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Aliases for TMEM131L Gene

Aliases for TMEM131L Gene

  • Transmembrane 131 Like 2 3 5
  • KIAA0922 2 3 4
  • Transmembrane Protein 131-Like 3

External Ids for TMEM131L Gene

Previous HGNC Symbols for TMEM131L Gene

  • KIAA0922

Summaries for TMEM131L Gene

GeneCards Summary for TMEM131L Gene

TMEM131L (Transmembrane 131 Like) is a Protein Coding gene. An important paralog of this gene is TMEM131.

UniProtKB/Swiss-Prot for TMEM131L Gene

  • Isoform 1: Membrane-associated form that antagonizes canonical Wnt signaling by triggering lysosome-dependent degradation of Wnt-activated LRP6. Regulates thymocyte proliferation.

Additional gene information for TMEM131L Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM131L Gene

Genomics for TMEM131L Gene

GeneHancer (GH) Regulatory Elements for TMEM131L Gene

Promoters and enhancers for TMEM131L Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J153463 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 650.7 +2.2 2173 10 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A FEZF1 DMAP1 IRF4 YY1 TMEM131L MND1 PIR44013
GH04J153438 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 23.7 -27.0 -27049 2.4 HDGF ZBED1 EBF1 MEF2B YBX1 ATF2 ZNF217 POLR2A TARDBP IKZF1 TMEM131L MND1 GC04P153424
GH04J153485 Enhancer 1.4 Ensembl ENCODE dbSUPER 18.1 +22.9 22921 7.9 HDGF PKNOX1 CLOCK SMAD1 ARNT FEZF1 ZNF2 IRF4 FOS JUNB TMEM131L MND1 PIR44013
GH04J153432 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 13 -32.6 -32648 2.4 HDGF PKNOX1 SMAD1 ARNT ARID4B YBX1 IRF4 ZNF48 YY1 GTF3C2 TMEM131L MND1 ARFIP1 TLR2 GC04P153424
GH04J153425 Enhancer 1.1 FANTOM5 Ensembl ENCODE dbSUPER 17.5 -38.7 -38686 4.4 SRF POLR2A HLF RUNX3 TMEM131L RNF175 GC04P153424
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TMEM131L on UCSC Golden Path with GeneCards custom track

Genomic Locations for TMEM131L Gene

Genomic Locations for TMEM131L Gene
171,263 bases
Plus strand
170,366 bases
Plus strand

Genomic View for TMEM131L Gene

Genes around TMEM131L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM131L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM131L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM131L Gene

Proteins for TMEM131L Gene

  • Protein details for TMEM131L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 131-like
    Protein Accession:
    Secondary Accessions:
    • B3KRV3
    • D3DP10
    • Q7LGA7
    • Q86Y92
    • Q8WU56
    • Q9H065
    • Q9Y2D7

    Protein attributes for TMEM131L Gene

    1609 amino acids
    Molecular mass:
    179339 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM131L Gene


neXtProt entry for TMEM131L Gene

Post-translational modifications for TMEM131L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TMEM131L Gene

Domains & Families for TMEM131L Gene

Gene Families for TMEM131L Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TMEM131L Gene


Suggested Antigen Peptide Sequences for TMEM131L Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TMEM131 family.
  • Belongs to the TMEM131 family.
genes like me logo Genes that share domains with TMEM131L: view

Function for TMEM131L Gene

Molecular function for TMEM131L Gene

UniProtKB/Swiss-Prot Function:
Isoform 1: Membrane-associated form that antagonizes canonical Wnt signaling by triggering lysosome-dependent degradation of Wnt-activated LRP6. Regulates thymocyte proliferation.

Phenotypes From GWAS Catalog for TMEM131L Gene

genes like me logo Genes that share phenotypes with TMEM131L: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMEM131L

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM131L Gene

Localization for TMEM131L Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM131L Gene

Cell membrane; Single-pass type I membrane protein. Cytoplasm. Note=During intrathymic development, resides in punctate cytoplasmic structures in DN1 and DN2 cells. In DN3 cells, found in large crescent-shaped membrane structures, which preferentially localize in cell-to-cell contact zones. {ECO:0000269 PubMed:23690469}.
Isoform 1: Endoplasmic reticulum. Note=Transmembrane localization is essential for Wnt signaling inhibition. {ECO:0000269 PubMed:23690469}.
Isoform 5: Cytoplasm. Note=Scattered throughout the cytoplasm in small-sized punctate structures. {ECO:0000269 PubMed:23690469}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM131L gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 3
extracellular 2
nucleus 2
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Vesicles (2)
  • Nucleoli fibrillar center (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TMEM131L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 23690469
GO:0005783 endoplasmic reticulum IEA --
GO:0005886 plasma membrane IDA,IEA 23690469
GO:0016020 membrane IEA,IBA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM131L: view

