Aliases for TMEM132B Gene

Aliases for TMEM132B Gene

  • Transmembrane Protein 132B 2 3 4 5
  • KIAA1786 4
  • KIAA1906 4

External Ids for TMEM132B Gene

Previous GeneCards Identifiers for TMEM132B Gene

  • GC12P124377
  • GC12P125811
  • GC12P122777
  • GC12P125671

Summaries for TMEM132B Gene

GeneCards Summary for TMEM132B Gene

TMEM132B (Transmembrane Protein 132B) is a Protein Coding gene. Diseases associated with TMEM132B include Intracranial Aneurysm. An important paralog of this gene is TMEM132C.

Additional gene information for TMEM132B Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TMEM132B Gene

Genomics for TMEM132B Gene

GeneHancer (GH) Regulatory Elements for TMEM132B Gene

Promoters and enhancers for TMEM132B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J125184 Promoter/Enhancer 1.5 Ensembl ENCODE CraniofacialAtlas 506.9 +0.5 467 4.5 CTCF ZNF639 ZIC2 ZBTB10 ZNF263 ZNF423 ZBTB26 EZH2 HDAC2 ZNF341 TMEM132B DHX37 AACS lnc-DHX37-15
GH12J125097 Enhancer 0.5 FANTOM5 Ensembl dbSUPER 38.5 -89.1 -89058 0.6 TMEM132B AACS LOC100131779 RF00017-1334 piR-40216-001
GH12J125314 Enhancer 0.6 Ensembl ENCODE CraniofacialAtlas 32.2 +127.8 127754 1.7 EGR1 TMEM132B lnc-AACS-8 lnc-DHX37-16 lnc-DHX37-17
GH12J125330 Promoter/Enhancer 1.1 ENCODE CraniofacialAtlas 10.3 +144.4 144381 0.6 CTCF REST MYC RAD21 SMC3 HDAC2 ZNF263 YY1 GABPB1 ZFHX2 TMEM132B lnc-DHX37-16 lnc-DHX37-17
GH12J125328 Enhancer 0.5 ENCODE 19.2 +142.7 142731 1.5 SIN3A SMARCA4 JUND CHD7 CTBP2 POLR2A TMEM132B lnc-DHX37-16 lnc-DHX37-17
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TMEM132B on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TMEM132B

Top Transcription factor binding sites by QIAGEN in the TMEM132B gene promoter:
  • Brachyury
  • CUTL1
  • GCNF
  • GCNF-1
  • GCNF-2
  • HFH-1
  • Lhx3a
  • LHX3b
  • RP58
  • RSRFC4

Genomic Locations for TMEM132B Gene

Genomic Locations for TMEM132B Gene
chr12:125,186,774-125,662,377
(GRCh38/hg38)
Size:
475,604 bases
Orientation:
Plus strand
chr12:125,671,382-126,146,917
(GRCh37/hg19)
Size:
475,536 bases
Orientation:
Plus strand

Genomic View for TMEM132B Gene

Genes around TMEM132B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM132B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM132B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM132B Gene

Proteins for TMEM132B Gene

  • Protein details for TMEM132B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14DG7-T132B_HUMAN
    Recommended name:
    Transmembrane protein 132B
    Protein Accession:
    Q14DG7
    Secondary Accessions:
    • A2RRG8
    • Q8NA73
    • Q96JN9
    • Q96PY1

    Protein attributes for TMEM132B Gene

    Size:
    1078 amino acids
    Molecular mass:
    119477 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM132B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM132B Gene

Post-translational modifications for TMEM132B Gene

  • Glycosylation at Asn343, Asn366, and Asn381
  • Modification sites at PhosphoSitePlus

Other Protein References for TMEM132B Gene

No data available for DME Specific Peptides for TMEM132B Gene

Domains & Families for TMEM132B Gene

Gene Families for TMEM132B Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TMEM132B Gene

Suggested Antigen Peptide Sequences for TMEM132B Gene

GenScript: Design optimal peptide antigens:
  • Transmembrane protein 132B (T132B_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q14DG7

UniProtKB/Swiss-Prot:

T132B_HUMAN :
  • Belongs to the TMEM132 family.
Family:
  • Belongs to the TMEM132 family.
genes like me logo Genes that share domains with TMEM132B: view

Function for TMEM132B Gene

Phenotypes From GWAS Catalog for TMEM132B Gene

Gene Ontology (GO) - Molecular Function for TMEM132B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with TMEM132B: view
genes like me logo Genes that share phenotypes with TMEM132B: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM132B Gene

Localization for TMEM132B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM132B Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM132B gene
Compartment Confidence
extracellular 1
nucleus 1
cytosol 1
plasma membrane 0
mitochondrion 0
peroxisome 0

Gene Ontology (GO) - Cellular Components for TMEM132B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM132B: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TMEM132B Gene

Pathways & Interactions for TMEM132B Gene

PathCards logo

SuperPathways for TMEM132B Gene

No Data Available

Interacting Proteins for TMEM132B Gene

STRING Interaction Network Preview (showing top 3 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000299308 Q14DG7-T132B_HUMAN for TMEM132B Gene via STRING IID

;

Gene Ontology (GO) - Biological Process for TMEM132B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with TMEM132B: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM132B Gene

Drugs & Compounds for TMEM132B Gene

No Compound Related Data Available

Transcripts for TMEM132B Gene

mRNA/cDNA for TMEM132B Gene

3 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM132B Gene

No ASD Table

Relevant External Links for TMEM132B Gene

GeneLoc Exon Structure for
TMEM132B

Expression for TMEM132B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TMEM132B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMEM132B Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x6.0), Brain - Anterior cingulate cortex (BA24) (x5.5), Brain - Cortex (x5.5), and Brain - Nucleus accumbens (basal ganglia) (x4.6).

