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Aliases for TMEM177 Gene

Aliases for TMEM177 Gene

  • Transmembrane Protein 177 2 3 5

External Ids for TMEM177 Gene

Previous GeneCards Identifiers for TMEM177 Gene

  • GC02P120153
  • GC02P120436
  • GC02P112761

Summaries for TMEM177 Gene

GeneCards Summary for TMEM177 Gene

TMEM177 (Transmembrane Protein 177) is a Protein Coding gene.

Additional gene information for TMEM177 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM177 Gene

Genomics for TMEM177 Gene

GeneHancer (GH) Regulatory Elements for TMEM177 Gene

Promoters and enhancers for TMEM177 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I119677 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 565.2 -0.1 -110 2.3 FOXA2 ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 POLR2B ZNF213 ZNF143 TMEM177 CFAP221
GH02I119541 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 5.2 -132.4 -132377 10.8 PKNOX1 CLOCK ATF1 ARNT ARID4B SIN3A ZNF48 TCF12 ZNF213 GATA2 CFAP221 SCTR TMEM185B TMEM177 EPB41L5
GH02I119682 Enhancer 0.6 ENCODE 14.3 +4.7 4673 2.3 PAF1 MAZ ZNF189 ZSCAN4 ZNF398 ZIC2 SSRP1 GLIS2 POLR2A GLIS1 TMEM177 PIR62578
GH02I119820 Enhancer 0.8 Ensembl 9.1 +141.2 141234 0.4 PKNOX1 JUN MZF1 ZIC2 ZFHX2 GLIS2 ZNF366 PRDM10 ZNF600 KLF8 PTPN4 EPB41L5 TMEM177 LOC101927764 GC02P119982
GH02I119641 Enhancer 0.8 ENCODE 6.3 -37.4 -37407 0.2 CTCF MXI1 PKNOX1 RB1 ARID4B MAX SIN3A RAD21 TEAD3 ZFHX2 TMEM177 CFAP221
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TMEM177 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TMEM177 gene promoter:

Genomic Locations for TMEM177 Gene

Genomic Locations for TMEM177 Gene
chr2:119,679,167-119,686,507
(GRCh38/hg38)
Size:
7,341 bases
Orientation:
Plus strand
chr2:120,436,743-120,444,083
(GRCh37/hg19)

Genomic View for TMEM177 Gene

Genes around TMEM177 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM177 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM177 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM177 Gene

Proteins for TMEM177 Gene

  • Protein details for TMEM177 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q53S58-TM177_HUMAN
    Recommended name:
    Transmembrane protein 177
    Protein Accession:
    Q53S58
    Secondary Accessions:
    • Q9BT20

    Protein attributes for TMEM177 Gene

    Size:
    311 amino acids
    Molecular mass:
    33760 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM177 Gene

Post-translational modifications for TMEM177 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM177 Gene

No data available for DME Specific Peptides for TMEM177 Gene

Domains & Families for TMEM177 Gene

Gene Families for TMEM177 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for TMEM177 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM177 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q53S58

UniProtKB/Swiss-Prot:

TM177_HUMAN :
  • Belongs to the TMEM177 family.
Family:
  • Belongs to the TMEM177 family.
genes like me logo Genes that share domains with TMEM177: view

Function for TMEM177 Gene

Gene Ontology (GO) - Molecular Function for TMEM177 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 29154948
genes like me logo Genes that share ontologies with TMEM177: view
genes like me logo Genes that share phenotypes with TMEM177: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TMEM177 Gene

Localization for TMEM177 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM177 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM177 gene
Compartment Confidence
plasma membrane 2
mitochondrion 2
extracellular 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli fibrillar center (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TMEM177 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
GO:0031305 integral component of mitochondrial inner membrane IDA 29154948
genes like me logo Genes that share ontologies with TMEM177: view

Pathways & Interactions for TMEM177 Gene

SuperPathways for TMEM177 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMEM177 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM177 Gene

Drugs & Compounds for TMEM177 Gene

No Compound Related Data Available

Transcripts for TMEM177 Gene

Unigene Clusters for TMEM177 Gene

Transmembrane protein 177:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM177 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c
SP1: - -
SP2: -
SP3:

Relevant External Links for TMEM177 Gene

GeneLoc Exon Structure for
TMEM177
ECgene alternative splicing isoforms for
TMEM177

Expression for TMEM177 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM177 Gene

Protein differential expression in normal tissues from HIPED for TMEM177 Gene

This gene is overexpressed in Heart (23.6), Frontal cortex (19.1), Adrenal (8.2), and Islet of Langerhans (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TMEM177 Gene



Protein tissue co-expression partners for TMEM177 Gene

NURSA nuclear receptor signaling pathways regulating expression of TMEM177 Gene:

TMEM177

SOURCE GeneReport for Unigene cluster for TMEM177 Gene:

Hs.439991
genes like me logo Genes that share expression patterns with TMEM177: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM177 Gene

Orthologs for TMEM177 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM177 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM177 33 34
  • 99.25 (n)
dog
(Canis familiaris)
Mammalia TMEM177 33 34
  • 85.1 (n)
cow
(Bos Taurus)
Mammalia TMEM177 33 34
  • 82.96 (n)
rat
(Rattus norvegicus)
Mammalia Tmem177 33
  • 82.42 (n)
mouse
(Mus musculus)
Mammalia Tmem177 33 16 34
  • 81.94 (n)
chicken
(Gallus gallus)
Aves TMEM177 33 34
  • 55.78 (n)
lizard
(Anolis carolinensis)
Reptilia TMEM177 34
  • 48 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem177 33
  • 55.04 (n)
zebrafish
(Danio rerio)
Actinopterygii tmem177 33 34
  • 54.61 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006719 33
  • 42.67 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG33506 33 34
  • 42.12 (n)
Species where no ortholog for TMEM177 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM177 Gene

ENSEMBL:
Gene Tree for TMEM177 (if available)
TreeFam:
Gene Tree for TMEM177 (if available)

Paralogs for TMEM177 Gene

No data available for Paralogs for TMEM177 Gene

Variants for TMEM177 Gene

Sequence variations from dbSNP and Humsavar for TMEM177 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000365311 -- 119,677,784(+) A/G upstream_transcript_variant
rs1000394814 -- 119,677,401(+) A/C upstream_transcript_variant
rs1001671427 -- 119,679,167(+) G/T 5_prime_UTR_variant
rs1001938081 -- 119,677,304(+) C/G upstream_transcript_variant
rs1002073620 -- 119,681,944(+) A/G 3_prime_UTR_variant

Variation tolerance for TMEM177 Gene

Residual Variation Intolerance Score: 79.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.35; 41.80% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM177 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM177

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TMEM177 Gene

Disorders for TMEM177 Gene

Additional Disease Information for TMEM177

No disorders were found for TMEM177 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM177 Gene

Publications for TMEM177 Gene

  1. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  4. The mitochondrial TMEM177 associates with COX20 during COX2 biogenesis. (PMID: 29154948) Lorenzi I … Rehling P (Biochimica et biophysica acta 2018) 3 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for TMEM177 Gene

Sources for TMEM177 Gene

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