Aliases for TMEM135 Gene

Aliases for TMEM135 Gene

  • Transmembrane Protein 135 2 3 4 5
  • Peroxisomal Membrane Protein 52 3 4
  • PMP52 3 4
  • FLJ22104 2
  • TMEM135 5

External Ids for TMEM135 Gene

Previous GeneCards Identifiers for TMEM135 Gene

  • GC11P086427
  • GC11P086749
  • GC11P083035

Summaries for TMEM135 Gene

GeneCards Summary for TMEM135 Gene

TMEM135 (Transmembrane Protein 135) is a Protein Coding gene. Diseases associated with TMEM135 include Melanoma, Cutaneous Malignant 1.

UniProtKB/Swiss-Prot Summary for TMEM135 Gene

  • Involved in mitochondrial metabolism by regulating the balance between mitochondrial fusion and fission. May act as a regulator of mitochondrial fission that promotes DNM1L-dependent fission through activation of DNM1L. May be involved in peroxisome organization.

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TMEM135 Gene

Genomics for TMEM135 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TMEM135 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TMEM135 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TMEM135

Top Transcription factor binding sites by QIAGEN in the TMEM135 gene promoter:
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • GATA-1
  • GATA-2
  • GATA-3
  • LCR-F1

Genomic Locations for TMEM135 Gene

Genomic Locations for TMEM135 Gene
chr11:87,037,844-87,328,824
(GRCh38/hg38)
Size:
290,981 bases
Orientation:
Plus strand
chr11:86,748,886-87,039,876
(GRCh37/hg19)
Size:
290,991 bases
Orientation:
Plus strand

Genomic View for TMEM135 Gene

Genes around TMEM135 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM135 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM135 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM135 Gene

Proteins for TMEM135 Gene

  • Protein details for TMEM135 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86UB9-TM135_HUMAN
    Recommended name:
    Transmembrane protein 135
    Protein Accession:
    Q86UB9
    Secondary Accessions:
    • Q6AW91
    • Q8ND01
    • Q9H6M3

    Protein attributes for TMEM135 Gene

    Size:
    458 amino acids
    Molecular mass:
    52291 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB15233.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for TMEM135 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM135 Gene

Post-translational modifications for TMEM135 Gene

  • Ubiquitination at Lys433
  • Modification sites at PhosphoSitePlus

Other Protein References for TMEM135 Gene

No data available for DME Specific Peptides for TMEM135 Gene

Domains & Families for TMEM135 Gene

Gene Families for TMEM135 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TMEM135 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM135 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ55090 (B4DKZ1_HUMAN)
  • TMEM135 protein (Q7Z760_HUMAN)
  • Transmembrane protein 135 (TM135_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q86UB9

UniProtKB/Swiss-Prot:

TM135_HUMAN :
  • Belongs to the TMEM135 family.
Family:
  • Belongs to the TMEM135 family.
genes like me logo Genes that share domains with TMEM135: view

Function for TMEM135 Gene

Molecular function for TMEM135 Gene

UniProtKB/Swiss-Prot Function:
Involved in mitochondrial metabolism by regulating the balance between mitochondrial fusion and fission. May act as a regulator of mitochondrial fission that promotes DNM1L-dependent fission through activation of DNM1L. May be involved in peroxisome organization.

Phenotypes From GWAS Catalog for TMEM135 Gene

genes like me logo Genes that share phenotypes with TMEM135: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMEM135

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM135 Gene

Localization for TMEM135 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM135 Gene

Mitochondrion membrane. Multi-pass membrane protein. Peroxisome membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM135 gene
Compartment Confidence
mitochondrion 4
peroxisome 4
nucleus 2
cytosol 2
cytoskeleton 1
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1
plasma membrane 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TMEM135 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005777 peroxisome ISS --
GO:0005778 peroxisomal membrane IEA --
GO:0005811 lipid droplet IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with TMEM135: view

Pathways & Interactions for TMEM135 Gene

PathCards logo

SuperPathways for TMEM135 Gene

No Data Available

Interacting Proteins for TMEM135 Gene

STRING Interaction Network Preview (showing top 2 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000306344 Q86UB9-TM135_HUMAN for TMEM135 Gene via STRING IID

Gene Ontology (GO) - Biological Process for TMEM135 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007031 peroxisome organization IEA,ISS --
GO:0009409 response to cold IEA --
GO:0032094 response to food IEA --
GO:0090140 regulation of mitochondrial fission IEA --
genes like me logo Genes that share ontologies with TMEM135: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM135 Gene

Drugs & Compounds for TMEM135 Gene

No Compound Related Data Available

Transcripts for TMEM135 Gene

mRNA/cDNA for TMEM135 Gene

2 REFSEQ mRNAs :
16 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMEM135

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM135 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b
SP1:
SP2: -

Relevant External Links for TMEM135 Gene

GeneLoc Exon Structure for
TMEM135

Expression for TMEM135 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TMEM135 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TMEM135 Gene

This gene is overexpressed in Liver (42.8) and Testis (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TMEM135 Gene



Protein tissue co-expression partners for TMEM135 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TMEM135

SOURCE GeneReport for Unigene cluster for TMEM135 Gene:

Hs.188591

Evidence on tissue expression from TISSUES for TMEM135 Gene

  • Nervous system(4.5)
genes like me logo Genes that share expression patterns with TMEM135: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM135 Gene