Pathways & Interactions for TMEM131L Gene

SuperPathways for TMEM131L Gene

No Data Available

Interacting Proteins for TMEM131L Gene

Gene Ontology (GO) - Biological Process for TMEM131L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002682 regulation of immune system process IBA --
GO:0016055 Wnt signaling pathway IEA --
GO:0033088 negative regulation of immature T cell proliferation in thymus IMP 23690469
GO:0090090 negative regulation of canonical Wnt signaling pathway IDA 23690469
genes like me logo Genes that share ontologies with TMEM131L: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM131L Gene

Drugs & Compounds for TMEM131L Gene

No Compound Related Data Available

Transcripts for TMEM131L Gene

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMEM131L

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM131L Gene

No ASD Table

Relevant External Links for TMEM131L Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM131L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of TMEM131L Gene:


mRNA Expression by UniProt/SwissProt for TMEM131L Gene:

Tissue specificity: Expressed in thymocytes.

Evidence on tissue expression from TISSUES for TMEM131L Gene

  • Nervous system(4.4)
  • Muscle(4.2)
genes like me logo Genes that share expression patterns with TMEM131L: view

Primer Products

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM131L Gene

Orthologs for TMEM131L Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM131L Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia KIAA0922 34 33
  • 99.52 (n)
(Canis familiaris)
Mammalia KIAA0922 34 33
  • 89.74 (n)
(Bos Taurus)
Mammalia KIAA0922 34 33
  • 84.78 (n)
(Rattus norvegicus)
Mammalia LOC679811 33
  • 82.1 (n)
(Mus musculus)
Mammalia D930015E06Rik 34 33
  • 81.86 (n)
Tmem131l 16
(Ornithorhynchus anatinus)
Mammalia KIAA0922 34
  • 70 (a)
(Monodelphis domestica)
Mammalia KIAA0922 34
  • 70 (a)
(Gallus gallus)
Aves KIAA0922 34 33
  • 71.18 (n)
(Anolis carolinensis)
Reptilia KIAA0922 34
  • 60 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia kiaa0922 33
  • 59.67 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.9794 33
(Danio rerio)
Actinopterygii si:ch211-208h7.4 34 33
  • 50.9 (n)
Dr.26860 33
fruit fly
(Drosophila melanogaster)
Insecta CG8370 34
  • 14 (a)
(Caenorhabditis elegans)
Secernentea C27F2.8 34
  • 13 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 23 (a)
Species where no ortholog for TMEM131L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMEM131L Gene

Gene Tree for TMEM131L (if available)
Gene Tree for TMEM131L (if available)
Evolutionary constrained regions (ECRs) for TMEM131L: view image

Paralogs for TMEM131L Gene

Paralogs for TMEM131L Gene

genes like me logo Genes that share paralogs with TMEM131L: view

Variants for TMEM131L Gene

Sequence variations from dbSNP and Humsavar for TMEM131L Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1000032399 -- 153,553,990(+) A/G genic_upstream_transcript_variant, intron_variant
rs1000038167 -- 153,561,391(+) A/G/T genic_upstream_transcript_variant, intron_variant
rs1000046089 -- 153,477,588(+) G/A genic_upstream_transcript_variant, intron_variant
rs1000071128 -- 153,517,269(+) C/A genic_upstream_transcript_variant, intron_variant
rs1000071667 -- 153,489,704(+) C/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM131L Gene

Variant ID Type Subtype PubMed ID
esv2661180 CNV deletion 23128226
esv2678129 CNV deletion 23128226
esv2728553 CNV deletion 23290073
esv3432324 CNV duplication 20981092
esv3602725 CNV loss 21293372
esv3602726 CNV loss 21293372
esv3602727 CNV loss 21293372
nsv1022081 CNV gain 25217958
nsv595749 CNV gain 21841781
nsv830118 CNV loss 17160897
nsv949833 CNV duplication 24416366

Variation tolerance for TMEM131L Gene

Residual Variation Intolerance Score: 17.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.61; 86.22% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM131L Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM131L Gene

Disorders for TMEM131L Gene

Additional Disease Information for TMEM131L

No disorders were found for TMEM131L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM131L Gene

Publications for TMEM131L Gene

  1. Identification of TMEM131L as a novel regulator of thymocyte proliferation in humans. (PMID: 23690469) Maharzi N … Canque B (Journal of immunology (Baltimore, Md. : 1950) 2013) 2 3 4 58
  2. Evolutionary conservation of Notch signaling inhibition by TMEM131L overexpression. (PMID: 28347816) Szuplewski S … Canque B (Biochemical and biophysical research communications 2017) 2 3 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 3 4 58
  5. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10231032) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 3 4 58

Products for TMEM131L Gene

Sources for TMEM131L Gene

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