Protein differential expression in normal tissues from HIPED for TMEM132B Gene

This gene is overexpressed in Plasma (57.3) and Pancreatic juice (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMEM132B Gene



Protein tissue co-expression partners for TMEM132B Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TMEM132B

SOURCE GeneReport for Unigene cluster for TMEM132B Gene:

Hs.524838

Evidence on tissue expression from TISSUES for TMEM132B Gene

  • Nervous system(4.5)
genes like me logo Genes that share expression patterns with TMEM132B: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM132B Gene

Orthologs for TMEM132B Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM132B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM132B 31 30
  • 99.55 (n)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM132B 31 30
  • 87.08 (n)
OneToOne
cow
(Bos Taurus)
Mammalia TMEM132B 31 30
  • 86.71 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem132b 30
  • 83.37 (n)
mouse
(Mus musculus)
Mammalia Tmem132b 17 31 30
  • 82.99 (n)
oppossum
(Monodelphis domestica)
Mammalia TMEM132B 31
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM132B 31
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM132B 31 30
  • 72.36 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM132B 31
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem132b 30
  • 66.41 (n)
zebrafish
(Danio rerio)
Actinopterygii si:dkey-215k6.1 31
  • 51 (a)
ManyToMany
si:dkey-112m2.1 31
  • 46 (a)
ManyToMany
si:dkeyp-14d3.1 31
  • 45 (a)
ManyToMany
CT027623.1 31
  • 41 (a)
ManyToMany
CT583723.1 31
  • 34 (a)
ManyToMany
si:dkey-1d7.3 31
  • 32 (a)
ManyToMany
FP102168.1 31
  • 26 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG14446 31
  • 19 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y71H2AM.10 31
  • 19 (a)
OneToMany
Species where no ortholog for TMEM132B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMEM132B Gene

ENSEMBL:
Gene Tree for TMEM132B (if available)
TreeFam:
Gene Tree for TMEM132B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TMEM132B: view image

Paralogs for TMEM132B Gene

Paralogs for TMEM132B Gene

(4) SIMAP similar genes for TMEM132B Gene using alignment to 1 proteins:

  • T132B_HUMAN

Pseudogenes.org Pseudogenes for TMEM132B Gene

genes like me logo Genes that share paralogs with TMEM132B: view

Variants for TMEM132B Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TMEM132B Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
769836 Benign: not provided 125,652,514(+) C/T MISSENSE_VARIANT
rs16919359 - p.Ala658Val

Additional dbSNP identifiers (rs#s) for TMEM132B Gene

Structural Variations from Database of Genomic Variants (DGV) for TMEM132B Gene

Variant ID Type Subtype PubMed ID
dgv204e201 CNV deletion 23290073
dgv205e201 CNV deletion 23290073
dgv892n106 CNV deletion 24896259
dgv929e59 CNV duplication 20981092
esv1336277 CNV insertion 17803354
esv2402185 CNV deletion 18987734
esv24345 CNV loss 19812545
esv2676387 CNV deletion 23128226
esv2676988 CNV deletion 23128226
esv2746571 CNV deletion 23290073
esv2746577 CNV deletion 23290073
esv2746578 CNV deletion 23290073
esv2746579 CNV deletion 23290073
esv2746580 CNV deletion 23290073
esv2746581 CNV deletion 23290073
esv274917 CNV loss 21479260
esv3310557 CNV novel sequence insertion 20981092
esv3351714 CNV duplication 20981092
esv3451232 CNV duplication 20981092
esv3580514 CNV loss 25503493
esv3631039 CNV gain 21293372
esv3631043 CNV loss 21293372
esv4399 CNV loss 18987735
esv7647 CNV loss 19470904
esv991637 CNV deletion 20482838
nsv1036206 CNV gain 25217958
nsv1051020 CNV gain 25217958
nsv1070141 CNV deletion 25765185
nsv1122782 CNV deletion 24896259
nsv1135798 CNV deletion 24896259
nsv471987 CNV novel sequence insertion 20440878
nsv473690 CNV novel sequence insertion 20440878
nsv518416 CNV loss 19592680
nsv832540 CNV gain 17160897
nsv832541 CNV gain 17160897
nsv918 CNV insertion 18451855
nsv919 CNV insertion 18451855
nsv976658 CNV duplication 23825009

Variation tolerance for TMEM132B Gene

Residual Variation Intolerance Score: 22.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.12; 93.86% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM132B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM132B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM132B Gene

Disorders for TMEM132B Gene

MalaCards: The human disease database

(1) MalaCards diseases for TMEM132B Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
intracranial aneurysm
  • brain aneurysm
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TMEM132B

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TMEM132B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TMEM132B Gene

Publications for TMEM132B Gene

  1. Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. (PMID: 11572484) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2001) 2 3 4 54
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41 54
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  4. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11347906) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2001) 3 4 54
  5. E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins. (PMID: 29676528) Khanna R … Parnaik VK (The FEBS journal 2018) 3 54

Products for TMEM132B Gene

Sources for TMEM132B Gene