This gene encodes a protein that belongs to the DRAM (damage-regulated autophagy modulator) family of membrane-spanning proteins. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013] See more...

Aliases for TMEM150B Gene

Aliases for TMEM150B Gene

  • Transmembrane Protein 150B 2 3 4 5
  • Transmembrane Protein 224 2 3 4
  • Modulator Of Macroautophagy TMEM150B 3 4
  • DRAM-Related/Associated Member 3 2 3
  • Protein DRAM-3 3 4
  • Tentonin 2 2 3
  • TMEM224 3 4
  • Transmembrane Protein LOC284417 3
  • HCG1651476 3
  • DRAM3 3
  • TTN2 3

External Ids for TMEM150B Gene

Previous HGNC Symbols for TMEM150B Gene

  • TMEM224

Previous GeneCards Identifiers for TMEM150B Gene

  • GC19M060519
  • GC19M055824
  • GC19M052146
  • GC19M055313

Summaries for TMEM150B Gene

Entrez Gene Summary for TMEM150B Gene

  • This gene encodes a protein that belongs to the DRAM (damage-regulated autophagy modulator) family of membrane-spanning proteins. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

GeneCards Summary for TMEM150B Gene

TMEM150B (Transmembrane Protein 150B) is a Protein Coding gene. Diseases associated with TMEM150B include Nemaline Myopathy 5 and Premature Ovarian Failure 1. An important paralog of this gene is TMEM150A.

UniProtKB/Swiss-Prot Summary for TMEM150B Gene

  • Modulator of macroautophagy that causes accumulation of autophagosomes under basal conditions and enhances autophagic flux (PubMed:25929859). Represses cell death and promotes long-term clonogenic survival of cells grown in the absence of glucose in a macroautophagy-independent manner (PubMed:25929859). May have some role in extracellular matrix engulfment or growth factor receptor recycling, both of which can modulate cell survival (PubMed:25929859).

Additional gene information for TMEM150B Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TMEM150B Gene

Genomics for TMEM150B Gene

GeneHancer (GH) Regulatory Elements for TMEM150B Gene

Promoters and enhancers for TMEM150B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J055319 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 511.7 +12.4 12397 4.1 ZNF217 SIX5 NR3C1 HCFC1 DEAF1 MBD2 ZNF316 ZBTB17 CREB3L1 ZNF76 TMEM150B FCAR FAM71E2 IL11 TMEM190 BRSK1 HSPBP1 PPP6R1 RPL28 TMEM238
GH19J055320 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 500.4 +9.1 9077 1.9 ZNF316 ZNF592 NFE2 NFE2L1 SUPT5H EP400 MAFK MAFG ZNF639 DPF2 TMEM150B ENSG00000268729
GH19J055333 Promoter/Enhancer 1.2 Ensembl ENCODE 500.7 -0.1 -52 1.4 POLR2G NCOR1 ZNF10 KDM6A ZBTB10 TRIM28 ZBTB25 TGIF2 ZBTB7A SKI TMEM150B KMT5C
GH19J055300 Promoter/Enhancer 1.4 Ensembl ENCODE CraniofacialAtlas 12.3 +32.2 32201 2 CTCF MYC NRF1 POLR2G ZBTB10 REST ZNF740 TOE1 CTBP1 RAD21 TMEM86B TMEM150B KMT5C HSPBP1 PPP6R1 RPL28 TMEM238 UBE2S TMEM190 ZNF628
GH19J055307 Enhancer 0.8 ENCODE 12.3 +28.4 28390 0.2 ZBTB40 ZNF217 SIX5 ZBTB11 HCFC1 DEAF1 MBD2 CREB3L1 ZNF263 GABPA TMEM150B KMT5C BRSK1 HSPBP1 PPP6R1 RPL28 TMEM238 UBE2S TMEM190 ZNF628
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TMEM150B on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TMEM150B

