This gene encodes a protein that is highly similar to the rat Grp78-binding protein (GBP). Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008] See more...

Aliases for TMEM132A Gene

Aliases for TMEM132A Gene

  • Transmembrane Protein 132A 2 3 4 5
  • Heat Shock 70kDa Protein 5 (Glucose-Regulated Protein, 78kDa) Binding Protein 1 2 3
  • HSPA5-Binding Protein 1 3 4
  • HSPA5BP1 3 4
  • Heat Shock 70kDa Protein 5 Binding Protein 1 3
  • Glucose-Regulated Protein, 78kDa 3
  • GRP78-Binding Protein 3
  • KIAA1583 4
  • GBP 3

External Ids for TMEM132A Gene

Previous HGNC Symbols for TMEM132A Gene

  • HSPA5BP1

Previous GeneCards Identifiers for TMEM132A Gene

  • GC11P060449
  • GC11P060691
  • GC11P057038

Summaries for TMEM132A Gene

Entrez Gene Summary for TMEM132A Gene

  • This gene encodes a protein that is highly similar to the rat Grp78-binding protein (GBP). Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for TMEM132A Gene

TMEM132A (Transmembrane Protein 132A) is a Protein Coding gene. An important paralog of this gene is TMEM132C.

UniProtKB/Swiss-Prot Summary for TMEM132A Gene

  • May play a role in embryonic and postnatal development of the brain. Increased resistance to cell death induced by serum starvation in cultured cells. Regulates cAMP-induced GFAP gene expression via STAT3 phosphorylation (By similarity).

Additional gene information for TMEM132A Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TMEM132A Gene

Genomics for TMEM132A Gene

GeneHancer (GH) Regulatory Elements for TMEM132A Gene

Promoters and enhancers for TMEM132A Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TMEM132A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TMEM132A gene promoter:
  • AP-4
  • CREB
  • deltaCREB
  • HNF-4alpha1
  • HNF-4alpha2
  • Olf-1

Genomic Locations for TMEM132A Gene

Genomic Locations for TMEM132A Gene
chr11:60,924,441-60,937,159
(GRCh38/hg38)
Size:
12,719 bases
Orientation:
Plus strand
chr11:60,691,913-60,704,631
(GRCh37/hg19)
Size:
12,719 bases
Orientation:
Plus strand

Genomic View for TMEM132A Gene

Genes around TMEM132A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM132A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM132A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM132A Gene

Proteins for TMEM132A Gene

  • Protein details for TMEM132A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q24JP5-T132A_HUMAN
    Recommended name:
    Transmembrane protein 132A
    Protein Accession:
    Q24JP5
    Secondary Accessions:
    • Q69YU7
    • Q86VZ8
    • Q86W97
    • Q9H8K3
    • Q9HCI9
    • Q9NWY0

    Protein attributes for TMEM132A Gene

    Size:
    1023 amino acids
    Molecular mass:
    110110 Da
    Quaternary structure:
    • Interacts with HSPA5/GRP78.
    SequenceCaution:
    • Sequence=BAB13409.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14613.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TMEM132A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM132A Gene

Post-translational modifications for TMEM132A Gene

  • Glycosylation at Asn280, Ser800, and Thr805
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TMEM132A Gene

Domains & Families for TMEM132A Gene

Gene Families for TMEM132A Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for TMEM132A Gene

Suggested Antigen Peptide Sequences for TMEM132A Gene

GenScript: Design optimal peptide antigens:
  • HSPA5-binding protein 1 (T132A_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q24JP5

UniProtKB/Swiss-Prot:

T132A_HUMAN :
  • Belongs to the TMEM132 family.
Family:
  • Belongs to the TMEM132 family.
genes like me logo Genes that share domains with TMEM132A: view

Function for TMEM132A Gene

Molecular function for TMEM132A Gene

UniProtKB/Swiss-Prot Function:
May play a role in embryonic and postnatal development of the brain. Increased resistance to cell death induced by serum starvation in cultured cells. Regulates cAMP-induced GFAP gene expression via STAT3 phosphorylation (By similarity).

