Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TMEM110-MUSTN1 Gene

Aliases for TMEM110-MUSTN1 Gene

  • TMEM110-MUSTN1 Readthrough 2 3 5

External Ids for TMEM110-MUSTN1 Gene

Previous GeneCards Identifiers for TMEM110-MUSTN1 Gene

  • GC03U901716
  • GC03M052868
  • GC03M052869
  • GC03M052876

Summaries for TMEM110-MUSTN1 Gene

Entrez Gene Summary for TMEM110-MUSTN1 Gene

  • This locus represents naturally occurring read-through transcription between the neighboring TMEM110 (transmembrane protein 110) and MUSTN1 (musculoskeletal, embryonic nuclear protein 1) genes. The read-through transcript encodes a fusion protein that shares sequence identity with each individual gene product. [provided by RefSeq, Nov 2010]

GeneCards Summary for TMEM110-MUSTN1 Gene

TMEM110-MUSTN1 (TMEM110-MUSTN1 Readthrough) is a Protein Coding gene. An important paralog of this gene is STIMATE.

Additional gene information for TMEM110-MUSTN1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM110-MUSTN1 Gene

Genomics for TMEM110-MUSTN1 Gene

GeneHancer (GH) Regulatory Elements for TMEM110-MUSTN1 Gene

Promoters and enhancers for TMEM110-MUSTN1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I052896 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 550.8 +0.3 292 1.9 HDGF ATF1 RB1 SIN3A ZNF335 GLIS2 ZNF366 SCRT2 ZNF143 ATF7 STIMATE TMEM110-MUSTN1 ITIH4 ITIH3 ENSG00000279144
GH03I052769 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 10.4 +126.7 126694 2.1 HDGF FOXA2 SMAD1 ARID4B SIN3A DMAP1 IRF4 YY1 SLC30A9 POLR2B NEK4 PBRM1 RRP9 RFT1 ITIH3 ITIH4-AS1 ITIH4 ENSG00000243696 SNORD69 GNL3
GH03I052778 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 10.9 +117.8 117835 2.3 PKNOX1 MAX EBF1 YY1 POLR2A ATF7 IKZF2 SMARCA5 ZNF687 RXRA ITIH1 ITIH4 PBRM1 ENSG00000243696 MUSTN1 TMEM110-MUSTN1 STIMATE WDR82 ITIH3
GH03I053071 Enhancer 1.3 FANTOM5 Ensembl ENCODE 10.4 -175.4 -175419 2.3 PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 ETS1 ZNF207 ZNF143 RXRA RFT1 ITIH4 STIMATE ITIH1 TMEM110-MUSTN1 ENSG00000243696 MUSTN1 SFMBT1 DCP1A GC03M053066
GH03I052774 Enhancer 1.1 Ensembl ENCODE 10.1 +121.9 121880 2.2 FOXA2 MLX ARID4B ZNF48 ETS1 YY1 RXRA REST PPARG KAT8 ITIH1 PBRM1 ITIH4-AS1 ITIH4 ENSG00000243696 MUSTN1 STIMATE TMEM110-MUSTN1 ITIH3 NEK4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TMEM110-MUSTN1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for TMEM110-MUSTN1 Gene

Genomic Locations for TMEM110-MUSTN1 Gene
chr3:52,833,115-52,897,581
(GRCh38/hg38)
Size:
64,467 bases
Orientation:
Minus strand
chr3:52,867,131-52,931,597
(GRCh37/hg19)

Genomic View for TMEM110-MUSTN1 Gene

Genes around TMEM110-MUSTN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM110-MUSTN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM110-MUSTN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM110-MUSTN1 Gene

Proteins for TMEM110-MUSTN1 Gene

  • Protein details for TMEM110-MUSTN1 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    A8MSY1
    Recommended name:
    TMEM110-MUSTN1 readthrough
    Protein Accession:
    A8MSY1

    Protein attributes for TMEM110-MUSTN1 Gene

    Size:
    372 amino acids
    Molecular mass:
    41634 Da
    Quaternary structure:
    No Data Available
  • Protein details for TMEM110-MUSTN1 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    H0Y8V1
    Recommended name:
    TMEM110-MUSTN1 readthrough
    Protein Accession:
    H0Y8V1

    Protein attributes for TMEM110-MUSTN1 Gene

    Size:
    148 amino acids
    Molecular mass:
    16632 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM110-MUSTN1 Gene

Protein Expression for TMEM110-MUSTN1 Gene

Post-translational modifications for TMEM110-MUSTN1 Gene

No Post-translational modifications

Other Protein References for TMEM110-MUSTN1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM110-MUSTN1 Gene

Domains & Families for TMEM110-MUSTN1 Gene

Gene Families for TMEM110-MUSTN1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for TMEM110-MUSTN1 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM110-MUSTN1: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for TMEM110-MUSTN1 Gene

Function for TMEM110-MUSTN1 Gene

Phenotypes From GWAS Catalog for TMEM110-MUSTN1 Gene

Phenotypes for TMEM110-MUSTN1 Gene

genes like me logo Genes that share phenotypes with TMEM110-MUSTN1: view

Animal Models for TMEM110-MUSTN1 Gene

MGI Knock Outs for TMEM110-MUSTN1:

