Aliases for TMEM161A Gene

Aliases for TMEM161A Gene

  • Transmembrane Protein 161A 2 3 4 5
  • Adaptive Response To Oxidative Stress Protein 29 3 4
  • AROS-29 3 4

External Ids for TMEM161A Gene

Previous GeneCards Identifiers for TMEM161A Gene

  • GC19M019231
  • GC19M018794

Summaries for TMEM161A Gene

GeneCards Summary for TMEM161A Gene

TMEM161A (Transmembrane Protein 161A) is a Protein Coding gene. An important paralog of this gene is TMEM161B.

UniProtKB/Swiss-Prot Summary for TMEM161A Gene

  • May play a role in protection against oxidative stress. Overexpression leads to reduced levels of oxidant-induced DNA damage and apoptosis.

Additional gene information for TMEM161A Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TMEM161A Gene

Genomics for TMEM161A Gene

GeneHancer (GH) Regulatory Elements for TMEM161A Gene

Promoters and enhancers for TMEM161A Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TMEM161A on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TMEM161A

Top Transcription factor binding sites by QIAGEN in the TMEM161A gene promoter:
  • CP2
  • E2F
  • E2F-1
  • FOXI1
  • HFH-3
  • Msx-1
  • NF-E2
  • p53
  • STAT3

Genomic Locations for TMEM161A Gene

Genomic Locations for TMEM161A Gene
19,386 bases
Minus strand
19,345 bases
Minus strand

Genomic View for TMEM161A Gene

Genes around TMEM161A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM161A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM161A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM161A Gene

Proteins for TMEM161A Gene

  • Protein details for TMEM161A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 161A
    Protein Accession:
    Secondary Accessions:
    • B3KUE0
    • G5E9M6
    • Q7L2Y1

    Protein attributes for TMEM161A Gene

    479 amino acids
    Molecular mass:
    53602 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM161A Gene


neXtProt entry for TMEM161A Gene

Post-translational modifications for TMEM161A Gene

  • Glycosylation at Asn34
  • Ubiquitination at Lys72
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TMEM161A Gene

Domains & Families for TMEM161A Gene

Gene Families for TMEM161A Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TMEM161A Gene


Suggested Antigen Peptide Sequences for TMEM161A Gene

GenScript: Design optimal peptide antigens:
  • Transmembrane protein 161A (T161A_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TMEM161 family.
  • Belongs to the TMEM161 family.
genes like me logo Genes that share domains with TMEM161A: view

Function for TMEM161A Gene

Molecular function for TMEM161A Gene

UniProtKB/Swiss-Prot Function:
May play a role in protection against oxidative stress. Overexpression leads to reduced levels of oxidant-induced DNA damage and apoptosis.
UniProtKB/Swiss-Prot Induction:
Up-regulated in cells which display transient adaptation to mild oxidative stress by treatment with diethylmaleate, a glutathione-depleting agent. Also induced by retinoic acid.

Phenotypes From GWAS Catalog for TMEM161A Gene

Gene Ontology (GO) - Molecular Function for TMEM161A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 28298427
genes like me logo Genes that share ontologies with TMEM161A: view
genes like me logo Genes that share phenotypes with TMEM161A: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TMEM161A

CRISPR Products

miRNA for TMEM161A Gene

miRTarBase miRNAs that target TMEM161A

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM161A Gene

Localization for TMEM161A Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM161A Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM161A gene
Compartment Confidence
plasma membrane 3
cytosol 2
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TMEM161A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM161A: view

Pathways & Interactions for TMEM161A Gene

PathCards logo

SuperPathways for TMEM161A Gene

No Data Available

Interacting Proteins for TMEM161A Gene


Gene Ontology (GO) - Biological Process for TMEM161A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032526 response to retinoic acid IDA 16551573
GO:0034599 cellular response to oxidative stress IDA 16551573
GO:0034644 cellular response to UV IDA 16551573
GO:0045739 positive regulation of DNA repair IMP 16551573
GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage IMP 16551573
genes like me logo Genes that share ontologies with TMEM161A: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM161A Gene

