Aliases for TMEM140 Gene

Aliases for TMEM140 Gene

  • Transmembrane Protein 140 2 3 4 5

External Ids for TMEM140 Gene

Previous GeneCards Identifiers for TMEM140 Gene

  • GC07P134483
  • GC07P134832
  • GC07P129135

Summaries for TMEM140 Gene

GeneCards Summary for TMEM140 Gene

TMEM140 (Transmembrane Protein 140) is a Protein Coding gene.

Additional gene information for TMEM140 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TMEM140 Gene

Genomics for TMEM140 Gene

GeneHancer (GH) Regulatory Elements for TMEM140 Gene

Promoters and enhancers for TMEM140 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TMEM140 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TMEM140

Top Transcription factor binding sites by QIAGEN in the TMEM140 gene promoter:
  • FOXJ2
  • FOXJ2 (long isoform)
  • FOXO4
  • GATA-1
  • IRF-2
  • IRF-7A
  • PPAR-gamma1
  • PPAR-gamma2
  • SREBP-1c

Genomic Locations for TMEM140 Gene

Genomic Locations for TMEM140 Gene
chr7:135,148,014-135,166,215
(GRCh38/hg38)
Size:
18,202 bases
Orientation:
Plus strand
chr7:134,832,766-134,850,967
(GRCh37/hg19)
Size:
18,202 bases
Orientation:
Plus strand

Genomic View for TMEM140 Gene

Genes around TMEM140 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM140 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM140 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM140 Gene

Proteins for TMEM140 Gene

  • Protein details for TMEM140 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NV12-TM140_HUMAN
    Recommended name:
    Transmembrane protein 140
    Protein Accession:
    Q9NV12
    Secondary Accessions:
    • A4D1P9
    • Q8WUC3

    Protein attributes for TMEM140 Gene

    Size:
    185 amino acids
    Molecular mass:
    20419 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM140 Gene

Post-translational modifications for TMEM140 Gene

  • Glycosylation at Asn38
  • Modification sites at PhosphoSitePlus

Other Protein References for TMEM140 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM140 Gene

Domains & Families for TMEM140 Gene

Gene Families for TMEM140 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TMEM140 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM140 Gene

GenScript: Design optimal peptide antigens:
  • Transmembrane protein 140 (TM140_HUMAN)
genes like me logo Genes that share domains with TMEM140: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for TMEM140 Gene

Function for TMEM140 Gene

Phenotypes From GWAS Catalog for TMEM140 Gene

Gene Ontology (GO) - Molecular Function for TMEM140 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TMEM140: view
genes like me logo Genes that share phenotypes with TMEM140: view

Animal Model Products

CRISPR Products

miRNA for TMEM140 Gene

miRTarBase miRNAs that target TMEM140

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM140 Gene

Localization for TMEM140 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM140 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM140 gene
Compartment Confidence
plasma membrane 3
nucleus 2
cytosol 2
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for TMEM140 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM140: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TMEM140 Gene

Pathways & Interactions for TMEM140 Gene

PathCards logo

SuperPathways for TMEM140 Gene

No Data Available

Interacting Proteins for TMEM140 Gene

;

Gene Ontology (GO) - Biological Process for TMEM140 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM140 Gene

Drugs & Compounds for TMEM140 Gene

No Compound Related Data Available

Transcripts for TMEM140 Gene

mRNA/cDNA for TMEM140 Gene

1 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM140 Gene

No ASD Table

Relevant External Links for TMEM140 Gene

GeneLoc Exon Structure for
TMEM140

Expression for TMEM140 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TMEM140 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMEM140 Gene

This gene is overexpressed in Whole Blood (x20.1).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TMEM140

SOURCE GeneReport for Unigene cluster for TMEM140 Gene:

Hs.521213

Evidence on tissue expression from TISSUES for TMEM140 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with TMEM140: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM140 Gene

Orthologs for TMEM140 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM140 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM140 31 30
  • 98.56 (n)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM140 31 30
  • 82.43 (n)
OneToOne
cow
(Bos Taurus)
Mammalia TMEM140 31 30
  • 80.71 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem140 30
  • 79.4 (n)
mouse
(Mus musculus)
Mammalia Tmem140 17 31 30
  • 76.97 (n)
oppossum
(Monodelphis domestica)
Mammalia TMEM140 31
  • 47 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM140 30
  • 52.44 (n)
lizard
(Anolis carolinensis)
Reptilia TMEM140 31
  • 39 (a)
OneToOne
Species where no ortholog for TMEM140 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TMEM140 Gene

ENSEMBL:
Gene Tree for TMEM140 (if available)
TreeFam:
Gene Tree for TMEM140 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TMEM140: view image

Paralogs for TMEM140 Gene

No data available for Paralogs for TMEM140 Gene

Variants for TMEM140 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TMEM140 Gene

SNP ID Clinical significance and condition Chr 07 pos Variation AA Info Type
rs292502 A colorectal cancer sample p.Ala112Glu
rs11558290 - p.Gln11Glu
rs292500 - p.Pro6Ser
rs292501 - p.Phe29Leu
rs3800592 - p.Arg7Gln

Additional dbSNP identifiers (rs#s) for TMEM140 Gene

Structural Variations from Database of Genomic Variants (DGV) for TMEM140 Gene

Variant ID Type Subtype PubMed ID
esv2665250 CNV deletion 23128226
esv3615115 CNV loss 21293372
nsv527014 CNV gain 19592680
nsv527174 CNV loss 19592680
nsv608458 CNV loss 21841781

Variation tolerance for TMEM140 Gene

Residual Variation Intolerance Score: 79.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.81; 67.00% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM140 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM140

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM140 Gene

Disorders for TMEM140 Gene

Additional Disease Information for TMEM140

No disorders were found for TMEM140 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM140 Gene

Publications for TMEM140 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  3. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer SW … Tsui LC (Science (New York, N.Y.) 2003) 3 4 54
  4. VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. (PMID: 29507755) Yue Y … Liu J (Cell discovery 2018) 3 54
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 54

Products for TMEM140 Gene

  • Biorbyt antibodies for TMEM140

Sources for TMEM140 Gene