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Aliases for TMEM143 Gene

Aliases for TMEM143 Gene

  • Transmembrane Protein 143 2 3 4 5

External Ids for TMEM143 Gene

Previous GeneCards Identifiers for TMEM143 Gene

  • GC19M053528
  • GC19M048835
  • GC19M045217

Summaries for TMEM143 Gene

GeneCards Summary for TMEM143 Gene

TMEM143 (Transmembrane Protein 143) is a Protein Coding gene. An important paralog of this gene is PROSER2.

Additional gene information for TMEM143 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM143 Gene

Genomics for TMEM143 Gene

GeneHancer (GH) Regulatory Elements for TMEM143 Gene

Promoters and enhancers for TMEM143 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J048362 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 606.5 +0.2 244 2.7 SP1 ZFX MNT SIX5 ZNF148 NKRF GTF2F1 ZNF687 NFIB FOS TMEM143 SYNGR4 CCDC114 TRPM4 TEAD2 ENSG00000268157 GRWD1 EMP3
GH19J048328 Promoter/Enhancer 2 FANTOM5 Ensembl ENCODE dbSUPER 24.8 +32.6 32551 5.8 HDGF SP1 CC2D1A SIX5 CBFA2T2 ZNF148 NKRF MLLT1 GTF2F1 ZNF687 BICRA SNRNP70 GRWD1 TMEM143 NOP53-AS1 CYTH2 CA11 NOP53 KDELR1 RPL18
GH19J048253 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.2 +106.8 106839 7.2 SP1 CC2D1A ELF3 CTCF ZKSCAN8 SIX5 NKRF POLR2A MLLT1 CEBPG CARD8-AS1 CARD8 BICRA NOP53-AS1 GRWD1 SNRNP70 KDELR1 NOP53 RPL18 SNORD23
GH19J048319 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 11.6 +40.3 40295 8.2 HDGF SP1 ZFX CC2D1A CTCF CBFA2T2 ZNF148 NKRF MLLT1 POLR2A CCDC114 EMP3 TMEM143 CARD8-AS1 GRIN2D
GH19J048203 Promoter/Enhancer 1.5 Ensembl ENCODE 10.6 +160.0 159963 2.3 SP1 NKRF ZNF121 RERE POLR2A CSDE1 ZNF687 ZSCAN21 ZBTB7A ELF1 ENSG00000268583 GRWD1 CARD8 BICRA KDELR1 NOP53-AS1 CCDC9 CYTH2 PLA2G4C NOP53
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TMEM143 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TMEM143 gene promoter:
  • Arnt
  • Meis-1
  • Meis-1a
  • Meis-1b
  • NF-1
  • p53
  • Pax-4a
  • SRF
  • SRF (504 AA)
  • ZID

Genomic Locations for TMEM143 Gene

Genomic Locations for TMEM143 Gene
31,882 bases
Minus strand
31,882 bases
Minus strand

Genomic View for TMEM143 Gene

Genes around TMEM143 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM143 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM143 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM143 Gene

Proteins for TMEM143 Gene

  • Protein details for TMEM143 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 143
    Protein Accession:
    Secondary Accessions:
    • A8K656
    • Q6UXY4
    • Q9NV49

    Protein attributes for TMEM143 Gene

    459 amino acids
    Molecular mass:
    51715 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM143 Gene


neXtProt entry for TMEM143 Gene

Post-translational modifications for TMEM143 Gene

  • Ubiquitination at posLast=405405
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TMEM143 Gene

Domains & Families for TMEM143 Gene

Gene Families for TMEM143 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for TMEM143 Gene


Suggested Antigen Peptide Sequences for TMEM143 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ57400 (B4DMT0_HUMAN)
  • cDNA FLJ57548 (B4DPF8_HUMAN)
  • Transmembrane protein 143 (TM143_HUMAN)

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM143: view

No data available for UniProtKB/Swiss-Prot for TMEM143 Gene

Function for TMEM143 Gene

Phenotypes From GWAS Catalog for TMEM143 Gene

Gene Ontology (GO) - Molecular Function for TMEM143 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with TMEM143: view

Phenotypes for TMEM143 Gene

genes like me logo Genes that share phenotypes with TMEM143: view

Animal Model Products

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for TMEM143 - Now 50% OFF >
  • * TMEM143 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * TMEM143 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TMEM143 Gene

Localization for TMEM143 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM143 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM143 gene
Compartment Confidence
mitochondrion 4
nucleus 2
plasma membrane 1
extracellular 1
endoplasmic reticulum 0
golgi apparatus 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli fibrillar center (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TMEM143 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM143: view