Orthologs for TMEM135 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM135 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TMEM135 30 31
  • 99.78 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia TMEM135 30 31
  • 93.74 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia TMEM135 30 31
  • 93.38 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia TMEM135 31
  • 93 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia TMEM135 31
  • 92 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Tmem135 30 17 31
  • 86.97 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Tmem135 30
  • 86.61 (n)
Chicken
(Gallus gallus)
Aves TMEM135 30 31
  • 80.06 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia TMEM135 31
  • 85 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia tmem135 30
  • 75.7 (n)
Zebrafish
(Danio rerio)
Actinopterygii tmem135 30 31
  • 69.07 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta CG11737 30 31
  • 43.93 (n)
OneToMany
CG31259 31
  • 30 (a)
OneToMany
CG31454 31
  • 29 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007085 30
  • 42.56 (n)
Worm
(Caenorhabditis elegans)
Secernentea tmem-135 30 31
  • 46.17 (n)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.3886 31
  • 35 (a)
OneToOne
Species where no ortholog for TMEM135 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for TMEM135 Gene

ENSEMBL:
Gene Tree for TMEM135 (if available)
TreeFam:
Gene Tree for TMEM135 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TMEM135: view image

Paralogs for TMEM135 Gene

(48) SIMAP similar genes for TMEM135 Gene using alignment to 7 proteins:

  • TM135_HUMAN
  • E9PIS2_HUMAN
  • E9PJX0_HUMAN
  • E9PQL0_HUMAN
  • F5H254_HUMAN
  • Q7Z760_HUMAN
  • Q8N605_HUMAN

Pseudogenes.org Pseudogenes for TMEM135 Gene

genes like me logo Genes that share paralogs with TMEM135: view

No data available for Paralogs for TMEM135 Gene

Variants for TMEM135 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TMEM135 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
726086 Benign: not provided 87,302,351(+) T/C MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT
763480 Likely Benign: not provided 87,038,126(+) C/T NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT
787597 Benign: not provided 87,067,726(+) C/G MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT
790321 Benign: not provided 87,067,759(+) A/G NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT
rs11235097 - p.Gly430Ala

Additional dbSNP identifiers (rs#s) for TMEM135 Gene

Structural Variations from Database of Genomic Variants (DGV) for TMEM135 Gene

Variant ID Type Subtype PubMed ID
dgv2056n54 CNV loss 21841781
dgv2057n54 CNV loss 21841781
esv1070532 CNV deletion 17803354
esv21627 CNV loss 19812545
esv2429813 CNV deletion 19546169
esv2631282 CNV deletion 19546169
esv2656806 CNV deletion 23128226
esv2744859 CNV deletion 23290073
esv2744860 CNV deletion 23290073
esv2744861 CNV deletion 23290073
esv2744862 CNV deletion 23290073
esv2744864 CNV deletion 23290073
esv2744865 CNV deletion 23290073
esv2762929 CNV loss 21179565
esv3153107 CNV deletion 24192839
esv3627099 CNV gain 21293372
esv3627113 CNV loss 21293372
esv3627114 CNV gain 21293372
esv3627115 CNV loss 21293372
esv3627116 CNV loss 21293372
esv3627117 CNV gain 21293372
esv3627119 CNV loss 21293372
esv3627122 CNV loss 21293372
esv999908 CNV deletion 20482838
nsv1042017 CNV gain 25217958
nsv1113417 CNV deletion 24896259
nsv1116678 CNV tandem duplication 24896259
nsv1138059 CNV deletion 24896259
nsv1149922 CNV duplication 26484159
nsv420 CNV deletion 18451855
nsv468776 CNV loss 19166990
nsv478956 CNV novel sequence insertion 20440878
nsv518332 CNV loss 19592680
nsv521810 CNV loss 19592680
nsv525787 CNV loss 19592680
nsv528940 CNV loss 19592680
nsv555706 CNV loss 21841781
nsv555707 CNV loss 21841781
nsv555708 CNV loss 21841781

Variation tolerance for TMEM135 Gene

Residual Variation Intolerance Score: 59.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.43; 63.94% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM135 Gene

Human Gene Mutation Database (HGMD)
TMEM135
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM135

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM135 Gene

Disorders for TMEM135 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TMEM135 Gene - From: DISEASES

Disorder Aliases PubMed IDs
melanoma, cutaneous malignant 1
  • melanoma, cutaneous malignant, susceptibility to, 1
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TMEM135

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with TMEM135: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TMEM135 Gene

Publications for TMEM135 Gene

  1. Evolution of the Tim17 protein family. (PMID: 27760563) Žárský V … Doležal P (Biology direct 2016) 2 3
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
  3. Stressed-induced TMEM135 protein is part of a conserved genetic network involved in fat storage and longevity regulation in Caenorhabditis elegans. (PMID: 21151927) Exil VJ … Aschner M (PloS one 2010) 2 3
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
  5. Genetic determinants of heel bone properties: genome-wide association meta-analysis and replication in the GEFOS/GENOMOS consortium. (PMID: 24430505) Moayyeri A … Kaptoge SK (Human molecular genetics 2014) 3

Products for TMEM135 Gene

Sources for TMEM135 Gene