Aliases for TMEM144 Gene

Aliases for TMEM144 Gene

  • Transmembrane Protein 144 2 3 4 5
  • FLJ11155 2
  • TMEM144 5

External Ids for TMEM144 Gene

Previous GeneCards Identifiers for TMEM144 Gene

  • GC04P159351
  • GC04P159131
  • GC04P154882

Summaries for TMEM144 Gene

GeneCards Summary for TMEM144 Gene

TMEM144 (Transmembrane Protein 144) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include carbohydrate transmembrane transporter activity.

Additional gene information for TMEM144 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TMEM144 Gene

Genomics for TMEM144 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TMEM144 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J158208 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 255.4 +8.9 8862 3.4 TBP MNT IKZF1 SMAD5 IRF2 MBD2 BHLHE40 ELF1 ZIC2 HOMEZ TMEM144 lnc-RXFP1-2 C4orf46 MN298143 RXFP1
GH04J158201 Promoter/Enhancer 0.9 EPDnew dbSUPER 250.7 0.0 -12 0.1 JUND FOSL1 BHLHE40 ZNF318 CEBPG ZBTB21 ATF4 CREM ATF3 ATF2 ENSG00000250604 MN298142 TMEM144 LOC101928007 GASK1B FAM198B-AS1
GH04J158202 Promoter/Enhancer 0.7 Ensembl dbSUPER 256.1 +0.5 504 0.2 EGR2 ZFHX2 TMEM144 ENSG00000250604 MN298142 FAM198B-AS1 RXFP1
GH04J158163 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 14.3 -32.3 -32342 11.9 MXD4 ZNF217 CTCF SAP130 KMT2B SMC3 GABPB1 RAD21 SIN3A TEAD3 FAM198B-AS1 GASK1B TMEM144 lnc-C4orf46-4 ENSG00000287822 HSALNG0038146 GRIA2
GH04J158155 Enhancer 0.9 Ensembl ENCODE 14.3 -45.1 -45059 2.8 CEBPA ZNF217 HOMEZ FOXA2 SMAD4 SAP130 CTBP1 RARA BCL6 FOXP1 FAM198B-AS1 TMEM144 GASK1B lnc-C4orf46-4 HSALNG0038146 GRIA2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TMEM144 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TMEM144

Top Transcription factor binding sites by QIAGEN in the TMEM144 gene promoter:
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • Lmo2
  • Nkx6-1
  • PPAR-gamma1
  • S8

Genomic Locations for TMEM144 Gene

Latest Assembly
chr4:158,201,597-158,255,416
(GRCh38/hg38)
Size:
53,820 bases
Orientation:
Plus strand

Previous Assembly
chr4:159,131,638-159,176,568
(GRCh37/hg19 by Entrez Gene)
Size:
44,931 bases
Orientation:
Plus strand

chr4:159,122,756-159,176,563
(GRCh37/hg19 by Ensembl)
Size:
53,808 bases
Orientation:
Plus strand

Genomic View for TMEM144 Gene

Genes around TMEM144 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM144 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM144 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM144 Gene

Proteins for TMEM144 Gene

  • Protein details for TMEM144 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z5S9-TM144_HUMAN
    Recommended name:
    Transmembrane protein 144
    Protein Accession:
    Q7Z5S9
    Secondary Accessions:
    • D3DP24
    • Q49A05
    • Q9NUT3

    Protein attributes for TMEM144 Gene

    Size:
    345 amino acids
    Molecular mass:
    37653 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM144 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM144 Gene

Post-translational modifications for TMEM144 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TMEM144 Gene

Domains & Families for TMEM144 Gene

Gene Families for TMEM144 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for TMEM144 Gene

InterPro:
Blocks:
  • Protein of unknown function DUF1632
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM144 Gene

GenScript: Design optimal peptide antigens:
  • Transmembrane protein 144 (TM144_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q7Z5S9

UniProtKB/Swiss-Prot:

TM144_HUMAN :
  • Belongs to the TMEM144 family.
Family:
  • Belongs to the TMEM144 family.
genes like me logo Genes that share domains with TMEM144: view

Function for TMEM144 Gene

Phenotypes From GWAS Catalog for TMEM144 Gene

Gene Ontology (GO) - Molecular Function for TMEM144 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 32296183
GO:0015144 carbohydrate transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with TMEM144: view
genes like me logo Genes that share phenotypes with TMEM144: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMEM144

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TMEM144 Gene

Localization for TMEM144 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM144 Gene

Membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM144 gene
Compartment Confidence
plasma membrane 3
mitochondrion 2
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TMEM144 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM144: view

Pathways & Interactions for TMEM144 Gene

PathCards logo

SuperPathways for TMEM144 Gene

No Data Available

Interacting Proteins for TMEM144 Gene

STRING Interaction Network Preview (showing top 1 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: Q7Z5S9-TM144_HUMAN ENSP00000296529 for TMEM144 Gene via UniProtKB STRING IID

Gene Ontology (GO) - Biological Process for TMEM144 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0034219 carbohydrate transmembrane transport IEA --
genes like me logo Genes that share ontologies with TMEM144: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM144 Gene

Drugs & Compounds for TMEM144 Gene

No Compound Related Data Available

Transcripts for TMEM144 Gene

mRNA/cDNA for TMEM144 Gene

1 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
17 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMEM144

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM144 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a ·
SP1: - - - - - - -
SP2: - - - - - - - -
SP3: - - - - -
SP4: - - - - -
SP5: -
SP6: - - - - -
SP7: - - - -
SP8: - - -
SP9: - - - - - -
SP10:
SP11: - - - -
SP12: - - - -
SP13: - -

ExUns: 14b ^ 15
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for TMEM144 Gene

GeneLoc Exon Structure for
TMEM144

Expression for TMEM144 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TMEM144 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMEM144 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x12.0), Brain - Substantia nigra (x6.7), and Brain - Hippocampus (x4.7).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TMEM144

SOURCE GeneReport for Unigene cluster for TMEM144 Gene:

Hs.176227

Evidence on tissue expression from TISSUES for TMEM144 Gene

  • Nervous system(5)
genes like me logo Genes that share expression patterns with TMEM144: view

Primer products for research

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM144 Gene

Orthologs for TMEM144 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM144 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TMEM144 30 31
  • 99.23 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia TMEM144 30 31
  • 91.3 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia TMEM144 30 31
  • 89.37 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Tmem144 30
  • 83.57 (n)
Mouse
(Mus musculus)
Mammalia Tmem144 30 17 31
  • 83.19 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia TMEM144 31
  • 76 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia TMEM144 31
  • 70 (a)
OneToOne
Chicken
(Gallus gallus)
Aves TMEM144 30 31
  • 73.47 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia TMEM144 31
  • 57 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia tmem144 30
  • 69.59 (n)
Str.16658 30
Zebrafish
(Danio rerio)
Actinopterygii tmem144a 30 31
  • 64.32 (n)
OneToMany
tmem144b 31
  • 50 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea R144.6 30 31
  • 51.81 (n)
OneToMany
W02D3.4 31
  • 39 (a)
OneToMany
T19A6.4 31
  • 34 (a)
OneToMany
F49C12.6 31
  • 33 (a)
OneToMany
W06A7.4 31
  • 32 (a)
OneToMany
K07F5.12 31
  • 30 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.4465 31
  • 41 (a)
OneToOne
Species where no ortholog for TMEM144 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for TMEM144 Gene

ENSEMBL:
Gene Tree for TMEM144 (if available)
TreeFam:
Gene Tree for TMEM144 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TMEM144: view image

Paralogs for TMEM144 Gene

No data available for Paralogs for TMEM144 Gene

Variants for TMEM144 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TMEM144 Gene

SNP ID Clinical significance and condition Chr 04 pos Variation AA Info Type
rs34277853 - p.Asp157Gly

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for TMEM144 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for TMEM144 Gene

Variant ID Type Subtype PubMed ID
nsv1021067 CNV gain 25217958

Variation tolerance for TMEM144 Gene

Residual Variation Intolerance Score: 33.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.33; 41.54% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM144 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM144

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM144 Gene

Disorders for TMEM144 Gene

Additional Disease Information for TMEM144

Genetic Association Database
(GAD)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for TMEM144 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM144 Gene

Publications for TMEM144 Gene

  1. The testosterone-dependent and independent transcriptional networks in the hypothalamus of Gpr54 and Kiss1 knockout male mice are not fully equivalent. (PMID: 21527035) Prentice LM … Aparicio SA (BMC genomics 2011) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  4. Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing. (PMID: 28611215) Fei T … Brown M (Proceedings of the National Academy of Sciences of the United States of America 2017) 3
  5. Systematic protein-protein interaction mapping for clinically relevant human GPCRs. (PMID: 28298427) Sokolina K … Stagljar I (Molecular systems biology 2017) 3

Products for TMEM144 Gene

Sources for TMEM144 Gene