Free for academic non-profit institutions. Other users need a Commercial license
Aliases for TMEM167B Gene
Aliases for TMEM167B Gene
External Ids for TMEM167B Gene
- HGNC: 30187
- Entrez Gene: 56900
- Ensembl: ENSG00000215717
- UniProtKB: Q9NRX6
Previous HGNC Symbols for TMEM167B Gene
- C1orf119
Previous GeneCards Identifiers for TMEM167B Gene
- GC01P109432
- GC01P109630
- GC01P107526
Summaries for TMEM167B Gene
GeneCards Summary for TMEM167B Gene
TMEM167B (Transmembrane Protein 167B) is a Protein Coding gene. Diseases associated with TMEM167B include Murray Valley Encephalitis. An important paralog of this gene is TMEM167A.
UniProtKB/Swiss-Prot Summary for TMEM167B Gene
-
Involved in the early part of the secretory pathway.
Additional gene information for TMEM167B Gene
- HGNC(30187)
- Entrez Gene(56900)
- Ensembl(ENSG00000215717)
- UniProtKB(Q9NRX6)
- Open Targets Platform(ENSG00000215717)
- Search for TMEM167B at DataMed
- Search for TMEM167B at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TMEM167B Gene
Genomics for TMEM167B Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for TMEM167B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around TMEM167B on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TMEM167B
- Top Transcription factor binding sites by QIAGEN in the TMEM167B gene promoter:
-
- C/EBPbeta
- COUP
- COUP-TF
- COUP-TF1
- E2F
- E2F-1
- HNF-4alpha1
- HNF-4alpha2
- SRY
- TBP
Genomic Locations for TMEM167B Gene
Genomic Locations for TMEM167B Gene
- chr1:109,090,764-109,096,934
- (GRCh38/hg38)
- Size:
- 6,171 bases
- Orientation:
- Plus strand
- chr1:109,632,425-109,639,556
- (GRCh37/hg19)
- Size:
- 7,132 bases
- Orientation:
- Plus strand
Genomic View for TMEM167B Gene
Genes around TMEM167B on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p13.3 by HGNC
- 1p13.3 by Entrez Gene
- 1p13.3 by Ensembl
TMEM167B Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TMEM167B Gene
Proteins for TMEM167B Gene
-
Protein details for TMEM167B Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9NRX6-KISHB_HUMAN
- Recommended name:
- Protein kish-B
- Protein Accession:
- Q9NRX6
- B2RUU9
Protein attributes for TMEM167B Gene
- Size:
- 74 amino acids
- Molecular mass:
- 8294 Da
- Quaternary structure:
- No Data Available
Protein Expression for TMEM167B Gene
Post-translational modifications for TMEM167B Gene
Other Protein References for TMEM167B Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
Protein Products
-
OriGene Purified Proteins for TMEM167B
- Search Origene for MassSpec and Protein Over-expression Lysates for TMEM167B
- Origene Custom Protein Services for TMEM167B
- Novus Biologicals lysates for TMEM167B
- antibodies-online: Show 3 available TMEM167B Proteins ranked by validation data
- Compare Top TMEM167B Proteins
-
Quality Products:
No data available for DME Specific Peptides for TMEM167B Gene
Domains & Families for TMEM167B Gene
Gene Families for TMEM167B Gene
- Human Protein Atlas (HPA):
-
- Predicted membrane proteins
Suggested Antigen Peptide Sequences for TMEM167B Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ76558 (B2RUU9_HUMAN)
- Protein kish-B (KISHB_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9NRX6- Family:
-
- Belongs to the KISH family.
Function for TMEM167B Gene
Molecular function for TMEM167B Gene
- UniProtKB/Swiss-Prot Function:
- Involved in the early part of the secretory pathway.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003674 | molecular_function | ND | -- |
Phenotypes for TMEM167B Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for TMEM167B - Select products 50% OFF >
- * TMEM167B CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for TMEM167B
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TMEM167B
-
Santa Cruz Biotechnology (SCBT) CRISPR for TMEM167B
miRNA for TMEM167B Gene
- miRTarBase miRNAs that target TMEM167B
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TMEM167B
- Browse OriGene Inhibitory RNA Products For TMEM167B
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMEM167B
Clone Products
- Applied Biological Materials (abm): Clones for TMEM167B - Select products 50% OFF >
- * TMEM167B as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for TMEM167B
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TMEM167B
Cell Line Products
-
Horizon Cell Lines for TMEM167B
No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM167B Gene
Localization for TMEM167B Gene
Subcellular locations from UniProtKB/Swiss-Prot for TMEM167B Gene
- Golgi apparatus membrane. Single-pass type I membrane protein.
