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Aliases for TMEM119 Gene

Aliases for TMEM119 Gene

  • Transmembrane Protein 119 2 3 4 5
  • Osteoblast Induction Factor 3 4
  • OBIF 3 4

External Ids for TMEM119 Gene

Previous GeneCards Identifiers for TMEM119 Gene

  • GC12M107487
  • GC12M108983
  • GC12M106047

Summaries for TMEM119 Gene

GeneCards Summary for TMEM119 Gene

TMEM119 (Transmembrane Protein 119) is a Protein Coding gene. Among its related pathways are Microglia Activation During Neuroinflammation: Steady-State Microglia.

UniProtKB/Swiss-Prot for TMEM119 Gene

  • Plays an important role in bone formation and normal bone mineralization. Promotes the differentiation of myoblasts into osteoblasts (PubMed:20025746). May induce the commitment and differentiation of myoblasts into osteoblasts through an enhancement of BMP2 production and interaction with the BMP-RUNX2 pathway. Upregulates the expression of ATF4, a transcription factor which plays a central role in osteoblast differentiation. Essential for normal spermatogenesis and late testicular differentiation (By similarity).

Additional gene information for TMEM119 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM119 Gene

Genomics for TMEM119 Gene

GeneHancer (GH) Regulatory Elements for TMEM119 Gene

Promoters and enhancers for TMEM119 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J108596 Promoter/Enhancer 2 EPDnew Ensembl ENCODE dbSUPER 613 +1.3 1335 3.6 ZNF473 ZNF148 GTF2F1 CDC5L ZNF24 POLR2A ZNF600 ZSCAN4 ZNF776 ZNF311 TMEM119 SART3 ALKBH2 UBE3B PWP1 LOC101929162 PRDM4 ISCU GC12M108565
GH12J108626 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.3 -35.1 -35126 13.4 SP1 CC2D1A ZFX ELF3 ZKSCAN8 CBFA2T2 ZNF148 NKRF MLLT1 ZNF121 SELPLG GC12P108633 SART3 PWP1 PRDM4 UBE3B CORO1C FICD LOC101929162 TMEM119
GH12J108611 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 15.3 -19.3 -19349 12.6 CC2D1A SP1 CTCF NKRF MLLT1 CEBPG CSDE1 ZNF384 ZNF687 BACH1 PRDM4 PWP1 TMEM119 SART3 ALKBH2 UBE3B CORO1C SELPLG ISCU CMKLR1
GH12J108559 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 7.1 +30.0 30015 18.2 MTA3 SP1 ZFX CC2D1A ELF3 CTCF MNT SIX5 CBFA2T2 ZNF148 SART3 ISCU PWP1 FICD PRDM4 UBE3B ALKBH2 TMEM119 CMKLR1 GC12P108558
GH12J108605 Enhancer 1.1 Ensembl dbSUPER 10.3 -7.5 -7481 1.2 ZNF473 ZSCAN21 MCM2 TFE3 MLLT1 ZNF680 ZNF704 IKZF1 ZNF24 ZNF544 GC12M108565 SART3 PWP1 ALKBH2 PRDM4 RNU4-32P LOC101929162 UBE3B USP30 TMEM119
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TMEM119 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TMEM119 gene promoter:
  • AML1a
  • E47
  • HSF1 (long)
  • HSF1short
  • MZF-1
  • POU2F1
  • Sp1
  • Tal-1
  • ZID

Genomic Locations for TMEM119 Gene

Genomic Locations for TMEM119 Gene
chr12:108,589,846-108,598,320
(GRCh38/hg38)
Size:
8,475 bases
Orientation:
Minus strand
chr12:108,983,622-108,992,096
(GRCh37/hg19)
Size:
8,475 bases
Orientation:
Minus strand

Genomic View for TMEM119 Gene

Genes around TMEM119 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM119 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM119 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM119 Gene

Proteins for TMEM119 Gene

  • Protein details for TMEM119 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q4V9L6-TM119_HUMAN
    Recommended name:
    Transmembrane protein 119
    Protein Accession:
    Q4V9L6
    Secondary Accessions:
    • Q6UXE5
    • Q8N2F5

    Protein attributes for TMEM119 Gene

    Size:
    283 amino acids
    Molecular mass:
    29203 Da
    Quaternary structure:
    • Interacts with SMAD1, SMAD5 and RUNX2.

neXtProt entry for TMEM119 Gene

Post-translational modifications for TMEM119 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM119 Gene

No data available for DME Specific Peptides for TMEM119 Gene

Domains & Families for TMEM119 Gene

Gene Families for TMEM119 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for TMEM119 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM119 Gene

GenScript: Design optimal peptide antigens:
  • Transmembrane protein 119 (TM119_HUMAN)

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM119: view

No data available for UniProtKB/Swiss-Prot for TMEM119 Gene

Function for TMEM119 Gene

Molecular function for TMEM119 Gene

UniProtKB/Swiss-Prot Function:
Plays an important role in bone formation and normal bone mineralization. Promotes the differentiation of myoblasts into osteoblasts (PubMed:20025746). May induce the commitment and differentiation of myoblasts into osteoblasts through an enhancement of BMP2 production and interaction with the BMP-RUNX2 pathway. Upregulates the expression of ATF4, a transcription factor which plays a central role in osteoblast differentiation. Essential for normal spermatogenesis and late testicular differentiation (By similarity).

