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Aliases for TMEM14B Gene

Aliases for TMEM14B Gene

  • Transmembrane Protein 14B 2 3 5

External Ids for TMEM14B Gene

Previous GeneCards Identifiers for TMEM14B Gene

  • GC06P010810
  • GC06P010856
  • GC06P010624

Summaries for TMEM14B Gene

GeneCards Summary for TMEM14B Gene

TMEM14B (Transmembrane Protein 14B) is a Protein Coding gene. An important paralog of this gene is TMEM14C.

Additional gene information for TMEM14B Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM14B Gene

Genomics for TMEM14B Gene

GeneHancer (GH) Regulatory Elements for TMEM14B Gene

Promoters and enhancers for TMEM14B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I010746 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.8 +0.7 743 3.5 HDGF PKNOX1 SMAD1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 ENSG00000272097 TMEM14B ENSG00000272162 RNA5SP203
GH06I010517 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.3 -226.5 -226471 7.1 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 ZNF2 POLR2B ZNF766 GCNT2 LOC101928146 PAK1IP1 C6orf52 TMEM14B RNA5SP203 SYCP2L GC06M010576
GH06I010398 Promoter/Enhancer 3.4 VISTA UCNEbase EPDnew FANTOM5 Ensembl ENCODE dbSUPER 3.7 -337.9 -337864 22.9 FEZF1 ZNF213 ZNF143 ZNF548 ZNF263 SP3 MEF2D ZNF610 GLIS1 NBN TFAP2A TFAP2A-AS1 RNA5SP203 ERVFRD-1 PAK1IP1 TMEM14C TMEM14B C6orf52
GH06I010440 Enhancer 1.2 FANTOM5 Ensembl ENCODE 2.3 -306.0 -306003 1.9 PKNOX1 SIN3A RAD21 RCOR1 FOS USF2 CEBPB REST SP1 MAFF TFAP2A TMEM14C TMEM14B PAK1IP1 GCNT2 MIR5689 MIR5689HG MRPL48P1
GH06I010587 Enhancer 1.1 FANTOM5 Ensembl ENCODE dbSUPER 2.4 -160.1 -160093 0.7 CTBP1 NRF1 RUNX3 EMSY GCNT2 TMEM14B RPL21P63 PIR63050
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TMEM14B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TMEM14B gene promoter:

Genomic Locations for TMEM14B Gene

Genomic Locations for TMEM14B Gene
chr6:10,747,759-10,852,753
(GRCh38/hg38)
Size:
104,995 bases
Orientation:
Plus strand
chr6:10,747,992-10,852,986
(GRCh37/hg19)

Genomic View for TMEM14B Gene

Genes around TMEM14B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM14B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM14B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM14B Gene

Proteins for TMEM14B Gene

  • Protein details for TMEM14B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NUH8-TM14B_HUMAN
    Recommended name:
    Transmembrane protein 14B
    Protein Accession:
    Q9NUH8
    Secondary Accessions:
    • Q5THN7
    • Q5THN8
    • Q96IX7
    • Q9BVN8

    Protein attributes for TMEM14B Gene

    Size:
    114 amino acids
    Molecular mass:
    12078 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM14B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM14B Gene

Post-translational modifications for TMEM14B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TMEM14B Gene

Domains & Families for TMEM14B Gene

Gene Families for TMEM14B Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TMEM14B Gene

Suggested Antigen Peptide Sequences for TMEM14B Gene

Graphical View of Domain Structure for InterPro Entry

Q9NUH8

UniProtKB/Swiss-Prot:

TM14B_HUMAN :
  • Belongs to the TMEM14 family.
Family:
  • Belongs to the TMEM14 family.
genes like me logo Genes that share domains with TMEM14B: view

Function for TMEM14B Gene

Phenotypes From GWAS Catalog for TMEM14B Gene

genes like me logo Genes that share phenotypes with TMEM14B: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TMEM14B Gene

