Aliases for TMEM167B Gene

Aliases for TMEM167B Gene

  • Transmembrane Protein 167B 2 3 4 5
  • Protein Kish-B 3 4
  • C1orf119 3 4
  • AD-020 2 3
  • Chromosome 1 Open Reading Frame 119 2
  • TMEM167B 5
  • FLJ90710 2

External Ids for TMEM167B Gene

Previous HGNC Symbols for TMEM167B Gene

  • C1orf119

Previous GeneCards Identifiers for TMEM167B Gene

  • GC01P109432
  • GC01P109630
  • GC01P107526

Summaries for TMEM167B Gene

GeneCards Summary for TMEM167B Gene

TMEM167B (Transmembrane Protein 167B) is a Protein Coding gene. Diseases associated with TMEM167B include Murray Valley Encephalitis. An important paralog of this gene is TMEM167A.

UniProtKB/Swiss-Prot Summary for TMEM167B Gene

Additional gene information for TMEM167B Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TMEM167B Gene

Genomics for TMEM167B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TMEM167B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TMEM167B on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TMEM167B

Top Transcription factor binding sites by QIAGEN in the TMEM167B gene promoter:
  • C/EBPbeta
  • COUP
  • COUP-TF
  • COUP-TF1
  • E2F
  • E2F-1
  • HNF-4alpha1
  • HNF-4alpha2
  • SRY
  • TBP

Genomic Locations for TMEM167B Gene

Latest Assembly
chr1:109,090,764-109,096,934
(GRCh38/hg38)
Size:
6,171 bases
Orientation:
Plus strand

Previous Assembly
chr1:109,633,386-109,639,556
(GRCh37/hg19 by Entrez Gene)
Size:
6,171 bases
Orientation:
Plus strand

chr1:109,632,425-109,639,556
(GRCh37/hg19 by Ensembl)
Size:
7,132 bases
Orientation:
Plus strand

Genomic View for TMEM167B Gene

Genes around TMEM167B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM167B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM167B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM167B Gene

Proteins for TMEM167B Gene

  • Protein details for TMEM167B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRX6-KISHB_HUMAN
    Recommended name:
    Protein kish-B
    Protein Accession:
    Q9NRX6
    Secondary Accessions:
    • B2RUU9

    Protein attributes for TMEM167B Gene

    Size:
    74 amino acids
    Molecular mass:
    8294 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM167B Gene

Post-translational modifications for TMEM167B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM167B Gene

No data available for DME Specific Peptides for TMEM167B Gene

Domains & Families for TMEM167B Gene

Gene Families for TMEM167B Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TMEM167B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM167B Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ76558 (B2RUU9_HUMAN)
  • Protein kish-B (KISHB_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9NRX6

UniProtKB/Swiss-Prot:

KISHB_HUMAN :
  • Belongs to the KISH family.
Family:
  • Belongs to the KISH family.
genes like me logo Genes that share domains with TMEM167B: view

Function for TMEM167B Gene

Molecular function for TMEM167B Gene

UniProtKB/Swiss-Prot Function:
Involved in the early part of the secretory pathway.

Phenotypes From GWAS Catalog for TMEM167B Gene

Gene Ontology (GO) - Molecular Function for TMEM167B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 32296183
genes like me logo Genes that share ontologies with TMEM167B: view
genes like me logo Genes that share phenotypes with TMEM167B: view

miRNA for TMEM167B Gene

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMEM167B

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM167B Gene

Localization for TMEM167B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM167B Gene

Golgi apparatus membrane. Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM167B gene
Compartment Confidence
golgi apparatus 5
extracellular 3

Gene Ontology (GO) - Cellular Components for TMEM167B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005794 Golgi apparatus IEA,IDA 19942856
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM167B: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TMEM167B Gene

Pathways & Interactions for TMEM167B Gene

PathCards logo

SuperPathways for TMEM167B Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMEM167B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045054 constitutive secretory pathway IGI 19942856
genes like me logo Genes that share ontologies with TMEM167B: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM167B Gene

Drugs & Compounds for TMEM167B Gene

No Compound Related Data Available

Transcripts for TMEM167B Gene

mRNA/cDNA for TMEM167B Gene

2 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMEM167B

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM167B Gene

No ASD Table

Relevant External Links for TMEM167B Gene

GeneLoc Exon Structure for
TMEM167B

Expression for TMEM167B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TMEM167B Gene

Protein differential expression in normal tissues from HIPED for TMEM167B Gene

This gene is overexpressed in Placenta (21.6), Oral epithelium (10.6), Prostate (8.1), and Gallbladder (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMEM167B Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TMEM167B

SOURCE GeneReport for Unigene cluster for TMEM167B Gene:

Hs.82933

Evidence on tissue expression from TISSUES for TMEM167B Gene

  • Nervous system(4.9)
  • Skin(4.3)
  • Adrenal gland(4.3)
  • Lung(2.6)
genes like me logo Genes that share expression patterns with TMEM167B: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM167B Gene

Orthologs for TMEM167B Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM167B Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TMEM167B 30 31
  • 100 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia TMEM167B 30 31
  • 96.4 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Tmem167b 30
  • 94.59 (n)
Cow
(Bos Taurus)
Mammalia TMEM167B 30 31
  • 94.59 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Tmem167b 30 17 31
  • 93.69 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia TMEM167B 31
  • 92 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia TMEM167B 31
  • 40 (a)
OneToOne
Chicken
(Gallus gallus)
Aves TMEM167B 30 31
  • 71.62 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia TMEM167B 31
  • 89 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia tmem167b 30
  • 72.52 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.19645 30
Zebrafish
(Danio rerio)
Actinopterygii tmem167b 30 31
  • 75.23 (n)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea K07F5.15 30
  • 63.43 (n)
Species where no ortholog for TMEM167B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for TMEM167B Gene

ENSEMBL:
Gene Tree for TMEM167B (if available)
TreeFam:
Gene Tree for TMEM167B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TMEM167B: view image

Paralogs for TMEM167B Gene

Paralogs for TMEM167B Gene

(1) SIMAP similar genes for TMEM167B Gene using alignment to 1 proteins:

  • KISHB_HUMAN
genes like me logo Genes that share paralogs with TMEM167B: view

Variants for TMEM167B Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for TMEM167B Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for TMEM167B Gene

Variant ID Type Subtype PubMed ID
esv3894001 CNV gain 25118596
nsv831026 CNV loss 17160897

Variation tolerance for TMEM167B Gene

Residual Variation Intolerance Score: 49.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.13; 3.05% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM167B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM167B

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TMEM167B Gene

Disorders for TMEM167B Gene

MalaCards: The human disease database

(1) MalaCards diseases for TMEM167B Gene - From: COP

Disorder Aliases PubMed IDs
murray valley encephalitis
  • australian encephalitis
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TMEM167B

genes like me logo Genes that share disorders with TMEM167B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TMEM167B Gene

Publications for TMEM167B Gene

  1. A genome-wide RNA interference screen identifies two novel components of the metazoan secretory pathway. (PMID: 19942856) Wendler F … Munro S (The EMBO journal 2010) 3 4
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3
  5. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PMID: 10931946) Hu RM … Chen JL (Proceedings of the National Academy of Sciences of the United States of America 2000) 3 4

Products for TMEM167B Gene

Sources for TMEM167B Gene