Aliases for TMEM151B Gene

Aliases for TMEM151B Gene

  • Transmembrane Protein 151B 2 3 4 5
  • Transmembrane Protein 193 2 3 4
  • BA444E17.5 2 3
  • C6orf137 3 4
  • TMEM193 3 4
  • Chromosome 6 Open Reading Frame 137 2
  • TMEM151B 5

External Ids for TMEM151B Gene

Previous HGNC Symbols for TMEM151B Gene

  • C6orf137
  • TMEM193

Previous GeneCards Identifiers for TMEM151B Gene

  • GC06P044349
  • GC06P044239
  • GC06P043960

Summaries for TMEM151B Gene

GeneCards Summary for TMEM151B Gene

TMEM151B (Transmembrane Protein 151B) is a Protein Coding gene. An important paralog of this gene is TMEM151A.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TMEM151B Gene

Genomics for TMEM151B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TMEM151B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J044270 Promoter/Enhancer 1.2 Ensembl ENCODE CraniofacialAtlas 250.7 +0.5 451 1.8 IKZF1 REST SP2 TAF1 GLIS1 SP3 EZH2 POLR2A KDM1A ZNF335 HSALNG0050284 TMEM151B ENSG00000272442 POLR1C
GH06J044269 Promoter 0.4 Ensembl 250.7 -1.0 -1049 0.4 ZKSCAN1 HSALNG0050281 HSALNG0050284 TMEM151B NFKBIE POLR1C
GH06J044255 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 16.1 -9.5 -9506 11.9 BCLAF1 SP1 ZNF207 ZNF654 ZNF600 NCOR1 IKZF1 MYC SSRP1 ZNF580 NFKBIE SLC35B2 ABCC10 ZNF318 ENSG00000220614 AARS2 RPS2P29 POLH GTPBP2 POLR1C
GH06J044232 Promoter/Enhancer 2.3 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 11 -34.6 -34573 6.4 BCLAF1 ZNF207 ZNF654 MYC ZNF600 IKZF1 SSRP1 JUND ZNF592 ATF2 HSALNG0050271 lnc-SLC29A1-2 ZNF318 ENSG00000220614 ABCC10 AARS2 POLH GTPBP2 CDC5L NFKBIE
GH06J044125 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 9.8 -143.2 -143249 4 SP1 NCOR1 IKZF1 MYC ZNF592 POLR2A ZNF10 NFIC ZIC2 ZBTB10 MRPL14 TMEM63B POLH ZNF318 XPO5 RPS2P29 POLR1C GTPBP2 AARS2 NFKBIE
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TMEM151B on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TMEM151B

Top Transcription factor binding sites by QIAGEN in the TMEM151B gene promoter:
  • c-Myb
  • E47
  • Egr-2
  • Egr-4
  • Elk-1
  • GATA-3
  • ISGF-3
  • MZF-1
  • p300
  • RORalpha1

Genomic Locations for TMEM151B Gene

Latest Assembly
chr6:44,270,450-44,307,506
(GRCh38/hg38)
Size:
37,057 bases
Orientation:
Plus strand

Previous Assembly
chr6:44,238,187-44,247,181
(GRCh37/hg19 by Entrez Gene)
Size:
8,995 bases
Orientation:
Plus strand

chr6:44,238,203-44,275,243
(GRCh37/hg19 by Ensembl)
Size:
37,041 bases
Orientation:
Plus strand

Genomic View for TMEM151B Gene

Genes around TMEM151B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM151B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM151B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM151B Gene

Proteins for TMEM151B Gene

  • Protein details for TMEM151B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IW70-T151B_HUMAN
    Recommended name:
    Transmembrane protein 151B
    Protein Accession:
    Q8IW70
    Secondary Accessions:
    • Q5T9V7

    Protein attributes for TMEM151B Gene

    Size:
    566 amino acids
    Molecular mass:
    61506 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM151B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM151B Gene

Post-translational modifications for TMEM151B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM151B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM151B Gene

Domains & Families for TMEM151B Gene

Gene Families for TMEM151B Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TMEM151B Gene

InterPro:

Suggested Antigen Peptide Sequences for TMEM151B Gene

GenScript: Design optimal peptide antigens:
  • Transmembrane protein 193 (T151B_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8IW70

UniProtKB/Swiss-Prot:

