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Aliases for TMEM161B Gene

Aliases for TMEM161B Gene

  • Transmembrane Protein 161B 2 3 5
  • FLB3342 3
  • PRO1313 3

External Ids for TMEM161B Gene

Previous GeneCards Identifiers for TMEM161B Gene

  • GC05M087527
  • GC05M082694
  • GC05M087487

Summaries for TMEM161B Gene

GeneCards Summary for TMEM161B Gene

TMEM161B (Transmembrane Protein 161B) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is TMEM161A.

Additional gene information for TMEM161B Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM161B Gene

Genomics for TMEM161B Gene

GeneHancer (GH) Regulatory Elements for TMEM161B Gene

Promoters and enhancers for TMEM161B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I088267 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 +0.6 552 3.1 PKNOX1 SMAD1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 POLR2B E2F8 TMEM161B-AS1 TMEM161B
GH05I088671 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 28.7 -405.5 -405456 7 ATF1 ARNT ZNF133 NEUROD1 SIN3A FEZF1 ZNF2 GLIS2 ZNF213 ELK1 MEF2C-AS2 TMEM161B MEF2C MEF2C-AS1 MIR9-2 LINC00461
GH05I088822 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 17.9 -559.3 -559276 12.6 HDGF FOXA2 PKNOX1 SMAD1 FEZF1 ZNF2 IRF4 YY1 JUNB MEF2D MEF2C TMEM161B MEF2C-AS1 ENSG00000250377
GH05I088679 Enhancer 1.3 Ensembl ENCODE dbSUPER 17.9 -410.7 -410695 1.9 GLI4 ZNF2 ZNF48 GLIS2 ARID2 ZNF207 ZNF143 ATF7 ZNF202 REST TMEM161B MEF2C-AS2 LINC00461
GH05I088140 Enhancer 1.1 Ensembl ENCODE 12.8 +128.1 128114 1.7 HDGF PKNOX1 SIN3A ZNF2 YY1 GLIS2 ZNF143 KLF7 ZNF548 ZNF263 TMEM161B LINC00461 MEF2C-AS2 MIR9-2 ENSG00000250555 ENSG00000250377 LOC105379070 GC05P088219
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TMEM161B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TMEM161B gene promoter:

Genomic Locations for TMEM161B Gene

Genomic Locations for TMEM161B Gene
83,902 bases
Minus strand

Genomic View for TMEM161B Gene

Genes around TMEM161B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM161B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM161B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM161B Gene

Proteins for TMEM161B Gene

  • Protein details for TMEM161B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 161B
    Protein Accession:
    Secondary Accessions:
    • Q5CZH7
    • Q6UWQ6

    Protein attributes for TMEM161B Gene

    487 amino acids
    Molecular mass:
    55482 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM161B Gene


neXtProt entry for TMEM161B Gene

Post-translational modifications for TMEM161B Gene

  • Glycosylation at isoforms=234, isoforms=2, 3135, and posLast=203203

No data available for DME Specific Peptides for TMEM161B Gene

Domains & Families for TMEM161B Gene

Gene Families for TMEM161B Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TMEM161B Gene


Suggested Antigen Peptide Sequences for TMEM161B Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TMEM161 family.
  • Belongs to the TMEM161 family.
genes like me logo Genes that share domains with TMEM161B: view

Function for TMEM161B Gene

Phenotypes From GWAS Catalog for TMEM161B Gene

Phenotypes for TMEM161B Gene

MGI mutant phenotypes for TMEM161B:
inferred from 1 alleles
GenomeRNAi human phenotypes for TMEM161B:
genes like me logo Genes that share phenotypes with TMEM161B: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM161B Gene

Localization for TMEM161B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM161B Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM161B gene
Compartment Confidence
plasma membrane 2

Gene Ontology (GO) - Cellular Components for TMEM161B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM161B: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TMEM161B Gene

