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Aliases for TMEM129 Gene

Aliases for TMEM129 Gene

  • Transmembrane Protein 129 2 3 5
  • Transmembrane Protein 129, E3 Ubiquitin Protein Ligase 2 3
  • RING-Type E3 Ubiquitin Transferase TM129 3 4
  • E3 Ubiquitin-Protein Ligase TM129 3
  • EC 4
  • D4S2561E 3

External Ids for TMEM129 Gene

Previous GeneCards Identifiers for TMEM129 Gene

  • GC04M001687
  • GC04M001717
  • GC04M001660

Summaries for TMEM129 Gene

GeneCards Summary for TMEM129 Gene

TMEM129 (Transmembrane Protein 129) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include ligase activity.

UniProtKB/Swiss-Prot for TMEM129 Gene

  • E3 ubiquitin-protein ligase involved in ER-associated protein degradation, preferentially associates with the E2 enzyme UBE2J2. Exploited by viral US11 proteins to mediate HLA class I proteins degradation.

Additional gene information for TMEM129 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM129 Gene

Genomics for TMEM129 Gene

GeneHancer (GH) Regulatory Elements for TMEM129 Gene

Promoters and enhancers for TMEM129 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04I001719 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 579.6 -0.9 -913 5.4 HDGF PKNOX1 ARID4B SIN3A DMAP1 YY1 ZNF207 ZNF143 FOS SP3 TMEM129 TACC3 ENSG00000270195 FAM53A SLBP ENSG00000233799 PIR44595 GC04P001740
GH04I001757 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 35.3 -39.4 -39394 7 HDGF PKNOX1 ARID4B RAD21 ZNF48 GLIS2 EGR2 SP5 KAT8 ZNF148 TMEM129 ENSG00000270195 FAM53A LOC100129917 FAM193A NELFA CTBP1-AS2 IDUA SLBP FGFR3
GH04I001710 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 13 +7.9 7935 5.7 HDGF PKNOX1 CLOCK SMAD1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ENSG00000270195 SLBP FAM53A RNF4 CRIPAK HAUS3 MAEA ENSG00000272588 TMEM129 GAK
GH04I001725 Enhancer 1 ENCODE dbSUPER 29.6 -5.8 -5783 3.8 HDGF FOXA2 ARID4B SIN3A ZNF2 KLF5 ZNF48 RAD21 GLIS2 ZNF143 ENSG00000270195 FAM53A TMEM129 SLBP TACC3 GC04P001740
GH04I001764 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 18 -47.5 -47528 8.9 FOXA2 MLX ZFP64 ARID4B ZNF48 ZNF121 GLIS2 ZNF207 RUNX3 PAF1 LOC100129917 TMEM129 FAM193A NELFA CTBP1-AS2 IDUA FGFR3 GC04M001751
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TMEM129 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TMEM129 gene promoter:

Genomic Locations for TMEM129 Gene

Genomic Locations for TMEM129 Gene
5,407 bases
Minus strand

Genomic View for TMEM129 Gene

Genes around TMEM129 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM129 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM129 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM129 Gene

Proteins for TMEM129 Gene

  • Protein details for TMEM129 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    E3 ubiquitin-protein ligase TM129
    Protein Accession:
    Secondary Accessions:
    • A6NH49
    • A6NI98
    • D3DVP8

    Protein attributes for TMEM129 Gene

    362 amino acids
    Molecular mass:
    40464 Da
    Quaternary structure:
    • Integral component of ER-resident dislocation complexes.

    Alternative splice isoforms for TMEM129 Gene


neXtProt entry for TMEM129 Gene

Post-translational modifications for TMEM129 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TMEM129 Gene

Domains & Families for TMEM129 Gene

Gene Families for TMEM129 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted membrane proteins

Protein Domains for TMEM129 Gene


Suggested Antigen Peptide Sequences for TMEM129 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The RING-type zinc finger domain is responsible for E3 ubiquitin ligase activity.
  • Belongs to the TMEM129 family.
  • The RING-type zinc finger domain is responsible for E3 ubiquitin ligase activity.
  • Belongs to the TMEM129 family.
genes like me logo Genes that share domains with TMEM129: view

Function for TMEM129 Gene

Molecular function for TMEM129 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.
UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase involved in ER-associated protein degradation, preferentially associates with the E2 enzyme UBE2J2. Exploited by viral US11 proteins to mediate HLA class I proteins degradation.

