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Aliases for TMEM139 Gene

Aliases for TMEM139 Gene

  • Transmembrane Protein 139 2 3 5

External Ids for TMEM139 Gene

Previous GeneCards Identifiers for TMEM139 Gene

  • GC07P142687
  • GC07P142977
  • GC07P137319
  • GC07P143306
  • GC07P143312
  • GC07P143324
  • GC07P143355
  • GC07P143419
  • GC07P143551
  • GC07P143687

Summaries for TMEM139 Gene

GeneCards Summary for TMEM139 Gene

TMEM139 (Transmembrane Protein 139) is a Protein Coding gene.

UniProtKB/Swiss-Prot for TMEM139 Gene

  • May be involved in cellular trafficking of proteins such as SLC4A1.

Additional gene information for TMEM139 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM139 Gene

Genomics for TMEM139 Gene

GeneHancer (GH) Regulatory Elements for TMEM139 Gene

Promoters and enhancers for TMEM139 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I143282 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE 550.4 +6.6 6590 7.1 HDGF FOXA2 PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 CASP2 GC07M143288 LOC105375545 PIR32183 TMEM139 LOC154761 RN7SL535P ZYX TRPV6
GH07I143278 Enhancer 0.9 Ensembl ENCODE 550.8 -0.1 -101 2.1 BCOR SOX13 MXI1 FOXA2 SAP130 ARID4B ZMYM3 BMI1 POLR2A FOXK2 TMEM139 CASP2 LOC154761 LOC105375545 GSTK1
GH07I143258 Enhancer 1.2 FANTOM5 Ensembl ENCODE 13.4 -20.7 -20688 2.2 HDAC1 FOXA2 YY1 FOS SP3 RXRA CAVIN1 ZEB2 ZNF592 MTA1 TMEM139 CASP2 LOC105375545 RN7SL535P EPHA1 EPHA1-AS1 FAM131B HINT1P1 CLCN1 ZYX
GH07I143248 Enhancer 1.1 Ensembl ENCODE 11.7 -30.0 -29954 2.6 ELF3 MLX ARID4B RAD21 RARA ETS1 YY1 ZNF280A THAP11 MIXL1 TMEM139 CASP2 LOC105375545 RN7SL535P FAM131B EPHB6 GSTK1 LOC105375546
GH07I143345 Enhancer 1.1 Ensembl ENCODE 11.1 +65.7 65668 1 ATF1 SIN3A GLI4 ZNF2 YY1 GLIS2 ARID2 KLF7 ATF7 REST CLCN1 HINT1P1 ZYX LOC100507507 RN7SL535P LOC105375545 CASP2 TMEM139 EPHA1-AS1 EPHA1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TMEM139 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TMEM139 gene promoter:

Genomic Locations for TMEM139 Gene

Genomic Locations for TMEM139 Gene
8,093 bases
Plus strand

Genomic View for TMEM139 Gene

Genes around TMEM139 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM139 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM139 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM139 Gene

Proteins for TMEM139 Gene

  • Protein details for TMEM139 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 139
    Protein Accession:
    Secondary Accessions:
    • B2RCL5
    • D3DXD4
    • Q6ZME2
    • Q8NC22
    • Q96AU8

    Protein attributes for TMEM139 Gene

    216 amino acids
    Molecular mass:
    23729 Da
    Quaternary structure:
    • Interacts with isoform 2 of SLC4A1 (PubMed:26049106).
    • Sequence=AAH16719.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for TMEM139 Gene

Post-translational modifications for TMEM139 Gene

No Post-translational modifications

No data available for DME Specific Peptides for TMEM139 Gene

Domains & Families for TMEM139 Gene

Gene Families for TMEM139 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for TMEM139 Gene


Suggested Antigen Peptide Sequences for TMEM139 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM139: view

No data available for UniProtKB/Swiss-Prot for TMEM139 Gene

Function for TMEM139 Gene

Molecular function for TMEM139 Gene

UniProtKB/Swiss-Prot Function:
May be involved in cellular trafficking of proteins such as SLC4A1.

