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Aliases for TMEM115 Gene

Aliases for TMEM115 Gene

  • Transmembrane Protein 115 2 3 5
  • Placental Protein 6 2 3 4
  • PL6 3 4
  • Testicular Tissue Protein Li 201 3
  • Protein PL6 4
  • PP6 3

External Ids for TMEM115 Gene

Previous GeneCards Identifiers for TMEM115 Gene

  • GC03M050368

Summaries for TMEM115 Gene

GeneCards Summary for TMEM115 Gene

TMEM115 (Transmembrane Protein 115) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include identical protein binding.

UniProtKB/Swiss-Prot for TMEM115 Gene

  • May play a role in retrograde transport of proteins from the Golgi to the endoplasmic reticulum. May indirectly play a role in protein glycosylation in the Golgi.

Additional gene information for TMEM115 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM115 Gene

Genomics for TMEM115 Gene

GeneHancer (GH) Regulatory Elements for TMEM115 Gene

Promoters and enhancers for TMEM115 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I050356 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 +1.4 1422 4 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 ZNF766 TMEM115 GC03P050359 NICN1 CYB561D2 ENSG00000272104 NPRL2
GH03I050598 Promoter/Enhancer 3.2 VISTA EPDnew FANTOM5 Ensembl ENCODE dbSUPER 23.6 -246.9 -246877 15 CLOCK MLX ZFP64 DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC CISH MAPKAPK3 HEMK1 RBM5 RBM6 TMEM115 RAD54L2 SEMA3F-AS1 C3orf18 DOCK3
GH03I050319 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 24.6 +37.1 37057 5.2 HDGF CLOCK ARNT ZFP64 ARID4B NEUROD1 SIN3A FEZF1 DMAP1 ZNF2 HYAL2 RBM6 RBM5 AMT SEMA3F-AS1 TMEM115 HYAL3 RHOA-IT1 RASSF1 HEMK1
GH03I050234 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 13.5 +114.4 114354 21.2 HDGF FOXA2 PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF213 ZNF207 GNAI2 HYAL3 RBM5 SEMA3F-AS1 RBM6 HYAL1 CYB561D2 RHOA-IT1 AMT HEMK1
GH03I050332 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 13.2 +21.9 21938 9.4 HDGF PKNOX1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 SLC30A9 POLR2B ZNF766 RASSF1 RASSF1-AS1 HYAL3 CYB561D2 RBM6 SEMA3F-AS1 NICN1 RBM5 RHOA-IT1 TMEM115
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TMEM115 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TMEM115 gene promoter:

Genomic Locations for TMEM115 Gene

Genomic Locations for TMEM115 Gene
4,862 bases
Minus strand

Genomic View for TMEM115 Gene

Genes around TMEM115 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM115 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM115 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM115 Gene

Proteins for TMEM115 Gene

  • Protein details for TMEM115 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 115
    Protein Accession:
    Secondary Accessions:
    • A2IDB7
    • O14568
    • Q6IAY4
    • Q9UIX3

    Protein attributes for TMEM115 Gene

    351 amino acids
    Molecular mass:
    38197 Da
    Quaternary structure:
    • Homooligomer (PubMed:24806965). Interacts with COPB1 (PubMed:24806965). May interact with LMAN1 (PubMed:24806965). Interacts with the COG complex; probably through COG3 (PubMed:24806965).
    • Sequence=AAB67308.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for TMEM115 Gene

Post-translational modifications for TMEM115 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM115 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM115 Gene

Domains & Families for TMEM115 Gene

Gene Families for TMEM115 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for TMEM115 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TMEM115 family.
  • Belongs to the TMEM115 family.
genes like me logo Genes that share domains with TMEM115: view

Function for TMEM115 Gene

Molecular function for TMEM115 Gene

UniProtKB/Swiss-Prot Function:
May play a role in retrograde transport of proteins from the Golgi to the endoplasmic reticulum. May indirectly play a role in protein glycosylation in the Golgi.

Phenotypes From GWAS Catalog for TMEM115 Gene

Gene Ontology (GO) - Molecular Function for TMEM115 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 24806965
GO:0042802 identical protein binding IDA 24806965
genes like me logo Genes that share ontologies with TMEM115: view

Phenotypes for TMEM115 Gene

GenomeRNAi human phenotypes for TMEM115:
genes like me logo Genes that share phenotypes with TMEM115: view

Animal Model Products

miRNA for TMEM115 Gene

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM115 Gene

Localization for TMEM115 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM115 Gene

Golgi apparatus, Golgi stack membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM115 gene
Compartment Confidence
nucleus 5
golgi apparatus 5
plasma membrane 3
cytoskeleton 2
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TMEM115 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005634 nucleus IDA 17973242
GO:0005794 Golgi apparatus IDA,IEA 17973242
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM115: view

Pathways & Interactions for TMEM115 Gene

genes like me logo Genes that share pathways with TMEM115: view

Gene Ontology (GO) - Biological Process for TMEM115 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006486 protein glycosylation IMP 24806965
GO:0006810 transport IEA --
GO:0006888 ER to Golgi vesicle-mediated transport TAS --
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER IMP 24806965
GO:0008285 negative regulation of cell proliferation NAS 17973242
genes like me logo Genes that share ontologies with TMEM115: view

No data available for SIGNOR curated interactions for TMEM115 Gene

Drugs & Compounds for TMEM115 Gene

No Compound Related Data Available

Transcripts for TMEM115 Gene

mRNA/cDNA for TMEM115 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(194) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMEM115 Gene

Transmembrane protein 115:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM115 Gene

No ASD Table

Relevant External Links for TMEM115 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM115 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM115 Gene

Protein differential expression in normal tissues from HIPED for TMEM115 Gene

This gene is overexpressed in Placenta (29.3), Testis (27.7), and Blymphocyte (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TMEM115 Gene

Protein tissue co-expression partners for TMEM115 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TMEM115 Gene:


SOURCE GeneReport for Unigene cluster for TMEM115 Gene:


mRNA Expression by UniProt/SwissProt for TMEM115 Gene:

Tissue specificity: Expressed strongly in kidney and skeletal muscle, followed by liver, placenta, pancreas, and lung, with low amounts in heart and only traces in brain (PubMed:11085536). Widely expressed with ubiquitous expression in epithelial tissues (at protein level) (PubMed:17973242).

Evidence on tissue expression from TISSUES for TMEM115 Gene

  • Nervous system(4.6)
  • Liver(4.3)
  • Muscle(4.2)
genes like me logo Genes that share expression patterns with TMEM115: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM115 Gene

Orthologs for TMEM115 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TMEM115 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMEM115 33 34
  • 99.34 (n)
(Mus musculus)
Mammalia Tmem115 34
  • 94 (a)
(Canis familiaris)
Mammalia TMEM115 33 34
  • 92.12 (n)
(Bos Taurus)
Mammalia TMEM115 33 34
  • 91.74 (n)
(Rattus norvegicus)
Mammalia Tmem115 33
  • 88.51 (n)
(Monodelphis domestica)
Mammalia TMEM115 34
  • 83 (a)
(Gallus gallus)
Aves TMEM115 33 34
  • 77.83 (n)
(Anolis carolinensis)
Reptilia TMEM115 34
  • 77 (a)
(Danio rerio)
Actinopterygii tmem115 33 34
  • 65.23 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG9536 34
  • 30 (a)
(Caenorhabditis elegans)
Secernentea F11A10.6 34
  • 24 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 34
  • 19 (a)
-- 36
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G07950 33
  • 45.2 (n)
(Oryza sativa)
Liliopsida Os07g0655400 33
  • 43.65 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8583 34
  • 43 (a)
Species where no ortholog for TMEM115 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TMEM115 Gene

Gene Tree for TMEM115 (if available)
Gene Tree for TMEM115 (if available)

Paralogs for TMEM115 Gene

No data available for Paralogs for TMEM115 Gene

Variants for TMEM115 Gene

Sequence variations from dbSNP and Humsavar for TMEM115 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000111239 -- 50,359,764(-) G/A upstream_transcript_variant
rs1000619900 -- 50,360,067(-) A/G upstream_transcript_variant
rs1001118108 -- 50,361,342(-) T/G upstream_transcript_variant
rs1002140246 -- 50,360,439(-) T/G upstream_transcript_variant
rs1002576811 -- 50,355,036(-) A/G 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM115 Gene

Variant ID Type Subtype PubMed ID
dgv8317n54 CNV loss 21841781
esv3584502 CNV gain 24956385
nsv460531 CNV loss 19166990
nsv470561 CNV loss 18288195
nsv523662 CNV loss 19592680
nsv590255 CNV loss 21841781
nsv834692 CNV loss 17160897
nsv834693 CNV loss 17160897
nsv954855 CNV deletion 24416366

Variation tolerance for TMEM115 Gene

Residual Variation Intolerance Score: 40.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.72; 15.20% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM115 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM115 Gene

Disorders for TMEM115 Gene

Additional Disease Information for TMEM115

No disorders were found for TMEM115 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM115 Gene

Publications for TMEM115 Gene

  1. The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. The International Lung Cancer Chromosome 3p21.3 Tumor Suppressor Gene Consortium. (PMID: 11085536) Lerman MI … Minna JD (Cancer research 2000) 2 3 4 58
  2. TMEM115 is an integral membrane protein of the Golgi complex involved in retrograde transport. (PMID: 24806965) Ong YS … Hong W (Journal of cell science 2014) 3 4 58
  3. Loss of PL6 protein expression in renal clear cell carcinomas and other VHL-deficient tumours. (PMID: 17973242) Ivanova AV … Lerman MI (The Journal of pathology 2008) 3 4 58
  4. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny DM … Gibbs RA (Nature 2006) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for TMEM115 Gene

Sources for TMEM115 Gene

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