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Aliases for TMEM11 Gene

Aliases for TMEM11 Gene

  • Transmembrane Protein 11 2 3 5
  • C17orf35 3 4
  • PM1 3 4
  • Transmembrane Protein 11, Mitochondrial 3
  • Chromosome 17 Open Reading Frame 35 2
  • Putative Receptor Protein 3
  • Protein PM1 4
  • Protein PMI 4
  • PMI 3

External Ids for TMEM11 Gene

Previous HGNC Symbols for TMEM11 Gene

  • C17orf35

Previous GeneCards Identifiers for TMEM11 Gene

  • GC17M021042
  • GC17M020303

Summaries for TMEM11 Gene

GeneCards Summary for TMEM11 Gene

TMEM11 (Transmembrane Protein 11) is a Protein Coding gene. Diseases associated with TMEM11 include Penicilliosis.

UniProtKB/Swiss-Prot for TMEM11 Gene

  • Plays a role in mitochondrial morphogenesis.

Additional gene information for TMEM11 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM11 Gene

Genomics for TMEM11 Gene

GeneHancer (GH) Regulatory Elements for TMEM11 Gene

Promoters and enhancers for TMEM11 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I021208 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 561.4 +1.9 1886 7.6 PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 ZNF207 ZNF143 TMEM11 ENSG00000235530 DHRS7B FAM106B NATD1 GC17M021160
GH17I021252 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 12.7 -38.7 -38719 1.9 ARID4B SIN3A FEZF1 ZNF121 GLIS2 ZNF213 NFYC REST SNIP1 GLIS1 NATD1 ENSG00000235530 TMEM11 PIR52097
GH17I021126 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 9.1 +87.5 87529 2.8 PKNOX1 FOXA2 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF207 FOS DHRS7B TMEM11 MAP2K3 KCNJ18 NATD1 GC17M021160
GH17I021198 Enhancer 1.1 Ensembl ENCODE dbSUPER 12 +14.2 14181 3.2 HDAC1 KLF1 TEAD4 BACH1 FOSL1 GATA3 ZNF766 ZNF316 SCRT2 RCOR1 DHRS7B TMEM11 FAM106B ENSG00000235530 GC17M021160
GH17I021257 Enhancer 1 Ensembl ENCODE 12.3 -42.6 -42577 0.4 HDAC1 NFIB INSM2 FEZF1 ZNF366 ZSCAN5C FOS SMARCA5 ZNF362 SP3 MAP2K3 ENSG00000235530 TMEM11 DHRS7B EIF1P5 NATD1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TMEM11 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TMEM11 gene promoter:

Genomic Locations for TMEM11 Gene

Genomic Locations for TMEM11 Gene
17,345 bases
Minus strand

Genomic View for TMEM11 Gene

Genes around TMEM11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM11 Gene

Proteins for TMEM11 Gene

  • Protein details for TMEM11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 11, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • Q53YB2

    Protein attributes for TMEM11 Gene

    192 amino acids
    Molecular mass:
    21541 Da
    Quaternary structure:
    • Associates with the mitochondrial contact site and cristae organizing system (MICOS) complex, composed of at least MINOS1/MIC10, CHCHD3/MIC19, CHCHD6/MIC25, APOOL/MIC27, IMMT/MIC60, APOO/MIC23/MIC26 and QIL1/MIC13. This complex was also known under the names MINOS or MitOS complex. The MICOS complex associates with mitochondrial outer membrane proteins SAMM50, MTX1, MTX2 and DNAJC11, mitochondrial inner membrane protein TMEM11 and with HSPA9. Interacts with IMMT/MIC60.

neXtProt entry for TMEM11 Gene

Post-translational modifications for TMEM11 Gene

  • Ubiquitination at isoforms=142
  • Modification sites at PhosphoSitePlus

Other Protein References for TMEM11 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM11 Gene

Domains & Families for TMEM11 Gene

Gene Families for TMEM11 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TMEM11 Gene


Suggested Antigen Peptide Sequences for TMEM11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TMEM11 family.
  • Belongs to the TMEM11 family.
genes like me logo Genes that share domains with TMEM11: view

Function for TMEM11 Gene

Molecular function for TMEM11 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in mitochondrial morphogenesis.

