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Aliases for TMEM151A Gene

Aliases for TMEM151A Gene

  • Transmembrane Protein 151A 2 3 5
  • Transmembrane Protein 151 2 3
  • TMEM151 3 4

External Ids for TMEM151A Gene

Previous HGNC Symbols for TMEM151A Gene

  • TMEM151

Previous GeneCards Identifiers for TMEM151A Gene

  • GC11P065819
  • GC11P066059
  • GC11P062384

Summaries for TMEM151A Gene

GeneCards Summary for TMEM151A Gene

TMEM151A (Transmembrane Protein 151A) is a Protein Coding gene. An important paralog of this gene is TMEM151B.

Additional gene information for TMEM151A Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM151A Gene

Genomics for TMEM151A Gene

GeneHancer (GH) Regulatory Elements for TMEM151A Gene

Promoters and enhancers for TMEM151A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I066291 Promoter/Enhancer 1.5 EPDnew Ensembl dbSUPER 550.8 +0.0 31 0.2 ZNF335 ZNF629 CREB1 ZBTB26 ATF2 EZH2 TMEM151A GC11M066294
GH11I066311 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.4 +23.5 23463 8.3 HDGF PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A YBX1 DMAP1 CD248 ENSG00000258297 ENSG00000255320 RBM14 EIF1AD PCNX3 RBM4 RIN1 KDM2A SART1
GH11I066324 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 11.7 +35.0 34985 5.4 HDGF CLOCK ARNT MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 RIN1 ACTN3 YIF1A TMEM151A LOC100505504 SLC29A2 ENSG00000255320 PACS1 ENSG00000201733 CTSF
GH11I066287 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 6.7 -2.9 -2923 3 HDGF PKNOX1 CLOCK SMAD1 MLX ARID4B SIN3A DMAP1 YY1 SLC30A9 YIF1A LOC105369352 EIF1AD RAB1B RBM14 SSSCA1 KDM2A SCYL1 RBM4 MRPL11
GH11I065910 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 4.8 -376.1 -376143 11.4 CLOCK MLX ZFP64 YY1 ZNF213 E2F8 ZNF143 SP3 MEF2D SSRP1 DRAP1 C11orf68 RBM14 LOC105369352 ZFPL1 ENSG00000254461 MUS81 ENSG00000258297 EIF1AD PCNX3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TMEM151A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TMEM151A gene promoter:

Genomic Locations for TMEM151A Gene

Genomic Locations for TMEM151A Gene
chr11:66,291,870-66,296,664
(GRCh38/hg38)
Size:
4,795 bases
Orientation:
Plus strand
chr11:66,059,341-66,064,135
(GRCh37/hg19)

Genomic View for TMEM151A Gene

Genes around TMEM151A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM151A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM151A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM151A Gene

Proteins for TMEM151A Gene

  • Protein details for TMEM151A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N4L1-T151A_HUMAN
    Recommended name:
    Transmembrane protein 151A
    Protein Accession:
    Q8N4L1
    Secondary Accessions:
    • Q8ND14

    Protein attributes for TMEM151A Gene

    Size:
    468 amino acids
    Molecular mass:
    51278 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM151A Gene

Post-translational modifications for TMEM151A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM151A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM151A Gene

Domains & Families for TMEM151A Gene

Gene Families for TMEM151A Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TMEM151A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM151A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N4L1

UniProtKB/Swiss-Prot:

T151A_HUMAN :
  • Belongs to the TMEM151 family.
Family:
  • Belongs to the TMEM151 family.
genes like me logo Genes that share domains with TMEM151A: view

Function for TMEM151A Gene

Phenotypes From GWAS Catalog for TMEM151A Gene

genes like me logo Genes that share phenotypes with TMEM151A: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM151A Gene

Localization for TMEM151A Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM151A Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM151A gene
Compartment Confidence
plasma membrane 3
peroxisome 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoli (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TMEM151A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM151A: view