Phenotypes From GWAS Catalog for TMEM132A Gene

Gene Ontology (GO) - Molecular Function for TMEM132A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with TMEM132A: view
genes like me logo Genes that share phenotypes with TMEM132A: view

Animal Models for TMEM132A Gene

MGI Knock Outs for TMEM132A:

Animal Model Products

CRISPR Products

miRNA for TMEM132A Gene

miRTarBase miRNAs that target TMEM132A

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TMEM132A Gene

Localization for TMEM132A Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM132A Gene

Golgi apparatus membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM132A gene
Compartment Confidence
endoplasmic reticulum 4
golgi apparatus 3
plasma membrane 2
extracellular 0
peroxisome 0
lysosome 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TMEM132A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005783 endoplasmic reticulum IBA 21873635
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005794 Golgi apparatus IBA 21873635
genes like me logo Genes that share ontologies with TMEM132A: view

Pathways & Interactions for TMEM132A Gene

PathCards logo

SuperPathways for TMEM132A Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMEM132A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0043687 post-translational protein modification TAS --
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with TMEM132A: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM132A Gene

Drugs & Compounds for TMEM132A Gene

(1) Drugs for TMEM132A Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
cyclic amp Experimental Pharma 0
genes like me logo Genes that share compounds with TMEM132A: view

Transcripts for TMEM132A Gene

mRNA/cDNA for TMEM132A Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM132A Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c ^ 13a ·
SP1: - - - - - - - - - -
SP2: - - - - - - - - - -
SP3:
SP4: - - - - - - - -
SP5:
SP6: - -
SP7: - - - -
SP8: -
SP9: - - - - - - - -
SP10:
SP11:
SP12: - - -
SP13:

ExUns: 13b · 13c ^ 14
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for TMEM132A Gene

GeneLoc Exon Structure for
TMEM132A
ECgene alternative splicing isoforms for
TMEM132A

Expression for TMEM132A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM132A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TMEM132A Gene

This gene is overexpressed in NK cells (39.8), Fetal testis (8.2), Fetal ovary (7.7), and Fetal Liver (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TMEM132A Gene



NURSA nuclear receptor signaling pathways regulating expression of TMEM132A Gene:

TMEM132A

SOURCE GeneReport for Unigene cluster for TMEM132A Gene:

Hs.118552

Evidence on tissue expression from TISSUES for TMEM132A Gene

  • Nervous system(4.8)
genes like me logo Genes that share expression patterns with TMEM132A: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM132A Gene

Orthologs for TMEM132A Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM132A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM132A 33 32
  • 99.19 (n)
OneToOne
cow
(Bos Taurus)
Mammalia TMEM132A 33 32
  • 87.94 (n)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM132A 33 32
  • 86.78 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem132a 17 33 32
  • 83.68 (n)
rat
(Rattus norvegicus)
Mammalia Tmem132a 32
  • 83.09 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM132A 33
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 33
  • 67 (a)
OneToMany
-- 33
  • 56 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia TMEM132A 33
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem132a 32
  • 46.93 (n)
zebrafish
(Danio rerio)
Actinopterygii TMEM132A 33
  • 23 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG14446 33
  • 18 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y71H2AM.10 33
  • 16 (a)
OneToMany
Species where no ortholog for TMEM132A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMEM132A Gene

ENSEMBL:
Gene Tree for TMEM132A (if available)
TreeFam:
Gene Tree for TMEM132A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TMEM132A: view image

Paralogs for TMEM132A Gene

Paralogs for TMEM132A Gene

(3) SIMAP similar genes for TMEM132A Gene using alignment to 5 proteins:

  • T132A_HUMAN
  • F5H765_HUMAN
  • H0YFB3_HUMAN
  • H0YFQ1_HUMAN
  • H0YFQ2_HUMAN
genes like me logo Genes that share paralogs with TMEM132A: view

Variants for TMEM132A Gene

Sequence variations from dbSNP and Humsavar for TMEM132A Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000126500 -- 60,935,104(+) G/A intron_variant
rs1000342054 -- 60,923,591(+) G/A upstream_transcript_variant
rs1000465634 -- 60,933,971(+) C/T intron_variant
rs1000589341 -- 60,927,990(+) C/T intron_variant
rs1000647072 -- 60,924,436(+) C/T upstream_transcript_variant

Variation tolerance for TMEM132A Gene

Residual Variation Intolerance Score: 66.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.11; 93.85% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM132A Gene

Human Gene Mutation Database (HGMD)
TMEM132A
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM132A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TMEM132A Gene

Disorders for TMEM132A Gene

Additional Disease Information for TMEM132A

No disorders were found for TMEM132A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM132A Gene

Publications for TMEM132A Gene

  1. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10997877) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 2 3 4 56
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56
  3. Cloning and characterization of a novel GRP78-binding protein in the rat brain. (PMID: 12514190) Oh-hashi K … Tanaka M (The Journal of biological chemistry 2003) 2 3 56
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 56
  5. The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery. (PMID: 29180619) Kumar R … Vertegaal ACO (Nature communications 2017) 3 56

Products for TMEM132A Gene

Sources for TMEM132A Gene