Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TMEM159 Gene

Aliases for TMEM159 Gene

  • Transmembrane Protein 159 2 3 4 5
  • Promethin 3 4

External Ids for TMEM159 Gene

Previous GeneCards Identifiers for TMEM159 Gene

  • GC16P021078
  • GC16P019705
  • GC16P021169

Summaries for TMEM159 Gene

GeneCards Summary for TMEM159 Gene

TMEM159 (Transmembrane Protein 159) is a Protein Coding gene.

Additional gene information for TMEM159 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM159 Gene

Genomics for TMEM159 Gene

GeneHancer (GH) Regulatory Elements for TMEM159 Gene

Promoters and enhancers for TMEM159 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J021157 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 618.7 +0.7 713 2.6 ZFX ELF3 ZNF148 NKRF AHR SP7 POLR2A SP5 EGR1 IKZF1 TMEM159 DNAH3
GH16J021116 Promoter/Enhancer 1.3 EPDnew ENCODE 611.4 -42.0 -41988 0.7 CC2D1A ELF3 TRIM24 EGR1 KAT8 ATF1 PKNOX1 HDAC1 GABPA ETV6 TMEM159 DNAH3 GC16P021120 GC16P021084
GH16J021156 Enhancer 0.9 ENCODE 618.5 -1.5 -1482 0.2 ZNF652 ELF3 CTCF CEBPG TFE3 SP7 RAD21 KAT8 IKZF1 HMG20B TMEM159 DNAH3 PIR41433
GH16J021300 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 11.4 +142.6 142625 6 ZNF652 CC2D1A ELF3 CTCF MNT NKRF POLR2A MLLT1 CEBPG RERE CRYM CRYM-AS1 ENSG00000283421 GC16M021264 ENSG00000260306 RRN3P1 MOSMO NPIPB3 NPIPB4 TMEM159
GH16J021279 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 11.1 +119.9 119924 1.4 SP1 ZNF652 CTCF ELF3 AHR ZBTB7A SP7 HNF1A PPARG SP5 CRYM DNAH3 TMEM159 ZP2 ENSG00000260306 LOC105371125 GC16M021264 LOC105371123
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TMEM159 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TMEM159 gene promoter:
  • Brachyury
  • HNF-3beta
  • IRF-7A
  • p53
  • Pax-6
  • POU2F1
  • POU2F1a
  • POU2F1b
  • POU2F1c
  • PPAR-gamma2

Genomic Locations for TMEM159 Gene

Genomic Locations for TMEM159 Gene
chr16:21,158,377-21,180,616
(GRCh38/hg38)
Size:
22,240 bases
Orientation:
Plus strand
chr16:21,169,698-21,191,937
(GRCh37/hg19)
Size:
22,240 bases
Orientation:
Plus strand

Genomic View for TMEM159 Gene

Genes around TMEM159 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM159 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM159 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM159 Gene

Proteins for TMEM159 Gene

  • Protein details for TMEM159 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96B96-TM159_HUMAN
    Recommended name:
    Promethin
    Protein Accession:
    Q96B96
    Secondary Accessions:
    • A6NMA9
    • B4DEC1
    • O00323

    Protein attributes for TMEM159 Gene

    Size:
    161 amino acids
    Molecular mass:
    17522 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM159 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM159 Gene

Post-translational modifications for TMEM159 Gene

  • Glycosylation at posLast=2929 and isoforms=2141
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TMEM159 Gene

Domains & Families for TMEM159 Gene

Gene Families for TMEM159 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for TMEM159 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM159 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ51796, highly similar to Homo sapiens promethin, mRNA (B4DEC1_HUMAN)
  • Transmembrane protein 159 (TM159_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96B96

UniProtKB/Swiss-Prot:

TM159_HUMAN :
  • Belongs to the TMEM159 family.
Family:
  • Belongs to the TMEM159 family.
genes like me logo Genes that share domains with TMEM159: view

Function for TMEM159 Gene

Phenotypes From GWAS Catalog for TMEM159 Gene

Gene Ontology (GO) - Molecular Function for TMEM159 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21516116
genes like me logo Genes that share ontologies with TMEM159: view
genes like me logo Genes that share phenotypes with TMEM159: view

Animal Model Products

CRISPR Products

miRNA for TMEM159 Gene

miRTarBase miRNAs that target TMEM159

Clone Products

  • Applied Biological Materials (abm): Clones for TMEM159 - Now 50% OFF >
  • * TMEM159 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * TMEM159 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM159 Gene

