Aliases for TMEM168 Gene

Aliases for TMEM168 Gene

  • Transmembrane Protein 168 2 3 4 5
  • TMEM168 5

External Ids for TMEM168 Gene

Previous GeneCards Identifiers for TMEM168 Gene

  • GC07M112193
  • GC07M112405
  • GC07M106773

Summaries for TMEM168 Gene

GeneCards Summary for TMEM168 Gene

TMEM168 (Transmembrane Protein 168) is a Protein Coding gene. Diseases associated with TMEM168 include Prostate Rhabdomyosarcoma and Prostate Sarcoma.

Additional gene information for TMEM168 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TMEM168 Gene

Genomics for TMEM168 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TMEM168 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J112788 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 611.1 +0.4 447 2.9 PRDM10 REST ZNF629 LEF1 IKZF1 NFKBIZ ZNF692 NFRKB POLR2A BACH1 TMEM168 lnc-LSMEM1-6 ENSG00000223646 LSMEM1
GH07J112791 Promoter 0.6 Ensembl 600.7 -1.7 -1677 1 IRF2 FOXA2 DMAP1 ZNF664 NFYC TMEM168 lnc-LSMEM1-6 HSALNG0060626 BMT2 ENSG00000223646
GH07J113085 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 16.4 -296.6 -296566 3.2 CREB1 PRDM10 ZNF629 ZNF512 IKZF1 ZNF692 ETV6 PRDM1 MTA2 ZSCAN4 GPR85 TMEM168 SMIM30 ENSG00000279288 lnc-GPR85-1 BMT2
GH07J112938 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 10.5 -148.7 -148678 3.8 SP1 CREB1 PRDM10 REST RFX1 BACH1 LARP7 GABPA DDX20 RBFOX2 BMT2 lnc-TMEM168-3 lnc-LSMEM1-7 SMIM30 TMEM168 piR-41399-451
GH07J112448 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 10.5 +339.0 339001 6.4 BRCA1 ARHGAP35 SP1 HNRNPL CREB1 ATF7 PRDM10 ZNF629 REST RFX1 IFRD1 NONHSAG048570.2 lnc-DOCK4-4 LSMEM1 TMEM168 GPR85 IMMP2L piR-43107-279
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TMEM168 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TMEM168

Top Transcription factor binding sites by QIAGEN in the TMEM168 gene promoter:
  • AML1a
  • Cdc5
  • CREB
  • deltaCREB
  • Egr-2
  • GR
  • GR-alpha
  • GR-beta
  • POU2F1
  • POU2F1a

Genomic Locations for TMEM168 Gene

Genomic Locations for TMEM168 Gene
chr7:112,762,377-112,790,423
(GRCh38/hg38)
Size:
28,047 bases
Orientation:
Minus strand
chr7:112,402,437-112,430,647
(GRCh37/hg19)
Size:
28,211 bases
Orientation:
Minus strand

Genomic View for TMEM168 Gene

Genes around TMEM168 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM168 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM168 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM168 Gene

Proteins for TMEM168 Gene

  • Protein details for TMEM168 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H0V1-TM168_HUMAN
    Recommended name:
    Transmembrane protein 168
    Protein Accession:
    Q9H0V1
    Secondary Accessions:
    • A4D0T9
    • B4DDS0
    • Q8NEK4
    • Q9H8J2

    Protein attributes for TMEM168 Gene

    Size:
    697 amino acids
    Molecular mass:
    79755 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAQ96836.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=BAB14624.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for TMEM168 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM168 Gene

Post-translational modifications for TMEM168 Gene

  • Glycosylation at Asn111, Asn533, and Asn598
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TMEM168 Gene

Domains & Families for TMEM168 Gene

Gene Families for TMEM168 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for TMEM168 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM168 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ57900 (B4DDS0_HUMAN)
  • Transmembrane protein 168 (TM168_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9H0V1

UniProtKB/Swiss-Prot:

TM168_HUMAN :
  • Belongs to the TMEM168 family.
Family:
  • Belongs to the TMEM168 family.
genes like me logo Genes that share domains with TMEM168: view

Function for TMEM168 Gene

Phenotypes From GWAS Catalog for TMEM168 Gene

genes like me logo Genes that share phenotypes with TMEM168: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TMEM168

