Aliases for TMEM150B Gene
External Ids for TMEM150B Gene
Previous HGNC Symbols for TMEM150B Gene
Previous GeneCards Identifiers for TMEM150B Gene
This gene encodes a protein that belongs to the DRAM (damage-regulated autophagy modulator) family of membrane-spanning proteins. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
GeneCards Summary for TMEM150B Gene
TMEM150B (Transmembrane Protein 150B) is a Protein Coding gene. Diseases associated with TMEM150B include Nemaline Myopathy 5 and Premature Ovarian Failure 1. An important paralog of this gene is TMEM150A.
UniProtKB/Swiss-Prot Summary for TMEM150B Gene
Modulator of macroautophagy that causes accumulation of autophagosomes under basal conditions and enhances autophagic flux (PubMed:25929859). Represses cell death and promotes long-term clonogenic survival of cells grown in the absence of glucose in a macroautophagy-independent manner (PubMed:25929859). May have some role in extracellular matrix engulfment or growth factor receptor recycling, both of which can modulate cell survival (PubMed:25929859).