Aliases for TMEM176A Gene

Aliases for TMEM176A Gene

  • Transmembrane Protein 176A 2 3 4 5
  • HCA112 2 3 4
  • Hepatocellular Carcinoma-Associated Antigen 112 3 4
  • MS4B1 2 3
  • Likley Ortholog Of Mouse GS188 3
  • TMEM176A 5
  • GS188 3

External Ids for TMEM176A Gene

Previous GeneCards Identifiers for TMEM176A Gene

  • GC07P150128
  • GC07P150497
  • GC07P144309

Summaries for TMEM176A Gene

GeneCards Summary for TMEM176A Gene

TMEM176A (Transmembrane Protein 176A) is a Protein Coding gene. Diseases associated with TMEM176A include Alpha-Methylacyl-Coa Racemase Deficiency and Galactosemia I. An important paralog of this gene is TMEM176B.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TMEM176A Gene

Genomics for TMEM176A Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TMEM176A Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TMEM176A on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TMEM176A

Top Transcription factor binding sites by QIAGEN in the TMEM176A gene promoter:
  • AML1a
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • Gfi-1
  • HNF-4alpha1
  • Nkx2-5

Genomic Locations for TMEM176A Gene

Latest Assembly
4,717 bases
Plus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
4,350 bases
Plus strand

(GRCh37/hg19 by Ensembl)
4,718 bases
Plus strand

Genomic View for TMEM176A Gene

Genes around TMEM176A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM176A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM176A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM176A Gene

Proteins for TMEM176A Gene

  • Protein details for TMEM176A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 176A
    Protein Accession:
    Secondary Accessions:
    • D3DX00
    • Q9NYC7

    Protein attributes for TMEM176A Gene

    235 amino acids
    Molecular mass:
    26116 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM176A Gene

Post-translational modifications for TMEM176A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TMEM176A Gene

Domains & Families for TMEM176A Gene

Gene Families for TMEM176A Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TMEM176A Gene


Suggested Antigen Peptide Sequences for TMEM176A Gene

GenScript: Design optimal peptide antigens:
  • Hepatocellular carcinoma-associated antigen 112 (T176A_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TMEM176 family.
  • Belongs to the TMEM176 family.
genes like me logo Genes that share domains with TMEM176A: view

Function for TMEM176A Gene

Phenotypes From GWAS Catalog for TMEM176A Gene

Gene Ontology (GO) - Molecular Function for TMEM176A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 32296183
genes like me logo Genes that share ontologies with TMEM176A: view
genes like me logo Genes that share phenotypes with TMEM176A: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMEM176A

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TMEM176A Gene

Localization for TMEM176A Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM176A Gene

Membrane. Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM176A gene
Compartment Confidence
plasma membrane 3
extracellular 2
mitochondrion 2
peroxisome 2
nucleus 1
endosome 1
cytosol 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TMEM176A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM176A: view

Pathways & Interactions for TMEM176A Gene

PathCards logo

SuperPathways for TMEM176A Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMEM176A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:2001199 negative regulation of dendritic cell differentiation IBA 21873635
genes like me logo Genes that share ontologies with TMEM176A: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM176A Gene

Drugs & Compounds for TMEM176A Gene

No Compound Related Data Available

Transcripts for TMEM176A Gene

mRNA/cDNA for TMEM176A Gene

4 NCBI additional mRNA sequence :
11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMEM176A

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM176A Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b · 10c · 10d
SP1: - - - - - -
SP2: - - - - - - - -
SP3: - - -
SP4: - - - - - -
SP5: - -
SP6: -
SP7: -
SP8: - -
SP9: - - - -

Relevant External Links for TMEM176A Gene

GeneLoc Exon Structure for

Expression for TMEM176A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TMEM176A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMEM176A Gene

This gene is overexpressed in Liver (x18.6) and Kidney - Cortex (x4.8).

Protein differential expression in normal tissues from HIPED for TMEM176A Gene

This gene is overexpressed in Urine (40.4), Ovary (10.4), and Liver (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMEM176A Gene

Protein tissue co-expression partners for TMEM176A Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TMEM176A

SOURCE GeneReport for Unigene cluster for TMEM176A Gene:


Evidence on tissue expression from TISSUES for TMEM176A Gene

  • Lung(4.3)
  • Liver(3.2)
  • Kidney(2.9)
  • Lymph node(2.5)
  • Intestine(2.4)
  • Nervous system(2.2)
  • Spleen(2.1)
  • Blood(2.1)
genes like me logo Genes that share expression patterns with TMEM176A: view

Primer products for research

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM176A Gene

Orthologs for TMEM176A Gene

This gene was present in the common ancestor of mammals.

Orthologs for TMEM176A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMEM176A 30 31
  • 98.58 (n)
(Canis familiaris)
Mammalia TMEM176A 30 31
  • 74.36 (n)
(Rattus norvegicus)
Mammalia Tmem176a 30
  • 68.28 (n)
(Mus musculus)
Mammalia Tmem176a 30 17 31
  • 66.67 (n)
(Bos Taurus)
Mammalia TMEM176A 31
  • 55 (a)
(Monodelphis domestica)
Mammalia TMEM176A 31
  • 32 (a)
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 27 (a)
Species where no ortholog for TMEM176A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for TMEM176A Gene

Gene Tree for TMEM176A (if available)
Gene Tree for TMEM176A (if available)
Evolutionary constrained regions (ECRs) for TMEM176A: view image

Paralogs for TMEM176A Gene

Paralogs for TMEM176A Gene

(1) SIMAP similar genes for TMEM176A Gene using alignment to 4 proteins:

  • T176A_HUMAN
  • C9JJ63_HUMAN
  • H7C4P5_HUMAN
genes like me logo Genes that share paralogs with TMEM176A: view

Variants for TMEM176A Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TMEM176A Gene

SNP ID Clinical significance and condition Chr 07 pos Variation AA Info Type
rs10378 - p.Leu187Phe
rs741064 - p.Thr122Ala
rs9088 - p.Thr208Ala

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for TMEM176A Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for TMEM176A Gene

Variant ID Type Subtype PubMed ID
dgv3695n106 OTHER inversion 24896259
nsv1030109 CNV gain 25217958
nsv1067934 OTHER inversion 25765185
nsv1151906 OTHER inversion 26484159
nsv608990 CNV gain 21841781
nsv831187 CNV loss 17160897

Variation tolerance for TMEM176A Gene

Residual Variation Intolerance Score: 80.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.06; 60.69% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM176A Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM176A Gene

Disorders for TMEM176A Gene

MalaCards: The human disease database

(3) MalaCards diseases for TMEM176A Gene - From: COP and GCD

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TMEM176A

genes like me logo Genes that share disorders with TMEM176A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TMEM176A Gene

Publications for TMEM176A Gene

  1. Large scale identification of human hepatocellular carcinoma-associated antigens by autoantibodies. (PMID: 12097419) Wang Y … Chen WF (Journal of immunology (Baltimore, Md. : 1950) 2002) 2 3 4
  2. TMEM176A and TMEM176B Are Candidate Regulators of Inhibition of Dendritic Cell Maturation and Function after Chronic Spinal Cord Injury. (PMID: 31354034) Picotto G … Battaglino R (Journal of neurotrauma 2020) 2 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 3 4
  5. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo MF … Soares MB (Genome research 1996) 2 3

Products for TMEM176A Gene

Sources for TMEM176A Gene