Pathways & Interactions for TMEM143 Gene

PathCards logo

SuperPathways for TMEM143 Gene

No Data Available

Interacting Proteins for TMEM143 Gene

STRING Interaction Network Preview (showing top 3 STRING interactants - click image to see details)
Selected Interacting proteins: ENSP00000293261 Q96AN5-TM143_HUMAN for TMEM143 Gene via STRING IID

Gene Ontology (GO) - Biological Process for TMEM143 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with TMEM143: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM143 Gene

Drugs & Compounds for TMEM143 Gene

No Compound Related Data Available

Transcripts for TMEM143 Gene

mRNA/cDNA for TMEM143 Gene

Unigene Clusters for TMEM143 Gene

Transmembrane protein 143:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for TMEM143 - Now 50% OFF >
  • * TMEM143 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * TMEM143 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM143 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9
SP1: - - -
SP2: - - - - - - - -
SP3: - -
SP4: - - - -
SP5: -
SP6: - - -
SP7: - - - - - -
SP8: -

Relevant External Links for TMEM143 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM143 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM143 Gene

mRNA differential expression in normal tissues according to GTEx for TMEM143 Gene

This gene is overexpressed in Muscle - Skeletal (x6.9) and Heart - Left Ventricle (x6.0).

Protein differential expression in normal tissues from HIPED for TMEM143 Gene

This gene is overexpressed in Heart (45.7) and Plasma (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMEM143 Gene

NURSA nuclear receptor signaling pathways regulating expression of TMEM143 Gene:


SOURCE GeneReport for Unigene cluster for TMEM143 Gene:


Evidence on tissue expression from TISSUES for TMEM143 Gene

  • Intestine(4.2)
  • Nervous system(3.9)
  • Muscle(2.2)
  • Heart(2.1)
genes like me logo Genes that share expression patterns with TMEM143: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM143 Gene

Orthologs for TMEM143 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM143 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMEM143 35 34
  • 99.71 (n)
(Canis familiaris)
Mammalia TMEM143 35 34
  • 87.75 (n)
(Bos Taurus)
Mammalia TMEM143 35 34
  • 85.41 (n)
(Rattus norvegicus)
Mammalia Tmem143 34
  • 84.21 (n)
(Mus musculus)
Mammalia Tmem143 17 35 34
  • 83.85 (n)
(Ornithorhynchus anatinus)
Mammalia TMEM143 35
  • 78 (a)
(Monodelphis domestica)
Mammalia TMEM143 35
  • 46 (a)
(Anolis carolinensis)
Reptilia TMEM143 35
  • 57 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem143 34
  • 61.45 (n)
Species where no ortholog for TMEM143 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TMEM143 Gene

Gene Tree for TMEM143 (if available)
Gene Tree for TMEM143 (if available)
Evolutionary constrained regions (ECRs) for TMEM143: view image

Paralogs for TMEM143 Gene

Paralogs for TMEM143 Gene

genes like me logo Genes that share paralogs with TMEM143: view

Variants for TMEM143 Gene

Sequence variations from dbSNP and Humsavar for TMEM143 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000014629 -- 48,339,136(-) G/A/C intron_variant
rs1000033332 -- 48,364,869(-) C/T upstream_transcript_variant
rs1000188953 -- 48,350,547(-) G/A intron_variant
rs1000288117 -- 48,357,550(-) G/T intron_variant
rs1000465163 -- 48,338,333(-) CCCC/CCC intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM143 Gene

Variant ID Type Subtype PubMed ID
dgv5e22 CNV deletion 17803354
esv2674971 CNV deletion 23128226
esv2718671 CNV deletion 23290073
esv2718672 CNV deletion 23290073
esv2718674 CNV deletion 23290073
esv3407988 CNV insertion 20981092
esv34181 CNV loss 18971310
esv3556504 CNV deletion 23714750
esv3644585 CNV loss 21293372
esv3893229 CNV loss 25118596
nsv1138715 CNV deletion 24896259
nsv137963 CNV deletion 16902084
nsv469623 CNV loss 16826518
nsv833854 CNV loss 17160897
nsv9739 CNV gain+loss 18304495

Variation tolerance for TMEM143 Gene

Residual Variation Intolerance Score: 83.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.49; 43.63% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM143 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM143 Gene

Disorders for TMEM143 Gene

Additional Disease Information for TMEM143

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for TMEM143 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM143 Gene

Publications for TMEM143 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 2 3 4 58
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 45 58
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 45 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing. (PMID: 28611215) Fei T … Brown M (Proceedings of the National Academy of Sciences of the United States of America 2017) 3 58

Products for TMEM143 Gene

  • Biorbyt antibodies for TMEM143

Sources for TMEM143 Gene

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