Drugs & Compounds for TMEM161A Gene

No Compound Related Data Available

Transcripts for TMEM161A Gene

mRNA/cDNA for TMEM161A Gene

9 NCBI additional mRNA sequence :
15 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM161A Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c
SP1: - - - - - -
SP2: - - - - - - - - - -
SP3: - -
SP4: - - -
SP6: -
SP7: - -
SP8: - -

Relevant External Links for TMEM161A Gene

GeneLoc Exon Structure for

Expression for TMEM161A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TMEM161A Gene

Protein differential expression in normal tissues from HIPED for TMEM161A Gene

This gene is overexpressed in Lung (25.8), Plasma (15.4), Heart (10.3), and Liver (9.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TMEM161A Gene

Protein tissue co-expression partners for TMEM161A Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TMEM161A

SOURCE GeneReport for Unigene cluster for TMEM161A Gene:


Evidence on tissue expression from TISSUES for TMEM161A Gene

  • Intestine(4.2)
  • Kidney(4.2)
  • Skin(4.2)
  • Nervous system(3)
genes like me logo Genes that share expression patterns with TMEM161A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM161A Gene

Orthologs for TMEM161A Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM161A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMEM161A 31 30
  • 99.65 (n)
(Bos Taurus)
Mammalia TMEM161A 31 30
  • 86.68 (n)
(Canis familiaris)
Mammalia TMEM161A 31 30
  • 85.59 (n)
(Mus musculus)
Mammalia Tmem161a 17 31 30
  • 82.88 (n)
(Rattus norvegicus)
Mammalia Tmem161a 30
  • 81.87 (n)
(Monodelphis domestica)
Mammalia TMEM161A 31
  • 70 (a)
(Ornithorhynchus anatinus)
Mammalia TMEM161A 31
  • 61 (a)
(Gallus gallus)
Aves TMEM161A 31 30
  • 71 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem161a 30
  • 61.52 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.18468 30
(Danio rerio)
Actinopterygii tmem161a 31 30
  • 61.13 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG7638 31
  • 33 (a)
(Caenorhabditis elegans)
Secernentea Y87G2A.13 31
  • 24 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 37 (a)
Species where no ortholog for TMEM161A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMEM161A Gene

Gene Tree for TMEM161A (if available)
Gene Tree for TMEM161A (if available)
Evolutionary constrained regions (ECRs) for TMEM161A: view image

Paralogs for TMEM161A Gene

Paralogs for TMEM161A Gene

(1) SIMAP similar genes for TMEM161A Gene using alignment to 8 proteins:

  • T161A_HUMAN
  • K7EQ34_HUMAN
genes like me logo Genes that share paralogs with TMEM161A: view

Variants for TMEM161A Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TMEM161A Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
VAR_036537 A breast cancer sample p.Glu85Val

Additional dbSNP identifiers (rs#s) for TMEM161A Gene

Structural Variations from Database of Genomic Variants (DGV) for TMEM161A Gene

Variant ID Type Subtype PubMed ID
nsv1113986 CNV deletion 24896259
nsv1151217 CNV deletion 26484159
nsv833779 CNV loss 17160897

Variation tolerance for TMEM161A Gene

Residual Variation Intolerance Score: 30.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.73; 57.61% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM161A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM161A Gene

Disorders for TMEM161A Gene

Additional Disease Information for TMEM161A

No disorders were found for TMEM161A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM161A Gene

Publications for TMEM161A Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 2 3 4 54
  2. AROS-29 is involved in adaptive response to oxidative stress. (PMID: 16551573) Montesano Gesualdi N … Esposito F (Free radical research 2006) 3 4 54
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  4. Quantitative mapping of RNA-mediated nuclear estrogen receptor β interactome in human breast cancer cells. (PMID: 29509190) Giurato G … Tarallo R (Scientific data 2018) 3 54
  5. Interrogating the protein interactomes of RAS isoforms identifies PIP5K1A as a KRAS-specific vulnerability. (PMID: 30194290) Adhikari H … Counter CM (Nature communications 2018) 3 54

Products for TMEM161A Gene

  • Signalway ELISA kits for TMEM161A
  • Signalway Proteins for TMEM161A

Sources for TMEM161A Gene