Aliases for TMEM145 Gene

Aliases for TMEM145 Gene

  • Transmembrane Protein 145 2 3 4 5
  • FLJ90805 2
  • TMEM145 5

External Ids for TMEM145 Gene

Previous GeneCards Identifiers for TMEM145 Gene

  • GC19P047510
  • GC19P042817
  • GC19P039247

Summaries for TMEM145 Gene

GeneCards Summary for TMEM145 Gene

TMEM145 (Transmembrane Protein 145) is a Protein Coding gene. An important paralog of this gene is GPR180.

Additional gene information for TMEM145 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TMEM145 Gene

Genomics for TMEM145 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TMEM145 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TMEM145 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TMEM145

Top Transcription factor binding sites by QIAGEN in the TMEM145 gene promoter:
  • Bach1
  • CUTL1
  • Elk-1
  • Gfi-1
  • HSF2
  • NF-1
  • Nkx2-5
  • STAT1
  • STAT1alpha
  • STAT1beta

Genomic Locations for TMEM145 Gene

Genomic Locations for TMEM145 Gene
chr19:42,313,309-42,325,064
(GRCh38/hg38)
Size:
11,756 bases
Orientation:
Plus strand
chr19:42,817,477-42,829,214
(GRCh37/hg19)
Size:
11,738 bases
Orientation:
Plus strand

Genomic View for TMEM145 Gene

Genes around TMEM145 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM145 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM145 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM145 Gene

Proteins for TMEM145 Gene

  • Protein details for TMEM145 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NBT3-TM145_HUMAN
    Recommended name:
    Transmembrane protein 145
    Protein Accession:
    Q8NBT3

    Protein attributes for TMEM145 Gene

    Size:
    493 amino acids
    Molecular mass:
    55534 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM145 Gene

Post-translational modifications for TMEM145 Gene

  • Glycosylation at Asn35 and Asn444
  • Modification sites at PhosphoSitePlus

Other Protein References for TMEM145 Gene

No data available for DME Specific Peptides for TMEM145 Gene

Domains & Families for TMEM145 Gene

Gene Families for TMEM145 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for TMEM145 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM145 Gene

GenScript: Design optimal peptide antigens:
  • Transmembrane protein 145 (TM145_HUMAN)
genes like me logo Genes that share domains with TMEM145: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for TMEM145 Gene

Function for TMEM145 Gene

Phenotypes From GWAS Catalog for TMEM145 Gene

genes like me logo Genes that share phenotypes with TMEM145: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMEM145

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM145 Gene

Localization for TMEM145 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM145 Gene

Membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM145 gene
Compartment Confidence
plasma membrane 3

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TMEM145 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM145: view

Pathways & Interactions for TMEM145 Gene

PathCards logo

SuperPathways for TMEM145 Gene

No Data Available

Interacting Proteins for TMEM145 Gene

Gene Ontology (GO) - Biological Process for TMEM145 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0019236 response to pheromone IEA --
genes like me logo Genes that share ontologies with TMEM145: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM145 Gene

Drugs & Compounds for TMEM145 Gene

No Compound Related Data Available

Transcripts for TMEM145 Gene

mRNA/cDNA for TMEM145 Gene

2 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMEM145

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM145 Gene

No ASD Table

Relevant External Links for TMEM145 Gene

GeneLoc Exon Structure for
TMEM145

Expression for TMEM145 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TMEM145 Gene

mRNA differential expression in normal tissues according to GTEx for TMEM145 Gene

This gene is overexpressed in Brain - Cerebellum (x16.3) and Brain - Cerebellar Hemisphere (x14.0).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TMEM145

SOURCE GeneReport for Unigene cluster for TMEM145 Gene:

Hs.382075

Evidence on tissue expression from TISSUES for TMEM145 Gene

  • Nervous system(2.2)
genes like me logo Genes that share expression patterns with TMEM145: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM145 Gene

Orthologs for TMEM145 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM145 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TMEM145 30 31
  • 99.46 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia TMEM145 31
  • 96 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia TMEM145 31
  • 93 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia TMEM145 30 31
  • 92.79 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia TMEM145 30 31
  • 92.19 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Tmem145 30
  • 90.91 (n)
Mouse
(Mus musculus)
Mammalia Tmem145 30 17 31
  • 90.45 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia TMEM145 31
  • 69 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia tmem145 30
  • 75.12 (n)
Zebrafish
(Danio rerio)
Actinopterygii tmem145 30 31
  • 68.76 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012225 30
  • 51.33 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta CG9304 31
  • 16 (a)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea C15A7.2 30 31
  • 45.78 (n)
OneToMany
T04F8.2 31
  • 17 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 50 (a)
OneToOne
Species where no ortholog for TMEM145 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for TMEM145 Gene

ENSEMBL:
Gene Tree for TMEM145 (if available)
TreeFam:
Gene Tree for TMEM145 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TMEM145: view image

Paralogs for TMEM145 Gene

Paralogs for TMEM145 Gene

(9) SIMAP similar genes for TMEM145 Gene using alignment to 3 proteins:

  • TM145_HUMAN
  • M0QZK1_HUMAN
  • M0QZX2_HUMAN
genes like me logo Genes that share paralogs with TMEM145: view

Variants for TMEM145 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TMEM145 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs7254227 - p.Leu256Met

Additional dbSNP identifiers (rs#s) for TMEM145 Gene

Structural Variations from Database of Genomic Variants (DGV) for TMEM145 Gene

Variant ID Type Subtype PubMed ID
esv2422471 CNV deletion 17116639
nsv1160627 CNV deletion 26073780
nsv520239 CNV loss 19592680
nsv522854 CNV gain 19592680
nsv526186 CNV gain 19592680
nsv833834 CNV loss 17160897

Variation tolerance for TMEM145 Gene

Residual Variation Intolerance Score: 26.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.62; 31.16% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM145 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM145

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM145 Gene

Disorders for TMEM145 Gene

No disorders were found for TMEM145 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM145 Gene

Publications for TMEM145 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3
  3. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PMID: 16303743) Otsuki T … Isogai T (DNA research : an international journal for rapid publication of reports on genes and genomes 2005) 3
  4. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 4

Products for TMEM145 Gene

Sources for TMEM145 Gene