Phenotypes From GWAS Catalog for TMEM119 Gene

Gene Ontology (GO) - Molecular Function for TMEM119 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with TMEM119: view
genes like me logo Genes that share phenotypes with TMEM119: view

Animal Models for TMEM119 Gene

MGI Knock Outs for TMEM119:

Animal Model Products

  • Taconic Biosciences Mouse Models for TMEM119

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for TMEM119 - Now 50% OFF >
  • * TMEM119 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * TMEM119 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TMEM119 Gene

Localization for TMEM119 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM119 Gene

Cell membrane; Single-pass type I membrane protein. Cytoplasm. Endoplasmic reticulum membrane.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM119 gene
Compartment Confidence
plasma membrane 5
extracellular 3
endoplasmic reticulum 3
lysosome 0

Gene Ontology (GO) - Cellular Components for TMEM119 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005886 plasma membrane IEA,IDA 20025746
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with TMEM119: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TMEM119 Gene

Pathways & Interactions for TMEM119 Gene

genes like me logo Genes that share pathways with TMEM119: view

Pathways by source for TMEM119 Gene

Interacting Proteins for TMEM119 Gene

STRING Interaction Network Preview (showing top 1 STRING interactants - click image to see details)
https://version11.string-db.org/api/image/network?species=9606&limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000376553%0d9606.ENSP00000251363%0d
Selected Interacting proteins: ENSP00000376553 Q4V9L6-TM119_HUMAN for TMEM119 Gene via STRING IID

Gene Ontology (GO) - Biological Process for TMEM119 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001649 osteoblast differentiation IEA --
GO:0001934 positive regulation of protein phosphorylation ISS --
GO:0001958 endochondral ossification ISS --
GO:0007283 spermatogenesis ISS --
GO:0010628 positive regulation of gene expression ISS --
genes like me logo Genes that share ontologies with TMEM119: view

No data available for SIGNOR curated interactions for TMEM119 Gene

Drugs & Compounds for TMEM119 Gene

No Compound Related Data Available

Transcripts for TMEM119 Gene

mRNA/cDNA for TMEM119 Gene

Unigene Clusters for TMEM119 Gene

Transmembrane protein 119:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for TMEM119 - Now 50% OFF >
  • * TMEM119 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * TMEM119 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM119 Gene

ExUns: 1 ^ 2 ^ 3a · 3b
SP1:
SP2: -

Relevant External Links for TMEM119 Gene

GeneLoc Exon Structure for
TMEM119
ECgene alternative splicing isoforms for
TMEM119

Expression for TMEM119 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM119 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TMEM119 Gene

This gene is overexpressed in Bone marrow stromal cell (39.4) and Pancreas (12.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMEM119 Gene



NURSA nuclear receptor signaling pathways regulating expression of TMEM119 Gene:

TMEM119

SOURCE GeneReport for Unigene cluster for TMEM119 Gene:

Hs.449718

mRNA Expression by UniProt/SwissProt for TMEM119 Gene:

Q4V9L6-TM119_HUMAN
Tissue specificity: Expressed in brain microglia (at protein level). Elevated expression levels seen in the brain of patients with Alzheimer disease. Expressed by osteoblast-like cells in bone tissues and follicular dendritic cells in lymphoid tissues.

Evidence on tissue expression from TISSUES for TMEM119 Gene

  • Liver(4.1)
genes like me logo Genes that share expression patterns with TMEM119: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM119 Gene

Orthologs for TMEM119 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM119 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM119 35 34
  • 99.18 (n)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM119 35 34
  • 82.68 (n)
OneToOne
cow
(Bos Taurus)
Mammalia TMEM119 35 34
  • 79.83 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem119 34
  • 75.55 (n)
mouse
(Mus musculus)
Mammalia Tmem119 17 35 34
  • 75.42 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM119 35
  • 47 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM119 35 34
  • 71.05 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM119 35
  • 49 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii tmem119b 35
  • 25 (a)
OneToOne
Species where no ortholog for TMEM119 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM119 Gene

ENSEMBL:
Gene Tree for TMEM119 (if available)
TreeFam:
Gene Tree for TMEM119 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TMEM119: view image

Paralogs for TMEM119 Gene

No data available for Paralogs for TMEM119 Gene

Variants for TMEM119 Gene

Sequence variations from dbSNP and Humsavar for TMEM119 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000234390 -- 108,590,552(-) C/A 3_prime_UTR_variant
rs1000306980 -- 108,599,486(-) G/A upstream_transcript_variant
rs1000373047 -- 108,594,169(-) G/A/T intron_variant
rs1000616343 -- 108,599,218(-) G/A upstream_transcript_variant
rs1001295586 -- 108,596,440(-) A/AA intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM119 Gene

Variant ID Type Subtype PubMed ID
nsv509475 CNV insertion 20534489
nsv524079 CNV loss 19592680
nsv883 CNV deletion 18451855

Variation tolerance for TMEM119 Gene

Residual Variation Intolerance Score: 66.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.84; 58.67% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM119 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM119

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM119 Gene

Disorders for TMEM119 Gene

Additional Disease Information for TMEM119

No disorders were found for TMEM119 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM119 Gene

Publications for TMEM119 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 2 3 4 58
  2. TMEM119 marks a subset of microglia in the human brain. (PMID: 26250788) Satoh J … Saito Y (Neuropathology : official journal of the Japanese Society of Neuropathology 2016) 3 4 58
  3. Isolation and characterization of a novel plasma membrane protein, osteoblast induction factor (obif), associated with osteoblast differentiation. (PMID: 20025746) Kanamoto T … Furukawa T (BMC developmental biology 2009) 3 4 58
  4. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PMID: 16303743) Otsuki T … Isogai T (DNA research : an international journal for rapid publication of reports on genes and genomes 2005) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for TMEM119 Gene

Sources for TMEM119 Gene

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