Localization for TMEM159 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM159 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM159 gene
Compartment Confidence
plasma membrane 3

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TMEM159 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM159: view

Pathways & Interactions for TMEM159 Gene

PathCards logo

SuperPathways for TMEM159 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMEM159 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM159 Gene

Drugs & Compounds for TMEM159 Gene

No Compound Related Data Available

Transcripts for TMEM159 Gene

Unigene Clusters for TMEM159 Gene

Transmembrane protein 159:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for TMEM159 - Now 50% OFF >
  • * TMEM159 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * TMEM159 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM159 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d · 8e · 8f
SP1: - -
SP2: - - -
SP3: - -
SP4:
SP5: - - - -
SP6: - - -
SP7: -

Relevant External Links for TMEM159 Gene

GeneLoc Exon Structure for
TMEM159
ECgene alternative splicing isoforms for
TMEM159

Expression for TMEM159 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM159 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TMEM159 Gene

This gene is overexpressed in Heart (25.1), Bone (9.8), and Lung (9.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TMEM159 Gene



NURSA nuclear receptor signaling pathways regulating expression of TMEM159 Gene:

TMEM159

SOURCE GeneReport for Unigene cluster for TMEM159 Gene:

Hs.258212

mRNA Expression by UniProt/SwissProt for TMEM159 Gene:

Q96B96-TM159_HUMAN
Tissue specificity: Expressed at high levels in the heart and skeletal muscle. Expressed at low levels in kidney, small intestine, lung and liver.

Evidence on tissue expression from TISSUES for TMEM159 Gene

  • Heart(4.4)
  • Nervous system(4.4)
  • Skin(4.3)
genes like me logo Genes that share expression patterns with TMEM159: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM159 Gene

Orthologs for TMEM159 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM159 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM159 35 34
  • 99.38 (n)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM159 35 34
  • 83.85 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem159 34
  • 80.17 (n)
mouse
(Mus musculus)
Mammalia Tmem159 17 35 34
  • 79.54 (n)
oppossum
(Monodelphis domestica)
Mammalia TMEM159 35
  • 65 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TMEM159 35
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM159 35
  • 60 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM159 35 34
  • 58.84 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM159 35
  • 39 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100486925 34
  • 56.98 (n)
Species where no ortholog for TMEM159 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TMEM159 Gene

ENSEMBL:
Gene Tree for TMEM159 (if available)
TreeFam:
Gene Tree for TMEM159 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TMEM159: view image

Paralogs for TMEM159 Gene

No data available for Paralogs for TMEM159 Gene

Variants for TMEM159 Gene

Sequence variations from dbSNP and Humsavar for TMEM159 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000094392 -- 21,171,653(+) A/C intron_variant
rs1000104829 -- 21,165,139(+) T/A intron_variant
rs1000658086 -- 21,169,299(+) A/G intron_variant
rs1000819565 -- 21,175,943(+) C/G intron_variant
rs1000877952 -- 21,156,707(+) A/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM159 Gene

Variant ID Type Subtype PubMed ID
esv33128 CNV loss 17666407
esv33636 CNV loss 17666407
nsv436835 CNV insertion 17901297
nsv457444 CNV loss 19166990
nsv571622 CNV loss 21841781
nsv571623 CNV gain 21841781
nsv833166 CNV gain+loss 17160897

Variation tolerance for TMEM159 Gene

Residual Variation Intolerance Score: 60.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.84; 67.18% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM159 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM159

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM159 Gene

Disorders for TMEM159 Gene

Additional Disease Information for TMEM159

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for TMEM159 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM159 Gene

Publications for TMEM159 Gene

  1. Identification of promethin and PGLP as two novel up-regulated genes in PPARgamma1-induced adipogenic mouse liver. (PMID: 15589683) Yu S … Reddy JK (Biochimie 2004) 2 3 4 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 58
  3. Large-scale concatenation cDNA sequencing. (PMID: 9110174) Yu W … Gibbs RA (Genome research 1997) 2 3 58
  4. A "double adaptor" method for improved shotgun library construction. (PMID: 8619474) Andersson B … Gibbs RA (Analytical biochemistry 1996) 2 3 58
  5. A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome. (PMID: 28065597) Yao Z … Stagljar I (Molecular cell 2017) 3 58

Products for TMEM159 Gene

Sources for TMEM159 Gene

Content
Loading form....