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Aliases for TMEM108 Gene

Aliases for TMEM108 Gene

  • Transmembrane Protein 108 2 3 5
  • Cancer/Testis Antigen 124 2 3
  • Retrolinkin 3 4
  • RTLN 3 4
  • KIAA1690 4
  • CT124 3

External Ids for TMEM108 Gene

Previous GeneCards Identifiers for TMEM108 Gene

  • GC03P134240
  • GC03P132757
  • GC03P130137

Summaries for TMEM108 Gene

GeneCards Summary for TMEM108 Gene

TMEM108 (Transmembrane Protein 108) is a Protein Coding gene.

UniProtKB/Swiss-Prot for TMEM108 Gene

  • Transmembrane protein required for proper cognitive functions. Involved in the development of dentate gyrus (DG) neuron circuitry, is neccessary for AMPA receptors surface expression and proper excitatory postsynaptic currents of DG granule neurons. Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. Through the interaction with DST, mediates the docking of the dynein/dynactin motor complex to vesicle cargos for retrograde axonal transport. In hippocampal neurons, required for BDNF-dependent dendrite outgrowth. Cooperates with SH3GL2 and recruits the WAVE1 complex to facilitate actin-dependent BDNF:NTRK2 early endocytic trafficking and mediate signaling from early endosomes.

Additional gene information for TMEM108 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM108 Gene

Genomics for TMEM108 Gene

GeneHancer (GH) Regulatory Elements for TMEM108 Gene

Promoters and enhancers for TMEM108 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I133037 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 550.8 +0.1 62 1.5 PKNOX1 ATF1 ZNF133 ZNF2 ZNF335 FOS CREM USF2 REST ZNF398 TMEM108 ENSG00000249725 TMEM108-AS1
GH03I133124 Promoter 0.6 EPDnew 560.1 +86.6 86553 0.1 RFX1 TMEM108 ENSG00000249725 BFSP2 TMEM108-AS1
GH03I133181 Promoter 0.5 EPDnew 550.1 +142.7 142748 0.1 TMEM108 TMEM108-AS1
GH03I133384 Enhancer 0.7 ENCODE 11 +346.4 346354 0.2 CTCF MXI1 ZSCAN26 NFIB RAD21 ZNF335 SMC3 ZNF143 PRDM10 RCOR1 LOC101927432 ENSG00000249725 TMEM108 TFP1 TMEM108-AS1 GC03M133285
GH03I133300 Enhancer 0.5 ENCODE 10 +263.1 263133 1.9 JUND ZNF157 JUN FOS GC03M133285 TMEM108-AS1 ENSG00000249725 TMEM108
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TMEM108 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TMEM108 gene promoter:

Genomic Locations for TMEM108 Gene

Genomic Locations for TMEM108 Gene
chr3:133,038,288-133,397,792
(GRCh38/hg38)
Size:
359,505 bases
Orientation:
Plus strand
chr3:132,757,171-133,116,636
(GRCh37/hg19)

Genomic View for TMEM108 Gene

Genes around TMEM108 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM108 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM108 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM108 Gene

Proteins for TMEM108 Gene

  • Protein details for TMEM108 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UXF1-TM108_HUMAN
    Recommended name:
    Transmembrane protein 108
    Protein Accession:
    Q6UXF1
    Secondary Accessions:
    • D3DNC9
    • Q9BQH1
    • Q9BW81
    • Q9C0H3

    Protein attributes for TMEM108 Gene

    Size:
    575 amino acids
    Molecular mass:
    59948 Da
    Quaternary structure:
    • Interacts with DST (isoform 1). Interacts with SH3GL2. Interacts (via N-terminus) with CYFIP1 and CYFIP2; the interactions associate TMEM108 with the WAVE1 complex.

    Alternative splice isoforms for TMEM108 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM108 Gene

Post-translational modifications for TMEM108 Gene

No data available for DME Specific Peptides for TMEM108 Gene

Domains & Families for TMEM108 Gene

Gene Families for TMEM108 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for TMEM108 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM108 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM108: view

No data available for UniProtKB/Swiss-Prot for TMEM108 Gene

Function for TMEM108 Gene

Molecular function for TMEM108 Gene

UniProtKB/Swiss-Prot Function:
Transmembrane protein required for proper cognitive functions. Involved in the development of dentate gyrus (DG) neuron circuitry, is neccessary for AMPA receptors surface expression and proper excitatory postsynaptic currents of DG granule neurons. Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. Through the interaction with DST, mediates the docking of the dynein/dynactin motor complex to vesicle cargos for retrograde axonal transport. In hippocampal neurons, required for BDNF-dependent dendrite outgrowth. Cooperates with SH3GL2 and recruits the WAVE1 complex to facilitate actin-dependent BDNF:NTRK2 early endocytic trafficking and mediate signaling from early endosomes.

