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Aliases for TMEM155 Gene

Aliases for TMEM155 Gene

  • Transmembrane Protein 155 2 3 5

External Ids for TMEM155 Gene

Previous GeneCards Identifiers for TMEM155 Gene

  • GC04M122899
  • GC04M122680
  • GC04M118407

Summaries for TMEM155 Gene

GeneCards Summary for TMEM155 Gene

TMEM155 (Transmembrane Protein 155) is a Protein Coding gene.

Additional gene information for TMEM155 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM155 Gene

Genomics for TMEM155 Gene

GeneHancer (GH) Regulatory Elements for TMEM155 Gene

Promoters and enhancers for TMEM155 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04I121765 Promoter 0.9 EPDnew 550.8 +0.7 747 0.1 MAZ SP2 ZBTB8A ZNF335 GLIS2 ZFHX2 ZBTB26 EGR2 EZH2 PP12613 TMEM155
GH04I121766 Promoter 0.9 Ensembl 550.8 +0.9 941 0.2 MAZ ZNF189 SP2 ZBTB8A HIC1 ZNF335 ZFHX2 GLIS2 ZBTB26 EGR2 PP12613 TMEM155 EXOSC9
GH04I121763 Promoter 0.6 EPDnew 550.8 +2.1 2052 0.1 EZH2 PP12613 TMEM155 ANXA5
GH04I121788 Enhancer 1.2 ENCODE dbSUPER 24.1 -24.5 -24527 3.3 PKNOX1 ATF1 ARNT IRF4 NCOA2 TCF12 ZNF766 GATA2 E2F8 FOS TMEM155 PP12613 CCNA2 BBS7 EXOSC9
GH04I121798 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 11.2 -34.7 -34717 3.5 SMAD1 FOXA2 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 POLR2B EXOSC9 BBS7 TMEM155 PP12613 ENSG00000237868
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TMEM155 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TMEM155 gene promoter:

Genomic Locations for TMEM155 Gene

Genomic Locations for TMEM155 Gene
chr4:121,758,930-121,766,042
(GRCh38/hg38)
Size:
7,113 bases
Orientation:
Minus strand
chr4:122,680,085-122,686,582
(GRCh37/hg19)

Genomic View for TMEM155 Gene

Genes around TMEM155 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM155 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM155 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM155 Gene

Proteins for TMEM155 Gene

  • Protein details for TMEM155 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q4W5P6-TM155_HUMAN
    Recommended name:
    Protein TMEM155
    Protein Accession:
    Q4W5P6
    Secondary Accessions:
    • D3DNW9
    • Q96NI2

    Protein attributes for TMEM155 Gene

    Size:
    130 amino acids
    Molecular mass:
    14221 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM155 Gene

Post-translational modifications for TMEM155 Gene

No Post-translational modifications

No data available for DME Specific Peptides for TMEM155 Gene

Domains & Families for TMEM155 Gene

Gene Families for TMEM155 Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for TMEM155 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for TMEM155 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM155: view

No data available for UniProtKB/Swiss-Prot for TMEM155 Gene

Function for TMEM155 Gene

Phenotypes From GWAS Catalog for TMEM155 Gene

Animal Model Products

CRISPR Products

miRNA for TMEM155 Gene

miRTarBase miRNAs that target TMEM155

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM155 Gene

Localization for TMEM155 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM155 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM155 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for TMEM155 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with TMEM155: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TMEM155 Gene

Pathways & Interactions for TMEM155 Gene

SuperPathways for TMEM155 Gene

No Data Available

Interacting Proteins for TMEM155 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000336987%0d%0a9606.ENSP00000326604%0d%0a9606.ENSP00000349087%0d%0a
Selected Interacting proteins: Q4W5P6-TM155_HUMAN ENSP00000336987 for TMEM155 Gene via IID STRING

Gene Ontology (GO) - Biological Process for TMEM155 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM155 Gene

Drugs & Compounds for TMEM155 Gene

No Compound Related Data Available

Transcripts for TMEM155 Gene

Unigene Clusters for TMEM155 Gene

Transmembrane protein 155:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM155 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6
SP1: - -
SP2:

Relevant External Links for TMEM155 Gene

GeneLoc Exon Structure for
TMEM155
ECgene alternative splicing isoforms for
TMEM155

Expression for TMEM155 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM155 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMEM155 Gene

This gene is overexpressed in Brain - Cortex (x13.9), Brain - Frontal Cortex (BA9) (x13.3), and Brain - Anterior cingulate cortex (BA24) (x12.6).

NURSA nuclear receptor signaling pathways regulating expression of TMEM155 Gene:

TMEM155

SOURCE GeneReport for Unigene cluster for TMEM155 Gene:

Hs.27524

Evidence on tissue expression from TISSUES for TMEM155 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with TMEM155: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM155 Gene

Orthologs for TMEM155 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TMEM155 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM155 33
  • 98.72 (n)
dog
(Canis familiaris)
Mammalia TMEM155 33
  • 85 (n)
cow
(Bos Taurus)
Mammalia LOC100337022 33
  • 84.11 (n)
Species where no ortholog for TMEM155 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TMEM155 Gene

ENSEMBL:
Gene Tree for TMEM155 (if available)
TreeFam:
Gene Tree for TMEM155 (if available)

Paralogs for TMEM155 Gene

No data available for Paralogs for TMEM155 Gene

Variants for TMEM155 Gene

Sequence variations from dbSNP and Humsavar for TMEM155 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1000120367 -- 121,765,057(-) G/A 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000471416 -- 121,765,195(-) A/G 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1001077142 -- 121,766,634(-) A/G upstream_transcript_variant
rs1001393452 -- 121,759,507(-) G/T 3_prime_UTR_variant
rs1001466926 -- 121,759,957(-) T/C 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM155 Gene

Variant ID Type Subtype PubMed ID
nsv508309 CNV deletion 20534489
nsv595357 CNV loss 21841781
nsv997539 CNV gain 25217958

Variation tolerance for TMEM155 Gene

Residual Variation Intolerance Score: 89.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.72; 32.66% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM155 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM155

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM155 Gene

Disorders for TMEM155 Gene

Additional Disease Information for TMEM155

No disorders were found for TMEM155 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM155 Gene

Publications for TMEM155 Gene

  1. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for TMEM155 Gene

Sources for TMEM155 Gene

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