Aliases for TMEM163 Gene

Aliases for TMEM163 Gene

  • Transmembrane Protein 163 2 3 4 5
  • SV31 2 3
  • DKFZP566N034 2
  • TMEM163 5
  • DC29 3

External Ids for TMEM163 Gene

Previous GeneCards Identifiers for TMEM163 Gene

  • GC02M134930
  • GC02M135213
  • GC02M127206

Summaries for TMEM163 Gene

GeneCards Summary for TMEM163 Gene

TMEM163 (Transmembrane Protein 163) is a Protein Coding gene. Diseases associated with TMEM163 include Febrile Seizures, Familial, 7 and Febrile Seizures, Familial, 2.

UniProtKB/Swiss-Prot Summary for TMEM163 Gene

  • May bind zinc and other divalent cations and recruit them to vesicular organelles.

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TMEM163 Gene

Genomics for TMEM163 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TMEM163 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J134718 Promoter 1.2 EPDnew Ensembl 256 +2.3 2333 2 KLF9 SP2 EZH2 CBX2 GLIS1 ZNF398 L3MBTL2 KLF1 ZBTB8A ZEB2 TMEM163 ENSG00000287463 LOC105373629 MGAT5
GH02J134678 Enhancer 1.2 FANTOM5 Ensembl ENCODE 23.9 +40.0 40034 8.6 BCL11A FEZF1 HES1 ZFP64 BHLHE40 HOMEZ CEBPB ZNF395 GTF2E2 FOXA2 TMEM163 piR-33614-160 HSALNG0019031 MGAT5
GH02J134668 Enhancer 1 FANTOM5 Ensembl ENCODE 25.8 +51.9 51933 8.8 BCL11A FEZF1 VEZF1 IRF4 ZNF843 PRDM6 BATF REST TCF7 MAFK TMEM163 MAP3K19 CCNT2 HSALNG0019031 piR-33614-160 MGAT5
GH02J134735 Enhancer 1.1 FANTOM5 Ensembl ENCODE 16.6 -17.8 -17766 6.6 SP1 BCL11A CEBPB IRF4 SMARCA5 CBFB SPI1 BHLHE40 ASH2L BATF TMEM163 MGAT5 CCNT2 RAB3GAP1 piR-48222-190 HSALNG0019033 ACMSD CCNT2-AS1
GH02J134770 Enhancer 0.9 Ensembl ENCODE 18 -52.6 -52627 5.7 IRF2 BHLHE40 VEZF1 GABPA TAL1 YY1 FOSL1 NFE2 HDAC2 FOXA1 HSALNG0019035 TMEM163 ACMSD lnc-ACMSD-4 CCNT2-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TMEM163 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TMEM163

Top Transcription factor binding sites by QIAGEN in the TMEM163 gene promoter:
  • AML1a
  • C/EBPalpha
  • Egr-3
  • Egr-4
  • HNF-1A
  • IRF-2
  • LyF-1
  • Pax-4a
  • Pax-5
  • Pbx1a

Genomic Locations for TMEM163 Gene

Latest Assembly
265,176 bases
Minus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
263,241 bases
Minus strand

(GRCh37/hg19 by Ensembl)
263,241 bases
Minus strand

Genomic View for TMEM163 Gene

Genes around TMEM163 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM163 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM163 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM163 Gene

Proteins for TMEM163 Gene

  • Protein details for TMEM163 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 163
    Protein Accession:
    Secondary Accessions:
    • Q53QM3
    • Q53SV7
    • Q69YH3
    • Q9UFG3

    Protein attributes for TMEM163 Gene

    289 amino acids
    Molecular mass:
    31469 Da
    Quaternary structure:
    No Data Available
    • Sequence=CAH10592.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
    • [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
    • [Isoform 3]: Dubious isoform that could be a cloning artifact.

    Alternative splice isoforms for TMEM163 Gene


neXtProt entry for TMEM163 Gene

Post-translational modifications for TMEM163 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM163 Gene

No data available for DME Specific Peptides for TMEM163 Gene

Domains & Families for TMEM163 Gene

Gene Families for TMEM163 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for TMEM163 Gene


Suggested Antigen Peptide Sequences for TMEM163 Gene

GenScript: Design optimal peptide antigens:
  • Transmembrane protein 163 (TM163_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TMEM163 family.
  • Belongs to the TMEM163 family.
genes like me logo Genes that share domains with TMEM163: view

Function for TMEM163 Gene

Molecular function for TMEM163 Gene

UniProtKB/Swiss-Prot Function:
May bind zinc and other divalent cations and recruit them to vesicular organelles.

Phenotypes From GWAS Catalog for TMEM163 Gene

Gene Ontology (GO) - Molecular Function for TMEM163 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA,ISS --
genes like me logo Genes that share ontologies with TMEM163: view
genes like me logo Genes that share phenotypes with TMEM163: view

miRNA for TMEM163 Gene

miRTarBase miRNAs that target TMEM163

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMEM163

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM163 Gene

Localization for TMEM163 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM163 Gene

Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane. Multi-pass membrane protein. Early endosome membrane. Note=Glutamatergic synaptic vesicles. {ECO:0000250}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM163 gene
Compartment Confidence
endosome 4
plasma membrane 3
extracellular 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
cytosol 1
lysosome 1
golgi apparatus 1
peroxisome 0

Gene Ontology (GO) - Cellular Components for TMEM163 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome IEA --
GO:0016020 membrane IBA 21873635
GO:0016021 integral component of membrane IEA --
GO:0030054 cell junction IEA --
GO:0030285 integral component of synaptic vesicle membrane IEA,ISS --
genes like me logo Genes that share ontologies with TMEM163: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TMEM163 Gene