Phenotypes From GWAS Catalog for TMEM108 Gene

Gene Ontology (GO) - Molecular Function for TMEM108 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with TMEM108: view
genes like me logo Genes that share phenotypes with TMEM108: view

Animal Models for TMEM108 Gene

MGI Knock Outs for TMEM108:

Animal Model Products

miRNA for TMEM108 Gene

miRTarBase miRNAs that target TMEM108

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TMEM108 Gene

Localization for TMEM108 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM108 Gene

Membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Endosome membrane. Cell projection, axon. Cell projection, dendrite. Early endosome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM108 gene
Compartment Confidence
endosome 4
plasma membrane 3
extracellular 2
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoli (2)
  • Plasma membrane (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TMEM108 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005768 endosome IEA --
GO:0005769 early endosome ISS --
GO:0005886 plasma membrane IEA --
GO:0010008 endosome membrane ISS --
genes like me logo Genes that share ontologies with TMEM108: view

Pathways & Interactions for TMEM108 Gene

SuperPathways for TMEM108 Gene

No Data Available

Interacting Proteins for TMEM108 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000324651%0d%0a9606.ENSP00000263388%0d%0a
Selected Interacting proteins: Q6UXF1-TM108_HUMAN ENSP00000324651 for TMEM108 Gene via MINT STRING IID

Gene Ontology (GO) - Biological Process for TMEM108 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006898 receptor-mediated endocytosis ISS --
GO:0008090 retrograde axonal transport ISS --
GO:0008150 biological_process ND --
GO:0021542 dentate gyrus development ISS --
GO:0031175 neuron projection development ISS --
genes like me logo Genes that share ontologies with TMEM108: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM108 Gene

Drugs & Compounds for TMEM108 Gene

No Compound Related Data Available

Transcripts for TMEM108 Gene

Unigene Clusters for TMEM108 Gene

Transmembrane protein 108:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM108 Gene

No ASD Table

Relevant External Links for TMEM108 Gene

GeneLoc Exon Structure for
TMEM108
ECgene alternative splicing isoforms for
TMEM108

Expression for TMEM108 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM108 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TMEM108 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TMEM108 Gene



Protein tissue co-expression partners for TMEM108 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TMEM108 Gene:

TMEM108

SOURCE GeneReport for Unigene cluster for TMEM108 Gene:

Hs.191616

Evidence on tissue expression from TISSUES for TMEM108 Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with TMEM108: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM108 Gene

Orthologs for TMEM108 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM108 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM108 33 34
  • 99.61 (n)
dog
(Canis familiaris)
Mammalia TMEM108 33 34
  • 87.4 (n)
cow
(Bos Taurus)
Mammalia LOC511034 33
  • 85.66 (n)
TMEM108 34
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem108 33
  • 81.47 (n)
mouse
(Mus musculus)
Mammalia Tmem108 33 16 34
  • 81.24 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM108 34
  • 45 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM108 33 34
  • 63.04 (n)
lizard
(Anolis carolinensis)
Reptilia TMEM108 34
  • 51 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem108 33
  • 62.03 (n)
zebrafish
(Danio rerio)
Actinopterygii tmem108 34
  • 26 (a)
OneToOne
Dr.10185 33
Species where no ortholog for TMEM108 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM108 Gene

ENSEMBL:
Gene Tree for TMEM108 (if available)
TreeFam:
Gene Tree for TMEM108 (if available)

Paralogs for TMEM108 Gene

No data available for Paralogs for TMEM108 Gene

Variants for TMEM108 Gene

Sequence variations from dbSNP and Humsavar for TMEM108 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000018591 -- 133,178,063(+) A/G intron_variant
rs1000032053 -- 133,146,693(+) G/A intron_variant
rs1000051906 -- 133,339,237(+) A/G intron_variant
rs1000069744 -- 133,045,929(+) A/T 5_prime_UTR_variant, genic_upstream_transcript_variant
rs1000070370 -- 133,089,514(+) AT/ genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM108 Gene

Variant ID Type Subtype PubMed ID
nsv591801 CNV loss 21841781
nsv591799 CNV gain 21841781
nsv514168 CNV gain+loss 21397061
nsv460857 CNV loss 19166990
nsv4016 CNV deletion 18451855
nsv1139161 CNV deletion 24896259
nsv1118704 CNV duplication 24896259
nsv1014344 CNV loss 25217958
esv9637 CNV gain 19470904
esv3597841 CNV loss 21293372
esv3597840 CNV loss 21293372
esv3597838 CNV loss 21293372
esv3562566 CNV deletion 23714750
esv3360224 CNV duplication 20981092
esv32760 CNV loss 17666407
esv28544 CNV loss 19812545
esv2760760 CNV loss 21179565
esv2759179 CNV loss 17122850
esv2725937 CNV deletion 23290073
esv2725936 CNV deletion 23290073
esv2669013 CNV deletion 23128226
esv2659873 CNV deletion 23128226
esv2635909 CNV insertion 19546169
dgv4902n100 CNV loss 25217958
dgv2603n106 CNV deletion 24896259

Variation tolerance for TMEM108 Gene

Residual Variation Intolerance Score: 38.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.97; 49.50% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM108 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM108

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM108 Gene

Disorders for TMEM108 Gene

Additional Disease Information for TMEM108

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for TMEM108 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM108 Gene

Publications for TMEM108 Gene

  1. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 2 3 4 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. (PMID: 21102462) Elks CE … Murray A (Nature genetics 2010) 3 44 58
  4. Molecular genetics of successful smoking cessation: convergent genome-wide association study results. (PMID: 18519826) Uhl GR … Lerman C (Archives of general psychiatry 2008) 3 44 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for TMEM108 Gene

Sources for TMEM108 Gene

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