T151B_HUMAN :
  • Belongs to the TMEM151 family.
Family:
  • Belongs to the TMEM151 family.
genes like me logo Genes that share domains with TMEM151B: view

Function for TMEM151B Gene

Phenotypes From GWAS Catalog for TMEM151B Gene

genes like me logo Genes that share phenotypes with TMEM151B: view

Animal Models for TMEM151B Gene

MGI Knock Outs for TMEM151B:

miRNA for TMEM151B Gene

miRTarBase miRNAs that target TMEM151B

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMEM151B

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TMEM151B Gene

Localization for TMEM151B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM151B Gene

Membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM151B gene
Compartment Confidence
plasma membrane 3
peroxisome 2
nucleus 1

Gene Ontology (GO) - Cellular Components for TMEM151B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM151B: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TMEM151B Gene

Pathways & Interactions for TMEM151B Gene

PathCards logo

SuperPathways for TMEM151B Gene

No Data Available

Interacting Proteins for TMEM151B Gene

Gene Ontology (GO) - Biological Process for TMEM151B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM151B Gene

Drugs & Compounds for TMEM151B Gene

No Compound Related Data Available

Transcripts for TMEM151B Gene

mRNA/cDNA for TMEM151B Gene

2 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMEM151B

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM151B Gene

No ASD Table

Relevant External Links for TMEM151B Gene

GeneLoc Exon Structure for
TMEM151B

Expression for TMEM151B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TMEM151B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TMEM151B Gene

This gene is overexpressed in Bone (42.7) and Adipocyte (24.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMEM151B Gene



Protein tissue co-expression partners for TMEM151B Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TMEM151B

SOURCE GeneReport for Unigene cluster for TMEM151B Gene:

Hs.632851

Evidence on tissue expression from TISSUES for TMEM151B Gene

  • Nervous system(4.8)
genes like me logo Genes that share expression patterns with TMEM151B: view

Primer products for research

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM151B Gene

Orthologs for TMEM151B Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM151B Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TMEM151B 29 30
  • 99.11 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia TMEM151B 29 30
  • 94.26 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia TMEM151B 30
  • 93 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia TMEM151B 29
  • 91.39 (n)
Mouse
(Mus musculus)
Mammalia Tmem151b 29 16 30
  • 90.23 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Tmem151b 29
  • 89.6 (n)
Chicken
(Gallus gallus)
Aves -- 30
  • 77 (a)
OneToMany
C6ORF137 29
  • 76 (n)
Lizard
(Anolis carolinensis)
Reptilia -- 30
  • 77 (a)
OneToMany
Zebrafish
(Danio rerio)
Actinopterygii si:ch73-387g8.1 30
  • 68 (a)
ManyToMany
tmem151b 29
  • 67.49 (n)
Worm
(Caenorhabditis elegans)
Secernentea ZK1067.4 30
  • 31 (a)
OneToMany
Species where no ortholog for TMEM151B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for TMEM151B Gene

ENSEMBL:
Gene Tree for TMEM151B (if available)
TreeFam:
Gene Tree for TMEM151B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TMEM151B: view image
Alliance of Genome Resources:
Additional Orthologs for TMEM151B

Paralogs for TMEM151B Gene

Paralogs for TMEM151B Gene

(1) SIMAP similar genes for TMEM151B Gene using alignment to 1 proteins:

  • T151B_HUMAN
genes like me logo Genes that share paralogs with TMEM151B: view

Variants for TMEM151B Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for TMEM151B Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for TMEM151B Gene

Variant ID Type Subtype PubMed ID
dgv10641n54 CNV loss 21841781
esv3571032 CNV loss 25503493
nsv1145100 CNV deletion 24896259
nsv462936 CNV loss 19166990
nsv524398 CNV loss 19592680
nsv603003 CNV gain 21841781

Variation tolerance for TMEM151B Gene

Gene Damage Index Score: 1.50; 29.16% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM151B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM151B
Leiden Open Variation Database (LOVD)
TMEM151B

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TMEM151B Gene

Disorders for TMEM151B Gene

Additional Disease Information for TMEM151B

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for TMEM151B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM151B Gene

Publications for TMEM151B Gene

  1. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PMID: 19773279) Hosgood HD … Lan Q (Occupational and environmental medicine 2009) 3 40
  2. Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism. (PMID: 32694731) Aregger M … Moffat J (Nature metabolism 2020) 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4
  5. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 4

Products for TMEM151B Gene

Sources for TMEM151B Gene