Gene Ontology (GO) - Molecular Function for TMEM139 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 26049106
genes like me logo Genes that share ontologies with TMEM139: view

Phenotypes for TMEM139 Gene

GenomeRNAi human phenotypes for TMEM139:
genes like me logo Genes that share phenotypes with TMEM139: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TMEM139 Gene

Localization for TMEM139 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM139 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM139 gene
Compartment Confidence
plasma membrane 2
extracellular 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Focal adhesion sites (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TMEM139 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM139: view

Pathways & Interactions for TMEM139 Gene

SuperPathways for TMEM139 Gene

No Data Available

Interacting Proteins for TMEM139 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: Q8IV31-TM139_HUMAN ENSP00000352284 for TMEM139 Gene via IID STRING MINT

Gene Ontology (GO) - Biological Process for TMEM139 Gene


No data available for Pathways by source and SIGNOR curated interactions for TMEM139 Gene

Drugs & Compounds for TMEM139 Gene

No Compound Related Data Available

Transcripts for TMEM139 Gene

Unigene Clusters for TMEM139 Gene

Transmembrane protein 139:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM139 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e
SP1: -
SP2: - -
SP3: - - - - -
SP4: - - -
SP5: -
SP6: -
SP7: - -

Relevant External Links for TMEM139 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM139 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM139 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMEM139 Gene

This gene is overexpressed in Kidney - Cortex (x10.0) and Brain - Spinal cord (cervical c-1) (x4.4).

NURSA nuclear receptor signaling pathways regulating expression of TMEM139 Gene:


SOURCE GeneReport for Unigene cluster for TMEM139 Gene:


Evidence on tissue expression from TISSUES for TMEM139 Gene

  • Intestine(4.2)
  • Lung(4.2)
  • Bone marrow(4.1)
genes like me logo Genes that share expression patterns with TMEM139: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM139 Gene

Orthologs for TMEM139 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM139 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMEM139 33 34
  • 99.38 (n)
(Canis familiaris)
Mammalia TMEM139 33 34
  • 82.61 (n)
(Bos Taurus)
Mammalia TMEM139 33 34
  • 81.89 (n)
(Rattus norvegicus)
Mammalia Tmem139 33
  • 74.53 (n)
(Mus musculus)
Mammalia Tmem139 33 16 34
  • 72.96 (n)
(Monodelphis domestica)
Mammalia TMEM139 34
  • 46 (a)
(Ornithorhynchus anatinus)
Mammalia TMEM139 34
  • 42 (a)
(Anolis carolinensis)
Reptilia TMEM139 34
  • 31 (a)
Species where no ortholog for TMEM139 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TMEM139 Gene

Gene Tree for TMEM139 (if available)
Gene Tree for TMEM139 (if available)

Paralogs for TMEM139 Gene

No data available for Paralogs for TMEM139 Gene

Variants for TMEM139 Gene

Sequence variations from dbSNP and Humsavar for TMEM139 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000525435 -- 143,285,162(+) T/G 5_prime_UTR_variant, intron_variant, non_coding_transcript_variant
rs1000593564 -- 143,283,825(+) C/A upstream_transcript_variant
rs1000856564 -- 143,287,015(+) A/C 3_prime_UTR_variant, non_coding_transcript_variant
rs1000956468 -- 143,285,533(+) G/A intron_variant
rs1001391691 -- 143,284,404(+) GAAGA/GA upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM139 Gene

Variant ID Type Subtype PubMed ID
nsv831169 CNV loss 17160897

Variation tolerance for TMEM139 Gene

Residual Variation Intolerance Score: 79.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.76; 33.34% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM139 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM139 Gene

Disorders for TMEM139 Gene

Additional Disease Information for TMEM139

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for TMEM139 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM139 Gene

Publications for TMEM139 Gene

  1. Transmembrane protein 139 (TMEM139) interacts with human kidney isoform of anion exchanger 1 (kAE1). (PMID: 26049106) Nuiplot NO … Akkarapatumwong V (Biochemical and biophysical research communications 2015) 3 4 58
  2. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PMID: 19773279) Hosgood HD … Lan Q (Occupational and environmental medicine 2009) 3 44 58
  3. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PMID: 16303743) Otsuki T … Isogai T (DNA research : an international journal for rapid publication of reports on genes and genomes 2005) 3 4 58
  4. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer SW … Tsui LC (Science (New York, N.Y.) 2003) 3 4 58
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58

Products for TMEM139 Gene

Sources for TMEM139 Gene

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