Aliases for TMEM109 Gene

Aliases for TMEM109 Gene

  • Transmembrane Protein 109 2 3 4 5
  • Mitsugumin-23 3 4
  • Mg23 3 4
  • TMEM109 5
  • MGC5508 2

External Ids for TMEM109 Gene

Previous GeneCards Identifiers for TMEM109 Gene

  • GC11P060439
  • GC11P060681
  • GC11P057027

Summaries for TMEM109 Gene

GeneCards Summary for TMEM109 Gene

TMEM109 (Transmembrane Protein 109) is a Protein Coding gene.

UniProtKB/Swiss-Prot Summary for TMEM109 Gene

  • May mediate cellular response to DNA damage by protecting against ultraviolet C-induced cell death (PubMed:23542032). Can form voltage-gated calcium and potassium channels in vitro (By similarity).

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TMEM109 Gene

Genomics for TMEM109 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TMEM109 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TMEM109 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TMEM109

Top Transcription factor binding sites by QIAGEN in the TMEM109 gene promoter:
  • AP-4
  • COUP
  • COUP-TF
  • COUP-TF1
  • CREB
  • deltaCREB
  • HNF-4alpha1
  • Lmo2

Genomic Locations for TMEM109 Gene

Latest Assembly
chr11:60,914,158-60,923,443
(GRCh38/hg38)
Size:
9,286 bases
Orientation:
Plus strand

Previous Assembly
chr11:60,681,630-60,690,915
(GRCh37/hg19 by Entrez Gene)
Size:
9,286 bases
Orientation:
Plus strand

chr11:60,681,346-60,690,915
(GRCh37/hg19 by Ensembl)
Size:
9,570 bases
Orientation:
Plus strand

Genomic View for TMEM109 Gene

Genes around TMEM109 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM109 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM109 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM109 Gene

Proteins for TMEM109 Gene

  • Protein details for TMEM109 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BVC6-TM109_HUMAN
    Recommended name:
    Transmembrane protein 109
    Protein Accession:
    Q9BVC6

    Protein attributes for TMEM109 Gene

    Size:
    243 amino acids
    Molecular mass:
    26210 Da
    Quaternary structure:
    • Homooligomer (By similarity). Interacts with CRYAB (PubMed:23542032).

neXtProt entry for TMEM109 Gene

Post-translational modifications for TMEM109 Gene

  • Ubiquitination at Lys215
  • Modification sites at PhosphoSitePlus

Other Protein References for TMEM109 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM109 Gene

Domains & Families for TMEM109 Gene

Gene Families for TMEM109 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for TMEM109 Gene

InterPro:

Suggested Antigen Peptide Sequences for TMEM109 Gene

GenScript: Design optimal peptide antigens:
  • Mitsugumin-23 (TM109_HUMAN)
genes like me logo Genes that share domains with TMEM109: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for TMEM109 Gene

Function for TMEM109 Gene

Molecular function for TMEM109 Gene

UniProtKB/Swiss-Prot Function:
May mediate cellular response to DNA damage by protecting against ultraviolet C-induced cell death (PubMed:23542032). Can form voltage-gated calcium and potassium channels in vitro (By similarity).

Phenotypes From GWAS Catalog for TMEM109 Gene

Gene Ontology (GO) - Molecular Function for TMEM109 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005244 voltage-gated ion channel activity IEA --
GO:0005515 protein binding IPI 32296183
genes like me logo Genes that share ontologies with TMEM109: view
genes like me logo Genes that share phenotypes with TMEM109: view

Animal Models for TMEM109 Gene

MGI Knock Outs for TMEM109:

miRNA for TMEM109 Gene

miRTarBase miRNAs that target TMEM109

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMEM109

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TMEM109 Gene

Localization for TMEM109 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM109 Gene