Enzyme Numbers (IUBMB) for TMEM129 Gene

Gene Ontology (GO) - Molecular Function for TMEM129 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016740 transferase activity IEA --
GO:0046872 metal ion binding IEA --
GO:0061630 ubiquitin protein ligase activity EXP 24807418
GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway IDA 24807418
genes like me logo Genes that share ontologies with TMEM129: view
genes like me logo Genes that share phenotypes with TMEM129: view

Animal Model Products

miRNA for TMEM129 Gene

miRTarBase miRNAs that target TMEM129

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM129 Gene

Localization for TMEM129 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM129 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM129 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3
extracellular 2
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TMEM129 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA 24807418
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM129: view

Pathways & Interactions for TMEM129 Gene

SuperPathways for TMEM129 Gene

No Data Available

UniProtKB/Swiss-Prot A0AVI4-TM129_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for TMEM129 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination IDA 24807418
GO:0006986 response to unfolded protein IEA --
GO:0016567 protein ubiquitination TAS --
GO:0030433 ubiquitin-dependent ERAD pathway IMP 24807418
GO:0030970 retrograde protein transport, ER to cytosol IMP 24807418
genes like me logo Genes that share ontologies with TMEM129: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM129 Gene

Drugs & Compounds for TMEM129 Gene

No Compound Related Data Available

Transcripts for TMEM129 Gene

Unigene Clusters for TMEM129 Gene

Transmembrane protein 129:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM129 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d
SP1: - - - -
SP3: - - - - -
SP4: -

Relevant External Links for TMEM129 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM129 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM129 Gene

Protein differential expression in normal tissues from HIPED for TMEM129 Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TMEM129 Gene

Protein tissue co-expression partners for TMEM129 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TMEM129 Gene:


SOURCE GeneReport for Unigene cluster for TMEM129 Gene:


Evidence on tissue expression from TISSUES for TMEM129 Gene

  • Nervous system(3.9)
genes like me logo Genes that share expression patterns with TMEM129: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM129 Gene

Orthologs for TMEM129 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM129 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMEM129 33 34
  • 99.88 (n)
(Bos Taurus)
Mammalia TMEM129 33 34
  • 89.32 (n)
(Canis familiaris)
Mammalia TMEM129 33 34
  • 88.12 (n)
(Rattus norvegicus)
Mammalia Tmem129 33
  • 84.9 (n)
(Mus musculus)
Mammalia Tmem129 33 16 34
  • 84.35 (n)
(Ornithorhynchus anatinus)
Mammalia TMEM129 34
  • 75 (a)
(Monodelphis domestica)
Mammalia TMEM129 34
  • 64 (a)
(Gallus gallus)
Aves TMEM129 33 34
  • 73.2 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem129 33
  • 72.65 (n)
(Danio rerio)
Actinopterygii tmem129 33 34
  • 65.1 (n)
wufc17d07 33
fruit fly
(Drosophila melanogaster)
Insecta CG14646 33 34
  • 49.2 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011818 33
  • 37.43 (n)
(Caenorhabditis elegans)
Secernentea C34F6.7 33 34
  • 39.49 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6846 34
  • 42 (a)
Species where no ortholog for TMEM129 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMEM129 Gene

Gene Tree for TMEM129 (if available)
Gene Tree for TMEM129 (if available)

Paralogs for TMEM129 Gene

No data available for Paralogs for TMEM129 Gene

Variants for TMEM129 Gene

Sequence variations from dbSNP and Humsavar for TMEM129 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1000045448 -- 1,715,655(-) C/T downstream_transcript_variant
rs1000204800 -- 1,718,582(-) G/A coding_sequence_variant, missense_variant
rs1000616773 -- 1,721,296(-) C/G 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1000747859 -- 1,717,051(-) G/A 3_prime_UTR_variant
rs1000790565 -- 1,722,759(-) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM129 Gene

Variant ID Type Subtype PubMed ID
dgv8901n54 CNV loss 21841781
esv2726832 CNV deletion 23290073
esv2759218 CNV gain 17122850
nsv1161027 CNV deletion 26073780
nsv292653 CNV deletion 16902084
nsv428434 CNV gain 18775914
nsv470000 CNV loss 18288195
nsv508989 CNV insertion 20534489
nsv593316 CNV gain 21841781
nsv949756 CNV deletion 24416366

Variation tolerance for TMEM129 Gene

Gene Damage Index Score: 4.59; 65.26% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM129 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM129 Gene

Disorders for TMEM129 Gene

Additional Disease Information for TMEM129

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for TMEM129 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM129 Gene

Publications for TMEM129 Gene

  1. A high-coverage shRNA screen identifies TMEM129 as an E3 ligase involved in ER-associated protein degradation. (PMID: 24807418) van de Weijer ML … Lebbink RJ (Nature communications 2014) 2 3 4 58
  2. TMEM129 is a Derlin-1 associated ERAD E3 ligase essential for virus-induced degradation of MHC-I. (PMID: 25030448) van den Boomen DJ … Lehner PJ (Proceedings of the National Academy of Sciences of the United States of America 2014) 2 3 58
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  4. The E3 Ubiquitin Ligase TMEM129 Is a Tri-Spanning Transmembrane Protein. (PMID: 27854284) van de Weijer ML … Lebbink RJ (Viruses 2016) 3 58
  5. Identifying the ERAD ubiquitin E3 ligases for viral and cellular targeting of MHC class I. (PMID: 26210183) van den Boomen DJ … Lehner PJ (Molecular immunology 2015) 3 58

Products for TMEM129 Gene

Sources for TMEM129 Gene

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