Genomic Locations for TMEM150B Gene

Genomic Locations for TMEM150B Gene
chr19:55,308,886-55,334,048
(GRCh38/hg38)
Size:
25,163 bases
Orientation:
Minus strand
chr19:55,824,169-55,845,416
(GRCh37/hg19)
Size:
21,248 bases
Orientation:
Minus strand

Genomic View for TMEM150B Gene

Genes around TMEM150B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM150B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM150B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM150B Gene

Proteins for TMEM150B Gene

  • Protein details for TMEM150B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NC51-T150B_HUMAN
    Recommended name:
    Modulator of macroautophagy TMEM150B
    Protein Accession:
    A6NC51
    Secondary Accessions:
    • B7ZW71

    Protein attributes for TMEM150B Gene

    Size:
    233 amino acids
    Molecular mass:
    25701 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM150B Gene

Post-translational modifications for TMEM150B Gene

  • Glycosylation at Asn30

No data available for DME Specific Peptides for TMEM150B Gene

Domains & Families for TMEM150B Gene

Gene Families for TMEM150B Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TMEM150B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM150B Gene

GenScript: Design optimal peptide antigens:
  • Transmembrane protein 224 (T150B_HUMAN)

Graphical View of Domain Structure for InterPro Entry

A6NC51

UniProtKB/Swiss-Prot:

T150B_HUMAN :
  • Belongs to the DRAM/TMEM150 family.
Family:
  • Belongs to the DRAM/TMEM150 family.
genes like me logo Genes that share domains with TMEM150B: view

Function for TMEM150B Gene

Molecular function for TMEM150B Gene

UniProtKB/Swiss-Prot Function:
Modulator of macroautophagy that causes accumulation of autophagosomes under basal conditions and enhances autophagic flux (PubMed:25929859). Represses cell death and promotes long-term clonogenic survival of cells grown in the absence of glucose in a macroautophagy-independent manner (PubMed:25929859). May have some role in extracellular matrix engulfment or growth factor receptor recycling, both of which can modulate cell survival (PubMed:25929859).
UniProtKB/Swiss-Prot Induction:
Is not markedly up- or down-regulated by DNA damage, nutrient deprivation or by exposure to TNF-alpha and IFN-gamma (PubMed:25929859).

Phenotypes From GWAS Catalog for TMEM150B Gene

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TMEM150B Gene

Localization for TMEM150B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM150B Gene

Cell membrane; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein. Cytoplasmic vesicle, autophagosome membrane; Multi-pass membrane protein. Note=Localizes mainly at the plasma membrane where it concentrates at actin-rich focal adhesions (PubMed:25608530, PubMed:25929859). {ECO:0000269 PubMed:25608530, ECO:0000269 PubMed:25929859}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM150B gene
Compartment Confidence
plasma membrane 5
endosome 3
lysosome 3
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for TMEM150B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000421 autophagosome membrane IEA --
GO:0005764 lysosome IBA 21873635
GO:0005768 endosome IEA --
GO:0005886 plasma membrane IEA --
GO:0005887 integral component of plasma membrane IDA 25608530
genes like me logo Genes that share ontologies with TMEM150B: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TMEM150B Gene

Pathways & Interactions for TMEM150B Gene

PathCards logo

SuperPathways for TMEM150B Gene

No Data Available

Interacting Proteins for TMEM150B Gene

STRING Interaction Network Preview (showing top 3 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000320757 for TMEM150B Gene via STRING

;

Gene Ontology (GO) - Biological Process for TMEM150B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006914 autophagy IEA --
GO:0010506 regulation of autophagy IBA 21873635
genes like me logo Genes that share ontologies with TMEM150B: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM150B Gene

Drugs & Compounds for TMEM150B Gene

No Compound Related Data Available

Transcripts for TMEM150B Gene

mRNA/cDNA for TMEM150B Gene

2 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM150B Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8
SP1:
SP2: - - -

Relevant External Links for TMEM150B Gene

GeneLoc Exon Structure for
TMEM150B

Expression for TMEM150B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TMEM150B Gene

mRNA differential expression in normal tissues according to GTEx for TMEM150B Gene

This gene is overexpressed in Whole Blood (x12.1), Small Intestine - Terminal Ileum (x9.5), and Colon - Transverse (x4.9).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TMEM150B

SOURCE GeneReport for Unigene cluster for TMEM150B Gene:

Hs.382625

mRNA Expression by UniProt/SwissProt for TMEM150B Gene:

A6NC51-T150B_HUMAN
Tissue specificity: Highly expressed in the colon and lung with comparatively high levels also detectable in the lymph nodes, placenta, duodenum, peripheral blood mononuclear cells and spleen (PubMed:25929859).

