Aliases for TMEM134 Gene

Aliases for TMEM134 Gene

  • Transmembrane Protein 134 2 3 4 5
  • FLJ21749 2
  • TMEM134 5

External Ids for TMEM134 Gene

Previous GeneCards Identifiers for TMEM134 Gene

  • GC11M066989
  • GC11M067231
  • GC11M063561

Summaries for TMEM134 Gene

GeneCards Summary for TMEM134 Gene

TMEM134 (Transmembrane Protein 134) is a Protein Coding gene. Diseases associated with TMEM134 include Hepatitis E and Hypopyon.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TMEM134 Gene

Genomics for TMEM134 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TMEM134 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J067466 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 250.7 +1.0 1039 3.9 SP1 ZNF207 MYC ZNF592 ZMYM3 KLF9 POLR2A NFIC ZBTB10 YY1 AIP TMEM134 lnc-GPR152-1 PTPRCAP CARNS1
GH11J067077 Enhancer 1.2 FANTOM5 ENCODE dbSUPER 1.4 +390.9 390947 2.5 BRCA1 CEBPB DEK MAX ZNF217 POLR2A CTBP1 SMC3 TBP TCF7L2 RF00017-861 RHOD KDM2A ANKRD13D CDK2AP2 GRK2 RBM4 CLCF1 SSH3 TMEM134
GH11J067462 Promoter/Enhancer 2 Ensembl ENCODE CraniofacialAtlas dbSUPER 0.7 +4.8 4806 3.5 IKZF1 JUND ZNF592 POLR2A CEBPA ZNF10 BRCA1 YY1 MXD4 CTCF HSALNG0085158 KMT5B RBM14 PPP6R3 RBM4 RAD9A CCS RCE1 KDM2A CORO1B
GH11J067482 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 0.4 -16.0 -15987 6.5 BCLAF1 SP1 ZNF207 IKZF1 SIX5 ZNF580 ZNF592 KLF9 POLR2A CHD4 AIP piR-46501-012 PTPRCAP KMT5B RBM14 RCE1 RBM4 RAD9A KDM2A PPP6R3
GH11J067490 Enhancer 0.6 Ensembl dbSUPER 0.4 -23.3 -23329 0.4 POLR2A ZMYM3 KDM1A BCOR RBFOX2 CDK2AP2 MIR6752 lnc-CDK2AP2-2 PITPNM1 TMEM134
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TMEM134 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TMEM134

Top Transcription factor binding sites by QIAGEN in the TMEM134 gene promoter:
  • c-Myb
  • NF-E2
  • NF-E2 p45
  • Pax-4a
  • Pax-5
  • PPAR-alpha
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for TMEM134 Gene

Latest Assembly
7,563 bases
Minus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
7,542 bases
Minus strand

(GRCh37/hg19 by Ensembl)
4,920 bases
Minus strand

Genomic View for TMEM134 Gene

Genes around TMEM134 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM134 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM134 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM134 Gene

Proteins for TMEM134 Gene

  • Protein details for TMEM134 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 134
    Protein Accession:
    Secondary Accessions:
    • Q08AK4
    • Q6PJN3

    Protein attributes for TMEM134 Gene

    195 amino acids
    Molecular mass:
    21586 Da
    Quaternary structure:
    • (Microbial infection) Interacts with Hepatitis E virus (HEV) ORF2.

    Alternative splice isoforms for TMEM134 Gene


neXtProt entry for TMEM134 Gene

Post-translational modifications for TMEM134 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TMEM134 Gene

Domains & Families for TMEM134 Gene

Gene Families for TMEM134 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for TMEM134 Gene


Suggested Antigen Peptide Sequences for TMEM134 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ54783 (B4DLG6_HUMAN)
  • cDNA FLJ53757 (B4E0E3_HUMAN)
  • Transmembrane protein 134 (TM134_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TMEM134/TMEM230 family.
  • Belongs to the TMEM134/TMEM230 family.
genes like me logo Genes that share domains with TMEM134: view

Function for TMEM134 Gene

Phenotypes From GWAS Catalog for TMEM134 Gene

Gene Ontology (GO) - Molecular Function for TMEM134 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 27899274
genes like me logo Genes that share ontologies with TMEM134: view
genes like me logo Genes that share phenotypes with TMEM134: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMEM134

Clone products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM134 Gene

Localization for TMEM134 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM134 Gene

Membrane. Multi-pass membrane protein. Cytoplasm, perinuclear region.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM134 gene
Compartment Confidence
plasma membrane 3
cytosol 2
cytoskeleton 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TMEM134 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0048471 perinuclear region of cytoplasm IEA,IDA 27899274
genes like me logo Genes that share ontologies with TMEM134: view

Pathways & Interactions for TMEM134 Gene

PathCards logo

SuperPathways for TMEM134 Gene

No Data Available

Interacting Proteins for TMEM134 Gene

STRING Interaction Network Preview (showing top 1 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000312615 Q9H6X4-TM134_HUMAN for TMEM134 Gene via STRING IID