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMEM168

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM168 Gene

Localization for TMEM168 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM168 Gene

Membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM168 gene
Compartment Confidence
plasma membrane 3
nucleus 1
golgi apparatus 1
endoplasmic reticulum 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TMEM168 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030133 transport vesicle IDA --
genes like me logo Genes that share ontologies with TMEM168: view

Pathways & Interactions for TMEM168 Gene

PathCards logo

SuperPathways for TMEM168 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMEM168 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM168 Gene

Drugs & Compounds for TMEM168 Gene

No Compound Related Data Available

Transcripts for TMEM168 Gene

mRNA/cDNA for TMEM168 Gene

2 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMEM168

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM168 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b
SP1: -
SP2: - - -
SP3: - - - - -
SP4:
SP5: -

Relevant External Links for TMEM168 Gene

GeneLoc Exon Structure for
TMEM168

Expression for TMEM168 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TMEM168 Gene

Protein differential expression in normal tissues from HIPED for TMEM168 Gene

This gene is overexpressed in Placenta (36.0), Breast (13.4), and Testis (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TMEM168 Gene



Protein tissue co-expression partners for TMEM168 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TMEM168

SOURCE GeneReport for Unigene cluster for TMEM168 Gene:

Hs.709689

Evidence on tissue expression from TISSUES for TMEM168 Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with TMEM168: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM168 Gene

Orthologs for TMEM168 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM168 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TMEM168 30 31
  • 99.82 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia TMEM168 30 31
  • 93.11 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia TMEM168 30 31
  • 93.07 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia TMEM168 31
  • 92 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Tmem168 30 17 31
  • 89.29 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Tmem168 30
  • 89.19 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia TMEM168 31
  • 87 (a)
OneToOne
Chicken
(Gallus gallus)
Aves TMEM168 30 31
  • 79.72 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia TMEM168 31
  • 85 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia tmem168 30
  • 75.05 (n)
Zebrafish
(Danio rerio)
Actinopterygii tmem168b 30 31
  • 61.73 (n)
OneToMany
tmem168a 31
  • 60 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 34 (a)
OneToMany
-- 31
  • 34 (a)
OneToMany
Species where no ortholog for TMEM168 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for TMEM168 Gene

ENSEMBL:
Gene Tree for TMEM168 (if available)
TreeFam:
Gene Tree for TMEM168 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TMEM168: view image

Paralogs for TMEM168 Gene

No data available for Paralogs for TMEM168 Gene

Variants for TMEM168 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TMEM168 Gene

SNP ID Clinical significance and condition Chr 07 pos Variation AA Info Type
769730 Benign: not provided 112,784,759(-) C/T MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for TMEM168 Gene

Structural Variations from Database of Genomic Variants (DGV) for TMEM168 Gene

Variant ID Type Subtype PubMed ID
esv2422365 CNV duplication 17116639
esv2752144 CNV gain 17911159
nsv464689 CNV gain 19166990
nsv608200 CNV gain 21841781
nsv608226 CNV gain 21841781
nsv7405 OTHER inversion 18451855

Variation tolerance for TMEM168 Gene

Residual Variation Intolerance Score: 14.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.36; 53.86% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM168 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM168

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM168 Gene

Disorders for TMEM168 Gene

MalaCards: The human disease database

(2) MalaCards diseases for TMEM168 Gene - From: DISEASES

Disorder Aliases PubMed IDs
prostate rhabdomyosarcoma
  • rhabdomyosarcoma of the prostate
prostate sarcoma
  • sarcoma of the prostate
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TMEM168

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with TMEM168: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TMEM168 Gene

Publications for TMEM168 Gene

  1. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G … Wijmenga C (Gut 2009) 3 41
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3
  4. PLEKHA4/kramer Attenuates Dishevelled Ubiquitination to Modulate Wnt and Planar Cell Polarity Signaling. (PMID: 31091453) Shami Shah A … Baskin JM (Cell reports 2019) 3
  5. Inhibition of Proliferation by Knockdown of Transmembrane (TMEM) 168 in Glioblastoma Cells via Suppression of Wnt/β-Catenin Pathway. (PMID: 30940290) Xu J … Lu B (Oncology research 2019) 3

Products for TMEM168 Gene

  • Signalway ELISA kits for TMEM168

Sources for TMEM168 Gene