Aliases for TMEM179 Gene

Aliases for TMEM179 Gene

  • Transmembrane Protein 179 2 3 4 5
  • TMEM179A 2 3 4
  • Transmembrane Protein 179A 3 4
  • C14orf90 3 4
  • Chromosome 14 Open Reading Frame 90 2
  • FLJ42486 2
  • TMEM179 5

External Ids for TMEM179 Gene

Previous HGNC Symbols for TMEM179 Gene

  • C14orf90

Previous GeneCards Identifiers for TMEM179 Gene

  • GC14M104132
  • GC14M105061
  • GC14M085256
  • GC14M104942

Summaries for TMEM179 Gene

GeneCards Summary for TMEM179 Gene

TMEM179 (Transmembrane Protein 179) is a Protein Coding gene.

Additional gene information for TMEM179 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TMEM179 Gene

Genomics for TMEM179 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TMEM179 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J104603 Promoter/Enhancer 1.4 Ensembl ENCODE CraniofacialAtlas 607.7 +0.8 847 0.8 REST TFE3 ZNF692 EZH2 NRF1 CTBP1 ZBTB26 TGIF2 YY1 TFDP1 TMEM179 NONHSAG016058.2 lnc-C14orf180-2 C14orf180
GH14J104606 Enhancer 0.3 Ensembl 600.7 +1.7 1746 0.2 ZFHX2 NONHSAG016058.2 lnc-C14orf180-2 TMEM179 C14orf180
GH14J104656 Enhancer 1.3 FANTOM5 ENCODE CraniofacialAtlas dbSUPER 6.3 -53.7 -53740 6.8 SP1 ZBTB33 PRDM10 BACH1 ZIC2 TCF12 IKZF2 POLR2A YY1 ZNF341 C14orf180 TMEM179 PLD4 INF2 lnc-INF2-2 MIR4710 LINC02280
GH14J104222 Promoter/Enhancer 1.9 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 1.8 +381.0 381022 4.3 CREB1 CTCF ZIC2 PKNOX1 PATZ1 NRF1 KLF9 EGR1 CTBP1 ESRRA LINC02691 KIF26A PPP1R13B TMEM179 RF00998-047 C14orf180
GH14J104665 Promoter/Enhancer 1.9 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 1.6 -60.9 -60863 2.9 HNRNPL CREB1 GATAD2A TEAD4 YBX1 SOX13 NFKBIZ CTCF TARDBP RFX1 MTA1 XRCC3 ENSG00000202275 ENSG00000257270 CDCA4 BRF1 ENSG00000270591 TMEM121 RPS20P33 CEP170B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TMEM179 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TMEM179

Top Transcription factor binding sites by QIAGEN in the TMEM179 gene promoter:
  • AML1a
  • Brachyury
  • E2F
  • NCX
  • Nkx2-5
  • NRSF form 1
  • NRSF form 2
  • p300

Genomic Locations for TMEM179 Gene

Genomic Locations for TMEM179 Gene
chr14:104,474,678-104,605,647
(GRCh38/hg38)
Size:
130,970 bases
Orientation:
Minus strand
chr14:104,941,015-105,071,984
(GRCh37/hg19)
Size:
130,970 bases
Orientation:
Minus strand

Genomic View for TMEM179 Gene

Genes around TMEM179 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM179 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM179 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM179 Gene

Proteins for TMEM179 Gene

  • Protein details for TMEM179 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZVK1-T179A_HUMAN
    Recommended name:
    Transmembrane protein 179
    Protein Accession:
    Q6ZVK1

    Protein attributes for TMEM179 Gene

    Size:
    233 amino acids
    Molecular mass:
    26378 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM179 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM179 Gene

Post-translational modifications for TMEM179 Gene

  • Glycosylation at Asn51
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TMEM179 Gene

Domains & Families for TMEM179 Gene

Gene Families for TMEM179 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Protein Domains for TMEM179 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM179 Gene

GenScript: Design optimal peptide antigens:
  • Transmembrane protein 179A (T179A_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6ZVK1

