Aliases for TMEM161A Gene

Aliases for TMEM161A Gene

  • Transmembrane Protein 161A 2 3 4 5
  • Adaptive Response To Oxidative Stress Protein 29 3 4
  • AROS-29 3 4

External Ids for TMEM161A Gene

Previous GeneCards Identifiers for TMEM161A Gene

  • GC19M019231
  • GC19M018794

Summaries for TMEM161A Gene

GeneCards Summary for TMEM161A Gene

TMEM161A (Transmembrane Protein 161A) is a Protein Coding gene. An important paralog of this gene is TMEM161B.

UniProtKB/Swiss-Prot Summary for TMEM161A Gene

  • May play a role in protection against oxidative stress. Overexpression leads to reduced levels of oxidant-induced DNA damage and apoptosis.

Additional gene information for TMEM161A Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TMEM161A Gene

Genomics for TMEM161A Gene

GeneHancer (GH) Regulatory Elements for TMEM161A Gene

Promoters and enhancers for TMEM161A Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TMEM161A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TMEM161A gene promoter:
  • CP2
  • E2F
  • E2F-1
  • FOXI1
  • HFH-3
  • Msx-1
  • NF-E2
  • p53
  • STAT3

Genomic Locations for TMEM161A Gene

Genomic Locations for TMEM161A Gene
chr19:19,119,169-19,138,554
(GRCh38/hg38)
Size:
19,386 bases
Orientation:
Minus strand
chr19:19,229,978-19,249,322
(GRCh37/hg19)
Size:
19,345 bases
Orientation:
Minus strand

Genomic View for TMEM161A Gene

Genes around TMEM161A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM161A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM161A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM161A Gene

Proteins for TMEM161A Gene

  • Protein details for TMEM161A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NX61-T161A_HUMAN
    Recommended name:
    Transmembrane protein 161A
    Protein Accession:
    Q9NX61
    Secondary Accessions:
    • B3KUE0
    • G5E9M6
    • Q7L2Y1

    Protein attributes for TMEM161A Gene

    Size:
    479 amino acids
    Molecular mass:
    53602 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM161A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM161A Gene

Post-translational modifications for TMEM161A Gene

  • Glycosylation at Asn34
  • Ubiquitination at Lys72
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TMEM161A Gene

Domains & Families for TMEM161A Gene

Gene Families for TMEM161A Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TMEM161A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM161A Gene

GenScript: Design optimal peptide antigens:
  • Transmembrane protein 161A (T161A_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9NX61

UniProtKB/Swiss-Prot:

T161A_HUMAN :
  • Belongs to the TMEM161 family.
Family:
  • Belongs to the TMEM161 family.
genes like me logo Genes that share domains with TMEM161A: view

Function for TMEM161A Gene

Molecular function for TMEM161A Gene

UniProtKB/Swiss-Prot Function:
May play a role in protection against oxidative stress. Overexpression leads to reduced levels of oxidant-induced DNA damage and apoptosis.
UniProtKB/Swiss-Prot Induction:
Up-regulated in cells which display transient adaptation to mild oxidative stress by treatment with diethylmaleate, a glutathione-depleting agent. Also induced by retinoic acid.

Phenotypes From GWAS Catalog for TMEM161A Gene

Gene Ontology (GO) - Molecular Function for TMEM161A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 28298427
genes like me logo Genes that share ontologies with TMEM161A: view
genes like me logo Genes that share phenotypes with TMEM161A: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TMEM161A

CRISPR Products

miRNA for TMEM161A Gene

miRTarBase miRNAs that target TMEM161A

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM161A Gene

Localization for TMEM161A Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM161A Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM161A gene
Compartment Confidence
plasma membrane 3
cytosol 2
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TMEM161A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM161A: view

Pathways & Interactions for TMEM161A Gene

PathCards logo

SuperPathways for TMEM161A Gene

No Data Available

Interacting Proteins for TMEM161A Gene

Gene Ontology (GO) - Biological Process for TMEM161A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032526 response to retinoic acid IDA 16551573
GO:0034599 cellular response to oxidative stress IDA 16551573
GO:0034644 cellular response to UV IDA 16551573
GO:0045739 positive regulation of DNA repair IMP 16551573
GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage IMP 16551573
genes like me logo Genes that share ontologies with TMEM161A: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM161A Gene

