Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TMEM170A Gene

Aliases for TMEM170A Gene

  • Transmembrane Protein 170A 2 3 5
  • Transmembrane Protein 170 2 3
  • TMEM170 3 4

External Ids for TMEM170A Gene

Previous HGNC Symbols for TMEM170A Gene

  • TMEM170

Previous GeneCards Identifiers for TMEM170A Gene

  • GC16M074039
  • GC16M075476
  • GC16M061232

Summaries for TMEM170A Gene

GeneCards Summary for TMEM170A Gene

TMEM170A (Transmembrane Protein 170A) is a Protein Coding gene. An important paralog of this gene is ENSG00000261717.

UniProtKB/Swiss-Prot for TMEM170A Gene

  • Acts as a regulator of endoplasmic reticulum (ER) and nuclear envelope (NE) morphogenesis. Affects the ratio between tubular ER and ER sheets by promoting sheet formation at the expense of tubules. Influences NE expansion, nuclear pore complex formation and proper localization of inner nuclear membrane proteins (PubMed:26906412).

Additional gene information for TMEM170A Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM170A Gene

Genomics for TMEM170A Gene

GeneHancer (GH) Regulatory Elements for TMEM170A Gene

Promoters and enhancers for TMEM170A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16I075461 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 +1.9 1877 3.5 HDGF PKNOX1 FOXA2 SMAD1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 TMEM170A ENSG00000261717 ENSG00000261783 RFWD3 ADAT1 GABARAPL2 KARS CFDP1 BCAR1 ENSG00000261476
GH16I075260 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 4.5 +200.8 200764 7.9 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A YBX1 FEZF1 DMAP1 ZNF2 BCAR1 ENSG00000259972 CTRB2 ENSG00000261783 TMEM170A TERF2IP LOC105371344
GH16I075564 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 4.9 -100.7 -100749 3.2 HDGF PKNOX1 CLOCK SMAD1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZBTB7B GABARAPL2 RFWD3 ADAT1 KARS WDR59 TMEM231 TMEM170A ENSG00000276408 ENSG00000259992
GH16I075482 Enhancer 1.1 ENCODE dbSUPER 6.3 -19.6 -19644 4.6 PKNOX1 FOXA2 DMAP1 ZNF48 ZNF121 ZNF548 FOS RUNX3 YY2 JUNB ENSG00000261783 BCAR1 RFWD3 CHST5 TMEM231 ADAT1 TMEM170A ENSG00000203472 CHST6
GH16I075732 Enhancer 0.9 Ensembl ENCODE 4.7 -268.2 -268190 1.7 HDAC1 MEIS2 KLF1 ZNF680 CBFA2T3 ZNF217 ZFHX2 GATA3 CTBP1 EGR1 CPHXL ADAT1 TMEM170A GC16P075766 TERF2IP
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TMEM170A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TMEM170A gene promoter:

Genomic Locations for TMEM170A Gene

Genomic Locations for TMEM170A Gene
chr16:75,443,054-75,465,497
(GRCh38/hg38)
Size:
22,444 bases
Orientation:
Minus strand
chr16:75,476,952-75,499,395
(GRCh37/hg19)

Genomic View for TMEM170A Gene

Genes around TMEM170A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM170A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM170A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM170A Gene

Proteins for TMEM170A Gene

  • Protein details for TMEM170A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WVE7-T170A_HUMAN
    Recommended name:
    Transmembrane protein 170A
    Protein Accession:
    Q8WVE7
    Secondary Accessions:
    • B2R4R3
    • B4DPS4
    • D3DUK2
    • Q7Z6F3

    Protein attributes for TMEM170A Gene

    Size:
    144 amino acids
    Molecular mass:
    15250 Da
    Quaternary structure:
    • Interacts with RTN4 (PubMed:26906412).

    Alternative splice isoforms for TMEM170A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM170A Gene

Post-translational modifications for TMEM170A Gene

  • Ubiquitination at posLast=2323
  • Glycosylation at isoforms=230 and isoforms=236
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TMEM170A Gene

Domains & Families for TMEM170A Gene

Gene Families for TMEM170A Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for TMEM170A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM170A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WVE7

UniProtKB/Swiss-Prot:

T170A_HUMAN :
  • Belongs to the TMEM170 family.
Family:
  • Belongs to the TMEM170 family.
genes like me logo Genes that share domains with TMEM170A: view

Function for TMEM170A Gene

Molecular function for TMEM170A Gene

UniProtKB/Swiss-Prot Function:
Acts as a regulator of endoplasmic reticulum (ER) and nuclear envelope (NE) morphogenesis. Affects the ratio between tubular ER and ER sheets by promoting sheet formation at the expense of tubules. Influences NE expansion, nuclear pore complex formation and proper localization of inner nuclear membrane proteins (PubMed:26906412).