Gene Ontology (GO) - Biological Process for TMEM134 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016032 viral process IEA --
genes like me logo Genes that share ontologies with TMEM134: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM134 Gene

Drugs & Compounds for TMEM134 Gene

No Compound Related Data Available

Transcripts for TMEM134 Gene

mRNA/cDNA for TMEM134 Gene

18 NCBI additional mRNA sequence :
17 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMEM134

Clone products for research

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM134 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d · 4e · 4f ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b ·
SP1: - - - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - - - -
SP4: - - - - - - - - - - -
SP5: - - - - - - - - - -
SP6: - - - - - - - - - - -
SP7: - - - - - - - - - - -
SP8: - - - - - - - - -
SP9: - - - - - - -
SP10: - - - - - - -
SP11: - - - -
SP12: - - - - - - - - -
SP13: - - -
SP14: - -
SP15: - - - - - - - - - - - - -
SP16: - - - -
SP17: - - -
SP18: - -
SP20: -

ExUns: 8c · 8d · 8e · 8f · 8g · 8h · 8i

Relevant External Links for TMEM134 Gene

GeneLoc Exon Structure for

Expression for TMEM134 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TMEM134 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TMEM134 Gene

This gene is overexpressed in Testis (38.1) and Blymphocyte (23.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TMEM134 Gene

Protein tissue co-expression partners for TMEM134 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TMEM134

SOURCE GeneReport for Unigene cluster for TMEM134 Gene:


Evidence on tissue expression from TISSUES for TMEM134 Gene

  • Intestine(4.2)
genes like me logo Genes that share expression patterns with TMEM134: view

Primer products for research

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM134 Gene

Orthologs for TMEM134 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM134 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMEM134 29 30
  • 100 (n)
(Canis familiaris)
Mammalia TMEM134 29 30
  • 93.73 (n)
(Bos Taurus)
Mammalia TMEM134 29 30
  • 92.41 (n)
(Mus musculus)
Mammalia Tmem134 29 16
  • 90.94 (n)
(Rattus norvegicus)
Mammalia Tmem134 29
  • 89.23 (n)
(Monodelphis domestica)
Mammalia TMEM134 30
  • 76 (a)
(Danio rerio)
Actinopterygii tmem134 29 30
  • 56.74 (n)
zgc64040 29
Fruit Fly
(Drosophila melanogaster)
Insecta CG12025 30
  • 31 (a)
Species where no ortholog for TMEM134 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for TMEM134 Gene

Gene Tree for TMEM134 (if available)
Gene Tree for TMEM134 (if available)
Evolutionary constrained regions (ECRs) for TMEM134: view image
Alliance of Genome Resources:
Additional Orthologs for TMEM134

Paralogs for TMEM134 Gene

(1) SIMAP similar genes for TMEM134 Gene using alignment to 5 proteins:

  • TM134_HUMAN
  • B4E0E3_HUMAN
  • F5H1I9_HUMAN
  • G3V1M5_HUMAN
genes like me logo Genes that share paralogs with TMEM134: view

No data available for Paralogs for TMEM134 Gene

Variants for TMEM134 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for TMEM134 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for TMEM134 Gene

Variant ID Type Subtype PubMed ID
dgv1977n54 CNV loss 21841781
dgv52n111 CNV deletion 26073780
esv2422195 CNV duplication 17116639
nsv468604 CNV loss 19166990
nsv521723 CNV loss 19592680
nsv527056 CNV loss 19592680

Variation tolerance for TMEM134 Gene

Gene Damage Index Score: 1.69; 32.29% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM134 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
Leiden Open Variation Database (LOVD)

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TMEM134 Gene

Disorders for TMEM134 Gene

MalaCards: The human disease database

(4) MalaCards diseases for TMEM134 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
hepatitis e
  • primary iridocyclitis
neuronal ceroid lipofuscinosis
  • hereditary ceroid lipofuscinosis
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TMEM134

genes like me logo Genes that share disorders with TMEM134: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TMEM134 Gene

Publications for TMEM134 Gene

  1. Systematic identification of hepatitis E virus ORF2 interactome reveals that TMEM134 engages in ORF2-mediated NF-κB pathway. (PMID: 27899274) Tian Y … Wang Y (Virus research 2017) 3 4
  2. Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRASG13D. (PMID: 31980649) Kennedy SA … Kolch W (Nature communications 2020) 3
  3. Identification of the Tetraspanin CD9 as an Interaction Partner of Organic Cation Transporters 1 and 2. (PMID: 31318583) Snieder B … Ciarimboli G (SLAS discovery : advancing life sciences R & D 2019) 3
  4. Identifying protein partners of CLN8, an ER-resident protein involved in neuronal ceroid lipofuscinosis. (PMID: 23142642) Passantino R … Guarneri P (Biochimica et biophysica acta 2013) 3
  5. Identification of transmembrane protein 134 as a novel LMP1-binding protein by using bimolecular fluorescence complementation and an enhanced retroviral mutagen. (PMID: 22855487) Talaty P … Everly DN (Journal of virology 2012) 3

Products for TMEM134 Gene

Sources for TMEM134 Gene