Pathways & Interactions for TMEM151A Gene

SuperPathways for TMEM151A Gene

No Data Available

Interacting Proteins for TMEM151A Gene

Gene Ontology (GO) - Biological Process for TMEM151A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM151A Gene

Drugs & Compounds for TMEM151A Gene

No Compound Related Data Available

Transcripts for TMEM151A Gene

mRNA/cDNA for TMEM151A Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(41) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMEM151A Gene

Transmembrane protein 151A:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM151A Gene

No ASD Table

Relevant External Links for TMEM151A Gene

GeneLoc Exon Structure for
TMEM151A
ECgene alternative splicing isoforms for
TMEM151A

Expression for TMEM151A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM151A Gene

mRNA differential expression in normal tissues according to GTEx for TMEM151A Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x9.5), Brain - Substantia nigra (x5.9), Brain - Hippocampus (x4.9), and Brain - Cortex (x4.2).

Protein differential expression in normal tissues from HIPED for TMEM151A Gene

This gene is overexpressed in Spinal cord (39.2) and Colon (22.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMEM151A Gene



NURSA nuclear receptor signaling pathways regulating expression of TMEM151A Gene:

TMEM151A

SOURCE GeneReport for Unigene cluster for TMEM151A Gene:

Hs.399779

Evidence on tissue expression from TISSUES for TMEM151A Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with TMEM151A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM151A Gene

Orthologs for TMEM151A Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM151A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM151A 33 34
  • 99.64 (n)
dog
(Canis familiaris)
Mammalia TMEM151A 34
  • 98 (a)
OneToOne
LOC483713 33
  • 91.45 (n)
cow
(Bos Taurus)
Mammalia TMEM151A 33 34
  • 93.02 (n)
oppossum
(Monodelphis domestica)
Mammalia TMEM151A 34
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem151a 33 16 34
  • 86.89 (n)
rat
(Rattus norvegicus)
Mammalia LOC100911978 33
  • 86.47 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC793560 33
  • 63.8 (n)
TMEM151A (1 of 2) 34
  • 43 (a)
OneToMany
tmem151a 34
  • 42 (a)
OneToMany
Dr.14563 33
worm
(Caenorhabditis elegans)
Secernentea ZK1067.4 33 34
  • 42.99 (n)
Species where no ortholog for TMEM151A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TMEM151A Gene

ENSEMBL:
Gene Tree for TMEM151A (if available)
TreeFam:
Gene Tree for TMEM151A (if available)

Paralogs for TMEM151A Gene

Paralogs for TMEM151A Gene

(1) SIMAP similar genes for TMEM151A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TMEM151A: view

Variants for TMEM151A Gene

Sequence variations from dbSNP and Humsavar for TMEM151A Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000851310 -- 66,292,211(+) T/C intron_variant
rs1001287599 -- 66,291,552(+) G/A upstream_transcript_variant
rs1001360571 -- 66,292,595(+) G/A intron_variant
rs1001896507 -- 66,292,901(+) G/A intron_variant
rs1002168631 -- 66,294,812(+) C/A/T coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM151A Gene

Variant ID Type Subtype PubMed ID
esv32849 CNV gain 17666407
nsv555223 CNV loss 21841781

Variation tolerance for TMEM151A Gene

Gene Damage Index Score: 1.18; 23.73% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM151A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM151A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM151A Gene

Disorders for TMEM151A Gene

Additional Disease Information for TMEM151A

No disorders were found for TMEM151A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM151A Gene

Publications for TMEM151A Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  3. Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4. (PMID: 21926972) Psychiatric GWAS Consortium Bipolar Disorder Working Group (Nature genetics 2011) 3 58
  4. The full-ORF clone resource of the German cDNA Consortium. (PMID: 17974005) Bechtel S … Schupp I (BMC genomics 2007) 4 58
  5. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo MF … Soares MB (Genome research 1996) 3 58

Products for TMEM151A Gene

Sources for TMEM151A Gene

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