Nucleus outer membrane. Multi-pass membrane protein. Endoplasmic reticulum membrane. Multi-pass membrane protein. Sarcoplasmic reticulum membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM109 gene
Compartment Confidence
extracellular 4
nucleus 4
endoplasmic reticulum 4
plasma membrane 2
cytosol 2
cytoskeleton 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nuclear membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TMEM109 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005640 nuclear outer membrane IEA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with TMEM109: view

Pathways & Interactions for TMEM109 Gene

PathCards logo

SuperPathways for TMEM109 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMEM109 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport IEA --
GO:0034220 ion transmembrane transport IEA --
GO:0034765 regulation of ion transmembrane transport IEA --
GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IBA 21873635
GO:0060548 negative regulation of cell death IMP 23542032
genes like me logo Genes that share ontologies with TMEM109: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM109 Gene

Drugs & Compounds for TMEM109 Gene

No Compound Related Data Available

Transcripts for TMEM109 Gene

mRNA/cDNA for TMEM109 Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMEM109

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM109 Gene

No ASD Table

Relevant External Links for TMEM109 Gene

GeneLoc Exon Structure for
TMEM109

Expression for TMEM109 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TMEM109 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TMEM109 Gene

This gene is overexpressed in Nasal epithelium (24.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TMEM109 Gene



Protein tissue co-expression partners for TMEM109 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TMEM109

SOURCE GeneReport for Unigene cluster for TMEM109 Gene:

Hs.13662

Evidence on tissue expression from TISSUES for TMEM109 Gene

  • Blood(4.2)
  • Nervous system(3.4)
  • Skin(3.3)
  • Muscle(2.5)
  • Kidney(2.1)
genes like me logo Genes that share expression patterns with TMEM109: view

Primer products for research

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM109 Gene

Orthologs for TMEM109 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM109 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TMEM109 29 30
  • 99.45 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia TMEM109 29 30
  • 86.56 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia TMEM109 29 30
  • 85.46 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Tmem109 29
  • 79.7 (n)
Mouse
(Mus musculus)
Mammalia Tmem109 29 16 30
  • 78.74 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia TMEM109 30
  • 69 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia TMEM109 30
  • 59 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia TMEM109 30
  • 44 (a)
OneToOne
Species where no ortholog for TMEM109 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for TMEM109 Gene

ENSEMBL:
Gene Tree for TMEM109 (if available)
TreeFam:
Gene Tree for TMEM109 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TMEM109: view image
Alliance of Genome Resources:
Additional Orthologs for TMEM109

Paralogs for TMEM109 Gene

No data available for Paralogs for TMEM109 Gene

Variants for TMEM109 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for TMEM109 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Variation tolerance for TMEM109 Gene

Residual Variation Intolerance Score: 38.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.68; 32.09% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM109 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM109
Leiden Open Variation Database (LOVD)
TMEM109

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Structural Variations from Database of Genomic Variants (DGV) for TMEM109 Gene

Disorders for TMEM109 Gene

Additional Disease Information for TMEM109

No disorders were found for TMEM109 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM109 Gene

Publications for TMEM109 Gene

  1. Protective role of the endoplasmic reticulum protein mitsugumin23 against ultraviolet C-induced cell death. (PMID: 23542032) Yamashita A … Yamazaki T (FEBS letters 2013) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. Large-scale concatenation cDNA sequencing. (PMID: 9110174) Yu W … Gibbs RA (Genome research 1997) 2 3
  4. A "double adaptor" method for improved shotgun library construction. (PMID: 8619474) Andersson B … Gibbs RA (Analytical biochemistry 1996) 2 3
  5. Wnt regulation: exploring Axin-Disheveled interactions and defining mechanisms by which the SCF E3 ubiquitin ligase is recruited to the destruction complex. (PMID: 32129710) Schaefer KN … Peifer M (Molecular biology of the cell 2020) 3

Products for TMEM109 Gene

  • Biorbyt antibodies for TMEM109

Sources for TMEM109 Gene