Localization for TMEM14B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM14B Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM14B gene
Compartment Confidence
extracellular 2
plasma membrane 1
mitochondrion 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for TMEM14B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM14B: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TMEM14B Gene

Pathways & Interactions for TMEM14B Gene

SuperPathways for TMEM14B Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMEM14B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM14B Gene

Drugs & Compounds for TMEM14B Gene

No Compound Related Data Available

Transcripts for TMEM14B Gene

Unigene Clusters for TMEM14B Gene

Transmembrane protein 14B:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM14B Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b
SP1: -
SP2: - - - -
SP3: - -
SP4: - -
SP5: - - - - -
SP6: - - -
SP7:
SP8: - - -

Relevant External Links for TMEM14B Gene

GeneLoc Exon Structure for
TMEM14B
ECgene alternative splicing isoforms for
TMEM14B

Expression for TMEM14B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM14B Gene

NURSA nuclear receptor signaling pathways regulating expression of TMEM14B Gene:

TMEM14B

SOURCE GeneReport for Unigene cluster for TMEM14B Gene:

Hs.95600

Evidence on tissue expression from TISSUES for TMEM14B Gene

  • Liver(4.5)
  • Nervous system(4.5)
  • Heart(2.6)
  • Kidney(2.5)
  • Muscle(2.4)
  • Spleen(2.4)
  • Lung(2.2)
genes like me logo Genes that share expression patterns with TMEM14B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM14B Gene

Orthologs for TMEM14B Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM14B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM14B 33 34
  • 99.71 (n)
dog
(Canis familiaris)
Mammalia -- 34
  • 71 (a)
ManyToMany
-- 34
  • 60 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Tmem14c 34
  • 71 (a)
OneToMany
cow
(Bos Taurus)
Mammalia TMEM14C 34
  • 68 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 62 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 31 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 62 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii tmem14ca 34
  • 58 (a)
ManyToMany
tmem14cb 34
  • 46 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG5532 34
  • 39 (a)
OneToMany
Species where no ortholog for TMEM14B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM14B Gene

ENSEMBL:
Gene Tree for TMEM14B (if available)
TreeFam:
Gene Tree for TMEM14B (if available)

Paralogs for TMEM14B Gene

Paralogs for TMEM14B Gene

genes like me logo Genes that share paralogs with TMEM14B: view

Variants for TMEM14B Gene

Sequence variations from dbSNP and Humsavar for TMEM14B Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000300013 -- 10,752,639(+) C/G intron_variant
rs1000313726 -- 10,747,717(+) T/A upstream_transcript_variant
rs1000506282 -- 10,756,769(+) C/A 3_prime_UTR_variant, intron_variant, non_coding_transcript_variant
rs1000568918 -- 10,754,967(+) G/A intron_variant
rs1000582266 -- 10,758,253(+) C/T genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM14B Gene

Variant ID Type Subtype PubMed ID
esv2663502 CNV deletion 23128226
esv2677566 CNV deletion 23128226
esv2731586 CNV deletion 23290073
esv3608082 CNV gain 21293372
esv3608084 CNV loss 21293372
nsv462631 CNV gain 19166990
nsv470800 CNV gain 18288195
nsv600979 CNV gain 21841781
nsv966670 CNV duplication 23825009

Variation tolerance for TMEM14B Gene

Residual Variation Intolerance Score: 79.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.77; 33.42% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM14B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM14B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM14B Gene

Disorders for TMEM14B Gene

Additional Disease Information for TMEM14B

No disorders were found for TMEM14B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM14B Gene

Publications for TMEM14B Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  2. A census of human soluble protein complexes. (PMID: 22939629) Havugimana PC … Emili A (Cell 2012) 3 58
  3. Next-generation sequencing to generate interactome datasets. (PMID: 21516116) Yu H … Vidal M (Nature methods 2011) 3 58
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P … Vidal M (Genomics 2007) 3 58
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58

Products for TMEM14B Gene

Sources for TMEM14B Gene

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