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Aliases for TMEM131 Gene

Aliases for TMEM131 Gene

  • Transmembrane Protein 131 2 3 5
  • RW1 3 4
  • 2610524E03Rik 3
  • Protein RW1 4
  • KIAA0257 4
  • PRO1048 3
  • YR-23 3
  • CC28 3

External Ids for TMEM131 Gene

Previous GeneCards Identifiers for TMEM131 Gene

  • GC02M098372
  • GC02M092138

Summaries for TMEM131 Gene

GeneCards Summary for TMEM131 Gene

TMEM131 (Transmembrane Protein 131) is a Protein Coding gene. Diseases associated with TMEM131 include Subdural Empyema and Streptococcal Meningitis. An important paralog of this gene is TMEM131L.

UniProtKB/Swiss-Prot for TMEM131 Gene

  • May play a role in the immune response to viral infection.

Additional gene information for TMEM131 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM131 Gene

Genomics for TMEM131 Gene

GeneHancer (GH) Regulatory Elements for TMEM131 Gene

Promoters and enhancers for TMEM131 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I097992 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 563.7 +1.0 982 4.3 HDGF PKNOX1 CLOCK FOXA2 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 TMEM131 ANKRD36B UNC50 ANKRD36 ZAP70 ACTR1B C2orf92 RNU7-96P
GH02I097644 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 20.3 +349.8 349773 2.8 HDGF PKNOX1 SMAD1 ZFP64 ARID4B SIN3A DMAP1 YY1 POLR2B ZNF766 COX5B PIR38581 ACTR1B TMEM131 UNC50 LOC100506123 ANKRD36 C2orf92
GH02I098908 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 29.7 -913.4 -913413 2.1 PKNOX1 FOXA2 MLX ARID4B SIN3A FEZF1 ZNF48 ZNF202 NFYC MXD4 LOC550644 REV1 ENSG00000273306 UNC50 MITD1 LIPT1 TMEM131 KIAA1211L RNU7-46P
GH02I097111 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 18.3 +882.5 882469 3.1 PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 POLR2B ZNF207 ZNF143 ANKRD36 SNRNP200 TMEM131 ACTR1B KANSL3 FAHD2B STARD7-AS1 SEMA4C CIAO1 PIR51533
GH02I098501 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 14.8 -509.8 -509787 8.6 PKNOX1 ATF1 ARNT YY1 TCF12 ZNF766 GATA2 ATF7 RUNX3 RXRA INPP4A MITD1 TMEM131 ENSG00000273306 REV1 UNC50 LOC550644 CNGA3 ENSG00000227987 MGAT4A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TMEM131 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TMEM131 gene promoter:

Genomic Locations for TMEM131 Gene

Genomic Locations for TMEM131 Gene
chr2:97,756,333-97,995,932
(GRCh38/hg38)
Size:
239,600 bases
Orientation:
Minus strand
chr2:98,372,799-98,612,388
(GRCh37/hg19)

Genomic View for TMEM131 Gene

Genes around TMEM131 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM131 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM131 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM131 Gene

Proteins for TMEM131 Gene

  • Protein details for TMEM131 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92545-TM131_HUMAN
    Recommended name:
    Transmembrane protein 131
    Protein Accession:
    Q92545

    Protein attributes for TMEM131 Gene

    Size:
    1883 amino acids
    Molecular mass:
    205138 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM131 Gene

Post-translational modifications for TMEM131 Gene

  • Glycosylation at posLast=300300
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TMEM131 Gene

Domains & Families for TMEM131 Gene

Gene Families for TMEM131 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for TMEM131 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM131 Gene

Graphical View of Domain Structure for InterPro Entry

Q92545

UniProtKB/Swiss-Prot:

TM131_HUMAN :
  • Belongs to the TMEM131 family.
Family:
  • Belongs to the TMEM131 family.
genes like me logo Genes that share domains with TMEM131: view

Function for TMEM131 Gene

Molecular function for TMEM131 Gene

UniProtKB/Swiss-Prot Function:
May play a role in the immune response to viral infection.

Phenotypes From GWAS Catalog for TMEM131 Gene

Gene Ontology (GO) - Molecular Function for TMEM131 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with TMEM131: view

Animal Model Products

CRISPR Products

miRNA for TMEM131 Gene

miRTarBase miRNAs that target TMEM131

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM131 Gene

Localization for TMEM131 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM131 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM131 gene
Compartment Confidence
plasma membrane 3
cytoskeleton 3
mitochondrion 1
peroxisome 1
nucleus 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Intermediate filaments (1)
  • Vesicles (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TMEM131 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0016020 membrane IBA,IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM131: view

Pathways & Interactions for TMEM131 Gene

SuperPathways for TMEM131 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMEM131 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with TMEM131: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM131 Gene

Drugs & Compounds for TMEM131 Gene

No Compound Related Data Available

Transcripts for TMEM131 Gene

Unigene Clusters for TMEM131 Gene

Transmembrane protein 131:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM131 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14a · 14b
SP1: - - -
SP2: - -
SP3:
SP4: -
SP5:
SP6:
SP7:
SP8:

Relevant External Links for TMEM131 Gene

GeneLoc Exon Structure for
TMEM131
ECgene alternative splicing isoforms for
TMEM131

Expression for TMEM131 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM131 Gene

Protein differential expression in normal tissues from HIPED for TMEM131 Gene

This gene is overexpressed in Serum (65.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TMEM131 Gene



NURSA nuclear receptor signaling pathways regulating expression of TMEM131 Gene:

TMEM131

SOURCE GeneReport for Unigene cluster for TMEM131 Gene:

Hs.469376

Evidence on tissue expression from TISSUES for TMEM131 Gene

  • Liver(4.3)
  • Bone marrow(4.2)
  • Nervous system(3.5)
genes like me logo Genes that share expression patterns with TMEM131: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM131 Gene

Orthologs for TMEM131 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM131 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM131 33 34
  • 99.63 (n)
dog
(Canis familiaris)
Mammalia TMEM131 33 34
  • 92.81 (n)
cow
(Bos Taurus)
Mammalia TMEM131 33 34
  • 89.4 (n)
rat
(Rattus norvegicus)
Mammalia Tmem131 33
  • 86.65 (n)
mouse
(Mus musculus)
Mammalia Tmem131 33 16 34
  • 86.58 (n)
oppossum
(Monodelphis domestica)
Mammalia TMEM131 34
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM131 34
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM131 33 34
  • 77.53 (n)
lizard
(Anolis carolinensis)
Reptilia TMEM131 34
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem131 33
  • 71.16 (n)
Str.20200 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.8560 33
zebrafish
(Danio rerio)
Actinopterygii tmem131 33 34
  • 63.89 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG8370 34
  • 21 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C27F2.8 34
  • 19 (a)
OneToMany
Species where no ortholog for TMEM131 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMEM131 Gene

ENSEMBL:
Gene Tree for TMEM131 (if available)
TreeFam:
Gene Tree for TMEM131 (if available)

Paralogs for TMEM131 Gene

Paralogs for TMEM131 Gene

genes like me logo Genes that share paralogs with TMEM131: view

Variants for TMEM131 Gene

Sequence variations from dbSNP and Humsavar for TMEM131 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000016619 -- 97,912,689(-) C/T intron_variant
rs1000016983 -- 97,832,972(-) C/T intron_variant
rs1000024284 -- 97,924,066(-) C/G intron_variant
rs1000044029 -- 97,773,654(-) G/T intron_variant
rs1000047958 -- 97,832,727(-) T/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM131 Gene

Variant ID Type Subtype PubMed ID
dgv222n21 CNV gain 19592680
dgv4027n100 CNV gain 25217958
dgv608e201 CNV deletion 23290073
esv2508372 CNV deletion 19546169
esv2672611 CNV deletion 23128226
esv2673220 CNV deletion 23128226
esv27014 CNV loss 19812545
esv2720425 CNV deletion 23290073
esv2720427 CNV deletion 23290073
esv3303867 CNV mobile element insertion 20981092
esv3323014 CNV insertion 20981092
esv3367587 CNV insertion 20981092
esv3421211 CNV insertion 20981092
esv3559825 CNV deletion 23714750
esv3575286 CNV gain 25503493
esv3583978 CNV loss 25503493
esv3591721 CNV loss 21293372
esv4457 CNV loss 18987735
nsv1013416 CNV gain 25217958
nsv1114118 CNV deletion 24896259
nsv1123361 CNV deletion 24896259
nsv1131494 CNV deletion 24896259
nsv1144906 CNV deletion 24896259
nsv1154097 CNV duplication 26484159
nsv2838 CNV insertion 18451855
nsv2839 CNV insertion 18451855
nsv518056 CNV gain 19592680
nsv819283 CNV loss 19587683
nsv953489 CNV duplication 24416366
nsv953490 CNV duplication 24416366
nsv953491 CNV duplication 24416366
nsv961841 CNV duplication 23825009

Variation tolerance for TMEM131 Gene

Residual Variation Intolerance Score: 13.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.38; 85.47% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM131 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM131

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM131 Gene

Disorders for TMEM131 Gene

MalaCards: The human disease database

(2) MalaCards diseases for TMEM131 Gene - From: DISEASES

Disorder Aliases PubMed IDs
subdural empyema
  • subdural abscess
streptococcal meningitis
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TMEM131

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TMEM131: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TMEM131 Gene

Publications for TMEM131 Gene

  1. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PMID: 9039502) Nagase T … Nomura N (DNA research : an international journal for rapid publication of reports on genes and genomes 1996) 2 3 4 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil SA … Gygi SP (Nature biotechnology 2006) 3 4 58
  4. Use of mRNA differential display to study the action of lymphocyte subsets in vivo and application to a murine model of herpes simplex virus infection. (PMID: 10996388) Tscharke DC … Simmons A (Immunology letters 2000) 2 3 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for TMEM131 Gene

Sources for TMEM131 Gene

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