Animal Model Products

CRISPR Products

miRNA for TMEM110-MUSTN1 Gene

miRTarBase miRNAs that target TMEM110-MUSTN1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TMEM110-MUSTN1 Gene

Localization for TMEM110-MUSTN1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM110-MUSTN1 gene
Compartment Confidence
plasma membrane 3

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TMEM110-MUSTN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM110-MUSTN1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TMEM110-MUSTN1 Gene

Pathways & Interactions for TMEM110-MUSTN1 Gene

SuperPathways for TMEM110-MUSTN1 Gene

No Data Available

Interacting Proteins for TMEM110-MUSTN1 Gene

Gene Ontology (GO) - Biological Process for TMEM110-MUSTN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035988 chondrocyte proliferation IEA --
GO:0042246 tissue regeneration IEA --
genes like me logo Genes that share ontologies with TMEM110-MUSTN1: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM110-MUSTN1 Gene

Drugs & Compounds for TMEM110-MUSTN1 Gene

No Compound Related Data Available

Transcripts for TMEM110-MUSTN1 Gene

mRNA/cDNA for TMEM110-MUSTN1 Gene

(1) REFSEQ mRNAs :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM110-MUSTN1 Gene

No ASD Table

Relevant External Links for TMEM110-MUSTN1 Gene

GeneLoc Exon Structure for
TMEM110-MUSTN1
ECgene alternative splicing isoforms for
TMEM110-MUSTN1

Expression for TMEM110-MUSTN1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM110-MUSTN1 Gene

mRNA expression in normal human tissues for TMEM110-MUSTN1 Gene

Protein differential expression in normal tissues from HIPED for TMEM110-MUSTN1 Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from MOPED for TMEM110-MUSTN1 Gene



Protein tissue co-expression partners for TMEM110-MUSTN1 Gene

genes like me logo Genes that share expression patterns with TMEM110-MUSTN1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM110-MUSTN1 Gene

Orthologs for TMEM110-MUSTN1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TMEM110-MUSTN1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM110 33 34
  • 99.32 (n)
cow
(Bos Taurus)
Mammalia TMEM110 33 34
  • 93.65 (n)
dog
(Canis familiaris)
Mammalia -- 34
  • 92 (a)
OneToMany
TMEM110 33
  • 90.31 (n)
mouse
(Mus musculus)
Mammalia Tmem110 33 16 34
  • 91.75 (n)
rat
(Rattus norvegicus)
Mammalia Tmem110 33
  • 90.36 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 88 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 86 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 34
  • 80 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 86 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem110.2 33
  • 72.01 (n)
zebrafish
(Danio rerio)
Actinopterygii tmem110 33 34
  • 71.77 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008662 33
  • 53.41 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 34
  • 26 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 41 (a)
OneToMany
Species where no ortholog for TMEM110-MUSTN1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM110-MUSTN1 Gene

ENSEMBL:
Gene Tree for TMEM110-MUSTN1 (if available)
TreeFam:
Gene Tree for TMEM110-MUSTN1 (if available)

Paralogs for TMEM110-MUSTN1 Gene

Paralogs for TMEM110-MUSTN1 Gene

(2) SIMAP similar genes for TMEM110-MUSTN1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TMEM110-MUSTN1: view

Variants for TMEM110-MUSTN1 Gene

Sequence variations from dbSNP and Humsavar for TMEM110-MUSTN1 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000004747 -- 52,842,960(-) C/A coding_sequence_variant, missense_variant
rs1000017797 -- 52,851,605(-) C/A intron_variant
rs1000030087 -- 52,840,397(-) G/A intron_variant
rs1000090614 -- 52,834,354(-) C/T intron_variant
rs1000117991 -- 52,846,084(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM110-MUSTN1 Gene

Variant ID Type Subtype PubMed ID
nsv834698 CNV gain 17160897
nsv508928 CNV insertion 20534489
esv3596163 CNV gain 21293372
esv2762328 CNV loss 21179565

Variation tolerance for TMEM110-MUSTN1 Gene

Residual Variation Intolerance Score: 51.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.30; 25.90% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM110-MUSTN1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM110-MUSTN1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM110-MUSTN1 Gene

Disorders for TMEM110-MUSTN1 Gene

Additional Disease Information for TMEM110-MUSTN1

No disorders were found for TMEM110-MUSTN1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM110-MUSTN1 Gene

Publications for TMEM110-MUSTN1 Gene

  1. Biological insights from 108 schizophrenia-associated genetic loci. (PMID: 25056061) Schizophrenia Working Group of the Psychiatric Genomics Consortium (Nature 2014) 3 58
  2. Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients. (PMID: 22610502) Kennedy RB … Poland GA (Human genetics 2012) 3 58
  3. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T … Taylor TD (PloS one 2010) 3 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for TMEM110-MUSTN1 Gene

Sources for TMEM110-MUSTN1 Gene

Content
Loading form....