Aliases for TMEM131 Gene

Aliases for TMEM131 Gene

  • Transmembrane Protein 131 2 3 4 5
  • RW1 2 3 4
  • KIAA0257 2 4
  • PRO1048 2 3
  • YR-23 2 3
  • CC28 2 3
  • 2610524E03Rik 3
  • Protein RW1 4
  • TMEM131 5

External Ids for TMEM131 Gene

Previous GeneCards Identifiers for TMEM131 Gene

  • GC02M097744
  • GC02M098372
  • GC02M092138

Summaries for TMEM131 Gene

GeneCards Summary for TMEM131 Gene

TMEM131 (Transmembrane Protein 131) is a Protein Coding gene. Diseases associated with TMEM131 include Subdural Empyema and Prostatic Cyst. An important paralog of this gene is TMEM131L.

UniProtKB/Swiss-Prot Summary for TMEM131 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TMEM131 Gene

Genomics for TMEM131 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TMEM131 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J097992 Promoter/Enhancer 1.9 Ensembl ENCODE CraniofacialAtlas dbSUPER 263.6 +1.2 1232 4.3 ZSCAN16 CHD2 TBP SP1 MXD4 CEBPA SIX5 NR2C1 MNT SMAD5 TMEM131 lnc-ACTR1B-11 ANKRD36B UNC50 ANKRD36 ZAP70 ACTR1B C2orf92 lnc-VWA3B-3
GH02J097997 Enhancer 0.4 Ensembl 250.7 -1.8 -1814 0.4 CUX1 KAT7 RXRB GATAD2A HSALNG0017176 TMEM131 VWA3B lnc-VWA3B-2
GH02J098908 Promoter/Enhancer 1.7 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 29.7 -913.0 -912976 2.4 MXD4 FEZF1 ZNF217 SIX4 ZNF623 SIN3A CUX1 FOXA2 SMAD4 SAP130 SMC3P1 ENSG00000273306 UNC50 REV1 MITD1 TMEM131 LIPT1 CRACDL lnc-TSGA10-1 HSALNG0017230
GH02J098606 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 16.9 -612.6 -612584 4.3 TBP ZBTB10 MXD4 CEBPA NR2C1 SMAD5 ETS1 ZNF217 POLR2A BHLHE40 UNC50 COA5 HSALNG0017209 lnc-MGAT4A-1 INPP4A ENSG00000273306 TMEM131 MITD1 REV1 RNU7-46P
GH02J098767 Promoter/Enhancer 1.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 12.4 -774.5 -774493 6.1 CEBPA ZNF217 ZNF623 FOXA2 SMAD4 SAP130 CTBP1 RARA TEAD3 BCL6 LINC02611 MGAT4A ENSG00000273306 REV1 MITD1 TMEM131 SMC3P1 UNC50 TSGA10 LYG1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TMEM131 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TMEM131

Top Transcription factor binding sites by QIAGEN in the TMEM131 gene promoter:
  • AhR
  • Arnt
  • Brachyury
  • CUTL1
  • Nkx3-1
  • Nkx3-1 v1
  • Nkx3-1 v2
  • Nkx3-1 v3
  • Nkx3-1 v4
  • Sp1

Genomic Locations for TMEM131 Gene

Latest Assembly
239,850 bases
Minus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
239,613 bases
Minus strand

(GRCh37/hg19 by Ensembl)
239,590 bases
Minus strand

Genomic View for TMEM131 Gene

Genes around TMEM131 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM131 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM131 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM131 Gene

Proteins for TMEM131 Gene

  • Protein details for TMEM131 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 131
    Protein Accession:

    Protein attributes for TMEM131 Gene

    1883 amino acids
    Molecular mass:
    205138 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM131 Gene

Post-translational modifications for TMEM131 Gene

  • Glycosylation at Asn168, Asn290, Asn300, and Asn959
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • TM131_HUMAN (1850)

No data available for DME Specific Peptides for TMEM131 Gene

Domains & Families for TMEM131 Gene

Gene Families for TMEM131 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for TMEM131 Gene

Suggested Antigen Peptide Sequences for TMEM131 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ55106, highly similar to Transmembrane protein 131 (B4DMG2_HUMAN)
  • TMEM131 protein (Q0P631_HUMAN)
  • Protein RW1 (TM131_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TMEM131 family.
  • Belongs to the TMEM131 family.
genes like me logo Genes that share domains with TMEM131: view

Function for TMEM131 Gene

Molecular function for TMEM131 Gene

UniProtKB/Swiss-Prot Function:
May play a role in the immune response to viral infection.