Phenotypes From GWAS Catalog for TMEM11 Gene

Gene Ontology (GO) - Molecular Function for TMEM11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with TMEM11: view
genes like me logo Genes that share phenotypes with TMEM11: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM11 Gene

Localization for TMEM11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM11 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM11 gene
Compartment Confidence
plasma membrane 5
mitochondrion 5
peroxisome 2
nucleus 1
endoplasmic reticulum 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TMEM11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA,IDA --
GO:0005743 mitochondrial inner membrane IEA --
GO:0005887 integral component of plasma membrane NAS 2110658
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM11: view

Pathways & Interactions for TMEM11 Gene

SuperPathways for TMEM11 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMEM11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007005 mitochondrion organization IMP 21274005
genes like me logo Genes that share ontologies with TMEM11: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM11 Gene

Drugs & Compounds for TMEM11 Gene

(1) Drugs for TMEM11 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with TMEM11: view

Transcripts for TMEM11 Gene

Unigene Clusters for TMEM11 Gene

Transmembrane protein 11:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM11 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c
SP1: -
SP3: - -
SP4: - - -

Relevant External Links for TMEM11 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM11 Gene

mRNA differential expression in normal tissues according to GTEx for TMEM11 Gene

This gene is overexpressed in Muscle - Skeletal (x4.6).

Protein differential expression in normal tissues from HIPED for TMEM11 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TMEM11 Gene

Protein tissue co-expression partners for TMEM11 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TMEM11 Gene:


SOURCE GeneReport for Unigene cluster for TMEM11 Gene:


Evidence on tissue expression from TISSUES for TMEM11 Gene

  • Nervous system(4.5)
  • Kidney(4.4)
  • Liver(4.4)
  • Muscle(2.4)
  • Intestine(2.3)
  • Lymph node(2.2)
genes like me logo Genes that share expression patterns with TMEM11: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM11 Gene

Orthologs for TMEM11 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM11 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMEM11 33 34
  • 100 (n)
(Monodelphis domestica)
Mammalia TMEM11 34
  • 97 (a)
(Ornithorhynchus anatinus)
Mammalia TMEM11 34
  • 97 (a)
(Canis familiaris)
Mammalia TMEM11 33 34
  • 94.79 (n)
(Rattus norvegicus)
Mammalia Tmem11 33
  • 91.93 (n)
(Bos Taurus)
Mammalia TMEM11 33 34
  • 91.67 (n)
(Mus musculus)
Mammalia Tmem11 33 16 34
  • 91.23 (n)
(Gallus gallus)
Aves TMEM11 33 34
  • 87.5 (n)
(Anolis carolinensis)
Reptilia TMEM11 34
  • 90 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem11 33
  • 80.04 (n)
Str.6511 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.14927 33
(Danio rerio)
Actinopterygii tmem11 33 34
  • 78.43 (n)
Dr.16878 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10266 33
fruit fly
(Drosophila melanogaster)
Insecta Pmi 33 34
  • 54.78 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005550 33
  • 51.61 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11331 34
  • 49 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13940 33
Species where no ortholog for TMEM11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM11 Gene

Gene Tree for TMEM11 (if available)
Gene Tree for TMEM11 (if available)

Paralogs for TMEM11 Gene

No data available for Paralogs for TMEM11 Gene

Variants for TMEM11 Gene

Sequence variations from dbSNP and Humsavar for TMEM11 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000091112 -- 21,208,912(-) G/A intron_variant
rs1000155343 -- 21,207,658(-) C/T intron_variant
rs1000229106 -- 21,202,992(-) G/A intron_variant
rs1000239197 -- 21,203,226(-) A/T intron_variant
rs1000351856 -- 21,210,927(-) T/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM11 Gene

Variant ID Type Subtype PubMed ID
esv2665619 CNV deletion 23128226
esv3554255 CNV deletion 23714750
esv3582570 CNV loss 25503493
esv3640229 CNV loss 21293372
nsv1059146 CNV gain 25217958
nsv1059210 CNV gain 25217958
nsv1078306 OTHER inversion 25765185

Variation tolerance for TMEM11 Gene

Residual Variation Intolerance Score: 23.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.28; 6.24% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM11 Gene

Disorders for TMEM11 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TMEM11 Gene - From: DISEASES

Disorder Aliases PubMed IDs
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TMEM11

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TMEM11: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TMEM11 Gene

Publications for TMEM11 Gene

  1. Inner-membrane proteins PMI/TMEM11 regulate mitochondrial morphogenesis independently of the DRP1/MFN fission/fusion pathways. (PMID: 21274005) Rival T … Royet J (EMBO reports 2011) 2 3 4 58
  2. Nucleotide sequence of a cDNA encoding a protein with primary structural similarity to G-protein coupled receptors. (PMID: 2110658) Murphy PM … Malech HL (Nucleic acids research 1990) 2 3 4 58
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for TMEM11 Gene

Sources for TMEM11 Gene

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