UniProtKB/Swiss-Prot:

T179A_HUMAN :
  • Belongs to the TMEM179 family.
Family:
  • Belongs to the TMEM179 family.
genes like me logo Genes that share domains with TMEM179: view

Function for TMEM179 Gene

Phenotypes From GWAS Catalog for TMEM179 Gene

Phenotypes for TMEM179 Gene

genes like me logo Genes that share phenotypes with TMEM179: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMEM179

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM179 Gene

Localization for TMEM179 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM179 Gene

Membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM179 gene
Compartment Confidence
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TMEM179 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM179: view

Pathways & Interactions for TMEM179 Gene

PathCards logo

SuperPathways for TMEM179 Gene

No Data Available

Interacting Proteins for TMEM179 Gene

Gene Ontology (GO) - Biological Process for TMEM179 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM179 Gene

Drugs & Compounds for TMEM179 Gene

No Compound Related Data Available

Transcripts for TMEM179 Gene

mRNA/cDNA for TMEM179 Gene

3 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMEM179

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM179 Gene

No ASD Table

Relevant External Links for TMEM179 Gene

GeneLoc Exon Structure for
TMEM179

Expression for TMEM179 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TMEM179 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMEM179 Gene

This gene is overexpressed in Pituitary (x7.9), Brain - Cortex (x4.5), Brain - Putamen (basal ganglia) (x4.4), Brain - Hypothalamus (x4.3), and Brain - Frontal Cortex (BA9) (x4.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TMEM179 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TMEM179

SOURCE GeneReport for Unigene cluster for TMEM179 Gene:

Hs.655004

Evidence on tissue expression from TISSUES for TMEM179 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with TMEM179: view

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM179 Gene

Orthologs for TMEM179 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM179 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TMEM179 30 31
  • 99.24 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia TMEM179 30 31
  • 93.53 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia TMEM179 30 31
  • 92.74 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Tmem179 30 17 31
  • 89.7 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Tmem179 30
  • 89.56 (n)
Oppossum
(Monodelphis domestica)
Mammalia TMEM179 31
  • 52 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia TMEM179 31
  • 50 (a)
OneToOne
Chicken
(Gallus gallus)
Aves TMEM179 30 31
  • 79.02 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia TMEM179 31
  • 61 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia tmem179 30
  • 73.13 (n)
Zebrafish
(Danio rerio)
Actinopterygii LOC100537383 30
  • 68.1 (n)
tmem179 31
  • 50 (a)
OneToMany
CABZ01084273.1 31
  • 50 (a)
OneToMany
TMEM179 (2 of 3) 31
  • 33 (a)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta CG13603 30 31
  • 50.24 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004210 30
  • 46.94 (n)
Species where no ortholog for TMEM179 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for TMEM179 Gene

ENSEMBL:
Gene Tree for TMEM179 (if available)
TreeFam:
Gene Tree for TMEM179 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TMEM179: view image

Paralogs for TMEM179 Gene

No data available for Paralogs for TMEM179 Gene

Variants for TMEM179 Gene

Additional dbSNP identifiers (rs#s) for TMEM179 Gene

Structural Variations from Database of Genomic Variants (DGV) for TMEM179 Gene

Variant ID Type Subtype PubMed ID
esv2761599 CNV gain 21179565
esv3635623 CNV gain 21293372
nsv1054574 CNV loss 25217958
nsv1134408 CNV deletion 24896259
nsv456445 CNV loss 19166990
nsv470676 CNV loss 18288195
nsv566047 CNV loss 21841781
nsv952271 CNV deletion 24416366

Variation tolerance for TMEM179 Gene

Residual Variation Intolerance Score: 49.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.89; 18.55% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM179 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM179

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TMEM179 Gene

Disorders for TMEM179 Gene

No disorders were found for TMEM179 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM179 Gene

Publications for TMEM179 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  2. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R … Weissenbach J (Nature 2003) 3 4

Products for TMEM179 Gene

Sources for TMEM179 Gene