| Compartment | Confidence |
|---|---|
| golgi apparatus | 5 |
| extracellular | 3 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000139 | Golgi membrane | IEA | -- |
| GO:0005794 | Golgi apparatus | IEA,IDA | 19942856 |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for TMEM167B Gene
Pathways & Interactions for TMEM167B Gene
Interacting Proteins for TMEM167B Gene
Selected Interacting proteins:
Q9NRX6-KISHB_HUMAN
ENSP00000342148
for TMEM167B Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for TMEM167B
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0045054 | constitutive secretory pathway | IGI | 19942856 |
No data available for Pathways by source and SIGNOR curated interactions for TMEM167B Gene
Transcripts for TMEM167B Gene
mRNA/cDNA for TMEM167B Gene
- 2 REFSEQ mRNAs :
- 15 NCBI additional mRNA sequence :
- 4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000338272 2769 nts (view in UCSC)
- ENST00000473828 964 nts (view in UCSC)
- ENST00000479160 897 nts (view in UCSC)
- ENST00000651489 2808 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for TMEM167B - Select products 50% OFF >
- * TMEM167B CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for TMEM167B
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TMEM167B
-
Santa Cruz Biotechnology (SCBT) CRISPR for TMEM167B
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TMEM167B
- Browse OriGene Inhibitory RNA Products For TMEM167B
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMEM167B
Clone Products
- Applied Biological Materials (abm): Clones for TMEM167B - Select products 50% OFF >
- * TMEM167B as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for TMEM167B
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TMEM167B
Relevant External Links for TMEM167B Gene
- GeneLoc Exon Structure for
- TMEM167B
Expression for TMEM167B Gene
This gene is overexpressed in Placenta (21.6), Oral epithelium (10.6), Prostate (8.1), and Gallbladder (7.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMEM167B Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TMEM167B
SOURCE GeneReport for Unigene cluster for TMEM167B Gene:
Hs.82933Evidence on tissue expression from TISSUES for TMEM167B Gene
- Nervous system(4.9)
- Skin(4.3)
- Adrenal gland(4.3)
- Lung(2.6)
Primer Products
-
OriGene qPCR primer pairs for TMEM167B
-
OriGene qPCR primer pairs and template standards for TMEM167B
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM167B Gene
Orthologs for TMEM167B Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | TMEM167B 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | TMEM167B 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Tmem167b 30 |
|
||
| Cow (Bos Taurus) |
Mammalia | TMEM167B 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Tmem167b 30 17 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | TMEM167B 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | TMEM167B 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | TMEM167B 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | TMEM167B 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | tmem167b 30 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.19645 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | tmem167b 30 31 |
|
OneToOne | |
| Worm (Caenorhabditis elegans) |
Secernentea | K07F5.15 30 |
|
- Species where no ortholog for TMEM167B was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for TMEM167B Gene
- ENSEMBL:
- Gene Tree for TMEM167B (if available)
- TreeFam:
- Gene Tree for TMEM167B (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for TMEM167B: view image
Paralogs for TMEM167B Gene
Variants for TMEM167B Gene
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3894001 | CNV | gain | 25118596 |
| nsv831026 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
49.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.13;
3.05% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for TMEM167B Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- TMEM167B
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TMEM167B Gene
Disorders for TMEM167B Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| murray valley encephalitis |
|
|
Search TMEM167B in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for TMEM167B
No data available for UniProtKB/Swiss-Prot and Genatlas for TMEM167B Gene
Publications for TMEM167B Gene
- A genome-wide RNA interference screen identifies two novel components of the metazoan secretory pathway. (PMID: 19942856) Wendler F … Munro S (The EMBO journal 2010) 3 4
- The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3
- Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PMID: 10931946) Hu RM … Chen JL (Proceedings of the National Academy of Sciences of the United States of America 2000) 3 4
ExternalLinks
Products for TMEM167B Gene
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for TMEM167B
- Search Origene for MassSpec and Protein Over-expression Lysates for TMEM167B
- Origene Custom Protein Services for TMEM167B
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TMEM167B
- Browse OriGene Inhibitory RNA Products For TMEM167B
- OriGene qPCR primer pairs for TMEM167B
- OriGene qPCR primer pairs and template standards for TMEM167B
- OriGene CRISPR knockouts for TMEM167B
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For TMEM167B
- Sino Biological Human cDNA Clone for TMEM167B
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals lysates for TMEM167B
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- VectorBuilder Custom and pre-made DNA vectors for TMEM167B (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for TMEM167B (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for TMEM167B (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for TMEM167B CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for TMEM167B
- antibodies-online: Search results for available TMEM167B related products ranked by validation data
- antibodies-online: Search results for available TMEM167B related products ranked by validation data
- antibodies-online: Show 3 available TMEM167B Proteins ranked by validation data
- Compare Top TMEM167B Proteins
- Quality Products:
- Horizon Cell Lines for TMEM167B
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TMEM167B
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TMEM167B
- Search GeneCopoeia for miRNA 3'UTR Target clone products for TMEM167B
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMEM167B
Sources for TMEM167B Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB