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Aliases for TMEM116 Gene

Aliases for TMEM116 Gene

  • Transmembrane Protein 116 2 3 4 5

External Ids for TMEM116 Gene

Previous GeneCards Identifiers for TMEM116 Gene

  • GC12M110832
  • GC12M112369
  • GC12M109382

Summaries for TMEM116 Gene

GeneCards Summary for TMEM116 Gene

TMEM116 (Transmembrane Protein 116) is a Protein Coding gene. An important paralog of this gene is GPR157.

Additional gene information for TMEM116 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM116 Gene

Genomics for TMEM116 Gene

GeneHancer (GH) Regulatory Elements for TMEM116 Gene

Promoters and enhancers for TMEM116 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J112011 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 627.9 -0.3 -344 4.3 SP1 CC2D1A ZFX ELF3 MNT CBFA2T2 NKRF POLR2A MLLT1 CEBPG TMEM116 ERP29 RPL6 MAPKAPK5 NAA25 HSPA8P14 TRAFD1 RPS2P41 GC12P112008 ENSG00000274227
GH12J112005 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 627.6 +7.4 7401 1.2 CC2D1A MLLT1 MAFK PRDM1 EGR1 SMARCA4 MTA1 IKZF1 ARID2 DPF2 TMEM116 TRAFD1 GC12P112008 LOC724085
GH12J112124 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 37.5 -115.0 -115049 7.2 ZNF652 SP1 ZFX NKRF POLR2A MLLT1 CEBPG GTF2F1 ZNF384 ZNF687 TRAFD1 TMEM116 MAPKAPK5 BRAP ADAM1A NAA25 ERP29 GC12P112151
GH12J112106 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 26.9 -95.6 -95579 4.6 ELF3 ZFX MNT NKRF MLLT1 ZNF121 CEBPG POLR2A ZNF384 ZNF687 GC12P112109 NAA25 TMEM116 ADAM1A ENSG00000200688
GH12J111991 Promoter/Enhancer 1.6 Ensembl ENCODE dbSUPER 27.6 +19.5 19482 4.1 SP1 CC2D1A CBFA2T2 MLLT1 MAFK SP7 TRIM24 RELA CREM SMARCA4 GC12P111993 SLC25A3P2 TMEM116 ADAM1A ALDH2 ENSG00000257624
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TMEM116 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TMEM116 gene promoter:
  • AML1a
  • Cdc5
  • E47
  • En-1
  • FOXO4
  • GATA-3
  • MyoD
  • Pbx1a
  • POU3F1
  • POU3F2 (N-Oct-5a)

Genomic Locations for TMEM116 Gene

Genomic Locations for TMEM116 Gene
chr12:111,894,930-112,013,219
(GRCh38/hg38)
Size:
118,290 bases
Orientation:
Minus strand
chr12:112,369,086-112,451,023
(GRCh37/hg19)
Size:
81,938 bases
Orientation:
Minus strand

Genomic View for TMEM116 Gene

Genes around TMEM116 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM116 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM116 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM116 Gene

Proteins for TMEM116 Gene

  • Protein details for TMEM116 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NCL8-TM116_HUMAN
    Recommended name:
    Transmembrane protein 116
    Protein Accession:
    Q8NCL8
    Secondary Accessions:
    • G3V1W7
    • G5E985
    • Q6NSH5
    • Q8IZ66

    Protein attributes for TMEM116 Gene

    Size:
    245 amino acids
    Molecular mass:
    27464 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM116 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM116 Gene

Post-translational modifications for TMEM116 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TMEM116 Gene

Domains & Families for TMEM116 Gene

Gene Families for TMEM116 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for TMEM116 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for TMEM116 Gene

GenScript: Design optimal peptide antigens:
  • TMEM116 protein (Q9BWF8_HUMAN)
  • Transmembrane protein 116 (TM116_HUMAN)

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM116: view

No data available for UniProtKB/Swiss-Prot for TMEM116 Gene

Function for TMEM116 Gene

Phenotypes From GWAS Catalog for TMEM116 Gene

Gene Ontology (GO) - Molecular Function for TMEM116 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with TMEM116: view
genes like me logo Genes that share phenotypes with TMEM116: view

Animal Models for TMEM116 Gene

MGI Knock Outs for TMEM116:
  • Tmem116 Tmem116<tm1b(EUCOMM)Hmgu>

Animal Model Products

CRISPR Products

miRNA for TMEM116 Gene

miRTarBase miRNAs that target TMEM116

Clone Products

  • Applied Biological Materials (abm): Clones for TMEM116 - Now 50% OFF >
  • * TMEM116 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * TMEM116 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TMEM116 Gene

Localization for TMEM116 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM116 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM116 gene
Compartment Confidence
plasma membrane 3
cytoskeleton 2
nucleus 2
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Microtubules (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TMEM116 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM116: view

Pathways & Interactions for TMEM116 Gene

PathCards logo

SuperPathways for TMEM116 Gene

No Data Available

Interacting Proteins for TMEM116 Gene

Gene Ontology (GO) - Biological Process for TMEM116 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with TMEM116: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM116 Gene

Drugs & Compounds for TMEM116 Gene

No Compound Related Data Available

Transcripts for TMEM116 Gene

Unigene Clusters for TMEM116 Gene

Transmembrane protein 116:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for TMEM116 - Now 50% OFF >
  • * TMEM116 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * TMEM116 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM116 Gene

No ASD Table

Relevant External Links for TMEM116 Gene

GeneLoc Exon Structure for
TMEM116
ECgene alternative splicing isoforms for
TMEM116

Expression for TMEM116 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM116 Gene

mRNA differential expression in normal tissues according to GTEx for TMEM116 Gene

This gene is overexpressed in Heart - Left Ventricle (x4.1).

NURSA nuclear receptor signaling pathways regulating expression of TMEM116 Gene:

TMEM116

SOURCE GeneReport for Unigene cluster for TMEM116 Gene:

Hs.506815

Evidence on tissue expression from TISSUES for TMEM116 Gene

  • Nervous system(4.4)
  • Lung(4.2)
genes like me logo Genes that share expression patterns with TMEM116: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM116 Gene

Orthologs for TMEM116 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM116 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM116 35 34
  • 99.41 (n)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM116 35 34
  • 88.69 (n)
OneToOne
cow
(Bos Taurus)
Mammalia TMEM116 35 34
  • 83.97 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem116 17 35 34
  • 78.34 (n)
rat
(Rattus norvegicus)
Mammalia Tmem116 34
  • 77.24 (n)
oppossum
(Monodelphis domestica)
Mammalia TMEM116 35
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM116 35
  • 58 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM116 35 34
  • 63.44 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM116 35
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100487315 34
  • 54.15 (n)
zebrafish
(Danio rerio)
Actinopterygii si:ch211-157p22.10 34
  • 53.4 (n)
TMEM116 35
  • 40 (a)
OneToOne
Species where no ortholog for TMEM116 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM116 Gene

ENSEMBL:
Gene Tree for TMEM116 (if available)
TreeFam:
Gene Tree for TMEM116 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TMEM116: view image

Paralogs for TMEM116 Gene

Paralogs for TMEM116 Gene

genes like me logo Genes that share paralogs with TMEM116: view

Variants for TMEM116 Gene

Sequence variations from dbSNP and Humsavar for TMEM116 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000064098 -- 111,940,887(-) T/C intron_variant
rs1000068238 -- 111,911,579(-) C/T genic_downstream_transcript_variant, intron_variant
rs1000092907 -- 111,962,323(-) T/C intron_variant
rs1000131772 -- 111,961,537(-) C/T intron_variant
rs1000134823 -- 112,009,857(-) A/C genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM116 Gene

Variant ID Type Subtype PubMed ID
esv2746360 CNV deletion 23290073
esv3630772 CNV loss 21293372
nsv1044606 CNV gain 25217958
nsv1045310 CNV gain 25217958
nsv887 CNV deletion 18451855

Variation tolerance for TMEM116 Gene

Residual Variation Intolerance Score: 65% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.46; 64.22% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM116 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM116

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM116 Gene

Disorders for TMEM116 Gene

Additional Disease Information for TMEM116

No disorders were found for TMEM116 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM116 Gene

Publications for TMEM116 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P … Vidal M (Genomics 2007) 3 58
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58

Products for TMEM116 Gene

Sources for TMEM116 Gene

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