Evidence on tissue expression from TISSUES for TMEM150B Gene

  • Nervous system(4)
genes like me logo Genes that share expression patterns with TMEM150B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM150B Gene

Orthologs for TMEM150B Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM150B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM150B 31 30
  • 99.14 (n)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM150B 31 30
  • 84.27 (n)
OneToOne
cow
(Bos Taurus)
Mammalia TMEM150B 31 30
  • 80.11 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem150b 17 31 30
  • 76.78 (n)
rat
(Rattus norvegicus)
Mammalia Tmem150b 30
  • 76.32 (n)
oppossum
(Monodelphis domestica)
Mammalia TMEM150B 31
  • 62 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM150B 31
  • 56 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM150B 31
  • 41 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem150b 30
  • 58.37 (n)
Str.10343 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.13381 30
zebrafish
(Danio rerio)
Actinopterygii zgc:123244 30
  • 53.14 (n)
TMEM150B 31
  • 40 (a)
OneToOne
Species where no ortholog for TMEM150B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM150B Gene

ENSEMBL:
Gene Tree for TMEM150B (if available)
TreeFam:
Gene Tree for TMEM150B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TMEM150B: view image

Paralogs for TMEM150B Gene

Paralogs for TMEM150B Gene

(2) SIMAP similar genes for TMEM150B Gene using alignment to 5 proteins:

  • T150B_HUMAN
  • K7EKL2_HUMAN
  • K7EKW5_HUMAN
  • K7EM00_HUMAN
  • K7ENI3_HUMAN
genes like me logo Genes that share paralogs with TMEM150B: view

Variants for TMEM150B Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TMEM150B Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs7246479 - p.Leu199Phe

Additional dbSNP identifiers (rs#s) for TMEM150B Gene

Structural Variations from Database of Genomic Variants (DGV) for TMEM150B Gene

Variant ID Type Subtype PubMed ID
nsv953624 CNV deletion 24416366

Variation tolerance for TMEM150B Gene

Residual Variation Intolerance Score: 68% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.88; 18.38% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM150B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM150B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM150B Gene

Disorders for TMEM150B Gene

MalaCards: The human disease database

(2) MalaCards diseases for TMEM150B Gene - From: DISEASES

Disorder Aliases PubMed IDs
nemaline myopathy 5
  • nem5
premature ovarian failure 1
  • pof1
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TMEM150B

genes like me logo Genes that share disorders with TMEM150B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TMEM150B Gene

Publications for TMEM150B Gene

  1. Another DRAM involved in autophagy and cell death. (PMID: 27046253) Mrschtik M … Ryan KM (Autophagy 2016) 2 3 54
  2. Tentonin 3/TMEM150c Confers Distinct Mechanosensitive Currents in Dorsal-Root Ganglion Neurons with Proprioceptive Function. (PMID: 27321926) Hong GS … Oh U (Neuron 2016) 2 3 54
  3. Plasticity of PI4KIIIα interactions at the plasma membrane. (PMID: 25608530) Chung J … De Camilli P (EMBO reports 2015) 3 4 54
  4. DRAM-3 modulates autophagy and promotes cell survival in the absence of glucose. (PMID: 25929859) Mrschtik M … Ryan KM (Cell death and differentiation 2015) 3 4 54
  5. Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways. (PMID: 22267201) Stolk L … Lunetta KL (Nature genetics 2012) 3 41 54

Products for TMEM150B Gene

Sources for TMEM150B Gene