Aliases for TMEM14B Gene

Aliases for TMEM14B Gene

  • Transmembrane Protein 14B 2 3 4 5
  • TMEM14B 5
  • MGC1223 2

External Ids for TMEM14B Gene

Previous GeneCards Identifiers for TMEM14B Gene

  • GC06P010810
  • GC06P010856
  • GC06P010624

Summaries for TMEM14B Gene

GeneCards Summary for TMEM14B Gene

TMEM14B (Transmembrane Protein 14B) is a Protein Coding gene. An important paralog of this gene is TMEM14C.

UniProtKB/Swiss-Prot Summary for TMEM14B Gene

  • Primate-specific protein involved in cortical expansion and folding in the developing neocortex. May drive neural progenitor proliferation through nuclear translocation of IQGAP1, which in turn promotes G1/S cell cycle transitions.

Additional gene information for TMEM14B Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TMEM14B Gene

Genomics for TMEM14B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TMEM14B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TMEM14B on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TMEM14B

Top Transcription factor binding sites by QIAGEN in the TMEM14B gene promoter:
  • Bach1
  • Lmo2
  • Pax-4a
  • Pax-6
  • POU2F1
  • POU2F1a
  • POU2F1b
  • POU2F1c
  • Sox9

Genomic Locations for TMEM14B Gene

Genomic Locations for TMEM14B Gene
chr6:10,747,759-10,852,753
(GRCh38/hg38)
Size:
104,995 bases
Orientation:
Plus strand
chr6:10,747,992-10,852,986
(GRCh37/hg19)
Size:
104,995 bases
Orientation:
Plus strand

Genomic View for TMEM14B Gene

Genes around TMEM14B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM14B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM14B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM14B Gene

Proteins for TMEM14B Gene

  • Protein details for TMEM14B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NUH8-TM14B_HUMAN
    Recommended name:
    Transmembrane protein 14B
    Protein Accession:
    Q9NUH8
    Secondary Accessions:
    • Q5THN7
    • Q5THN8
    • Q96IX7
    • Q9BVN8

    Protein attributes for TMEM14B Gene

    Size:
    114 amino acids
    Molecular mass:
    12078 Da
    Quaternary structure:
    • Interacts with IQGAP1; this interaction promotes phosphorylation and nuclear translocation of IQGAP1.
    Miscellaneous:
    • When expressed in embryonic mouse neocortex, induces intermediate progenitor cells and outer radial glia expansion, cortical thickening and induces gyrification (PubMed:29033352).

    Alternative splice isoforms for TMEM14B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM14B Gene

Post-translational modifications for TMEM14B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TMEM14B Gene

Domains & Families for TMEM14B Gene

Gene Families for TMEM14B Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TMEM14B Gene

InterPro:
Blocks:
  • Protein of unknown function UPF0136
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM14B Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ58456, highly similar to Transmembrane protein 14B (B4DFL6_HUMAN)
  • Transmembrane protein 14B (TM14B_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9NUH8

UniProtKB/Swiss-Prot:

TM14B_HUMAN :
  • Belongs to the TMEM14 family.
Family:
  • Belongs to the TMEM14 family.
genes like me logo Genes that share domains with TMEM14B: view

Function for TMEM14B Gene

Molecular function for TMEM14B Gene

UniProtKB/Swiss-Prot Function:
Primate-specific protein involved in cortical expansion and folding in the developing neocortex. May drive neural progenitor proliferation through nuclear translocation of IQGAP1, which in turn promotes G1/S cell cycle transitions.

Phenotypes From GWAS Catalog for TMEM14B Gene

Gene Ontology (GO) - Molecular Function for TMEM14B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 29033352
genes like me logo Genes that share ontologies with TMEM14B: view
genes like me logo Genes that share phenotypes with TMEM14B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMEM14B

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TMEM14B Gene

Localization for TMEM14B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM14B Gene

Membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM14B gene
Compartment Confidence
mitochondrion 3
extracellular 2
nucleus 1
plasma membrane 0
peroxisome 0
endoplasmic reticulum 0

Gene Ontology (GO) - Cellular Components for TMEM14B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005743 mitochondrial inner membrane IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031966 mitochondrial membrane IBA 21873635
genes like me logo Genes that share ontologies with TMEM14B: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TMEM14B Gene

