMEM179B Gene

Sources for TMEM179B Gene