Aliases for TMEM125 Gene

Aliases for TMEM125 Gene

  • Transmembrane Protein 125 2 3 4 5

External Ids for TMEM125 Gene

Previous GeneCards Identifiers for TMEM125 Gene

  • GC01P043508
  • GC01P043735
  • GC01P041855

Summaries for TMEM125 Gene

GeneCards Summary for TMEM125 Gene

TMEM125 (Transmembrane Protein 125) is a Protein Coding gene. Diseases associated with TMEM125 include Ovary Adenocarcinoma.

Additional gene information for TMEM125 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TMEM125 Gene

Genomics for TMEM125 Gene

GeneHancer (GH) Regulatory Elements for TMEM125 Gene

Promoters and enhancers for TMEM125 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J043270 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 750.6 +0.8 771 2.2 MNT SP1 EGR1 CREB1 ZNF316 POLR2A SCRT2 RFX1 ZBTB48 CTBP1 EBNA1BP2 TMEM125 lnc-EBNA1BP2-1 piR-34509 CFAP57 C1orf210 KDM4A-AS1
GH01J043272 Promoter/Enhancer 0.5 EPDnew dbSUPER 750.6 +2.3 2306 0.1 EBNA1BP2 TMEM125 lnc-EBNA1BP2-1 piR-34509 C1orf210
GH01J043269 Enhancer 0.3 dbSUPER 750.6 -0.7 -691 0.3 CUX1 EBNA1BP2 TMEM125 lnc-EBNA1BP2-1 piR-34509 LOC105378685
GH01J043238 Enhancer 1 Ensembl ENCODE 22 -30.7 -30651 2.6 ZNF24 CTCF NR2F1 NR2F6 MIXL1 RAD21 ELF3 SP1 MLLT1 PPARG TMEM125 CDC20 ENSG00000234694 ELOVL1 MPL ENSG00000229431 MED8 SZT2 SZT2-AS1 HYI
GH01J043283 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE dbSUPER 9.3 +15.3 15346 3.2 CTCF CREB1 ZNF121 SP1 ZNF148 SP5 POLR2A EGR1 ZBTB26 FOXA2 C1orf210 CFAP57 SZT2 MPL ENSG00000229431 MED8 CDC20 ENSG00000234694 ELOVL1 TMEM125
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TMEM125 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TMEM125 gene promoter:
  • AREB6
  • ATF
  • HNF-4alpha1
  • HNF-4alpha2
  • MIF-1
  • NCX
  • POU2F1
  • POU2F1a
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for TMEM125 Gene

Genomic Locations for TMEM125 Gene
chr1:43,269,951-43,274,002
(GRCh38/hg38)
Size:
4,052 bases
Orientation:
Plus strand
chr1:43,735,665-43,739,673
(GRCh37/hg19)
Size:
4,009 bases
Orientation:
Plus strand

Genomic View for TMEM125 Gene

Genes around TMEM125 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM125 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM125 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM125 Gene

Proteins for TMEM125 Gene

  • Protein details for TMEM125 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96AQ2-TM125_HUMAN
    Recommended name:
    Transmembrane protein 125
    Protein Accession:
    Q96AQ2
    Secondary Accessions:
    • D3DPX1

    Protein attributes for TMEM125 Gene

    Size:
    219 amino acids
    Molecular mass:
    22172 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM125 Gene

Post-translational modifications for TMEM125 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM125 Gene

No data available for DME Specific Peptides for TMEM125 Gene

Domains & Families for TMEM125 Gene

Gene Families for TMEM125 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for TMEM125 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM125 Gene

GenScript: Design optimal peptide antigens:
  • Transmembrane protein 125 (TM125_HUMAN)
genes like me logo Genes that share domains with TMEM125: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for TMEM125 Gene

Function for TMEM125 Gene

Gene Ontology (GO) - Molecular Function for TMEM125 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with TMEM125: view
genes like me logo Genes that share phenotypes with TMEM125: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TMEM125 Gene