Drugs & Compounds for TMEM161A Gene

No Compound Related Data Available

Transcripts for TMEM161A Gene

mRNA/cDNA for TMEM161A Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM161A Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c
SP1: - - - - - -
SP2: - - - - - - - - - -
SP3: - -
SP4: - - -
SP5:
SP6: -
SP7: - -
SP8: - -
SP9:

Relevant External Links for TMEM161A Gene

GeneLoc Exon Structure for
TMEM161A
ECgene alternative splicing isoforms for
TMEM161A

Expression for TMEM161A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM161A Gene

Protein differential expression in normal tissues from HIPED for TMEM161A Gene

This gene is overexpressed in Lung (25.8), Plasma (15.4), Heart (10.3), and Liver (9.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TMEM161A Gene



Protein tissue co-expression partners for TMEM161A Gene

NURSA nuclear receptor signaling pathways regulating expression of TMEM161A Gene:

TMEM161A

SOURCE GeneReport for Unigene cluster for TMEM161A Gene:

Hs.631629

Evidence on tissue expression from TISSUES for TMEM161A Gene

  • Intestine(4.2)
  • Kidney(4.2)
  • Skin(4.2)
  • Nervous system(3)
genes like me logo Genes that share expression patterns with TMEM161A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM161A Gene

Orthologs for TMEM161A Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM161A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM161A 33 32
  • 99.65 (n)
OneToOne
cow
(Bos Taurus)
Mammalia TMEM161A 33 32
  • 86.68 (n)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM161A 33 32
  • 85.59 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem161a 17 33 32
  • 82.88 (n)
rat
(Rattus norvegicus)
Mammalia Tmem161a 32
  • 81.87 (n)
oppossum
(Monodelphis domestica)
Mammalia TMEM161A 33
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM161A 33
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM161A 33 32
  • 71 (n)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem161a 32
  • 61.52 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.18468 32
zebrafish
(Danio rerio)
Actinopterygii tmem161a 33 32
  • 61.13 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG7638 33
  • 33 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y87G2A.13 33
  • 24 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 33
  • 37 (a)
OneToMany
Species where no ortholog for TMEM161A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMEM161A Gene

ENSEMBL:
Gene Tree for TMEM161A (if available)
TreeFam:
Gene Tree for TMEM161A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TMEM161A: view image

Paralogs for TMEM161A Gene

Paralogs for TMEM161A Gene

(1) SIMAP similar genes for TMEM161A Gene using alignment to 8 proteins:

  • T161A_HUMAN
  • K7EJK6_HUMAN
  • K7EKY7_HUMAN
  • K7EPA3_HUMAN
  • K7EQ34_HUMAN
  • K7EQE7_HUMAN
  • U3KQT6_HUMAN
  • V9GYP8_HUMAN
genes like me logo Genes that share paralogs with TMEM161A: view

Variants for TMEM161A Gene

Sequence variations from dbSNP and Humsavar for TMEM161A Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
VAR_036537 A breast cancer sample p.Glu85Val
rs1000273895 -- 19,137,826(-) AA/ genic_upstream_transcript_variant, intron_variant
rs1000352558 -- 19,133,062(-) C/A genic_upstream_transcript_variant, intron_variant
rs1000385418 -- 19,131,578(-) T/C genic_upstream_transcript_variant, intron_variant
rs1000390681 -- 19,122,384(-) T/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM161A Gene

Variant ID Type Subtype PubMed ID
nsv1113986 CNV deletion 24896259
nsv1151217 CNV deletion 26484159
nsv833779 CNV loss 17160897

Variation tolerance for TMEM161A Gene

Residual Variation Intolerance Score: 30.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.73; 57.61% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM161A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM161A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM161A Gene

Disorders for TMEM161A Gene

Additional Disease Information for TMEM161A

No disorders were found for TMEM161A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM161A Gene

Publications for TMEM161A Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 2 3 4 56
  2. AROS-29 is involved in adaptive response to oxidative stress. (PMID: 16551573) Montesano Gesualdi N … Esposito F (Free radical research 2006) 3 4 56
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56
  4. Quantitative mapping of RNA-mediated nuclear estrogen receptor β interactome in human breast cancer cells. (PMID: 29509190) Giurato G … Tarallo R (Scientific data 2018) 3 56
  5. RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. (PMID: 29117863) Choudhury NR … Michlewski G (BMC biology 2017) 3 56

Products for TMEM161A Gene

Sources for TMEM161A Gene