Pathways & Interactions for TMEM163 Gene

PathCards logo

SuperPathways for TMEM163 Gene

No Data Available

Interacting Proteins for TMEM163 Gene

Gene Ontology (GO) - Biological Process for TMEM163 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0099180 zinc ion import into synaptic vesicle IEA --
genes like me logo Genes that share ontologies with TMEM163: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM163 Gene

Drugs & Compounds for TMEM163 Gene

No Compound Related Data Available

Transcripts for TMEM163 Gene

mRNA/cDNA for TMEM163 Gene

9 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMEM163

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM163 Gene

No ASD Table

Relevant External Links for TMEM163 Gene

GeneLoc Exon Structure for

Expression for TMEM163 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TMEM163 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMEM163 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x6.7), Brain - Cerebellum (x5.8), and Pancreas (x5.3).

Protein differential expression in normal tissues from HIPED for TMEM163 Gene

This gene is overexpressed in Frontal cortex (15.9), Pancreas (14.5), Fetal Brain (12.7), and Platelet (10.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMEM163 Gene

Protein tissue co-expression partners for TMEM163 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TMEM163

SOURCE GeneReport for Unigene cluster for TMEM163 Gene:


Evidence on tissue expression from TISSUES for TMEM163 Gene

  • Stomach(4.2)
  • Kidney(4.1)
  • Nervous system(2.4)
genes like me logo Genes that share expression patterns with TMEM163: view

Primer products for research

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM163 Gene

Orthologs for TMEM163 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM163 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMEM163 30 31
  • 99.77 (n)
(Canis familiaris)
Mammalia TMEM163 30 31
  • 93.82 (n)
(Bos Taurus)
Mammalia TMEM163 30 31
  • 91.99 (n)
(Monodelphis domestica)
Mammalia TMEM163 31
  • 89 (a)
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 85 (a)
-- 31
  • 57 (a)
(Rattus norvegicus)
Mammalia Tmem163 30
  • 84.95 (n)
(Mus musculus)
Mammalia Tmem163 30 17 31
  • 84.03 (n)
(Gallus gallus)
Aves TMEM163 30 31
  • 77.6 (n)
(Anolis carolinensis)
Reptilia TMEM163 31
  • 86 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia tmem163 30
  • 76.48 (n)
(Danio rerio)
Actinopterygii tmem163b 30 31
  • 72.34 (n)
tmem163a 31
  • 68 (a)
Species where no ortholog for TMEM163 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for TMEM163 Gene

Gene Tree for TMEM163 (if available)
Gene Tree for TMEM163 (if available)
Evolutionary constrained regions (ECRs) for TMEM163: view image

Paralogs for TMEM163 Gene

No data available for Paralogs for TMEM163 Gene

Variants for TMEM163 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for TMEM163 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for TMEM163 Gene

Variant ID Type Subtype PubMed ID
dgv2046n106 CNV deletion 24896259
dgv2253e59 CNV duplication 20981092
esv1185737 CNV insertion 17803354
esv1198411 CNV deletion 17803354
esv1203818 CNV deletion 17803354
esv24078 CNV gain+loss 19812545
esv2595055 CNV deletion 19546169
esv2662661 CNV deletion 23128226
esv2674764 CNV deletion 23128226
esv2676369 CNV deletion 23128226
esv2720857 CNV deletion 23290073
esv2720858 CNV deletion 23290073
esv2720859 CNV deletion 23290073
esv3560183 CNV deletion 23714750
esv3592555 CNV loss 21293372
esv3592556 CNV loss 21293372
esv3592557 CNV loss 21293372
esv3592558 CNV loss 21293372
esv3592559 CNV loss 21293372
esv3592560 CNV loss 21293372
esv9502 CNV loss 19470904
nsv1004271 CNV loss 25217958
nsv1004843 CNV gain 25217958
nsv1009691 CNV gain 25217958
nsv1118883 CNV deletion 24896259
nsv1128818 CNV duplication 24896259
nsv1146003 CNV duplication 26484159
nsv821400 CNV deletion 20802225
nsv834385 CNV gain 17160897
nsv953185 CNV deletion 24416366

Variation tolerance for TMEM163 Gene

Residual Variation Intolerance Score: 41% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.48; 10.55% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM163 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TMEM163 Gene

Disorders for TMEM163 Gene

MalaCards: The human disease database

(3) MalaCards diseases for TMEM163 Gene - From: COP

Disorder Aliases PubMed IDs
febrile seizures, familial, 7
  • feb7
febrile seizures, familial, 2
  • feb2
familial febrile seizures
  • familial febrile convulsions
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TMEM163

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with TMEM163: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TMEM163 Gene

Publications for TMEM163 Gene

  1. TMEM163 Regulates ATP-Gated P2X Receptor and Behavior. (PMID: 32492420) Salm EJ … Tomita S (Cell reports 2020) 2 3
  2. The mucolipin-1 (TRPML1) ion channel, transmembrane-163 (TMEM163) protein, and lysosomal zinc handling. (PMID: 28199205) Cuajungco MP … Kiselyov K (Frontiers in bioscience (Landmark edition) 2017) 2 3
  3. Identification and characterization of SV31, a novel synaptic vesicle membrane protein and potential transporter. (PMID: 17623043) Burré J … Volknandt W (Journal of neurochemistry 2007) 2 3
  4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for TMEM163 Gene

Sources for TMEM163 Gene