Pathways & Interactions for TMEM14B Gene

PathCards logo

SuperPathways for TMEM14B Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMEM14B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006839 mitochondrial transport IBA 21873635
GO:0007275 multicellular organism development IEA --
GO:0007399 nervous system development IEA --
GO:0021987 cerebral cortex development IMP 29033352
GO:0061351 neural precursor cell proliferation IDA 29033352
genes like me logo Genes that share ontologies with TMEM14B: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM14B Gene

Drugs & Compounds for TMEM14B Gene

No Compound Related Data Available

Transcripts for TMEM14B Gene

mRNA/cDNA for TMEM14B Gene

5 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
20 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMEM14B

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM14B Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b
SP1: -
SP2: - - - -
SP3: - -
SP4: - -
SP5: - - - - -
SP6: - - -
SP7:
SP8: - - -

Relevant External Links for TMEM14B Gene

GeneLoc Exon Structure for
TMEM14B

Expression for TMEM14B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TMEM14B Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TMEM14B

SOURCE GeneReport for Unigene cluster for TMEM14B Gene:

Hs.95600

mRNA Expression by UniProt/SwissProt for TMEM14B Gene:

Q9NUH8-TM14B_HUMAN
Tissue specificity: Mainly expressed in the outer subventricular zone (OSVZ) of the fetal brains.

Evidence on tissue expression from TISSUES for TMEM14B Gene

  • Nervous system(4.6)
  • Liver(4.5)
  • Heart(2.6)
  • Kidney(2.5)
  • Muscle(2.4)
  • Spleen(2.4)
  • Lung(2.2)
genes like me logo Genes that share expression patterns with TMEM14B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM14B Gene

Orthologs for TMEM14B Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM14B Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TMEM14B 30 31
  • 99.71 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Tmem14c 31
  • 71 (a)
OneToMany
Dog
(Canis familiaris)
Mammalia -- 31
  • 71 (a)
ManyToMany
-- 31
  • 60 (a)
ManyToMany
Cow
(Bos Taurus)
Mammalia TMEM14C 31
  • 68 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 62 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 31 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 62 (a)
OneToMany
Zebrafish
(Danio rerio)
Actinopterygii tmem14ca 31
  • 58 (a)
ManyToMany
tmem14cb 31
  • 46 (a)
ManyToMany
Fruit Fly
(Drosophila melanogaster)
Insecta CG5532 31
  • 39 (a)
OneToMany
Species where no ortholog for TMEM14B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for TMEM14B Gene

ENSEMBL:
Gene Tree for TMEM14B (if available)
TreeFam:
Gene Tree for TMEM14B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TMEM14B: view image

Paralogs for TMEM14B Gene

Paralogs for TMEM14B Gene

genes like me logo Genes that share paralogs with TMEM14B: view

Variants for TMEM14B Gene

Additional dbSNP identifiers (rs#s) for TMEM14B Gene

Structural Variations from Database of Genomic Variants (DGV) for TMEM14B Gene

Variant ID Type Subtype PubMed ID
esv2663502 CNV deletion 23128226
esv2677566 CNV deletion 23128226
esv2731586 CNV deletion 23290073
esv3608082 CNV gain 21293372
esv3608084 CNV loss 21293372
nsv462631 CNV gain 19166990
nsv470800 CNV gain 18288195
nsv600979 CNV gain 21841781
nsv966670 CNV duplication 23825009

Variation tolerance for TMEM14B Gene

Residual Variation Intolerance Score: 79.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.77; 33.42% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM14B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM14B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TMEM14B Gene

Disorders for TMEM14B Gene

No disorders were found for TMEM14B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM14B Gene

Publications for TMEM14B Gene

  1. The Primate-Specific Gene TMEM14B Marks Outer Radial Glia Cells and Promotes Cortical Expansion and Folding. (PMID: 29033352) Liu J … Wang X (Cell stem cell 2017) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  4. Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy. (PMID: 29987050) Xiao T … Brown M (Proceedings of the National Academy of Sciences of the United States of America 2018) 3
  5. RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. (PMID: 29117863) Choudhury NR … Michlewski G (BMC biology 2017) 3

Products for TMEM14B Gene

  • Signalway Proteins for TMEM14B

Sources for TMEM14B Gene