Pathways & Interactions for TMEM161B Gene

SuperPathways for TMEM161B Gene

No Data Available

Interacting Proteins for TMEM161B Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: Q8NDZ6-T161B_HUMAN ENSP00000296595 for TMEM161B Gene via IID STRING

Gene Ontology (GO) - Biological Process for TMEM161B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015074 DNA integration IEA --
genes like me logo Genes that share ontologies with TMEM161B: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM161B Gene

Drugs & Compounds for TMEM161B Gene

No Compound Related Data Available

Transcripts for TMEM161B Gene

Unigene Clusters for TMEM161B Gene

Transmembrane protein 161B:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM161B Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c
SP1: - -
SP2: - - -

Relevant External Links for TMEM161B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM161B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM161B Gene

Protein differential expression in normal tissues from HIPED for TMEM161B Gene

This gene is overexpressed in Heart (55.7) and Retina (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TMEM161B Gene

Protein tissue co-expression partners for TMEM161B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TMEM161B Gene:


SOURCE GeneReport for Unigene cluster for TMEM161B Gene:

genes like me logo Genes that share expression patterns with TMEM161B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM161B Gene

Orthologs for TMEM161B Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM161B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMEM161B 33 34
  • 99.79 (n)
(Canis familiaris)
Mammalia TMEM161B 33 34
  • 95.89 (n)
(Bos Taurus)
Mammalia TMEM161B 33 34
  • 95 (n)
(Ornithorhynchus anatinus)
Mammalia TMEM161B 34
  • 92 (a)
(Mus musculus)
Mammalia Tmem161b 33 16 34
  • 91.31 (n)
(Rattus norvegicus)
Mammalia Tmem161b 33
  • 91.3 (n)
(Monodelphis domestica)
Mammalia TMEM161B 34
  • 67 (a)
(Gallus gallus)
Aves TMEM161B 33 34
  • 83.54 (n)
(Anolis carolinensis)
Reptilia TMEM161B 34
  • 86 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem161b 33
  • 78.14 (n)
Str.15030 33
(Danio rerio)
Actinopterygii tmem161b 33 34
  • 69.44 (n)
wufc31d04 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6252 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004945 33
  • 50.41 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG7638 33 34
  • 48.87 (n)
(Caenorhabditis elegans)
Secernentea Y87G2A.13 33 34
  • 42.73 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 41 (a)
Species where no ortholog for TMEM161B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMEM161B Gene

Gene Tree for TMEM161B (if available)
Gene Tree for TMEM161B (if available)

Paralogs for TMEM161B Gene

Paralogs for TMEM161B Gene

(1) SIMAP similar genes for TMEM161B Gene using alignment to 8 proteins: Pseudogenes for TMEM161B Gene

genes like me logo Genes that share paralogs with TMEM161B: view

Variants for TMEM161B Gene

Sequence variations from dbSNP and Humsavar for TMEM161B Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000047986 -- 88,226,973(-) A/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000081214 -- 88,250,885(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000083978 -- 88,205,579(-) C/T intron_variant
rs1000111495 -- 88,191,497(-) T/C genic_downstream_transcript_variant, intron_variant
rs1000146926 -- 88,256,136(-) C/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM161B Gene

Variant ID Type Subtype PubMed ID
nsv473243 CNV novel sequence insertion 20440878
nsv830384 CNV gain 17160897
nsv830385 CNV gain 17160897

Variation tolerance for TMEM161B Gene

Residual Variation Intolerance Score: 15.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.63; 65.60% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM161B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM161B Gene

Disorders for TMEM161B Gene

Additional Disease Information for TMEM161B

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for TMEM161B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM161B Gene

Publications for TMEM161B Gene

  1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Identification of 15 genetic loci associated with risk of major depression in individuals of European descent. (PMID: 27479909) Hyde CL … Winslow AR (Nature genetics 2016) 3 58

Products for TMEM161B Gene

Sources for TMEM161B Gene

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