Phenotypes From GWAS Catalog for TMEM170A Gene

Gene Ontology (GO) - Molecular Function for TMEM170A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 26906412
genes like me logo Genes that share ontologies with TMEM170A: view
genes like me logo Genes that share phenotypes with TMEM170A: view

Animal Model Products

CRISPR Products

miRNA for TMEM170A Gene

miRTarBase miRNAs that target TMEM170A

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM170A Gene

Localization for TMEM170A Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM170A Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus envelope.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM170A gene
Compartment Confidence
nucleus 5
endoplasmic reticulum 5
plasma membrane 3
extracellular 1

Gene Ontology (GO) - Cellular Components for TMEM170A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005635 nuclear envelope IEA,IDA 26906412
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IDA,IEA 26906412
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with TMEM170A: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TMEM170A Gene

Pathways & Interactions for TMEM170A Gene

SuperPathways for TMEM170A Gene

No Data Available

Interacting Proteins for TMEM170A Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000454404%0d%0a9606.ENSP00000363055%0d%0a9606.ENSP00000369373%0d%0a9606.ENSP00000381717%0d%0a
Selected Interacting proteins: ENSP00000454404 for TMEM170A Gene via STRING

Gene Ontology (GO) - Biological Process for TMEM170A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006998 nuclear envelope organization IMP 26906412
GO:0051292 nuclear pore complex assembly IMP 26906412
GO:0071786 endoplasmic reticulum tubular network organization IMP 26906412
genes like me logo Genes that share ontologies with TMEM170A: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM170A Gene

Drugs & Compounds for TMEM170A Gene

No Compound Related Data Available

Transcripts for TMEM170A Gene

Unigene Clusters for TMEM170A Gene

Transmembrane protein 170A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM170A Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d · 7e
SP1: -
SP2: - - - - - - -
SP3: - - - - - -
SP4: - - - - -
SP5: - - - -
SP6: - - - -
SP7:

Relevant External Links for TMEM170A Gene

GeneLoc Exon Structure for
TMEM170A
ECgene alternative splicing isoforms for
TMEM170A

Expression for TMEM170A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM170A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TMEM170A Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMEM170A Gene



Protein tissue co-expression partners for TMEM170A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TMEM170A Gene:

TMEM170A

SOURCE GeneReport for Unigene cluster for TMEM170A Gene:

Hs.487510

Evidence on tissue expression from TISSUES for TMEM170A Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with TMEM170A: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM170A Gene

Orthologs for TMEM170A Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM170A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM170A 33 34
  • 99.07 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 97 (a)
OneToMany
dog
(Canis familiaris)
Mammalia TMEM170A 33
  • 95.14 (n)
cow
(Bos Taurus)
Mammalia TMEM170A 33 34
  • 92.84 (n)
rat
(Rattus norvegicus)
Mammalia Tmem170a 33
  • 92.13 (n)
mouse
(Mus musculus)
Mammalia Tmem170 33 16 34
  • 91.9 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 83 (a)
OneToMany
chicken
(Gallus gallus)
Aves TMEM170A 33 34
  • 77.86 (n)
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 69 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem170a 33
  • 73.13 (n)
zebrafish
(Danio rerio)
Actinopterygii tmem170a 33 34
  • 59.9 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005150 33
  • 53.09 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG12341 33 34
  • 52.91 (n)
Species where no ortholog for TMEM170A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM170A Gene

ENSEMBL:
Gene Tree for TMEM170A (if available)
TreeFam:
Gene Tree for TMEM170A (if available)

Paralogs for TMEM170A Gene

Paralogs for TMEM170A Gene

(1) SIMAP similar genes for TMEM170A Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with TMEM170A: view

Variants for TMEM170A Gene

Sequence variations from dbSNP and Humsavar for TMEM170A Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000009800 -- 75,464,189(-) C/G genic_upstream_transcript_variant, intron_variant
rs1000098741 -- 75,459,546(-) C/A/G intron_variant
rs1000100254 -- 75,456,914(-) G/T intron_variant
rs1000118170 -- 75,456,712(-) G/A intron_variant
rs1000369283 -- 75,455,041(-) A/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM170A Gene

Variant ID Type Subtype PubMed ID
esv2714709 CNV deletion 23290073
esv2758657 CNV gain 17122850
esv3553676 CNV deletion 23714750
nsv1063718 CNV gain 25217958
nsv1065995 CNV loss 25217958
nsv457521 CNV gain 19166990
nsv521596 CNV loss 19592680
nsv525955 CNV loss 19592680
nsv572979 CNV gain 21841781

Variation tolerance for TMEM170A Gene

Residual Variation Intolerance Score: 61.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.50; 10.84% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM170A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM170A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM170A Gene

Disorders for TMEM170A Gene

Additional Disease Information for TMEM170A

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for TMEM170A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM170A Gene

Publications for TMEM170A Gene

  1. Transmembrane protein TMEM170A is a newly discovered regulator of ER and nuclear envelope morphogenesis in human cells. (PMID: 26906412) Christodoulou A … Mattaj IW (Journal of cell science 2016) 2 3 4 58
  2. Fine mapping and association studies of a high-density lipoprotein cholesterol linkage region on chromosome 16 in French-Canadian subjects. (PMID: 19844255) Dastani Z … Genest J (European journal of human genetics : EJHG 2010) 3 44 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer. (PMID: 25086665) Wolpin BM … Amundadottir LT (Nature genetics 2014) 3 58
  5. Identification of the BCAR1-CFDP1-TMEM170A locus as a determinant of carotid intima-media thickness and coronary artery disease risk. (PMID: 23152477) Gertow K … Hamsten A (Circulation. Cardiovascular genetics 2012) 3 58

Products for TMEM170A Gene

Sources for TMEM170A Gene

Content
Loading form....