Phenotypes From GWAS Catalog for TMEM131 Gene

Gene Ontology (GO) - Molecular Function for TMEM131 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with TMEM131: view

Phenotypes for TMEM131 Gene

genes like me logo Genes that share phenotypes with TMEM131: view

miRNA for TMEM131 Gene

miRTarBase miRNAs that target TMEM131

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMEM131

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM131 Gene

Localization for TMEM131 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM131 Gene

Membrane. Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM131 gene
Compartment Confidence
plasma membrane 3
cytoskeleton 2
extracellular 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
peroxisome 0
cytosol 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Intermediate filaments (1)
  • Vesicles (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TMEM131 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0016020 membrane IEA,IBA 21873635
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM131: view

Pathways & Interactions for TMEM131 Gene

PathCards logo

SuperPathways for TMEM131 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMEM131 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with TMEM131: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM131 Gene

Drugs & Compounds for TMEM131 Gene

No Compound Related Data Available

Transcripts for TMEM131 Gene

mRNA/cDNA for TMEM131 Gene

9 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMEM131

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM131 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14a · 14b
SP1: - - -
SP2: - -
SP4: -

Relevant External Links for TMEM131 Gene

GeneLoc Exon Structure for

Expression for TMEM131 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TMEM131 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TMEM131 Gene

This gene is overexpressed in Serum (65.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TMEM131 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TMEM131

SOURCE GeneReport for Unigene cluster for TMEM131 Gene:


Evidence on tissue expression from TISSUES for TMEM131 Gene

  • Liver(4.4)
  • Bone marrow(4.2)
  • Nervous system(3.7)
  • Skin(2.1)
genes like me logo Genes that share expression patterns with TMEM131: view

Primer products for research

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM131 Gene

Orthologs for TMEM131 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM131 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMEM131 30 31
  • 99.63 (n)
(Canis familiaris)
Mammalia TMEM131 30 31
  • 92.81 (n)
(Bos Taurus)
Mammalia TMEM131 30 31
  • 89.4 (n)
(Rattus norvegicus)
Mammalia Tmem131 30
  • 86.65 (n)
(Mus musculus)
Mammalia Tmem131 30 17 31
  • 86.58 (n)
(Monodelphis domestica)
Mammalia TMEM131 31
  • 84 (a)
(Ornithorhynchus anatinus)
Mammalia TMEM131 31
  • 73 (a)
(Gallus gallus)
Aves TMEM131 30 31
  • 77.53 (n)
(Anolis carolinensis)
Reptilia TMEM131 31
  • 75 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia tmem131 30
  • 71.16 (n)
Str.20200 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.8560 30
(Danio rerio)
Actinopterygii tmem131 30 31
  • 63.89 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta CG8370 31
  • 21 (a)
(Caenorhabditis elegans)
Secernentea C27F2.8 31
  • 19 (a)
Species where no ortholog for TMEM131 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for TMEM131 Gene

Gene Tree for TMEM131 (if available)
Gene Tree for TMEM131 (if available)
Evolutionary constrained regions (ECRs) for TMEM131: view image

Paralogs for TMEM131 Gene

Paralogs for TMEM131 Gene

genes like me logo Genes that share paralogs with TMEM131: view

Variants for TMEM131 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TMEM131 Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
rs149366039 Benign: not provided 97,927,482(-) C/T
NM_015348.2(TMEM131):c.193G>A (p.Val65Ile)

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for TMEM131 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for TMEM131 Gene

Variant ID Type Subtype PubMed ID
dgv222n21 CNV gain 19592680
dgv4027n100 CNV gain 25217958
dgv608e201 CNV deletion 23290073
esv2508372 CNV deletion 19546169
esv2672611 CNV deletion 23128226
esv2673220 CNV deletion 23128226
esv27014 CNV loss 19812545
esv2720425 CNV deletion 23290073
esv2720427 CNV deletion 23290073
esv3303867 CNV mobile element insertion 20981092
esv3323014 CNV insertion 20981092
esv3367587 CNV insertion 20981092
esv3421211 CNV insertion 20981092
esv3559825 CNV deletion 23714750
esv3575286 CNV gain 25503493
esv3583978 CNV loss 25503493
esv3591721 CNV loss 21293372
esv4457 CNV loss 18987735
nsv1013416 CNV gain 25217958
nsv1114118 CNV deletion 24896259
nsv1123361 CNV deletion 24896259
nsv1131494 CNV deletion 24896259
nsv1144906 CNV deletion 24896259
nsv1154097 CNV duplication 26484159
nsv2838 CNV insertion 18451855
nsv2839 CNV insertion 18451855
nsv518056 CNV gain 19592680
nsv819283 CNV loss 19587683
nsv953489 CNV duplication 24416366
nsv953490 CNV duplication 24416366
nsv953491 CNV duplication 24416366
nsv961841 CNV duplication 23825009

Variation tolerance for TMEM131 Gene

Residual Variation Intolerance Score: 13.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.38; 85.47% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM131 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM131 Gene

Disorders for TMEM131 Gene

MalaCards: The human disease database

(3) MalaCards diseases for TMEM131 Gene - From: COP

Disorder Aliases PubMed IDs
subdural empyema
  • subdural abscess
prostatic cyst
  • cyst of prostate
streptococcal meningitis
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TMEM131

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with TMEM131: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TMEM131 Gene

Publications for TMEM131 Gene

  1. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PMID: 9039502) Nagase T … Nomura N (DNA research : an international journal for rapid publication of reports on genes and genomes 1996) 2 3 4
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
  3. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil SA … Gygi SP (Nature biotechnology 2006) 3 4
  4. Use of mRNA differential display to study the action of lymphocyte subsets in vivo and application to a murine model of herpes simplex virus infection. (PMID: 10996388) Tscharke DC … Simmons A (Immunology letters 2000) 2 3
  5. Quantitative Proteomics Links the LRRC59 Interactome to mRNA Translation on the ER Membrane. (PMID: 32788342) Hannigan MM … Nicchitta CV (Molecular & cellular proteomics : MCP 2020) 3

Products for TMEM131 Gene

Sources for TMEM131 Gene