Localization for TMEM125 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM125 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Midbody (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TMEM125 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM125: view

No data available for Subcellular locations from COMPARTMENTS for TMEM125 Gene

Pathways & Interactions for TMEM125 Gene

PathCards logo

SuperPathways for TMEM125 Gene

No Data Available

Interacting Proteins for TMEM125 Gene

Selected Interacting proteins: Q96AQ2-TM125_HUMAN for TMEM125 Gene via IID

Symbol External ID(s) Details
KIAA1328
MAP7D1

Gene Ontology (GO) - Biological Process for TMEM125 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with TMEM125: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM125 Gene

Drugs & Compounds for TMEM125 Gene

No Compound Related Data Available

Transcripts for TMEM125 Gene

mRNA/cDNA for TMEM125 Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM125 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b
SP1: -
SP2:
SP3: -

Relevant External Links for TMEM125 Gene

GeneLoc Exon Structure for
TMEM125
ECgene alternative splicing isoforms for
TMEM125

Expression for TMEM125 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM125 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMEM125 Gene

This gene is overexpressed in Pancreas (x7.3), Lung (x5.6), and Brain - Spinal cord (cervical c-1) (x4.6).

NURSA nuclear receptor signaling pathways regulating expression of TMEM125 Gene:

TMEM125

SOURCE GeneReport for Unigene cluster for TMEM125 Gene:

Hs.104476

Evidence on tissue expression from TISSUES for TMEM125 Gene

  • Intestine(4)
genes like me logo Genes that share expression patterns with TMEM125: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM125 Gene

Orthologs for TMEM125 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM125 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM125 33 32
  • 100 (n)
OneToOne
cow
(Bos Taurus)
Mammalia TMEM125 33 32
  • 86.76 (n)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM125 33 32
  • 86.05 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem125 17 33 32
  • 84.04 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM125 33
  • 67 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMEM125 33
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM125 32
  • 62.93 (n)
lizard
(Anolis carolinensis)
Reptilia TMEM125 33
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem125 32
  • 52.45 (n)
zebrafish
(Danio rerio)
Actinopterygii CABZ01069519.1 33
  • 41 (a)
OneToMany
tmem125b 33
  • 37 (a)
OneToMany
Species where no ortholog for TMEM125 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM125 Gene

ENSEMBL:
Gene Tree for TMEM125 (if available)
TreeFam:
Gene Tree for TMEM125 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TMEM125: view image

Paralogs for TMEM125 Gene

No data available for Paralogs for TMEM125 Gene

Variants for TMEM125 Gene

Sequence variations from dbSNP and Humsavar for TMEM125 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
VAR_035669 A breast cancer sample p.Arg107Leu
rs1000558724 -- 43,271,112(+) A/T 5_prime_UTR_variant, intron_variant
rs1000611000 -- 43,270,741(+) C/A/T 5_prime_UTR_variant
rs1002115261 -- 43,271,585(+) G/A intron_variant
rs1002189948 -- 43,269,683(+) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM125 Gene

Variant ID Type Subtype PubMed ID
nsv508009 OTHER sequence alteration 20534489
nsv829693 CNV loss 17160897

Variation tolerance for TMEM125 Gene

Residual Variation Intolerance Score: 93.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.59; 30.62% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM125 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM125

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM125 Gene

Disorders for TMEM125 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TMEM125 Gene - From: DISEASES

Disorder Aliases PubMed IDs
ovary adenocarcinoma
  • adenocarcinoma of the ovary
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TMEM125

genes like me logo Genes that share disorders with TMEM125: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TMEM125 Gene

Publications for TMEM125 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
  2. The consensus coding sequences of human breast and colorectal cancers. (PMID: 16959974) Sjöblom T … Velculescu VE (Science (New York, N.Y.) 2006) 4 56
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 56
  4. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo MF … Soares MB (Genome research 1996) 3 56

Products for TMEM125 Gene

Sources for TMEM125 Gene